The clinical safety and efficacy of conventional transcatheter arterial chemoembolization and drug-eluting beads-transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma: A meta-analysis.
Authors: Han T, Yang X, Zhang Y, Li G, Liu L, Chen T, Zheng Z Abstract Transcatheter arterial chemoembolization (TACE) plays an important role in the treatment of unresectable liver cancer. We conducted this meta-analysis to compare the clinical safety and efficacy of conventional TACE (C-TACE) and drug-eluting beads (DEB)-TACE. A search for those procedures was performed using the PubMed, EMBASE, and Cochrane Library databases. A meta-analysis of patients who underwent C-TACE or DEB-TACE was conducted. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Of 334 studies, 30 were analyzed. The compl...
Source: BioScience Trends - October 17, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Dioscin improves postmenopausal osteoporosis through inducing bone formation and inhibiting apoptosis in ovariectomized rats.
In this study, the effects of dioscin on PMO were examined and the mechanisms were analyzed. The results indicated that the bone mineral density and ultimate load of PMO rats were increased after being treated with dioscin. H&E staining and immunohistochemical staining showed the bone trabeculae formation and bone differentiation of PMO rats were promoted by dioscin. Western blots revealed that dioscin could activate the PI3K/P38/AKT signaling pathway and inhibit the apoptosis signaling pathway in bone tissue cells of PMO rats. In addition, MTT assays showed that MC3T3-E1 cell viability could be improved by dioscin. Th...
Source: BioScience Trends - October 17, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Laparoscopic duodenum and spleen-preserving total pancreatectomy: A novel surgical technique for pancreatic intraductal papillary mucinous neoplasms.
Authors: Wu J, Hu Q, Jin L, Yao W, Zhang C, Hu Z, Zhang Y Abstract Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is no longer a rarely diagnosed disease, because of the development of medical imaging. With a high incidence of canceration, especially in the main duct type, surgery is strongly recommended. Pancreatoduodenectomy, distal pancreatectomy and central pancreatectomy are applied in those cases. For this potentially malignant disease, function-preserving surgery seems more appropriate. An old female was enrolled in our research, who was diagnosed with IPMN. Diameter of the main pancreatic du...
Source: BioScience Trends - October 17, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Neuron loss and dysfunctionality in hippocampus explain aircraft noise induced working memory impairment: a resting-state fMRI study on military pilots.
This study provided direct evidence of dysfunctional hippocampus serving as the structural and functional bases for neuropsychological impairment under aircraft noise exposure. PMID: 31611544 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - October 17, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Growth-promoting effects of the hydrogen-sulfide compounds produced by Desulfovibrio desulfuricans subsp. desulfuricans co-cultured with Escherichia coli (DH5 α) on the growth of Entamoeba and Endolimax species isolates from swine.
In this study, we evaluated the growth-promoting effects of D. desulfuricans co-cultured with Escherichia coli (DH5α) and its products [e.g., hydrogen sulfide (H2S) and certain iron-sulfide (FeS) compounds] using Robinson's medium, on the 4 amoeba isolates from swine-Entamoeba polecki subtype (ST)-1, E. polecki ST-3, Entamoeba suis, and Endolimax sp., and, consequently, a continuous culture system for these amoebae was established. However, this novel culture system was required to regulate the excess H2S dissolved in the medium by increasing air space as amoeba isolates thrive only in large air spaces (30-40%). The ...
Source: BioScience Trends - October 11, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Anti-oxidant, anti-apoptotic, anti-hypoxic and anti-inflammatory conditions induced by PTY-2 against STZ-induced stress in islets.
Authors: Srivastava S, Pandey H, Singh SK, Tripathi YB Abstract The earlier assessment of Pueraria tuberosa (PT) has shown anti-diabetic effects through enhancing incretin action and DPP-IV (Dipeptidyl peptidase-IV) inhibition. The aim of this work was to further explore the protective role of aqueous extract of Pueraria tuberosa tuber (PTY-2) against streptozotocin (STZ) induced islet stress in rats. Diabetes was induced by STZ (65 mg/kg body weight) in charles foster male rats. After 60 days of STZ administration, animals with blood glucose levels> 200 g/dL were considered as diabetic. All the rats were later ...
Source: BioScience Trends - October 11, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

The toxicity and safety of traditional Chinese medicines: Please treat with rationality.
Authors: Cai P, Qiu H, Qi F, Zhang X Abstract For a long time, many people have believed that traditional Chinese medicines (TCMs) are safe because they derive from natural products. However, this belief has been greatly challenged in recent years especially after some reports on aristolochic acid involved in the genesis of cancer. According to the Chinese pharmacopoeia, many TCMs are known to be toxic, causing damage to the nervous, liver, renal, respiratory, and reproductive system. How to reduce the toxicity of TCMs and how to avoid abuse of TCMs in daily practice is the question? Here, we will give a brief summ...
Source: BioScience Trends - October 1, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Challenges and advances in stem cell therapy.
Authors: Tang W Abstract After decades of research, stem cells have shown tremendous promise to treat a range of diseases, such as heart disease, diabetes, and neurodegenerative disease. However, many challenges remain in their transformation from bench to bedside, such as the potential risk of tumorigenicity from undifferentiated human induced pluripotent stem cells (hiPSC), the lack of large-scale culture systems for clinical treatment, and the inconvenience of cell therapy itself. "Cell sheet technology" and secretome therapy represent advances in these regards. With gradual breakthroughs in theory and...
Source: BioScience Trends - September 20, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Recent progress in induced pluripotent stem cell-derived cardiac cell sheets for tissue engineering.
Authors: Gao B, Matsuura K, Shimizu T Abstract The past decade has witnessed remarkable development in tissue engineering technologies and stem cells. Our lab has developed a novel technology - "cell sheet technology" for tissue engineering. After the confluent cells are cultured on an innovative temperature-responsive culture dish, the cells can be harvested as an intact sheet by lowering temperature. We have successfully created multiple cell sheet-based tissues for therapies of a vast variety of diseases, in particular, myocardial diseases. On the other side, the discovery of human induced pluripotent ...
Source: BioScience Trends - September 20, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Stem cell secretome as a new booster for regenerative medicine.
Authors: Xia J, Minamino S, Kuwabara K, Arai S Abstract Stem cells are an undifferentiated cell population that has the ability to develop into many different cell types and also has the ability to repair damaged tissues in some cases. For a long time, the stem cell regenerative paradigm has been based on the assumption that progenitor cells play a critical role in tissue repair by means of their plasticity and differentiation potential. However, recent works suggest that the mechanism underlying the benefits of stem cell transplantation might relate to a paracrine modulatory effect rather than the replacement of a...
Source: BioScience Trends - September 20, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Lab on the eye: A review of tear-based wearable devices for medical use and health management.
Authors: Yu L, Yang Z, An M Abstract Wearable sensors have garnered considerable interest because of their great promise in terms of personalized health and disease management. Tears are a superior target for wireless, non-invasive wearable devices, and tear-based platforms have developed rapidly over the past decade. Although an increasing number of tear analytes have been found to be associated with multiple diseases, glucose still serves as a main target for tear-based wearable devices. There has been much investment and efforts to develop tear-based wearable biosensors, with contact lens-based and spring-like s...
Source: BioScience Trends - September 20, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Cordycepin induces apoptosis in human bladder cancer T24 cells through ROS-dependent inhibition of the PI3K/Akt signaling pathway.
In this study, we examined the effect of cordycepin on the proliferation and apoptosis of human bladder cancer T24 cells and its mechanism of action. Cordycepin treatment significantly reduced the cell survival rate of T24 cells in a concentration-dependent manner, which was associated with the induction of apoptosis. Cordycepin activated caspase-8 and -9, which are involved in the initiation of extrinsic and intrinsic apoptosis pathways, respectively, and also increased caspase-3 activity, a typical effect caspase, subsequently leading to poly (ADP-ribose) polymerase cleavage. Additionally, cordycepin increased the Bax/Bc...
Source: BioScience Trends - September 20, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

GRIM-19 over-expression represses the proliferation and invasion of orthotopically implanted hepatocarcinoma tumors associated with downregulation of Stat3 signaling.
Authors: Kong D, Chen J, Sun X, Lin Y, Du Y, Huang D, Cheng H, He P, Yang L, Wu S, Zhao L, Meng X Abstract The retinoid-interferon-induced mortality-19 (GRIM-19) gene has been identified as a negative regulator associated with tumor development. The current study created a model of an orthotopically implanted hepatocarcinoma tumor to verify the inhibitory effect of GRIM-19 in vivo. After treatment with GRIM-19 carried by attenuated Salmonella, transplanted tumors were measured with an Imaging System. The expression of GRIM-19, Stat3/p-Stat3, cyclinD1, CDK4, PCNA, Bax/Bcl-2, cleaved caspase-9/3, VEGF, and MMP-2/9 wa...
Source: BioScience Trends - September 20, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

The combination of the preoperative albumin-bilirubin grade and the fibrosis-4 index predicts the prognosis of patients with hepatocellular carcinoma after liver resection.
In this study, we aimed to analyze the predictive ability of a combination of the ALBI grade and the FIB-4 score (ALBI-FIB-4) for HCC patients within the Milan criteria after liver resection. The data of HCC patients within the Milan criteria who underwent liver resection between 2011 and 2019 at our center were reviewed (n = 544). Patients with an FIB-4 index> 3.25 were considered to have a high FIB-4 index and were given a score of 1, whereas patients with an FIB-4 index ≤ 3.25 were considered to have a low FIB-4 index and were given a score of 0. The ALBI-FIB-4 score was a summary score that combined the ALBI grad...
Source: BioScience Trends - September 20, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

China should take more measures to raise its breastfeeding rate.
Authors: Wang Y, Zhou C Abstract A growing number of studies show that breastfeeding is the best source of nutrition for infants and young children and one of the most effective measures to ensure the healthy growth and development of children. However, a study from the China Development Research Fund found that the rate of exclusive breastfeeding among Chinese infants within six months of birth is only 29%, a rate that is lower than that in other countries and regions of the world. Other data provided by the World Bank shows that the rate of exclusive breastfeeding in China declined from 1998 to 2013 and that it i...
Source: BioScience Trends - September 20, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Difference in distribution of malignant melanoma and melanocytic nevus in the palm and finger.
Authors: Nishiguchi M, Yamamoto Y, Hara T, Okuhira H, Inaba Y, Kunimoto K, Mikita N, Kaminaka C, Kanazawa N, Jinnin M Abstract We conducted a study to try to plot the lesions of melanocytic nevus and malignant melanoma on the palm and fingers, and compared them to identify the different distribution pattern of both lesions. Data on 8 patients with melanomas (4 male and 4 female) and 26 patients with melanocytic nevus (6 male and 20 female) of palm and finger pulp who visited Wakayama Medical University Hospital between 1986 and 2018 was retrospectively collected. We found that all of the 8 lesions of melanoma were ...
Source: BioScience Trends - September 20, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Accidental awareness while under general anaesthesia.
Authors: Chang L, Luo Q, Chai Y, Shu H Abstract Accidental awareness during general anaesthesia may cause many intraoperative discomforts and bring further moderate to severe long-term symptoms including flashbacks, nightmares, hyperarousal or post-traumatic stress disorder. The incidence of awareness varied from 0.017% to 4% among studies. The relatively reliable incidence of intraoperative awareness with postoperative recall is 0.02%. The reason causing awareness was unclear. Insufficient anaesthetic dosing was thought as the principal cause. Even awareness was not comprehensively understood, some endeavors have ...
Source: BioScience Trends - September 20, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Rapid advances in research on and development of anticancer drugs in China.
Authors: Yao X, Du N, Hu S, Wang L, Gao J Abstract Cancer is a major public health issue in China, and effective anticancer drugs remain a huge unmet need. Generic drugs have long been the main products of pharmaceutical companies in China. In this decade, research on and development of innovative drugs has greatly advanced thanks to policy reforms and economic growth. Five innovative anticancer drugs - anlotinib, pyrotinib, fruquintinib, sintilimab, and toripalimab - that were developed by Chinese domestic pharmaceutical companies were approved by the National Medical Products Administration (NMPA) of China in 201...
Source: BioScience Trends - September 14, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

China has faster pace than Japan in population aging in next 25 years.
Authors: Chen R, Xu P, Song P, Wang M, He J Abstract The aging of a population structure is an inevitable path of demographic transition, as an inescapable result of decline in fertility rate and extension in life expectancy. Although demographic transition occurred earlier in Japan than in China, the two countries had similar patterns, both of which took a much shorter period of time than Western countries to complete demographic transition, as well as have been aging at a rapid speed that has rarely been seen in the world. Japan has the highest level of population aging in the world, and China has been experienci...
Source: BioScience Trends - August 24, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Middle-aged female rats lack changes in histone H3 acetylation in the anterior hypothalamus observed in young females on the day of a luteinizing hormone surge.
This study aims to determine the involvement of histone acetylation in mediating E2-induced luteinizing hormone (LH) surge to understand the mechanism underlying LH surge dysfunction in female reproductive aging. Young and middle-aged female rats were ovariectomized (OVX) and treated with hormone or oil once per day for two days. At the time of the expected LH surge, blood samples were taken for LH assay. The anterior and posterior hypothalami were dissected, histone H3/H4 acetylation and histone deacetylases (HDACs) 4, -5, -10 and -11 protein expressions were measured using Western blotting. Our results show that in the y...
Source: BioScience Trends - August 24, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Overview on social security system of rare diseases in China.
Authors: He J, Song P, Kang Q, Zhang X, Hu J, Yang Y, Tang M, Chen D, Hu S, Jin C Abstract China has initiated the special security project for rare diseases from the national strategic level since 2018. Chinese government has formulated China's First List of Rare Diseases (121 diseases included), established Expert Committee of Diagnosis, Treatment and Security of Rare Diseases and China Alliance of Rare Diseases. The government also encouraged all the provinces to include the security plan and strategies of rare diseases into key work and promoted the establishment of rare diseases clinical research center and th...
Source: BioScience Trends - August 24, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

The epidemic of major sexually transmitted diseases in Shanghai, China, 2009-2018.
Authors: Tang Q, Zhang X, Lu H Abstract Acquired immune deficiency syndrome (AIDS), hepatitis B virus (HBV), hepatitis C virus (HCV), gonorrhea and syphilis are the major sexually transmitted diseases (STDs) in the world, which are the focus of epidemic prevention and control in China. The epidemiological trend analysis of STDs in Shanghai could reflect the epidemic situation of these diseases in high-income areas of China, providing a reference for how to control their epidemic. Although the overall incidence rate of infectious diseases levelled off after 2009, Shanghai still faces many new obstacles in the fight ...
Source: BioScience Trends - July 24, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Super-aged society: Constructing an integrated information platform of self-recording lifelogs and medical records to support health care in Japan.
Authors: Karako K, Chen Y, Song P, Tang W Abstract As the super-aged society, Japan is facing challenges in health care system. As one of measures to cope with challenges, the Ministry of Health, Labor, and Welfare started to construct an open medical information platform, named PeOPLe, in 2016 for personalized medical care, improvement of medical services, and the redistribution of medical resources. The Ministry plans to build the platform infrastructure by 2020 and put the platform into full-scale operation by 2025. PeOPLe collects only medical records, but it should collect lifelogs as well in order to better i...
Source: BioScience Trends - July 24, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

The community-based integrated care system in Japan: Health care and nursing care challenges posed by super-aged society.
Authors: Song P, Tang W Abstract Japan is experiencing unprecedented aging of its population. People age 65 years or older accounted for 28.1% of the total population in 2018, and that proportion is expected to reach 33.3% in 2036 and 38.4% in 2065. In 2017, the average life expectancy in Japan was 81.09 years for men and 87.26 years for women. By 2065, it is expected to reach 84.95 years for men and 91.35 years for women. Population aging affects health and long-term care systems. The government proposed the establishment of "a community-based integrated care system" by 2025 with the purpose of comprehen...
Source: BioScience Trends - July 24, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Overshadowed prospect of programmed cell death protein-1 (PD-1) inhibitor as monotherapy for patients with advanced hepatocellular carcinoma.
Authors: Yao X, Wang L, Gao J Abstract Hepatocellular carcinoma (HCC) is a prevalent and refractory cancer in the world and very few drugs are available for the disease treatment currently. Programmed cell death protein-1 (PD-1) monoclonal antibodies including nivolumab and pembrolizumab has received accelerated approval for treatment of advanced HCC based on phase 1/2 clinical trials. However, the recently disclosed results of phase 3 clinical trials showed that both nivolumab and pembrolizumab as monotherapy failed to meet the primary objectives, which might overshadow the prospect of PD-1 inhibitors as monothera...
Source: BioScience Trends - July 24, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

New thoughts in exploring the pathogenesis, diagnosis, and treatment of threatened abortion.
Authors: Zhou J, Huang Z, Pan X, Leung WT, Li C, Chen L, Zhang Y, Wang L, Sima Y, Zhang N, Qiu X, Li L, Wang L Abstract Threatened abortion is a common complication of pregnancy. Since the underlying mechanisms behind this condition are complicated, predicting and treating threatened abortion is a challenge for clinicians. Interestingly, a recent article in Bioscience Trends (Biosci Trends 2019; DOI: 10.5582/bst.2019.01111) revealed a higher, not lower, level of ꞵ-human chorionic gonadotropin (hCG) and estrogen during the first 6 weeks of pregnancy, suggesting a novel association between ꞵ-hCG, estrogen, and th...
Source: BioScience Trends - July 24, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Analysis of mutations in the FOXI1 and KCNJ10 genes in infants with a single-allele SLC26A4 mutation.
Authors: Zhao X, Cheng X, Huang L, Wang X, Wen C, Wang X, Zhao L Abstract The current study investigated how the FOXI1 and KCNJ10 genes were affected in infants with a single-allele mutation in the SLC26A4 gene, and it determined the audiological phenotypes of infants with double heterozygous mutations (DHMs) in the three genes. Subjects were 562 infants with a single-allele SLC26A4 mutation detected during neonatal deafness genetic screening; the infants were seen as outpatients by Otology at Beijing Tongren Hospital. All subjects underwent SLC26A4 sequencing. Twenty infants had a second-allele variant while the r...
Source: BioScience Trends - June 29, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Protection of paeonol against epirubicin-induced hepatotoxicity: A metabolomic study.
This study evaluated the protective effect of paeonol on EPI-induced hepatotoxicity and explored the underlying metabolomic mechanism. Breast tumor-bearing mice were randomly divided into three groups: control, EPI, and EPI + paeonol treatment. Mice received a tail i.v. injection of EPI every other day for 3 cycles or/and intragastrically (i.g.) administered paeonol daily for 6 days. Hematoxylin-eosin (HE) staining and biochemical detection were used to determine the degree of damage. A gas chromatography-mass spectrometry (GC-MS) technique was established to determine the metabolites. PLS-DA and PCA were used to investiga...
Source: BioScience Trends - June 25, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Knockdown expression of MECR, a novel gene of mitochondrial FAS II inhibits growth and colony-formation, promotes apoptosis of hepatocelluar carcinoma cells.
Authors: Cai Y, Lin Y, Xiong X, Lu J, Zhou R, Jin Y, You Z, Ye H, Li F, Cheng N Abstract Mitochondrial trans-2-enoyl-CoA reductase (MECR) is a protein-coding gene, and the protein encoded by this gene is an oxidoreductase that catalyzes the last step in mitochondrial fatty acid synthesis (mtFASII). Numerous studies have shown disorder of lipid metabolism is closely related with malignance, especially in liver cancer. Through pre-experiment, we found that the expression of MECR gene was highly expressed in hepatocelluar carcinoma (HCC) cell lines in vitro. This suggests that the MECR gene may play a role of oncogene...
Source: BioScience Trends - June 12, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

MLS128 antibody-induced suppression of colon cancer cell growth is mediated by a desmocollin and a 110 kDa glycoprotein.
Authors: Shuck SC, Hong T, Kalkum M, Igarashi R, Kajiya K, Termini J, Yamamoto K, Fujita-Yamaguchi Y Abstract Protein glycosylation is a diverse form of post-translational modification. Two to three consecutive O-linked N-acetylgalactosamines (Tn-antigens) are recognized by antibodies such as MLS128. MLS128 mAb inhibited cell growth and bound to a 110 kDa glycoprotein (GP) in LS180 and HT29 colon cancer cells. However, purification and identification of the 110 kDa GP was unsuccessful due to its low abundance. The present study used a highly sophisticated and sensitive mass spectrometry method to identify proteins ...
Source: BioScience Trends - June 8, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Design and synthesis of novel histone deacetylase 6 inhibitors with benzyl-triazole as the core skeleton.
In this study, we designed and synthesized twenty-seven novel hydroxamic acid-based HDAC inhibitors (HDACis) with benzyl-triazole as the core skeleton. Most target compounds displayed excellent inhibition rates toward HDACs. Among them, compounds ZM-22 to ZM-27 with inhibition rates more than 90% toward HDACs exhibited potent inhibitory activity toward HDAC6, and ZM-23 possessed the best selectivity to HDAC6 over HDAC1. The high potency of compound ZM-23 toward HDAC6 was rationalized by molecular docking simulation. This series of compounds is worthy for further anti-cancer activity evaluation and structural optimization w...
Source: BioScience Trends - June 5, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Conserved amino acids around the DIII-DI linker region of the Newcastle disease virus fusion protein are critical for protein folding and fusion activity.
Authors: Chi M, Xie W, Liu Y, Zhang C, Liu Y, Wen H, Zhao L, Song Y, Liu N, Chi L, Wang Z Abstract Newcastle disease virus (NDV), an avian paramyxovirus, causes Newcastle disease (ND) which is a highly contagious and fatal viral disease affecting poultry and most species of birds. The fusion (F) protein of NDV mediates membrane fusion, which is essential to the processes of viral entry, replication, and dissemination. Although several domains of NDV F are known to have important effects on regulating the membrane fusion activity, the role of the region around domain III (DIII) and domain I (DI) still remains ill-de...
Source: BioScience Trends - June 1, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Higher ꞵ-human chorionic gonadotropin and estrogen levels during the first 6 weeks of pregnancy are associated with threatened abortion.
In conclusion, β-hCG and estrogen levels in the first half of the first trimester are factors associated with threatened abortion. PMID: 31130576 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - May 29, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Treatment modalities and relative survival in patients with brain metastasis from colorectal cancer.
Authors: Lu X, Cai Y, Xia L, Ju H, Zhao X Abstract Standard treatment options for brain metastases (BM) from colorectal cancer (CRC) are controversial. The purpose of this study was to evaluate the efficacy of multidisciplinary treatment modalities and provide optimal therapeutic strategies for selected patients with different clinical characteristics. All eligible patients diagnosed with BM from CRC during the past two decades (1997-2016) were identified in our center. Clinical characteristics, treatment modalities and relative survival were retrospectively analyzed. Median overall survival after the identificatio...
Source: BioScience Trends - May 9, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Preoperative albumin-bilirubin grade combined with aspartate aminotransferase-to-platelet count ratio index predict outcomes of patients with hepatocellular carcinoma within Milan criteria after liver resection.
Authors: Luo H, Li C, Chen L Abstract There is little information concerning the prognostic significance of combined albumin- bilirubin (ALBI) grade and aspartate aminotransferase-to-platelet count ratio index (APRI) in hepatocellular carcinoma (HCC). Therefore, we performed this study to assess the prognostic utility of combining ALBI and APRI (ALBI-APRI score) for predicting the prognosis of patients with HCC within Milan criteria after liver resection. Two hundred thirty-nine patients were involved in this study. Patients with a high APRI score were allocated a score of 1, whereas patients with a low APRI score ...
Source: BioScience Trends - May 9, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Design, synthesis and biological evaluation of 4-piperidin-4-yl-triazole derivatives as novel histone deacetylase inhibitors.
In this study, we designed and synthesized a series of twenty-one novel hydroxamic acid-based histone deacetylase inhibitors with 4-piperidin-4-yl-triazole as the core skeleton. Most target compounds displayed excellent inhibition rates toward histone deacetylases at the concentration of 1 μM. Among them, the inhibition rates of two compounds MH1-18 and MH1-21 exceeded 90%. Furthermore, these two compounds selectively inhibited the activity of histone deacetylase 6 with low IC50 values. The high potency of them toward histone deacetylase 6 was rationalized by molecular docking studies. We found that MH1-18 and MH1-21 mo...
Source: BioScience Trends - April 26, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Circular RNA profiling reveals circRNA1656 as a novel biomarker in high grade serous ovarian cancer.
This study aimed to investigate the expression profile of circRNAs in HGSOC. Expression profiles of circRNAs differential expression based on circRNAs High-throughput sequencing were identified in 3 HGSOC specimens and 3 normal ovarian tissues. A total of 710 differentially expressed circRNAs were found (354 expressions up-regulated and 356 expressions down-regulated). CircRNA sequencing data were verified by qRT-PCR in HGSOC tissue and benign ovarian lesions. Differential expression of 7 circRNAs (circRNA385, circRNA2058, circRNA3336, circRNA2606, circRNA1656, circRNA1312 and circRNA7474) in HGSOC tissue was confirmed by ...
Source: BioScience Trends - April 26, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

A selective oral vasopressin V2-receptor antagonist for patients with end-stage liver disease awaiting liver transplantation: a preliminary study.
Authors: Kiritani S, Kaneko J, Miyata Y, Matsumura M, Akamatsu N, Ishizawa T, Arita J, Tamura S, Kokudo N, Hasegawa K Abstract Administration of the selective arginine vasopressin V2 receptor antagonist tolvaptan to cirrhotic patients is controversial. There are no reports of tolvaptan use for patients with far-advanced end-stage liver disease (ESLD) and refractory ascites awaiting liver transplantation. Between 2013 and 2016, 64 patients awaiting adult-to-adult living donor liver transplantation (LDLT) were screened for enrollment. Patients with refractory ascites and on dual conventional diuretics (≥ 50 mg/day...
Source: BioScience Trends - April 26, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Driving factors and mode transformation regarding health technology assessment (HTA) in China: Problems and recommendations.
Authors: Wang H, Jin C, Bai F, Lin X, Fang L, Sun H, Cheng W, Song P Abstract As the reform of Chinese medical and health undertakings has advanced (since 2015), the admission, pricing and payment policies regarding the new health technologies of China have undergone significant changes, and health technology assessment (HTA) has gradually become one of the current reform and research hotspots in China. Based on the perspective of HTA driving factors and the development mode, this paper proposes a two-stage mode of HTA development in China, namely, the mode driven by the management of new heath technology admission...
Source: BioScience Trends - April 23, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Methanol extract of Lonicera caerulea var. emphyllocalyx fruit has antibacterial and anti-biofilm activity against Streptococcus pyogenes in vitro.
In this study, we investigated the antibacterial effect of methanol extracts of the fruit, stem, and leaf of LCE (LCEEs) against S. pyogenes using disk diffusion assay. As LCEE (fruit) had the strongest antibacterial activity among the three LCEEs, we focused on functional analysis of antibacterial effects of LCEE (fruit). LCEE (fruit) suppressed the growth of S. pyogenes in a dose-dependent manner. Morphological analysis by transmission electron microscopy demonstrated that LCEE (fruit) damaged the shape of S. pyogenes. Microplate and confocal laser microscopy analysis showed that biofilm formation was also suppressed by ...
Source: BioScience Trends - April 19, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Living donor liver transplantation for a patient with a history of total gastrectomy.
Authors: Shimata K, Irie T, Kadohisa M, Kawabata S, Ibuki S, Narita Y, Yamamoto H, Sugawara Y, Hibi T Abstract Adhesions due to previous upper abdominal surgery may complicate later liver transplantation. Here we report successful living donor liver transplantation (LDLT) in a patient with a history of total gastrectomy. A 32-year-old Japanese woman developed end-stage liver failure due to alcoholic cirrhosis. She had undergone total gastrectomy, pancreato-splenectomy, and partial colectomy due to rupture of a pancreatic cyst. LDLT was performed using a right lobe graft from her sister. To minimize blood loss and i...
Source: BioScience Trends - April 16, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Sperm DNA fragmentation valued by SCSA and its correlation with conventional sperm parameters in male partner of recurrent spontaneous abortion couple.
The objective of this study is to evaluate the predictive value of sperm DNA fragmentation Index (DFI) in unexplained recurrent spontaneous abortion (RSA) and to investigate its correlation with conventional sperm parameters. Besides, we aimed to reveal the necessity of establishing a DFI clinical threshold of each laboratory for the prognostic diagnosis of RSA and establish our own DFI threshold. Semen samples were collected from male partners of RSA patients (n = 139) and healthy recent fathers (control, n = 200). DFI was tested using SCSA and conventional semen analysis was performed using an automatic semen analyzer. T...
Source: BioScience Trends - April 13, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Predictive value of some pro-oxidants in type 2 diabetes mellitus with vascular complications.
Authors: Goycheva P, Nikolova G, Ivanova M, Kundurdzhiev T, Gadjeva V Abstract The study aims to analyze oxidative stress levels in circulation of some reactive molecules and products of biomolecular modification in type 2 diabetes mellitus (T2DM) with diabetes-specific vascular complications in order to determine their predictive value. Also, the alterations of their serum concentration with reference to disease characteristics were assessed. Reactive oxygen species (ROS), nitric oxide radicals (•NO), malondialdehyde (MDA), protein carbonyl (CO) and 8-hydroxydeoxyguanosin (8-OHdG) in serum were measured in 93...
Source: BioScience Trends - April 9, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Daucosterol induces autophagic-dependent apoptosis in prostate cancer via JNK activation.
This study was designed to investigate the functions of daucosterol in prostate cancer progression and its possible molecular mechanisms. Our results showed that daucosterol inhibited cell proliferation and induced cell cycle arrest. Moreover, daucosterol treatment obviously promoted apoptosis and autophagy. An autophagy inhibitor, 3-methyladenine (3-MA) was proved to counteract daucosterol-triggered autophagy, growth inhibition, and apoptosis, indicating that daucosterol-induced apoptotic response was dependent on autophagy. Additionally, treatment with daucosterol resulted in increased phosphorylation of c-Jun N-terminal...
Source: BioScience Trends - April 6, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Chinese herbal medicine for acute upper respiratory tract infections and reproductive safety: A systematic review.
Authors: Huang Z, Pan X, Zhou J, Leung WT, Li C, Wang L Abstract Acute upper respiratory tract infections (AURTIs) are common and self-limited in people with normal immunity but sometimes lead to poor clinical outcomes under specific conditions such as pregnancy if not treated appropriately. Chinese herbal medicines (CHM), which are widely used to treat AURTIs, have proven to be effective in preclinical and clinical studies. This review focuses on the bioactivities of typical CHM and the adverse reactions they cause, and especially issues with reproductive safety when treating AURTIs. The main mechanisms for clinic...
Source: BioScience Trends - April 3, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

IPS-1 polymorphisms in regulating interferon response in HBV infection.
Authors: Liu K, Chen L, Zhao G, Cao Z, Li F, Lin L, Zhu C, Xie Q, Xu Y, Bao S, Wang H Abstract Single nucleotide polymorphisms (SNP) influence the outcome of antiviral therapy in chronic hepatitis B patients. Interferon β promoter stimulator 1 polymorphisms (IPS-1) regulate interferon (IFN) mediated viral clearance in hepatitis B virus (HBV) infection. In our study, HepG2 and HepG2.2.15 were transfected with different SNP genotype expression vectors of IPS-1 (wild-type, rs17857295, rs7262903 and rs7269320). The production of IPS-1 and IFN were evaluated in these transfected cells. IPS-1 in the HepG2.2.15 cells...
Source: BioScience Trends - April 3, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

A Clinical scoring model to predict mortality in HIV/TB co-infected patients at end stage of AIDS in China: An observational cohort study.
Authors: Zhang Z, Xu L, Pang X, Zeng Y, Hao Y, Wang Y, Wu L, Gao G, Yang D, Zhao H, Xiao J Abstract We construct and validate a non-invasive clinical scoring model to predict mortality in HIV/TB patients at end stage of AIDS in China. There were 1,007 HIV/TB patients admitted to Beijing Ditan Hospital from August 2009 to January 2018 included in this study, who were randomly assigned to form derivation cohort and validation cohort. A clinical scoring model was developed based on predictors associated with mortality identified with Cox proportional hazard models. The discrimination and accuracy of model were further...
Source: BioScience Trends - April 3, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Improvement in the diagnosis and treatment of T2 gallbladder carcinoma is pivotal to improvement in the overall prognosis for this disease.
Authors: Zhou D, Wang J, Quan Z, Yang Y, Ma F Abstract Since the American Joint Committee on Cancer (AJCC) subdivided the T2 stage of gallbladder carcinoma (GBC) into T2a and T2b, the diagnosis and treatment of those stages have been a subject of heated discussion and controversy. T2 is a stage of GBC that might be treatable. Based on the extent of lymph node metastasis and distant metastasis, T2 GBC can be classified into various pathological stages such as IIA, IIB, IIIB, and IVB, leading to controversy in clinical settings. This review aims to discuss the effectiveness of and controversies concerning S4b+5 resec...
Source: BioScience Trends - March 16, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Effects of BENC-511, a novel PI3K inhibitor, on the proliferation and apoptosis of A549 human lung adenocarcinoma cells.
In conclusion, BENC-511 inhibited the proliferation of A549 human lung adenocarcinoma cells via S phase arrest as a result of up-regulation of p21 and reduction of Cyclin A/cyclin-dependent kinase 2 (CDK2)/PCNA complex and it induced apoptosis by reducing the mitochondrial membrane potential via the Akt/Bcl-2/Caspase-9 mitochondrial pathway of apoptosis. PMID: 30867372 [PubMed - in process] (Source: BioScience Trends)
Source: BioScience Trends - March 16, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Preoperative evaluation of the degree of liver fibrosis based on matter-element analysis using serological indicators in patients with hepatocellular carcinoma.
Authors: Liu W, Li X, Zheng W, Yao R, Zheng J Abstract Evaluation of the degree of liver fibrosis is an important basis for the clinical diagnosis and treatment of patients with hepatocellular carcinoma (HCC). It is meaningful to make a preoperative evaluation with non-invasive methods. In the current study, 12 commonly used preoperative serological indicators from 161 HCC patients with different degree of liver fibrosis were collected retrospectively, and 8 of the indicators (ALB, PA, TBil, INR, AST, GGT, ALP, and PT) were ultimately used in matter-element analysis to create a formula. The relationship between tho...
Source: BioScience Trends - March 16, 2019 Category: Biomedical Science Tags: Biosci Trends Source Type: research