Revisiting airway epithelial dysfunction and mechanisms in chronic obstructive pulmonary disease: Role of mitochondrial damage
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 16. doi: 10.1152/ajplung.00362.2023. Online ahead of print.ABSTRACTChronic exposure to environmental hazards causes airway epithelial dysfunction, primarily impaired physical barriers, immune dysfunction, and repair or regeneration. Impairment of airway epithelial function subsequently leads to exaggerated airway inflammation and remodeling, the main features of chronic obstructive pulmonary disease (COPD). Mitochondrial damage has been identified as one of the mechanisms of airway abnormalities in COPD, which is closely related to airway inflammation and airflow limitation. In ...
Source: Am J Physiol Lung Ce... - April 16, 2024 Category: Respiratory Medicine Authors: Qinglan He Peijun Li Lihua Han Chen Yang Meiling Jiang Yingqi Wang Xiaoyu Han Yuanyuan Cao Xiaodan Liu Weibing Wu Source Type: research
A systematic review on the biochemical threshold of mitochondrial genetic variants
Genome Res. 2024 Apr 16. doi: 10.1101/gr.278200.123. Online ahead of print.ABSTRACTMitochondrial DNA (mtDNA) variants cause a range of diseases from severe pediatric syndromes to aging-related conditions. The percentage of mtDNA copies carrying a pathogenic variant, variant allele frequency (VAF), must reach a threshold before a biochemical defect occurs, termed the biochemical threshold. Whether the often-cited biochemical threshold of >60% VAF is similar across mtDNA variants and cell types is unclear. In our systematic review, we sought to identify the biochemical threshold of mtDNA variants in relation to VAF by hum...
Source: Cell Research - April 16, 2024 Category: Cytology Authors: Karan K Smith Jesse D Moreira Callum R Wilson June O Padera Ashlee N Lamason Liying Xue Deepa M Gopal David B Flynn Jessica L Fetterman Source Type: research
Revisiting airway epithelial dysfunction and mechanisms in chronic obstructive pulmonary disease: Role of mitochondrial damage
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 16. doi: 10.1152/ajplung.00362.2023. Online ahead of print.ABSTRACTChronic exposure to environmental hazards causes airway epithelial dysfunction, primarily impaired physical barriers, immune dysfunction, and repair or regeneration. Impairment of airway epithelial function subsequently leads to exaggerated airway inflammation and remodeling, the main features of chronic obstructive pulmonary disease (COPD). Mitochondrial damage has been identified as one of the mechanisms of airway abnormalities in COPD, which is closely related to airway inflammation and airflow limitation. In ...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - April 16, 2024 Category: Cytology Authors: Qinglan He Peijun Li Lihua Han Chen Yang Meiling Jiang Yingqi Wang Xiaoyu Han Yuanyuan Cao Xiaodan Liu Weibing Wu Source Type: research
A crazy trio in Parkinson's disease: metabolism alteration, α-synuclein aggregation, and oxidative stress
Mol Cell Biochem. 2024 Apr 16. doi: 10.1007/s11010-024-04985-3. Online ahead of print.ABSTRACTParkinson's disease (PD) is an aging-associated neurodegenerative disorder, characterized by the progressive loss of dopaminergic neurons in the pars compacta of the substantia nigra and the presence of Lewy bodies containing α-synuclein within these neurons. Oligomeric α-synuclein exerts neurotoxic effects through mitochondrial dysfunction, glial cell inflammatory response, lysosomal dysfunction and so on. α-synuclein aggregation, often accompanied by oxidative stress, is generally considered to be a key factor in PD pathology...
Source: Molecular and Cellular Biochemistry - April 16, 2024 Category: Biochemistry Authors: Sheng Li Yanbing Liu Sen Lu Jiayi Xu Xiaokun Liu Di Yang Yuxuan Yang Lin Hou Ning Li Source Type: research
Revisiting airway epithelial dysfunction and mechanisms in chronic obstructive pulmonary disease: Role of mitochondrial damage
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 16. doi: 10.1152/ajplung.00362.2023. Online ahead of print.ABSTRACTChronic exposure to environmental hazards causes airway epithelial dysfunction, primarily impaired physical barriers, immune dysfunction, and repair or regeneration. Impairment of airway epithelial function subsequently leads to exaggerated airway inflammation and remodeling, the main features of chronic obstructive pulmonary disease (COPD). Mitochondrial damage has been identified as one of the mechanisms of airway abnormalities in COPD, which is closely related to airway inflammation and airflow limitation. In ...
Source: Am J Physiol Lung Ce... - April 16, 2024 Category: Respiratory Medicine Authors: Qinglan He Peijun Li Lihua Han Chen Yang Meiling Jiang Yingqi Wang Xiaoyu Han Yuanyuan Cao Xiaodan Liu Weibing Wu Source Type: research
Revisiting airway epithelial dysfunction and mechanisms in chronic obstructive pulmonary disease: Role of mitochondrial damage
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 16. doi: 10.1152/ajplung.00362.2023. Online ahead of print.ABSTRACTChronic exposure to environmental hazards causes airway epithelial dysfunction, primarily impaired physical barriers, immune dysfunction, and repair or regeneration. Impairment of airway epithelial function subsequently leads to exaggerated airway inflammation and remodeling, the main features of chronic obstructive pulmonary disease (COPD). Mitochondrial damage has been identified as one of the mechanisms of airway abnormalities in COPD, which is closely related to airway inflammation and airflow limitation. In ...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - April 16, 2024 Category: Cytology Authors: Qinglan He Peijun Li Lihua Han Chen Yang Meiling Jiang Yingqi Wang Xiaoyu Han Yuanyuan Cao Xiaodan Liu Weibing Wu Source Type: research
Revisiting airway epithelial dysfunction and mechanisms in chronic obstructive pulmonary disease: Role of mitochondrial damage
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 16. doi: 10.1152/ajplung.00362.2023. Online ahead of print.ABSTRACTChronic exposure to environmental hazards causes airway epithelial dysfunction, primarily impaired physical barriers, immune dysfunction, and repair or regeneration. Impairment of airway epithelial function subsequently leads to exaggerated airway inflammation and remodeling, the main features of chronic obstructive pulmonary disease (COPD). Mitochondrial damage has been identified as one of the mechanisms of airway abnormalities in COPD, which is closely related to airway inflammation and airflow limitation. In ...
Source: Am J Physiol Lung Ce... - April 16, 2024 Category: Respiratory Medicine Authors: Qinglan He Peijun Li Lihua Han Chen Yang Meiling Jiang Yingqi Wang Xiaoyu Han Yuanyuan Cao Xiaodan Liu Weibing Wu Source Type: research
Revisiting airway epithelial dysfunction and mechanisms in chronic obstructive pulmonary disease: Role of mitochondrial damage
Am J Physiol Lung Cell Mol Physiol. 2024 Apr 16. doi: 10.1152/ajplung.00362.2023. Online ahead of print.ABSTRACTChronic exposure to environmental hazards causes airway epithelial dysfunction, primarily impaired physical barriers, immune dysfunction, and repair or regeneration. Impairment of airway epithelial function subsequently leads to exaggerated airway inflammation and remodeling, the main features of chronic obstructive pulmonary disease (COPD). Mitochondrial damage has been identified as one of the mechanisms of airway abnormalities in COPD, which is closely related to airway inflammation and airflow limitation. In ...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - April 16, 2024 Category: Cytology Authors: Qinglan He Peijun Li Lihua Han Chen Yang Meiling Jiang Yingqi Wang Xiaoyu Han Yuanyuan Cao Xiaodan Liu Weibing Wu Source Type: research
The unique interplay between antinuclear antibodies and nuclear molecules in the pathogenesis of SLE
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that primarily affects young women and causes a wide range of inflammatory manifestations. The hallmark of SLE is the production of antibodies to components of the cell nucleus (antinuclear antibodies or ANAs). These antibodies can bind to DNA, RNA and protein complexes with nucleic acids. Among ANAs, antibodies to DNA (anti-DNA) are markers for classification and disease activity, waxing and waning in many patients. In the blood, anti-DNA antibodies can bind DNA to form immune complexes with two distinct roles in pathogenesis: renal deposition to provok...
Source: Arthritis and Rheumatology - April 16, 2024 Category: Rheumatology Authors: David S. Pisetsky Tags: Review Source Type: research
A systematic review on the biochemical threshold of mitochondrial genetic variants [REVIEW]
Mitochondrial DNA (mtDNA) variants cause a range of diseases from severe pediatric syndromes to aging-related conditions. The percentage of mtDNA copies carrying a pathogenic variant, variant allele frequency (VAF), must reach a threshold before a biochemical defect occurs, termed the biochemical threshold. Whether the often-cited biochemical threshold of >60% VAF is similar across mtDNA variants and cell types is unclear. In our systematic review, we sought to identify the biochemical threshold of mtDNA variants in relation to VAF by human tissue/cell type. We used controlled vocabulary terms to identify articles measu...
Source: Genome Research - April 16, 2024 Category: Genetics & Stem Cells Authors: Smith, K. K., Moreira, J. D., Wilson, C. R., Padera, J. O., Lamason, A. N., Xue, L., Gopal, D. M., Flynn, D. B., Fetterman, J. L. Tags: REVIEW Source Type: research
Effects of Dietary Restriction on PGC-1 α Regulation in the Development of Age-associated Diseases
In conclusion, dietary interventions may delay ageing by regulating healthy mitochondria in various organs, presenting the possibility of a new primary prevention for many age-related diseases.PMID:38616758 | DOI:10.2174/0118746098301226240402051508 (Source: Current Aging Science)
Source: Current Aging Science - April 15, 2024 Category: Geriatrics Authors: Shefilyn Widjaja Radiana Dhewayani Antarianto Novi Silvia Hardiany Source Type: research
Extracellular mitochondrial components as new biomarkers for lupus nephritis
This study has evaluated extracellular mitochondrial components, including cell-free mitochondria, and cell-free mitochondrial DNA as probable biomarkers of the degree of nephritis. Both showed a significant correlation with proteinuria and protein-creatinine ratio. Our study substantiates their usage as clinical biomarkers of nephritis upon their validation in a larger cohort of lupus nephritis patients and other forms of nephritis. Although the current data suggest using cell-free mitochondria as a biomarker of lupus nephritis is better than the cell-free mitochondrial DNA.PMID:38621786 | DOI:10.1177/09612033241247622 (Source: Lupus)
Source: Lupus - April 15, 2024 Category: Rheumatology Authors: Sharath Gowda Khushboo Rana Ankit Kumar Pradip Kumar Prajapati Namisha Patel Sapan Pandya Ratika Srivastava Source Type: research
Interplay between lipid dysregulation and ferroptosis in chondrocytes and the targeted therapy effect of metformin on osteoarthritis
CONCLUSION: We establish a critical role of polyunsaturated fatty acids metabolic process in OA cartilage degradation and define metformin as a potential OA treatment. Metformin reshapes lipid availability and ameliorates chondrocyte ferroptosis sensitivity via the AMPK/ACC pathway. In the future, gene-edited animals and extensive omics technologies will be utilized to reveal detailed lipids' involvement in cartilage lesions.PMID:38621621 | DOI:10.1016/j.jare.2024.04.012 (Source: Adv Data)
Source: Adv Data - April 15, 2024 Category: Epidemiology Authors: Zhi Zou Wenhui Hu Fei Kang Zhonghua Xu Yuheng Li Jing Zhang Jianmei Li Yuan Zhang Shiwu Dong Source Type: research
