Regulatory effects of Ningdong granule on microglia-mediated neuroinflammation in a rat model of Tourette's syndrome.
In conclusion, microglia might play key roles in mediating neuroinflammatory responses in TS, triggering the release of TNF-α, IL-6, and MCP-1.NDG inhibited tics in rats with TS, and this mechanism may be associated with a reduction in the increased number of activated microglia and a decrease in the expression of pro-inflammatory cytokines and chemokines in the striatum and/or serum. PMID: 32741856 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - August 5, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

High platelet count as a poor prognostic factor for liver cancer patients without cirrhosis.
In this study, we retrospectively investigated whether high platelet count negatively affects the survival of patients with hepatocellular carcinoma (HCC). Patients undergoing initial and curative resection for HCC were included. Surgical outcomes were compared between the high platelet (platelet count ≥ 20 × 104/μL) and control (
Source: BioScience Trends - July 28, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

RETRACTED: Polyphosphate-induced matrix metalloproteinase-3-mediated proliferation in rat dental pulp fibroblast-like cells is mediated by a Wnt5 signaling cascade.
Authors: PMID: 32713868 [PubMed - in process] (Source: BioScience Trends)
Source: BioScience Trends - July 28, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

RETRACTED: Products of dentin matrix protein-1 degradation by interleukin-1 β-induced matrix metalloproteinase-3 promote proliferation of odontoblastic cells.
RETRACTED: Products of dentin matrix protein-1 degradation by interleukin-1β-induced matrix metalloproteinase-3 promote proliferation of odontoblastic cells. Biosci Trends. 2020;14(3):E3 Authors: PMID: 32713869 [PubMed - in process] (Source: BioScience Trends)
Source: BioScience Trends - July 28, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Are inflammation-based markers useful in patients with hepatocellular carcinoma and clinically significant portal hypertension after liver resection?
In this study, 1452 patients were enrolled. Independent risk factors for recurrence-free survival (RFS) and overall survival (OS) were analyzed for patients with and without CSPH. For HCC patients without CSPH, multivariate analysis suggested that microvascular invasion (MVI), neutrophil-to-lymphocyte ratio (NLR) ≥ 3, platelet-to-lymphocyte ratio (PLR) ≥ 150, tumor size> 5 cm, and the presence of a satellite lesion were independently associated with RFS. MVI, NLR ≥ 3, PLR ≥ 150, and advanced Barcelona clinical liver cancer (BCLC) stage contributed to mortality. However, neither NLR nor PLR showed any prognos...
Source: BioScience Trends - July 11, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Descriptive epidemiology of high frequency component based on heart rate variability from 10-second ECG data and daily physical activity among community adult residents: the Nagahama Study.
Authors: Takahashi N, Takahashi Y, Tabara Y, Kawaguchi T, Kuriyama A, Ueshima K, Kosugi S, Sekine A, Yamada R, Matsuda F, Nakayama T, Nagahama Study Group Abstract Characteristics of high frequency (HF) component based on heart rate variability (HRV) in a large general population remain unclear, particularly on the relationship with daily physical activity. We aimed to characterize the distribution of HF component and examine the association with daily physical activity among community residents. We performed spectral analysis of HRV from 10-second ECG recordings among 9135 residents aged 30 to 74 years in Nagahama...
Source: BioScience Trends - July 7, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Insecticide Resistance of Aedes albopictus in Zhejiang Province, China.
Authors: Hou J, Liu Q, Wang J, Wu Y, Li T, Gong Z Abstract From 2003 until 2018, a total of 12 outbreaks with 1,654 confirmed dengue cases have been reported in Zhejiang Province. The emergence of insecticide resistance in mosquitoes will affect the control of dengue. Our study aims to investigate the current situation of insecticide resistance of Ae. albopictus in Zhejiang Province and compares it with the situation in 2016. Ae. albopictus were collected from 12 Zhejiang Province cities in 2019. Resistance to three major categories of insecticides, including 8 commonly used insecticides, was evaluated according to...
Source: BioScience Trends - July 1, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Exploration and correlation analysis of changes in Krebs von den Lungen-6 levels in COVID-19 patients with different types in China.
This study aimed to determine the clinical significance of Krebs von den Lungen-6 (KL-6) in patients with COVID-19, so as to find a marker with high sensitivity, specificity and easy detection to evaluate the lung injury and inflammation of COVID-19. Sixty-three COVID-19 patients and 43 non-COVID-19 patients with similar clinical phenotypes and/or imaging findings were enrolled to test the levels of KL-6 using chemiluminescent immunoassay. In addition, the blood gas, imaging and lymphocyte factors tests were collected from all participants. The data was finally analyzed using multivariate statistical analysis. The results ...
Source: BioScience Trends - June 24, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Potential for jaktinib hydrochloride to treat cytokine storms in patients with COVID-19.
Authors: Meng X, Ling Y, Zhang L, Zhang Q, Dong P, Zhu T, Lu H Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has become a serious public health threat to the whole world, and the number of infected is still rising dramatically at this moment. Several studies have confirmed that cytokine storms play a critical role in causing a case to worsen from mild to severe or critical. The current treatment for cytokine storms is limited, so the international medical community is focusing on a specific and effective remedy. Jaktinib hydrochloride is a broad spectrum JAK inhibitor. It can inhib...
Source: BioScience Trends - June 17, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Correlation between reticulum ribosome-binding protein 1 (RRBP1) overexpression and prognosis in cervical squamous cell carcinoma.
In conclusion, compared with healthy cervical tissues, RRBP1 was overexpressed in CSCC tissues, illustrating that RRBP1 may be a new biomarker for the diagnosis of CSCC. The study on RRBP1 may contribute to exploring the pathogenesis of CSCC and may also guide targeted therapy for CSCC in the future. PMID: 32536673 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - June 17, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

High C-reactive protein/albumin ratio associated with reduced survival due to advanced stage of intrahepatic cholangiocarcinoma.
This study aimed to elucidate whether a high CRP/Alb ratio is associated with the surgical outcome of ICC patients. Patients who underwent initial and curative resection for ICC were included in this study, and were divided into the High and Low CRP/Alb groups based on their preoperative CRP and Alb values. The surgical outcomes were compared between the two groups. The median CRP/Alb ratio amongst 88 patients was 0.033 (range, 0.019-3.636); 44 patients with CRP/Alb> 0.033 were allocated to the High CRP/Alb group and 44 patients were allocated to the Low CRP/Alb group. The operative data did not differ between the two g...
Source: BioScience Trends - June 10, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

The cytotoxicity of advanced glycation end products was attenuated by UCMSCs in human vaginal wall fibroblasts by inhibition of an inflammatory response and activation of PI3K/AKT/PTEN.
This study demonstrated that UCMSCs inhibited the cytotoxic effect of AGE in cells from patients with POP by inducing an anti-inflammatory reaction and activating the PI3K/AKT/PTEN signaling pathway. The current results provide important insights into use of stem cells to treat POP. PMID: 32493859 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - June 6, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Predicting intervention effect for COVID-19 in Japan: state space modeling approach.
This study analyzes the real time data from March 1 to April 22, 2020 by adopting a sophisticated statistical modeling based on the state space model combined with the well-known susceptible-infected-recovered (SIR) model. The model estimation and forecasting are conducted using the Bayesian methodology. The present study provides the parameter estimates of the unknown parameters that critically determine the epidemic process derived from the SIR model and prediction of the future transition of the infectious proportion including the size and timing of the epidemic peak with the prediction intervals that naturally accounts...
Source: BioScience Trends - May 30, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

A breathing movement sensor for chest radiography during inspiration in children aged less than 3 years: a prospective randomized controlled study.
Authors: Honda M, Haruyama R, Sugiura Y, Ohara K, Mochigi K, Kono Y, Shichino H, Uryu H, Mizoue T, Marutani T, Ebihara T, Uchiyama F, Makise S, Akashi H Abstract Chest radiographs should be obtained at the peak of inspiration so that radiological findings can be precisely interpreted. However, this is not easily achieved, particularly in young children who do not follow the instruction to hold their breath. We developed a sensor that detects the breathing movements and conducted a randomized controlled study to determine whether the sensor would increase the proportion of chest radiographs obtained in the inspirati...
Source: BioScience Trends - May 19, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

The impact of social capital on civil society organizations delivering voluntary counseling and testing HIV/AIDS service: a cross-sectional study in China.
Authors: Liu L, Wang D, Qin X, Hu Z, Chen R Abstract In China, Voluntary HIV Counseling and Testing (VCT) services are mostly provided by Civil Society Organizations (CSOs). This cross-sectional study investigated the association between CSOs' social capital and VCT service availability in eight Chinese provinces during July-December 2015. Data on CSOs' characteristics were collected through questionnaire-based interviews. Social capital was measured using a purpose-developed questionnaire. Logistic regression models tested the association between social capital and the scale of VCT services. A total of 103 CSOs th...
Source: BioScience Trends - May 19, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Does immune privilege result in recovered patients testing positive for COVID-19 again?
Authors: Xia J Abstract Recently, an increasing number of reports have indicated that a few patients who were believed to have recovered from COVID-19 initially tested negative but later tested positive. Several hospitals in different countries have detected SARS-CoV-2 RNA in the semen and cerebrospinal fluid of patients with severe COVID-19. Given the fact that the testes and central nervous system are both immune privilege sites and the fact that Ebola virus and Zika virus can avoid immune clearance and continue proliferating and spreading by hiding in those sites, the question of whether SARS-CoV-2 is present in...
Source: BioScience Trends - May 19, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Design, synthesis, and biological evaluation of 4-phenoxybenzenesulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors.
Authors: Mao J, Zhang H, Wang X, Gao J, Tang J, Zhang J Abstract A series of 4-phenoxybenzenesulfonyl pyrrolidine derivatives were designed, synthesized, and evaluated as matrix metalloproteinases (MMPs) inhibitors. All of the synthesized compounds displayed inhibitory activity against MMP-2 and MMP-9. Compounds 4a, 4e, and 4i displayed more potent activity than the other compounds. While the three compounds mildly or moderately inhibited the proliferation of cancer cells, they significantly suppressed the migration and invasion of cancer cells at relatively low concentrations as determined by a wound healing assay...
Source: BioScience Trends - May 12, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Current status of laparoscopic radical hilar cholangiocarcinoma in Mainland China.
In conclusions, laparoscopic radical hilar cholangiocarcinoma is safe and feasible in experienced hands after careful selection of HCCA cases. PMID: 32389939 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - May 12, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

An international comparison analysis of reserve and supply system for emergency medical supplies between China, the United States, Australia, and Canada.
Authors: Wang X, Wu W, Song P, He J Abstract Coronavirus disease 19 (COVID-19) has become a pandemic around the world. With the explosive growth of confirmed cases, emergency medical supplies are facing global shortage, which restricts the treatment of seriously ill patients and protection of medical staff. Taking China, the United States, Australia, and Canada as examples, this study compares and analyzes the reserve and supply systems of emergency medical supplies and problems exposed in response to the COVID-19 epidemic. Some common problems were found, such as insufficient types and quantities of emergency medi...
Source: BioScience Trends - May 12, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Introduction on collective quarantine of close contacts of patients with COVID-19 for medical observation in China: from the perspective of frontline staff.
This article briefly describes the placement of close contacts of patients with COVID-19 under collective quarantine for medical observation in China from the perspective of frontline staff. This article focuses on a community in the Jiading District of Shanghai to provide a reference for placement of close contacts of patients with COVID-19 under collective quarantine for medical observation in other countries and regions. PMID: 32389941 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - May 12, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Exploration of Salmonella effector mutant strains on MTR4 and RRP6 degradation.
In this study, we examined a series of Salmonella mutant strains, most of which are strains with genes related to effectors translocated by T3SSs encoded on Salmonella pathogenic islands, SPI-1 and SPI-2, that have been depleted. Among 42 Salmonella mutants, 6 mutants' infections canceled loss of MTR4 and RRP6. Proliferation assay of Salmonella in the cell revealed that six mutants showed poor proliferation in the host cell, demonstrating that poor proliferation contributed to cancellation of MTR4 and RRP6 loss. This result indicates that certain events associated with Salmonella proliferation in host cells cause loss of M...
Source: BioScience Trends - May 2, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Analysis of coagulation parameters in patients with COVID-19 in Shanghai, China.
Authors: Zou Y, Guo H, Zhang Y, Zhang Z, Liu Y, Wang J, Lu H, Qian Z Abstract To investigate the characteristic of coagulation function in 303 patients with Coronavirus disease 2019 (COVID-19), we evaluated the correlation between coagulation function and disease status. We retrospectively analyzed 303 patients diagnosed with COVID-19 and evaluated the clinical data of 240 patients who were discharged. The coagulation function of the two groups (mild and severe) was compared. Compared with the mild group, majority of patients in the severe group were male (76.9% vs. 49.8%) and elderly (median age 65 vs. 50), and th...
Source: BioScience Trends - May 2, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Suggestions on surgical treatment during coronavirus disease 2019 (COVID-19) pandemic.
Authors: Zhao Z, Li M, Liu R Abstract Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2 virus, is now generating a global epidemic, leading to a severe public health emergency. Until April 12, 2020 around 1,700,954 confirmed cases and 105,633 deaths have been reported all over the world. The World Health Organization (WHO) has declared COVID-19 as a Public Health Emergency of International Concern. Under this circumstance, surgical activities should be carefully evaluated to avoid excessive occupation of limited medical resources, and to reduce the possibility of hospital infection. China has achieved an in...
Source: BioScience Trends - April 28, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Comparative transcriptome analysis of transcultured human skin-derived precursors (tSKPs) from adherent monolayer culture system and tSKPs-derived fibroblasts (tFBs) by RNA-Seq.
Authors: Dai R, Chen W, Hua W, Xiong L, Li Y, Li L Abstract Transcultured human skin derived precursors (tSKPs) from adherent monolayer culture system have similar characteristics as traditional skin derived precursors (SKPs), making tSKPs a suitable candidate for regenerative medicine. tSKPs can differentiate into fibroblasts. However, little is known about the molecular mechanism of the transition from tSKPs to fibroblasts. Here, we compared the transcriptional profiles of human tSKPs and tSKPs-derived fibroblasts (tFBs) by RNA-Sequence aiming to determine the candidate genes and pathways involving in the differe...
Source: BioScience Trends - April 25, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

A practice of anesthesia scenario design for emergency cesarean section in patients with COVID-19 infection based on the role of standard patient.
Authors: Kang Y, Deng L, Zhang D, Wang Y, Wang G, Mei L, Zhou G, Shu H Abstract The new coronavirus (COVID-19) has been characterized as a world pandemic by WHO since March 11, 2020. Although it is likely that COVID-19 transmission is primarily via droplets and close contact, airborne transmission and fecal-oral route remains a possibility. The medical staff working in the operating room, such as anesthesiologists, surgeons and nurses, are at high risk of exposure to virus due to closely contacting patients. The perioperative management is under great challenge while performing surgeries for patients suffering COVI...
Source: BioScience Trends - April 25, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Asymptomatic carriers of COVID-19 as a concern for disease prevention and control: more testing, more follow-up.
Authors: Zhang J, Wu S, Xu L Abstract Following a containment phase of two months, China has transitioned to the mitigation phase. However, China still faces the risk of COVID-19 spreading due to not only to sporadic new cases and imported cases but also asymptomatic carriers. According to daily reports from the National Health Commission of the People's Republic of China from March 31, 2020 to April 7, 2020, the number of new asymptomatic cases reported daily greatly exceeded that of new imported cases. As of 24:00 on April 7, there were a total of 1,095 asymptomatic cases with COVID-19 under medical observation o...
Source: BioScience Trends - April 25, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Neuropsychiatric adverse events of chloroquine: a real-world pharmacovigilance study using the FDA Adverse Event Reporting System (FAERS) database.
In this study, aiming to investigate these adverse events (AEs) using a large self-reporting database, we conducted a disproportionality analysis for the detection of neuropsychiatric AE signals associated with the use of chloroquine (or hydroxychloroquine), reported to FDA Adverse Event Reporting System (FAERS) database between the fourth quarter of 2012 and the fourth quarter of 2019. We included 2,389,474 AE cases, among which 520 cases developed neuropsychiatric AE following the use of chloroquine. Adjusted reporting odds ratio (ROR) for the development of each of the neuropsychiatric AEs following the use of chloroqui...
Source: BioScience Trends - April 25, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

NEK7: a potential therapy target for NLRP3-related diseases.
Authors: Liu G, Chen X, Wang Q, Yuan L Abstract NLRP3 inflammasome plays an essential role in innate immunity, yet the activation mechanism of NLRP3 inflammasome is not clear. In human or animal models, inappropriate NLRP3 inflammasome activation is implicated in many NLRP3-related diseases, such as tumors, inflammatory diseases and autoimmune diseases. Until now, a great number of inhibitors have been used to disturb the related signaling pathways, such as IL-1β blockade, IL-18 blockade and caspase-1 inhibitors. Unfortunately, most of these inhibitors just disturb the signaling pathways after the activation o...
Source: BioScience Trends - April 18, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Identification and characterization of the V3 promoter of the ST3GAL4 gene.
The objective of this work was to identify and characterize the V3 promoter of the ST3GAL4 gene. For this, the putative V3 promoter of the ST3GAL4 gene was delimited by in silico analysis. The complete promoter and smaller versions were cloned in a reporter plasmid. The constructs were transfected in the HaCaT cells and the promoter activity was evaluated by luciferase reporter assays. The cloned region showed promoter activity, and the basal activity was not dependent on TATA boxes. However, the GC boxes, an initiator element (Inr) and downstream promoter element (DPE) could contribute to basal activity. The promoter cont...
Source: BioScience Trends - April 18, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Update on use of chloroquine/hydroxychloroquine to treat coronavirus disease 2019 (COVID-19).
Authors: Gao J, Hu S Abstract Drugs that are specifically efficacious against SARS-CoV-2 have yet to be established. Chloroquine and hydroxychloroquine have garnered considerable attention for their potential to treat coronavirus disease 2019 (COVID-19). Increasing evidence obtained from completed clinical studies indicates the prospects for chloroquine/hydroxychloroquine to treat COVID-19. More randomized control clinical studies are warranted to determine the feasibility of these two drugs in treating COVID-19. PMID: 32281583 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - April 15, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Macrolide treatment for COVID-19: Will this be the way forward?
Authors: Ohe M, Shida H, Jodo S, Kusunoki Y, Seki M, Furuya K, Goudarzi H Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic that has developed in late 2019 and 2020 is a serious threat to human health. With no vaccines or drugs approved for prevention and treatment until now, all efforts at drug design and/or clinical trials of already approved drugs are worthy and creditable. Using structure-based drug selection for identification of SARS-CoV-2 protease inhibitors, old drugs such as macrolides (MAC) were predicted to be effective for COVID-19. Lately, the anti-viral effects of macr...
Source: BioScience Trends - April 8, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Corrigendum.
Authors: PMID: 32238667 [PubMed - in process] (Source: BioScience Trends)
Source: BioScience Trends - April 4, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Dimethylarginine dimethylaminohydrolase-1 contributes to exercise-induced cardiac angiogenesis in mice.
In this study, we focused on the change in DDAH1 in response to moderate exercise and the underlying mechanism of exercise-induced cardiac angiogenesis. Eight-week-old male DDAH1 global knockout (KO) mice and DDAH1flox/flox mice (wild-type) were randomly divided into sedentary groups (control) and swimming groups (exercise). After eight weeks of swimming at five days per week, all the mice were anesthetized and sacrificed. Histological examination and Western blot analysis were performed. There were low levels of myocardial capillaries in DDAH1 KO mice under control and exercise conditions. Notably, exercise elevated DDAH1...
Source: BioScience Trends - April 4, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Mobile field hospitals, an effective way of dealing with COVID-19 in China: sharing our experience.
This article describes some of our experiences operating mobile field hospitals in order to provide a reference and to better inform countries that are dealing with this crisis. PMID: 32238673 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - April 4, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Health care reform in China from the perspective of physicians.
Authors: Lin J, Zhou J, Wang L Abstract Health care reform is a worldwide problem. To address the problems of costs, access, quality, efficiency, and equity, China initiated healthcare reform in 2009. The progress of China's healthcare reform has been internationally recognized as the reform has expanded insurance coverage and improved access to and reduced the costs of care over the ten-year period from 2008 to 2018. To achieve sustainable goals, attention must be focused on whether and how the reform encourages physicians. This paper highlights the role of physicians, the challenges that need to be addressed, and...
Source: BioScience Trends - April 2, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Analysis of COVID-19 infection spread in Japan based on stochastic transition model.
In conclusions The infection spread in Japan will be gradually contained by reducing the time spent in the crowded zone to less than 4 hours. PMID: 32188819 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - March 20, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

A steroidal saponin form Paris vietnamensis (Takht.) reverses temozolomide resistance in glioblastoma cells via inducing apoptosis through ROS/PI3K/Akt pathway.
In this study, we use cellular methodological experiments including cell counting kit-8 (CCK-8) assay, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining assay, flow cytometry assay, transmission electron microscopy (TEM) and Western blot. The results show that N45 significantly suppresses the proliferation of glioblastoma cells and TMZ-resistant glioblastoma cells (U87R) by inducing mitochondrial apoptosis through reactive oxygen species (ROS)/phosphoinositide 3-kinase (PI3K)/Akt signal pathway, and the N-acetyl-L-cysteine (NAC) combined with N45 effectively reduced N45-mediated apoptosis and re...
Source: BioScience Trends - March 18, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Novel conjugates of endoperoxide and 4-anilinoquinazoline induce myeloma cell apoptosis by inhibiting the IGF1-R/AKT/mTOR signaling pathway.
Authors: Xu Y, Zeng K, Wang X, Zhang J, Cao B, Zhang Z, Qiao C, Xu X, Wang Q, Zeng Y, Mao X Abstract 4-anilinoquinazoline-containing inhibitors of the epidermal growth factor receptor (EGFR) are widely used in non-small cell lung cancer patients with mutated EGFR, but they are less effective in multiple myeloma (MM), a fatal malignancy derived from plasma cells. The present study designed a series of novel compounds by conjugating a peroxide bridge to the 4-anilinoquinazoline pharmacophore. Further studies showed that these agents such as 4061 and 4065B displayed potent activity to induce MM cell apoptosis by upreg...
Source: BioScience Trends - March 18, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Overexpression of DJ-1 enhances colorectal cancer cell proliferation through the cyclin-D1/MDM2-p53 signaling pathway.
In conclusion, the current findings provide compelling evidence that DJ-1 might be a promoter of CRC cell invasion, proliferation, and migration via the cyclin-D1/MDM2-p53 signaling pathway. Findings also suggest its potential role as a postoperative adjuvant therapy for patients with CRC. PMID: 32132307 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - March 8, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Suppression of tumor growth and metastasis by ethanol extract of Angelica dahurica Radix in murine melanoma B16F10 cells.
In this study, we investigated the effect of ethanol extract from the roots of this plant on metastatic melanoma, a highly aggressive skin cancer, in B16F10 melanoma cells and B16F10 cell inoculated-C57BL/6 mice. Our results showed that the ethanol extracts of Angelicae dahuricae Radix (EEAD) suppressed cell growth and induced apoptotic cell death in B16F10 cells. EEAD also activated the mitochondria-mediated intrinsic apoptosis pathway, with decreased mitochondrial membrane potential, and increased production of intracellular reactive oxygen species and ration of Bax/Bcl-2 expression. Furthermore, EEAD reduced the migrati...
Source: BioScience Trends - February 25, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Technical details of and prognosis for the "China stitch", a novel technique for totally laparoscopic hand-sewn esophagojejunostomy.
In conclusion, the "China stitch", a novel hand-sewn technique, is a cost-effective, safe, and reliable method for esophagojejunostomy in totally laparoscopic total gastrectomy. PMID: 32092746 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - February 25, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Effects of different mark-up drug policies on drug-related expenditures in tertiary public hospitals: an interrupted time series study in Shanghai, China, 2015-2018.
This study aimed to investigate the impact of different mark-up drug policies on drug-related expenditures in tertiary public hospitals in Shanghai, China. Data were drawn from the audited financial statement in 24 tertiary public hospitals in Shanghai from January 2015 to December 2018. Drug-related revenue data and per capita cost data pre- and post-intervention were included. Interrupted time series design was applied to assess the actual effects of Fixed Percent Mark-up Drug (FPM) policy and Zero Mark-up Drug (ZMD) policy respectively. Results showed that ZMD policy achieved better intervention effects on declining dru...
Source: BioScience Trends - February 25, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

COVID-19: Real-time dissemination of scientific information to fight a public health emergency of international concern.
Authors: Song P, Karako T Abstract Rapidly sharing scientific information is an effective way to reduce public panic about COVID-19, and doing so is the key to providing real-time guidance to epidemiologists working to contain the outbreak, clinicians managing patients, and modelers helping to understand future developments and the possible effectiveness of various interventions. This issue has rapidly reviewed and published articles describing COVID-19, including the drug treatment options for SARS-CoV-2, its clinical characteristics, and therapies involving a combination of Chinese and Western medicine, the effic...
Source: BioScience Trends - February 25, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Electrocardiographic abnormalities among people with HIV in Shanghai, China.
Authors: Shen F, Zhu B, Ding Y, Gao M, He N Abstract People living with HIV (PLWH) have an excess risk of cardiovascular diseases (CVD). Electrocardiographic (ECG) abnormalities are independently predictive of incident cardiovascular events in the general population. Our study aimed to evaluate the prevalence and correlates of ECG abnormalities among PLWH in Shanghai, China. We used a cross-sectional design to collect data from Shanghai Public Health Clinical Center, China. A total of 587 HIV-infected patients aged between 18 and 75 years were recruited between January 2015 and February 2016. The overall prevalence...
Source: BioScience Trends - February 21, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies.
Authors: Gao J, Tian Z, Yang X Abstract The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People's Republi...
Source: BioScience Trends - February 21, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Challenges to the system of reserve medical supplies for public health emergencies: reflections on the outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in China.
Authors: Wang X, Zhang X, He J Abstract On December 31, 2019, the Wuhan Municipal Health Commission announced an outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), China is now at a critical period in the control of the epidemic. The Chinese Government has been taking a series of rapid, comprehensive, and effective prevention and control measures. As the pandemic has developed, a fact has become apparent: there is a serious dearth of emergency medical supplies, and especially an extreme shortage of personal protective equipment such as masks and medical protective clothing. This is one of the...
Source: BioScience Trends - February 20, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment.
We report here the clinical characteristics and therapeutic procedure for four patients with mild or severe 2019-nCoV pneumonia admitted to Shanghai Public Health Clinical Center. All the patients were given antiviral treatment including lopinavir/ritonavir (Kaletra®), arbidol, and Shufeng Jiedu Capsule (SFJDC, a traditional Chinese medicine) and other necessary support care. After treatment, three patients gained significant improvement in pneumonia associated symptoms, two of whom were confirmed 2019-nCoV negative and discharged, and one of whom was virus negative at the first test. The remaining patient with severe ...
Source: BioScience Trends - February 12, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Fast time perception is associated with high levels of anxiety in cancer patients prior to starting chemotherapy.
Authors: Donev IS, Ivanova MS, Conev NV Abstract Our study explored the potential relationship between time perception and the level of anxiety in cancer patients prior to starting chemotherapy. Time perception was assessed in 162 chemonaïve patients with solid tumors by evaluating each subject's prospective estimation of how fast one minute passed compared to the actual amount of time passed. The median value of time perception was used to stratify the patients into two categories of fast and slow time perception. We used the generalized anxiety disorder questionnaire (GAD-7) as a screening tool for detecting...
Source: BioScience Trends - February 7, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Neutrophil to lymphocyte ratio as a potential predictive marker for treatment with pembrolizumab as a second line treatment in patients with non-small cell lung cancer.
Authors: Petrova MP, Eneva MI, Arabadjiev JI, Conev NV, Dimitrova EG, Koynov KD, Karanikolova TS, Valev SS, Gencheva RB, Zhbantov GA, Ivanova AI, Sarbianova II, Timcheva CV, Donev IS Abstract The aim of this multicentric retrospective study is to evaluate the predictive and prognostic performance of neutrophil to lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and their dynamics in patients with non-small cell lung cancer (NSCLC) treated with pembrolizumab as a second line. Patients with metastatic NSCLC (n = 119), whose tumors expressed programmed death-ligand 1 (PD-L1) ≥ 1%, were retrospectively analyz...
Source: BioScience Trends - February 7, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Long-term outcomes of living donor liver transplantation in patients with a prior history of nonhepatic malignancy.
In conclusion, the patients with PTM had comparable outcomes with regard to mortality and cancer-specific mortality compared with those without PTM. This study showed that the patients with PTM can obtain an acceptable outcome after LDLT when carefully selected. PMID: 32023575 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - February 7, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research