Management of Ptosis in Kearns-Sayre Syndrome: A Case Report and Literature Review
We report a case of KSS revealed by severe bilateral ptosis and confirmed by a muscle biopsy with "ragged red fibers." The ptosis was surgically managed by cautious Frontal suspension under local anesthesia "Frontal nerve block." Through this case, we discuss challenges in the management of KSS patients.PMID:38596148 | PMC:PMC11001462 | DOI:10.1055/a-2207-7587 (Source: Archives of Plastic Surgery)
Source: Archives of Plastic Surgery - April 10, 2024 Category: Cosmetic Surgery Authors: Moulay O Moustaine Zakaria Azemour Frarchi Mohammed Othman Benlanda Hicham Nassik Mehdi Karkouri Source Type: research
Replication and Transcription of Human Mitochondrial DNA
Annu Rev Biochem. 2024 Apr 9. doi: 10.1146/annurev-biochem-052621-092014. Online ahead of print.ABSTRACTMammalian mitochondrial DNA (mtDNA) is replicated and transcribed by phage-like DNA and RNA polymerases, and our understanding of these processes has progressed substantially over the last several decades. Molecular mechanisms have been elucidated by biochemistry and structural biology and essential in vivo roles established by cell biology and mouse genetics. Single molecules of mtDNA are packaged by mitochondrial transcription factor A into mitochondrial nucleoids, and their level of compaction influences the initiatio...
Source: Annual Review of Biochemistry - April 10, 2024 Category: Biochemistry Authors: Maria Falkenberg Nils-G öran Larsson Claes M Gustafsson Source Type: research
MITOCHONDRIAL IMPORT STRESS and PINK1-MEDIATED MITOPHAGY: THE ROLE of the PINK1-TOMM-TIMM23 SUPERCOMPLEX
Autophagy. 2024 Apr 10. doi: 10.1080/15548627.2024.2340399. Online ahead of print.ABSTRACTMutations in the PINK1 kinase cause Parkinson disease (PD) through physiological processes that are not yet fully elucidated. PINK1 kinase accumulates selectively on damaged mitochondria, where it recruits the E3 ubiquitin ligase PRKN/Parkin to mediate mitophagy. Upon mitochondrial import failure, PINK1 accumulates in association with the translocase of outer mitochondrial membrane (TOMM). However, the molecular basis of this PINK1 accumulation on the TOMM complex remain elusive. We recently demonstrated that TIMM23 (translocase of th...
Source: Autophagy - April 10, 2024 Category: Cytology Authors: Mohamed A Eldeeb Armaan Fallahi Andrea Soumbasis Andrew N Bayne Jean-Fran çois Trempe Edward A Fon Source Type: research
NAD(P)H-quinone oxidoreductase 1 induces complicated effects on mitochondrial dysfunction and ferroptosis in an expression level-dependent manner
In this study, we examined how levels of NQO1 expression affects cell survival in response to toxic insults causing mitochondrial dysfunction and ferroptosis, and whether NQO1 has a potential as a biomarker in different stressed conditions. Following treatment with rotenone, overexpressed NQO1 in SH-SY5Y cells improved cell survival by reducing mitochondrial reductive stress via increased NAD+ supply without mitochondrial biogenesis. However, NQO1 overexpression boosted lipid peroxidation following treatment with RSL3 and erastin. A lipid droplet staining assay showed increased lipid droplets in cells overexpressing NQO1. ...
Source: BioScience Trends - April 10, 2024 Category: Biomedical Science Authors: Jaewang Lee Dong-Hoon Hyun Source Type: research
Targeting VDAC: A potential therapeutic approach for mitochondrial dysfunction in Alzheimer's disease
This article aims to provide an overview of the role of VDAC in mitochondrial dysfunction, its association with Alzheimer's disease, and the potential of targeting VDAC for developing novel therapeutic interventions. Understanding the involvement of VDAC in Alzheimer's disease may pave the way for the development of effective treatments that can restore mitochondrial function and halt disease progression.PMID:38599511 | DOI:10.1016/j.brainres.2024.148920 (Source: Brain Research)
Source: Brain Research - April 10, 2024 Category: Neurology Authors: Yaqian Yang Xiaotao Jia Xinmao Yang Jie Wang Yan Fang Xiaoping Ying Meiqian Zhang Jing Wei Yanfang Pan Source Type: research
Management of Ptosis in Kearns-Sayre Syndrome: A Case Report and Literature Review
We report a case of KSS revealed by severe bilateral ptosis and confirmed by a muscle biopsy with "ragged red fibers." The ptosis was surgically managed by cautious Frontal suspension under local anesthesia "Frontal nerve block." Through this case, we discuss challenges in the management of KSS patients.PMID:38596148 | PMC:PMC11001462 | DOI:10.1055/a-2207-7587 (Source: Archives of Plastic Surgery)
Source: Archives of Plastic Surgery - April 10, 2024 Category: Cosmetic Surgery Authors: Moulay O Moustaine Zakaria Azemour Frarchi Mohammed Othman Benlanda Hicham Nassik Mehdi Karkouri Source Type: research
NAD(P)H-quinone oxidoreductase 1 induces complicated effects on mitochondrial dysfunction and ferroptosis in an expression level-dependent manner
In this study, we examined how levels of NQO1 expression affects cell survival in response to toxic insults causing mitochondrial dysfunction and ferroptosis, and whether NQO1 has a potential as a biomarker in different stressed conditions. Following treatment with rotenone, overexpressed NQO1 in SH-SY5Y cells improved cell survival by reducing mitochondrial reductive stress via increased NAD+ supply without mitochondrial biogenesis. However, NQO1 overexpression boosted lipid peroxidation following treatment with RSL3 and erastin. A lipid droplet staining assay showed increased lipid droplets in cells overexpressing NQO1. ...
Source: BioScience Trends - April 10, 2024 Category: Biomedical Science Authors: Jaewang Lee Dong-Hoon Hyun Source Type: research
Management of Ptosis in Kearns-Sayre Syndrome: A Case Report and Literature Review
We report a case of KSS revealed by severe bilateral ptosis and confirmed by a muscle biopsy with "ragged red fibers." The ptosis was surgically managed by cautious Frontal suspension under local anesthesia "Frontal nerve block." Through this case, we discuss challenges in the management of KSS patients.PMID:38596148 | PMC:PMC11001462 | DOI:10.1055/a-2207-7587 (Source: Archives of Plastic Surgery)
Source: Archives of Plastic Surgery - April 10, 2024 Category: Cosmetic Surgery Authors: Moulay O Moustaine Zakaria Azemour Frarchi Mohammed Othman Benlanda Hicham Nassik Mehdi Karkouri Source Type: research
NAD(P)H-quinone oxidoreductase 1 induces complicated effects on mitochondrial dysfunction and ferroptosis in an expression level-dependent manner
In this study, we examined how levels of NQO1 expression affects cell survival in response to toxic insults causing mitochondrial dysfunction and ferroptosis, and whether NQO1 has a potential as a biomarker in different stressed conditions. Following treatment with rotenone, overexpressed NQO1 in SH-SY5Y cells improved cell survival by reducing mitochondrial reductive stress via increased NAD+ supply without mitochondrial biogenesis. However, NQO1 overexpression boosted lipid peroxidation following treatment with RSL3 and erastin. A lipid droplet staining assay showed increased lipid droplets in cells overexpressing NQO1. ...
Source: BioScience Trends - April 10, 2024 Category: Biomedical Science Authors: Jaewang Lee Dong-Hoon Hyun Source Type: research
Management of Ptosis in Kearns-Sayre Syndrome: A Case Report and Literature Review
We report a case of KSS revealed by severe bilateral ptosis and confirmed by a muscle biopsy with "ragged red fibers." The ptosis was surgically managed by cautious Frontal suspension under local anesthesia "Frontal nerve block." Through this case, we discuss challenges in the management of KSS patients.PMID:38596148 | PMC:PMC11001462 | DOI:10.1055/a-2207-7587 (Source: Archives of Plastic Surgery)
Source: Archives of Plastic Surgery - April 10, 2024 Category: Cosmetic Surgery Authors: Moulay O Moustaine Zakaria Azemour Frarchi Mohammed Othman Benlanda Hicham Nassik Mehdi Karkouri Source Type: research
