Mongolian Medicine echinops prevented postmenopausal osteoporosis and induced ER/AKT/ERK pathway in BMSCs.
In this study, we explored the mechanism underlying echinops prevents and treats postmenopausal osteoporosis. Osteoporosis model was established by ovariectomy in rats. Rats were treated to Echinops (16.26, 32.5, or 65 mg/kg/day) by oral gavage for 3 months. Bone mineral density (BMD) was detected by micro-CT detection of left proximal medial metaphyseal tibia. Hematoxylin and eosin (H&E) and toluidine blue O staining were also performed. Serum levels of E2, ALP and testosterone were examined. Bone marrow-derived bone marrow stem cells (BMSCs) were isolated and treated with echinops-containing serum. Estrogen receptors...
Source: BioScience Trends - June 1, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Cinobufacini inhibits epithelial-mesenchymal transition of human hepatocellular carcinoma cells through c-Met/ERK signaling pathway.
In conclusion, the current study suggested cinobufacini could prevent HepG2 cells migration and invasion via inhibiting EMT through c-Met/ERK signaling pathway, which might provide experimental evidence for cinobufacini treatment of HCC. PMID: 29794405 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - June 1, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Expression of glucocorticoid receptor shows negative correlation with human B-cell engraftment in PBMC-transplanted NOGhIL-4-Tg mice.
In this study, we analyzed the relationship between human lymphocyte subsets and the expression level of the glucocorticoid receptor (GR) to clarify the humoral immune condition in human PBMC-transplanted NOG-hIL-4 mice. The results showed that the human GR mRNA level was significantly lower in NOG-hIL-4-Tg splenocytes than in conventional NOG splenocytes after immunization. Whereas no obvious difference of the proportion of T helper-cell subsets was observed between the NOG and NOG-hIL-4-Tg mouse strains, the B-cell proportion and antigen-specific IgG concentration in plasma showed strong negative correlations with the GR...
Source: BioScience Trends - June 1, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

pH-Dependent exhibition of hemolytic activity by an extract of Hypsizygus marmoreus fruiting bodies.
Authors: Saito K, Hazama S, Oda Y, Nakata M Abstract The current study found that an extract from the fruiting bodies of the edible mushroom Hypsizygus marmoreus exhibited hemolytic activity against sheep red blood cells when its pH was lowered. Although hemolytic activity was not detected when an extract had a neutral pH, an extract with a low pH exhibited potent hemolytic activity. The maximal hemolytic activity was exhibited by an extract with a pH of 5.5. A heat-treated extract did not exhibit hemolytic activity before its pH was lowered, and that activity was inhibited in the presence of PMSF and EDTA. The tur...
Source: BioScience Trends - June 1, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Development of health technology assessment in China: New challenges.
This article reviews how the field of HTA has developed in China, analyzes what factors have been influencing China's HTA development, and proposes policy recommendations. PMID: 29760354 [PubMed - in process] (Source: BioScience Trends)
Source: BioScience Trends - May 16, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Interventions integrating non-communicable disease prevention and reproductive, maternal, newborn, and child health: A systematic review.
Authors: Kikuchi K, Ayer R, Okawa S, Nishikitani M, Yokota F, Jimba M, Nakashima N Abstract Reproductive, maternal, newborn, and child health (RMNCH) care services could be critical entry points for preventing non-communicable diseases in women and children. In high-income countries, non-communicable diseases screening has been integrated into both the medical and public health systems. To integrate these services in low- and middle-income countries, it is necessary to closely examine its effectiveness and feasibility. In this systematic review, we evaluated the effectiveness of integrating gestational and non-gest...
Source: BioScience Trends - May 16, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

The impact of parental migration on injuries among left behind young people aged 10 years to 24 years in Botswana.
This study shows clearly that injuries take an insufficiently high toll on children's health and on society. Additionally, if parental migration trends continue, Botswana's burden of injuries are expected to rise in the next 10 years. PMID: 29760356 [PubMed - in process] (Source: BioScience Trends)
Source: BioScience Trends - May 16, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Intimate partner violence victimization and HIV infection among men who have sex with men in Shanghai, China.
In this study, 732 MSM recruited from Shanghai, China between March and August 2015 were administered with a questionnaire survey and HIV blood testing. IPV victimization was measured by 25 forced-choice items capturing lifetime experience of physical, sexual, psychological, deprivation or neglect, and other forms of violence. Of them, 179 (24.3%) reported having experienced at least one type of IPV victimization. In separate multivariable analyses, sexual violence was associated with age over 35 years (AOR = 0.26, 95% CI: 0.07-1.02), ever had male-to-male commercial sex (AOR = 2.53, 95%CI: 1.19-5.39), and diagnosis of a s...
Source: BioScience Trends - May 16, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

A reliable grading system for prediction of hematoma expansion in intracerebral hemorrhage in the basal ganglia.
In conclusion, the grading system demonstrated reliable accuracy at predicting HE. The grading system demonstrated acceptable accuracy in an independent single-institution study. The role of the grading system in predicting HE and poor outcome in patients with ICH is significant. NCCT imaging markers may serve as key markers for HE prediction. PMID: 29760358 [PubMed - in process] (Source: BioScience Trends)
Source: BioScience Trends - May 16, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

A simple and economical method of gas chromatography-mass spectrometry to determine the presence of 6 pesticides in human plasma and its clinical application in patients with acute poisoning.
Authors: Yuan G, Zhang R, Chen X, Wang B, Guo R Abstract An economical, rapid, and sensitive method of gas chromatography-mass spectrometry (GC-MS) was developed and validated to determine the presence of six pesticides (dichlorvos, acetochlor, atrazine, chlorpyrifos, α-endosulfan, and β-endosulfan) in human plasma. The pesticides were extracted with acetonitrile and concentrated using anhydrous sodium sulfate. Then, the target compounds were analyzed and quantified with GC-MS using borneol as an internal standard. Separation was performed on a HP-5MS capillary column (30 m × 0.25 mm × 0.25 &...
Source: BioScience Trends - May 16, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Performing laparoscopic surgery - Perspectives of young Chinese hepatobiliary surgeons.
Authors: Zhao X, Song P, Zhang Y, Huang J Abstract Laparoscopic liver resection (LLR) has garnered attention as a new form of liver surgery. In China, many hepatobiliary surgeons are now encouraging the examination and assessment of LLC in order to improve its outcomes, and several young hepatobiliary surgeons recently shared their clinical experiences and the results of their research in presentations at the Akamon Forum as part of the 118th Annual Congress of the Japan Surgical Society, which was held April 5-7, 2018 in Tokyo, Japan. In China, LLR has gradually improved over the past 20 years, including both expa...
Source: BioScience Trends - May 16, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Renal protective effect of Paeoniflorin by inhibition of JAK2/STAT3 signaling pathway in diabetic mice.
Authors: Li X, Wang Y, Wang K, Wu Y Abstract Paeoniflorin is the main bioactive components of the root of P.lactiflora Pall., and has been widely used as an anti-inflammation and immunomodulatory agent. However, the effect and mechanisms of Paeoniflorin in diabetic nephropathy (DN) remains to be elucidated. In the present study, streptozotocin (STZ)-induced type 1 diabetic mice model was used to investigate the protective effect of Paeoniflorin and the role of the Janus kinase (JAK) 2/signal transducer (STAT) 3 signaling pathway on DN. After treatment with Paeoniflorin at a dose of 25, 50 and 100 mg/kg once a day f...
Source: BioScience Trends - April 21, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Diagnosis-related group (DRG)-based case-mix funding system, a promising alternative for fee for service payment in China.
This article briefly describes the DRG-based case-mix payment system, it comparatively analyzes differences between FFS and case-mix funding systems, and it describes the implementation of DRGs in China. China's social and economic conditions differ across regions, so establishment of a national payment standard will take time and involve difficulties. No single method of provider payment is perfect. Measures to monitor and minimize the negative ethical implications and unintended effects of a DRG-based case-mix payment system are essential to ensuring the lasting social benefits of payment reform in Chinese public hospita...
Source: BioScience Trends - April 18, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Distinct pattern of Th17/Treg cells in pregnant women with a history of unexplained recurrent spontaneous abortion.
In conclusion, peripheral Treg cells did not increase in pregnant women with URSA. The decrease in Treg cells and levels of CTLA-4 and TGF-β1 and as well as the increase in levels of IL-6 and TNF-ɑ, and the Th17/Treg ratio at the maternal-fetal interface might contribute to inappropriate maternal-fetal immune tolerance in URSA. PMID: 29657243 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - April 18, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Infiltration characteristics and influencing factors of retroperitoneal liposarcoma: Novel evidence for extended surgery and a tumor grading system.
In conclusion, RPLS has a high infiltration tendency, such that it frequently infiltrates organs and surrounding fat tissue. Therefore, extended resection of the tumor and the adjacent organs is recommended. The percentage of lipoblasts was associated with the tumor grade and infiltration characteristics; thus, lipoblast percentage may become a new grading factor for RPLS. PMID: 29657244 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - April 18, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Strengthening maternal and child health in China: Lessons from transforming policy proposals into action.
Authors: Yang X, Tang S, Yamey G, Qian X Abstract China has made impressive achievements in improving maternal and child health (MCH) over the past few decades. This paper uses a policy lens to examine reasons for these achievements as well as barriers to further success. We found that strong governmental commitment and leadership, effective coordination, proactive participation of different stakeholders, and the provision of adequate resources were associated with China's success in improving MCH outcomes. Other low- and middle-income countries can learn valuable lessons from China's experience. These lessons incl...
Source: BioScience Trends - April 18, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Effects of three forms of local anesthesia on perioperative fentanyl-induced hyperalgesia.
Authors: Chang L, Ye F, Luo Q, Wang Z, Wang Y, Xia Z, Shu H Abstract Both local infiltration analgesia (LIA) and nerve block are common analgesic modalities for pain relief after surgery. The aim of the current study was to investigate the effects of those two modalities on pain behavior and the expression of pro-inflammatory cytokines such as interleukin (IL)-1β and IL-6 and tumor necrosis factor-α (TNF-α) in the spinal cord and dorsal root ganglion (DRG) in a rat model of perioperative fentanyl induced hyperalgesia. Rats were injected with fentanyl (60 μg/kg) 4 times and received a plantar inc...
Source: BioScience Trends - April 18, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Internal migration and regional differences of population aging: An empirical study of 287 cities in China.
Authors: Chen R, Xu P, Li F, Song P Abstract In addition to birth and death, migration is also an important factor that determines the level of population aging in different regions, especially under the current context of low fertility and low mortality in China. Drawing upon data from the fifth and sixth national population census of 287 prefecture-level cities in China, this study explored the spatial patterns of population aging and its trends from 2000 to 2010 in China. We further examined how the large-scale internal migration was related to the spatial differences and the changes of aging by using multivaria...
Source: BioScience Trends - April 4, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Astraglaus polysaccharide protects diabetic cardiomyopathy by activating NRG1/ErbB pathway.
Authors: Chang X, Lu K, Wang L, Lv M, Fu W Abstract Diabetic cardiomyopathy (DCM) is one of the main cardiac complications among diabetic patients. According to previous studies, the pathogenesis of DCM is associated with oxidative stress, apoptosis and proliferation of local cardiac cells. It showed, NRG1 can improve the function of mitochondria, and thereby, increasing proliferation and decreasing apoptosis of cardiac muscle cell via ErbB/AKT signaling, also, exert antioxidative function. Besides, NRG1/ErbB pathway was impaired in the DCM model which suggested this signaling played key role in DCM. Astraglaus pol...
Source: BioScience Trends - April 4, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Association of biobehavioral factors with non-coding RNAs in cervical cancer.
Authors: Liu Q, Lu C, Dai W, Li K, Xu J, Huang Y, Li G, Kang Y, Sood AK, Xu C Abstract In order to elucidate the mechanisms underlying the biobehavioral factors responsible for cervical cancer from the perspective of lncRNAs. Tumor samples were obtained from patients with stage Ib-IIb squamous cervical cancer, which were divided into high- and low-risk groups according to biobehavioral risk factors. A lncRNA + mRNA microarray was performed, and the results were validated using qRT-PCR. Gene ontology (GO), pathway, and lncRNA-mRNA co-expression analysis were performed to predict the potential functions of the differ...
Source: BioScience Trends - March 27, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Chromosomal karyotype in chorionic villi of recurrent spontaneous abortion patients.
Authors: Du Y, Chen L, Lin J, Zhu J, Zhang N, Qiu X, Li D, Wang L Abstract Recurrent spontaneous abortion (RSA) is a multifactorial disease of which the exact causes are still unknown. In the current study, we aimed to analyze the distribution of abnormal embryonic karyotypes in RSA. 781 RSA patients of 17 hospitals in Shanghai from January 2014 to September 2016 were enrolled. Fetal villus tissues were collected during uterine curettage and then cultured in situ for karyotyping. All of the 781 cases were successfully cultured. There were 393 cases of abnormal karyotypes, accounting for 50.3% of the total cases. Wo...
Source: BioScience Trends - March 27, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

FL118, a novel camptothecin analogue, suppressed migration and invasion of human breast cancer cells by inhibiting epithelial-mesenchymal transition via the Wnt/ β-catenin signaling pathway.
FL118, a novel camptothecin analogue, suppressed migration and invasion of human breast cancer cells by inhibiting epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway. Biosci Trends. 2018;12(1):40-46 Authors: Yang Z, Ji L, Jiang G, Liu R, Liu Z, Yang Y, Ma Q, Zhao H Abstract The aim of the current study was to investigate the effects of FL118, a novel camptothecin analogue, on migration and invasion of human breast cancer cells and the underlying mechanisms of those effects. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and a plate clone forma...
Source: BioScience Trends - March 27, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Pain perception after colorectal surgery: A propensity score matched prospective cohort study.
Authors: Grass F, Cachemaille M, Martin D, Fournier N, Hahnloser D, Blanc C, Demartines N, Hübner M Abstract The purpose of this prospective cohort study was to compare multimodal pain management and pain perception after open vs. laparoscopic colorectal surgery within enhanced recovery care. Pain scores at rest and at mobilization were prospectively assessed in consecutive patients using Visual Analog Scales (VAS 0-10) and consumption of different analgesics was recorded daily until 96 hours postoperatively. Uni- and multivariate risk factors for pain peaks (≥ 4/10) were identified by logistic regression a...
Source: BioScience Trends - March 27, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Outcome of elderly patients after acute biliary pancreatitis.
Authors: Roulin D, Girardet R, Duran R, Hajdu S, Denys A, Halkic N, Demartines N, Melloul E Abstract The specific management and outcome of acute biliary pancreatitis in elderly patients is not well established. The aim of this study was to assess the outcome of elderly compared to younger patients after acute biliary pancreatitis. Retrospective analysis of consecutive patients admitted with acute biliary pancreatitis between January 2006 and December 2012. Elderly patients (≥ 70 years) were compared to younger patients ( 70 years (35.8%). Elderly patients had a higher Charlson comorbidity index score at admission (p
Source: BioScience Trends - March 27, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Safety and feasibility of a novel non-thermal device for tissue dissection: A preliminary study of the DD1 differential dissector.
Authors: Yoshida N, Yamazaki S, Sugitani M, Takayama T Abstract Energy devices can cause significant thermal damage to surrounding tissues causing unanticipated organ trauma. To evaluate the safety and feasibility of a novel electric device (DD1) for soft tissue dissection. Three series of measurements were performed in a pig model. First, macro- and microscopic tissue damage was compared between the DD1 and an electric scalpel (ES). Second, the time course of tissue temperature was measured for the DD1 and three other energy devices (ES, Harmonic and LigaSure). Third, the time required for mobilization of a periph...
Source: BioScience Trends - March 27, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Neither ischemic parenchymal volume nor severe grade complication correlate transient high transaminase elevation after liver resection.
Authors: Higaki T, Yamazaki S, Mitsuka Y, Aoki M, Yoshida N, Midorikawa Y, Nakayama H, Takayama T Abstract To clarify whether high transient elevation of serum transaminase predicts severe complications and is related to the ischemic area on CT. Postoperative laboratory data and ischemia area on CT were analyzed on the basis of the presence of high transaminase elevation (aspartate aminotransferase (AST)> 1,000 IU/L within postoperative day (POD) 2 after liver resection. In the high elevation group, volume of ischemic areas was assessed by CT on POD2. The 538 patients were divided into a high transaminase group ...
Source: BioScience Trends - March 27, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Arterial infusion of cisplatin plus S-1 against unresectable intrahepatic cholangiocarcinoma.
Authors: Higaki T, Aramaki O, Moriguchi M, Nakayama H, Midorikawa Y, Takayama T Abstract Conventional regimens for unresectable intrahepatic cholangiocarcinoma are considered of limited effectiveness. To evaluate the efficacy and toxicity of combination chemotherapy with hepatic arterial infusion of IA-call (a fine-powder formulation of cisplatin) plus oral S-1 in patients with unresectable intrahepatic cholangiocarcinoma. The clinicopathological data and long-term outcome of 12 patients who were received with IA-call plus S-1 were compared with those of 16 patients who were received other treatments, such as radia...
Source: BioScience Trends - March 27, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Tracking hospital costs in the last year of life - The Shanghai experience.
Authors: Zhu B, Li F, Wang C, Wang L, He Z, Zhang X, Song P, Ding L, Jin C Abstract One aim of the current study was to track end-of-life care using individual data in Shanghai, China to profile hospital costs for decedents and those for the entire population. A second aim of this study was to clarify the effect of proximity to death. Data from the Information Center of the Shanghai Municipal Commission of Health and Family Planning (SMCHFP) were examined. For decedents who died in medical facilities in 2015, inpatient care was tracked for 1 year before death. A total of 43,765 decedents were included in the study,...
Source: BioScience Trends - March 27, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Exploring the determinants that influence end-of-life hospital costs of the elderly in Shanghai, China.
This study suggested that the PTD should be considered when predicting medical cost. Primary medical care should be enhanced and gaps in insurance coverage should be reduced to improve the efficiency and equity of medical funding. More attention should be paid to the population with a heavier disease burden. PMID: 29553107 [PubMed - in process] (Source: BioScience Trends)
Source: BioScience Trends - March 27, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Japan's healthcare policy for the elderly through the concepts of self-help (Ji-jo), mutual aid (Go-jo), social solidarity care (Kyo-jo), and governmental care (Ko-jo).
Authors: Sudo K, Kobayashi J, Noda S, Fukuda Y, Takahashi K Abstract Elderly care is an emerging global issue threatening both developed and developing countries. The elderly in Japan increased to 26.7% of the population in 2015, and Japan is classified as a super-aged society. In this article, we introduce the financial aspects of the medical care and welfare services policy for the elderly in Japan. Japan's universal health insurance coverage system has been in place since 1961. Long-term care includes welfare services, which were separated from the medical care insurance scheme in 2000 when Japan was already rec...
Source: BioScience Trends - February 28, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Core factors promoting a continuum of care for maternal, newborn, and child health in Japan.
Authors: Akashi H, Ishioka M, Hagiwara A, Akashi R, Osanai Y Abstract Providing a continuum of care (CoC) is important strategy for improving maternal, newborn, and child health (MNCH). Japan's current very low maternal and infant mortality rates suggest that its CoC for MNCH is good. In this paper, we attempt to clarify how CoC and low mortality rates are being maintained in Japan, by examining the entire MNCH service provision system. First, we examine two important tools for integrated service provision, the Maternal and Child Health (MCH) Handbook and registration of pregnant women with local governments, both ...
Source: BioScience Trends - February 28, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

The response of common marmoset immunity against cedar pollen extract.
Authors: Yamada Y, Takabayashi S, Kato H, Ishiwata K, Watanabe N, Sasaki E, Habu S Abstract The in vivo model of pollinosis has been established using rodents, but the model cannot completely mimic human pollinosis. We used Callithrix jacchus, the common marmoset (CM), to establish a pollinosis animal model using intranasal weekly administration of cedar pollen extract with cholera toxin adjuvant. Some of the treated CMs exhibited the symptoms of snitching, excess nasal mucus and/or sneezing, but the period was very short, and the symptoms disappeared after several weeks. The CD4+CD25+ cell ratio in the peripheral ...
Source: BioScience Trends - January 17, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Optical coherence tomography for precision brain imaging, neurosurgical guidance and minimally invasive theranostics.
Authors: Fan Y, Xia Y, Zhang X, Sun Y, Tang J, Zhang L, Liao H Abstract This review focuses on optical coherence tomography (OCT)-based neurosurgical application for imaging and treatment of brain tumors. OCT has emerged as one of the most innovative and successful translational biomedical-diagnostic techniques. It is a useful imaging tool for noninvasive, in vivo, in situ and real-time imaging in soft biological tissues, such as brain tumor imaging. OCT can detect the structure of biological tissue in a micrometer scale, and functional OCT has some clinical researches and applications, such as nerve fiber tracts a...
Source: BioScience Trends - January 17, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Shenqi detoxification granule combined with P311 inhibits epithelial-mesenchymal transition in renal fibrosis via TGF- β1-Smad-ILK pathway.
Shenqi detoxification granule combined with P311 inhibits epithelial-mesenchymal transition in renal fibrosis via TGF-β1-Smad-ILK pathway. Biosci Trends. 2017;11(6):640-650 Authors: Cai P, Liu X, Xu Y, Qi F, Si G Abstract Shenqi detoxification granule (SDG), a traditional Chinese herbal formula, has been shown to have nephroprotective and anti-fibrotic activities in patients with chronic kidney disease (CKD). However, its mechanisms in renal fibrosis and the progression of CKD remain largely unknown. P311, a highly conserved 8-kDa intracellular protein, plays a key role in renal fibrosis by regula...
Source: BioScience Trends - January 11, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Evaluation of insulin resistance improvement after laparoscopic sleeve gastrectomy or gastric bypass surgery with HOMA-IR.
Authors: Zhu Y, Sun Z, Du Y, Xu G, Gong K, Zhu B, Zhang N Abstract Our purpose was to explore the remission of insulin resistance after bariatric surgery to discover the mechanism of diabetes remission excluding dietary factors. A retrospective case control study was conducted on patients with type 2 diabetes, who underwent laparoscopic sleeve gastrectomy (LSG) or laparoscopic gastric bypass surgery (LGB) in Beijing Shijitan Hospital from April 1, 2012 to April 1, 2013. The laboratory and anthropometric data was analyzed pre-surgery and during a 2-year follow-up. HOMA-IR was calculated and evaluated. The two surgic...
Source: BioScience Trends - January 11, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

A comparative study of the blend sign and the black hole sign on CT as a predictor of hematoma expansion in spontaneous intracerebral hemorrhage.
In conclusion, the blend sign and the black hole sign on CT are both good predictors of HE in patients with sICH, though the blend sign seems to have a higher level of accuracy. PMID: 29311451 [PubMed - in process] (Source: BioScience Trends)
Source: BioScience Trends - January 11, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Competency and challenges in malaria microscopy in China.
Authors: Yin J, Yan H, Li M, Ruan Y, Zhang X, Wang L, Cao C, Xia Z, Zhou S Abstract Precise diagnosis is a key measure for malaria control and elimination, and malaria microscopy is still the gold standard method recommended by the World Health Organization (WHO) for malaria diagnosis. Analysis of the competency in malaria microscopy in China will benefit to identify the challenges in this skill and provide some suggestions for improvement in order to reach the requirement of WHO procedures for certification of malaria elimination, and finally contribute to malaria elimination by 2020 in China. According to a serie...
Source: BioScience Trends - January 11, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Researchers of chronic obstructive pulmonary disease gathered at the 2017 Japan-China Joint Medical Workshop on Aging and Health.
Authors: Sawakami T, Xia J, Song P Abstract As the number of elderly and the size of the total population increase, population aging will become a major problem because of an increase in diseases associated with aging, such as chronic obstructive pulmonary disease (COPD). The 2017 Japan-China Joint Medical Workshop on Aging and Health was held at The University of Tokyo on December 2, 2017 with a focus on management of COPD. More than 50 experts in the fields of respiratory medicine, emergency medicine, traditional Chinese medicine, and Kampo (traditional Japanese medicine) from Japan and China presented the result...
Source: BioScience Trends - January 11, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

The effects of health education and promotion with regard to severe fever with thrombocytopenia syndrome (SFTS) in rural residents: A pilot study in China.
Authors: Wu Y, Fu G, Guo S, Ye L, Hou J, Wang J, Gong Z Abstract Severe fever with thrombocytopenia syndrome (SFTS) has spread throughout Asia, including China, South Korea, and Japan. In China, the main victims of SFTS were farmers. Measures to protect farmers were urgently needed but limited, and health education and promotion was proposed as an option. A pilot community trial was conducted to provide health education about SFTS in 2013 in Daishan County, Zhejiang Province, China, and results indicated that health education had promise. An educational campaign was conducted for three years. The incidence of SFTS ...
Source: BioScience Trends - December 23, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Low-density lipoprotein receptor deficiency impaired mice osteoblastogenesis in vitro.
Authors: Zhang N, Zhang Y, Lin J, Qiu X, Chen L, Pan X, Lu Y, Zhang J, Wang Y, Li D, Wang L Abstract Postmenopausal osteoporosis affected most elderly women with co-existence of lipid and bone metabolism disorders. However, the cellular and molecular mechanisms underlying the parallel progression and cross-talk of these systems remained unclear. In the present study, low-density lipoprotein receptor knockout (LDLR-/-) mice were chosen to elucidate the effect of LDLR in regulating the differentiation of osteoblasts, which were responsible for bone formation and modulation of osteoclastogenesis. Primary osteoblasts w...
Source: BioScience Trends - December 23, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Expression, purification, and biological characterization of Anaplasma phagocytophilum enolase.
In conclusion, A. phagocytophilum enolase is a multifunctional protein which can catalyze the dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate, and facilitate binding to host plasminogen. PMID: 29249727 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - December 20, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Does pneumoperitoneum affect perfusion index and pleth variability index in patients receiving combined epidural and general anesthesia?
Authors: Wajima Z, Shiga T, Imanaga K Abstract Plethysmographic variability index (PVI) is a dynamic index used for the purpose of fluid responsiveness in patients, and the effect of pneumoperitoneum on PVI is still unclear. We therefore attempted to determine whether PVI and perfusion index (PI) change before/after pneumoperitoneum in patients receiving combined epidural and general anesthesia, which is a common anesthesia method with intravenous remifentanil. Twenty patients underwent laparoscopic cholecystectomy or colectomy. Immediately before pneumoperitoneum, variables were measured at baseline I and were the...
Source: BioScience Trends - December 20, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Effects of lifestyle advice provided by pharmacists on blood pressure: The COMmunity Pharmacists ASSist for Blood Pressure (COMPASS-BP) randomized trial.
Authors: Okada H, Onda M, Shoji M, Sakane N, Nakagawa Y, Sozu T, Kitajima Y, Tsuyuki RT, Nakayama T Abstract The COMmunity Pharamcists ASSist for Blood Pressure (COMPASS-BP) study aimed to assess the effectiveness of lifestyle support programs administered in community pharmacies on hypertension control. This open-label, two-armed parallel group, cluster-randomized controlled trial included 73 pharmacies (clusters) in Japan randomized to a control or intervention group. Eligible hypertensive patients (n = 125), aged 20-75 years, received the intervention (n = 64) or the control treatment (n = 61), as dictated by th...
Source: BioScience Trends - December 20, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Yin-yang regulating effects of cancer-associated genes, proteins, and cells: An ancient Chinese concept in vogue in modern cancer research.
Authors: Wei S Abstract Great achievements have been made in human cancer research, but most of this research is focused on conditions at the microscopic rather than the systemic level. Recent studies have increasingly cited the ancient Chinese theory of yin-yang in an effort to expand beyond the microscopic level. Various cancer-associated genes and proteins such as mitogen-activated protein kinase (MAPK), p38, p53, c-Myc, tumor necrosis factor (TNF)-α, NF-κB, Cyclin D1, and cyclin-dependent kinase (CDK) and cells such as T cells, B cells, macrophages, neutrophils, and fibroblasts have been reported to...
Source: BioScience Trends - December 16, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Direct-acting agents for hepatitis C virus before and after liver transplantation.
Authors: Sugawara Y, Hibi T Abstract Chronic hepatitis C virus (HCV) infection remains a widespread public health concern and many people are infected with HCV. HCV is one of the leading indications for liver transplantation. Direct-acting antiviral agents (DAAs) against HCV have changed the course of chronic HCV infection, however, making it a curable disease. DAA treatment may be initiated before or after liver transplantation. In the present review, we present the available data on DAA treatment of HCV in liver transplant recipients. PMID: 29238003 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - December 16, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Effect of electrolyzed water produced using carbon electrodes on HeLa cell proliferation.
Authors: Nakamura K, Muraoka O Abstract We developed electrolyzed water (EW) using carbon electrodes and investigated the ability of the developed EW to inhibit the proliferation of human cervical carcinoma HeLa cells. We observed that EW-containing media inhibited HeLa cell proliferation. Many very small black dots were produced in EW and these were associated with the inhibitory effect on the cell proliferation. Furthermore, the very small black dots that could inhibit cell proliferation were produced only at pH 3 to 3.5 of EW. Additional experiments showed that this inhibition of proliferation is reversible. The...
Source: BioScience Trends - December 13, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

The impact of population aging on medical expenses: A big data study based on the life table.
This study shed light on the amount and structure of utilization and medical expenses on Shanghai permanent residents based on big data, simulated lifetime medical expenses through combining of expenses data and life table model, and explored the dynamic pattern of aging on medical expenditures. 5 years were taken as the class interval, the study collected and did the descriptive analysis on the medical services utilization and medical expenses information for all ages of Shanghai permanent residents in 2015, simulated lifetime medical expenses by using current life table and cross-section expenditure data. The results sho...
Source: BioScience Trends - December 13, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Individual nursing care for the elderly among China's aging population.
Authors: Bao J, Tang Q, Chen Y Abstract By the end of 2014, China had an elderly population age 60 or over totaling 212 million; this group accounted for 15.5% of the country's total population of 1.37 billion, which means that China has passed the threshold for an aging population. As China's population ages and the disease spectrum changes, nursing services for the elderly must be expanded. Given differences in the health status, financial situation, and family composition of each elderly person, modern society is tending towards individual nursing care for the elderly. Adapting to the changing composition of soc...
Source: BioScience Trends - December 2, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Chinese single herbs and active ingredients for postmenopausal osteoporosis: From preclinical evidence to action mechanism.
This article reviews the experimental evidence of both in vitro and in vivo preclinical studies with the theme of the application of Chinese single herbs and active ingredients in postmenopausal osteoporosis. It includes three single herbs (Herba Epimedium, Rhizoma Drynariae, and Salvia miltiorrhiza) and eight active ingredients (saikosaponins, linarin, echinacoside, sweroside, psoralen, poncirin, vanillic acid, and osthole). The experimental studies indicated their potential use as treatment for postmenopausal osteoporosis and investigated the underlying mechanisms including osteoprotegerin/receptor activator of nuclear f...
Source: BioScience Trends - November 22, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Social support and care needs of the disabled elderly population: An empirical study based on survey data from Beijing, China.
Authors: Hao X, Gu J, Ying X, Bo T, Fu W Abstract In order to describe and examine differences in social support and care needs among disabled Chinese elderly, the current study used stratified sampling to survey local residents of Beijing age 60 or over in the districts of Xicheng, Chaoyang, and Tongzhou in 2016. Structured in-person interviews were conducted with a 7-domain questionnaire. Multiple logistic regressions were used to compare social support and care needs among functioning, partially disabled, and completely disabled elderly. All statistical analyses were performed using SPSS 19.0 with a significance...
Source: BioScience Trends - November 22, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research