Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid- β clearance in animal models of Alzheimer’s disease

Age-dependent accumulation of amyloid plaques in patients with sporadic Alzheimer ’s disease (AD) is associated with reduced amyloid clearance. Older microglia have a reduced ability to phagocytose amyloid, so ...

Source: Molecular Neurodegeneration - March 16, 2024 Category: Neurology Authors: Hyo Jung Shin, In Soo Kim, Seung Gyu Choi, Kayoung Lee, Hyewon Park, Juhee Shin, Dayoung Kim, Jaewon Beom, Yoon Young Yi, Deepak Prasad Gupta, Gyun Jee Song, Won-Suk Chung, C. Justin Lee and Dong Woon Kim Tags: Research article Source Type: research