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Shenqi detoxification granule combined with P311 inhibits epithelial-mesenchymal transition in renal fibrosis via TGF- β1-Smad-ILK pathway.
Shenqi detoxification granule combined with P311 inhibits epithelial-mesenchymal transition in renal fibrosis via TGF-β1-Smad-ILK pathway. Biosci Trends. 2017;11(6):640-650 Authors: Cai P, Liu X, Xu Y, Qi F, Si G Abstract Shenqi detoxification granule (SDG), a traditional Chinese herbal formula, has been shown to have nephroprotective and anti-fibrotic activities in patients with chronic kidney disease (CKD). However, its mechanisms in renal fibrosis and the progression of CKD remain largely unknown. P311, a highly conserved 8-kDa intracellular protein, plays a key role in renal fibrosis by regula...
Source: BioScience Trends - January 11, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Evaluation of insulin resistance improvement after laparoscopic sleeve gastrectomy or gastric bypass surgery with HOMA-IR.
Authors: Zhu Y, Sun Z, Du Y, Xu G, Gong K, Zhu B, Zhang N Abstract Our purpose was to explore the remission of insulin resistance after bariatric surgery to discover the mechanism of diabetes remission excluding dietary factors. A retrospective case control study was conducted on patients with type 2 diabetes, who underwent laparoscopic sleeve gastrectomy (LSG) or laparoscopic gastric bypass surgery (LGB) in Beijing Shijitan Hospital from April 1, 2012 to April 1, 2013. The laboratory and anthropometric data was analyzed pre-surgery and during a 2-year follow-up. HOMA-IR was calculated and evaluated. The two surgic...
Source: BioScience Trends - January 11, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

A comparative study of the blend sign and the black hole sign on CT as a predictor of hematoma expansion in spontaneous intracerebral hemorrhage.
In conclusion, the blend sign and the black hole sign on CT are both good predictors of HE in patients with sICH, though the blend sign seems to have a higher level of accuracy. PMID: 29311451 [PubMed - in process] (Source: BioScience Trends)
Source: BioScience Trends - January 11, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Competency and challenges in malaria microscopy in China.
Authors: Yin J, Yan H, Li M, Ruan Y, Zhang X, Wang L, Cao C, Xia Z, Zhou S Abstract Precise diagnosis is a key measure for malaria control and elimination, and malaria microscopy is still the gold standard method recommended by the World Health Organization (WHO) for malaria diagnosis. Analysis of the competency in malaria microscopy in China will benefit to identify the challenges in this skill and provide some suggestions for improvement in order to reach the requirement of WHO procedures for certification of malaria elimination, and finally contribute to malaria elimination by 2020 in China. According to a serie...
Source: BioScience Trends - January 11, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Researchers of chronic obstructive pulmonary disease gathered at the 2017 Japan-China Joint Medical Workshop on Aging and Health.
Authors: Sawakami T, Xia J, Song P Abstract As the number of elderly and the size of the total population increase, population aging will become a major problem because of an increase in diseases associated with aging, such as chronic obstructive pulmonary disease (COPD). The 2017 Japan-China Joint Medical Workshop on Aging and Health was held at The University of Tokyo on December 2, 2017 with a focus on management of COPD. More than 50 experts in the fields of respiratory medicine, emergency medicine, traditional Chinese medicine, and Kampo (traditional Japanese medicine) from Japan and China presented the result...
Source: BioScience Trends - January 11, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

The effects of health education and promotion with regard to severe fever with thrombocytopenia syndrome (SFTS) in rural residents: A pilot study in China.
Authors: Wu Y, Fu G, Guo S, Ye L, Hou J, Wang J, Gong Z Abstract Severe fever with thrombocytopenia syndrome (SFTS) has spread throughout Asia, including China, South Korea, and Japan. In China, the main victims of SFTS were farmers. Measures to protect farmers were urgently needed but limited, and health education and promotion was proposed as an option. A pilot community trial was conducted to provide health education about SFTS in 2013 in Daishan County, Zhejiang Province, China, and results indicated that health education had promise. An educational campaign was conducted for three years. The incidence of SFTS ...
Source: BioScience Trends - December 23, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Low-density lipoprotein receptor deficiency impaired mice osteoblastogenesis in vitro.
Authors: Zhang N, Zhang Y, Lin J, Qiu X, Chen L, Pan X, Lu Y, Zhang J, Wang Y, Li D, Wang L Abstract Postmenopausal osteoporosis affected most elderly women with co-existence of lipid and bone metabolism disorders. However, the cellular and molecular mechanisms underlying the parallel progression and cross-talk of these systems remained unclear. In the present study, low-density lipoprotein receptor knockout (LDLR-/-) mice were chosen to elucidate the effect of LDLR in regulating the differentiation of osteoblasts, which were responsible for bone formation and modulation of osteoclastogenesis. Primary osteoblasts w...
Source: BioScience Trends - December 23, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Expression, purification, and biological characterization of Anaplasma phagocytophilum enolase.
In conclusion, A. phagocytophilum enolase is a multifunctional protein which can catalyze the dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate, and facilitate binding to host plasminogen. PMID: 29249727 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - December 20, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Does pneumoperitoneum affect perfusion index and pleth variability index in patients receiving combined epidural and general anesthesia?
Authors: Wajima Z, Shiga T, Imanaga K Abstract Plethysmographic variability index (PVI) is a dynamic index used for the purpose of fluid responsiveness in patients, and the effect of pneumoperitoneum on PVI is still unclear. We therefore attempted to determine whether PVI and perfusion index (PI) change before/after pneumoperitoneum in patients receiving combined epidural and general anesthesia, which is a common anesthesia method with intravenous remifentanil. Twenty patients underwent laparoscopic cholecystectomy or colectomy. Immediately before pneumoperitoneum, variables were measured at baseline I and were the...
Source: BioScience Trends - December 20, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Effects of lifestyle advice provided by pharmacists on blood pressure: The COMmunity Pharmacists ASSist for Blood Pressure (COMPASS-BP) randomized trial.
Authors: Okada H, Onda M, Shoji M, Sakane N, Nakagawa Y, Sozu T, Kitajima Y, Tsuyuki RT, Nakayama T Abstract The COMmunity Pharamcists ASSist for Blood Pressure (COMPASS-BP) study aimed to assess the effectiveness of lifestyle support programs administered in community pharmacies on hypertension control. This open-label, two-armed parallel group, cluster-randomized controlled trial included 73 pharmacies (clusters) in Japan randomized to a control or intervention group. Eligible hypertensive patients (n = 125), aged 20-75 years, received the intervention (n = 64) or the control treatment (n = 61), as dictated by th...
Source: BioScience Trends - December 20, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Yin-yang regulating effects of cancer-associated genes, proteins, and cells: An ancient Chinese concept in vogue in modern cancer research.
Authors: Wei S Abstract Great achievements have been made in human cancer research, but most of this research is focused on conditions at the microscopic rather than the systemic level. Recent studies have increasingly cited the ancient Chinese theory of yin-yang in an effort to expand beyond the microscopic level. Various cancer-associated genes and proteins such as mitogen-activated protein kinase (MAPK), p38, p53, c-Myc, tumor necrosis factor (TNF)-α, NF-κB, Cyclin D1, and cyclin-dependent kinase (CDK) and cells such as T cells, B cells, macrophages, neutrophils, and fibroblasts have been reported to...
Source: BioScience Trends - December 16, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Direct-acting agents for hepatitis C virus before and after liver transplantation.
Authors: Sugawara Y, Hibi T Abstract Chronic hepatitis C virus (HCV) infection remains a widespread public health concern and many people are infected with HCV. HCV is one of the leading indications for liver transplantation. Direct-acting antiviral agents (DAAs) against HCV have changed the course of chronic HCV infection, however, making it a curable disease. DAA treatment may be initiated before or after liver transplantation. In the present review, we present the available data on DAA treatment of HCV in liver transplant recipients. PMID: 29238003 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - December 16, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Effect of electrolyzed water produced using carbon electrodes on HeLa cell proliferation.
Authors: Nakamura K, Muraoka O Abstract We developed electrolyzed water (EW) using carbon electrodes and investigated the ability of the developed EW to inhibit the proliferation of human cervical carcinoma HeLa cells. We observed that EW-containing media inhibited HeLa cell proliferation. Many very small black dots were produced in EW and these were associated with the inhibitory effect on the cell proliferation. Furthermore, the very small black dots that could inhibit cell proliferation were produced only at pH 3 to 3.5 of EW. Additional experiments showed that this inhibition of proliferation is reversible. The...
Source: BioScience Trends - December 13, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

The impact of population aging on medical expenses: A big data study based on the life table.
This study shed light on the amount and structure of utilization and medical expenses on Shanghai permanent residents based on big data, simulated lifetime medical expenses through combining of expenses data and life table model, and explored the dynamic pattern of aging on medical expenditures. 5 years were taken as the class interval, the study collected and did the descriptive analysis on the medical services utilization and medical expenses information for all ages of Shanghai permanent residents in 2015, simulated lifetime medical expenses by using current life table and cross-section expenditure data. The results sho...
Source: BioScience Trends - December 13, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Individual nursing care for the elderly among China's aging population.
Authors: Bao J, Tang Q, Chen Y Abstract By the end of 2014, China had an elderly population age 60 or over totaling 212 million; this group accounted for 15.5% of the country's total population of 1.37 billion, which means that China has passed the threshold for an aging population. As China's population ages and the disease spectrum changes, nursing services for the elderly must be expanded. Given differences in the health status, financial situation, and family composition of each elderly person, modern society is tending towards individual nursing care for the elderly. Adapting to the changing composition of soc...
Source: BioScience Trends - December 2, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Chinese single herbs and active ingredients for postmenopausal osteoporosis: From preclinical evidence to action mechanism.
This article reviews the experimental evidence of both in vitro and in vivo preclinical studies with the theme of the application of Chinese single herbs and active ingredients in postmenopausal osteoporosis. It includes three single herbs (Herba Epimedium, Rhizoma Drynariae, and Salvia miltiorrhiza) and eight active ingredients (saikosaponins, linarin, echinacoside, sweroside, psoralen, poncirin, vanillic acid, and osthole). The experimental studies indicated their potential use as treatment for postmenopausal osteoporosis and investigated the underlying mechanisms including osteoprotegerin/receptor activator of nuclear f...
Source: BioScience Trends - November 22, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Social support and care needs of the disabled elderly population: An empirical study based on survey data from Beijing, China.
Authors: Hao X, Gu J, Ying X, Bo T, Fu W Abstract In order to describe and examine differences in social support and care needs among disabled Chinese elderly, the current study used stratified sampling to survey local residents of Beijing age 60 or over in the districts of Xicheng, Chaoyang, and Tongzhou in 2016. Structured in-person interviews were conducted with a 7-domain questionnaire. Multiple logistic regressions were used to compare social support and care needs among functioning, partially disabled, and completely disabled elderly. All statistical analyses were performed using SPSS 19.0 with a significance...
Source: BioScience Trends - November 22, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Activity outside the home, environmental barriers, and healthy aging for community-dwelling elderly individuals in China.
Authors: Niu Y, Li N, Jin C, Chen D, Yang Y, Ding H Abstract Elderly individuals benefit from frequently engaging in activities outside the home because such activities sustain the overall health and functioning of an aging body. However, environmental barriers can limit participation in activities outside the home by elderly individuals. The current study examined the factors that influence the frequency with which elderly individuals living in China engage in activity outside the home. Data were collected from 2,402 elderly individuals residing in the Jiangning district of Shanghai, China in 2015. Face-to-face in...
Source: BioScience Trends - November 22, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Statin use is associated with a reduced risk of hepatocellular carcinoma recurrence after initial liver resection.
Authors: Kawaguchi Y, Sakamoto Y, Ito D, Ito K, Arita J, Akamatsu N, Kaneko J, Hasegawa K, Moriya K, Kokudo N Abstract Effective adjuvant therapies have not been established for hepatocellular carcinoma (HCC). The study aimed to determine prognostic influence of statin against HCC recurrence after initial resection. From 2003 to 2013, 734 patients underwent initial HCC resection. Exposure to statins was defined as the use at the recommended daily dosage for> 90 days after surgery. Outcomes were compared between patients who did and did not receive statins. Of 734 patients, 31 (4.2%) received statins for dyslipid...
Source: BioScience Trends - October 31, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

PCSK9 rs7552841 is associated with plasma lipids profiles in female Chinese adolescents without posttraumatic stress disorder.
Authors: Guo Q, Si Y, Su M, Fan M, Lin J, Memon NH, Fang D Abstract To explain the inconsistent relationship between proprotein convertase subtilisin/kexin type 9 (PCSK9) rs7552841 and plasma lipids profiles, we hypothesized that interplays might occur among gender, PCSK9 rs7552841 and posttraumatic stress disorder (PTSD) on plasma lipids levels. To test this hypothesis, a population of 704 Chinese Han high school students was used, which had been recruited after the 2008 Wenchuan Earthquake. In this population, the plasma levels of glucose, triglyceride (TG), total cholesterol (TC), high-density lipoprotein choles...
Source: BioScience Trends - October 31, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Total bilirubin amount in drainage fluid can be an early predictor for severe biliary fistula after hepatobiliary surgery.
In conclusion, TBA may be a more reliable predictor of sBF than the conventionally used d-Bil/s-Bil ratio. Early prediction of sBF may be useful for early removal of unnecessary prophylactic drainage tubes after hepatobiliary surgery. PMID: 29070759 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - October 29, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Induction of apoptosis by ethanol extract of Citrus unshiu Markovich peel in human bladder cancer T24 cells through ROS-mediated inactivation of the PI3K/Akt pathway.
In this study, the inhibitory effect of ethanol extract of C. unshiu peel (EECU) on the growth of human bladder cancer T24 cells was evaluated and the underlying mechanism was investigated. The present study demonstrated that the suppression of T24 cell viability by EECU is associated with apoptosis induction. EECU-induced apoptosis was found to correlate with an activation of caspase-8, -9, and -3 in concomitance with a decrease in the expression of the inhibitor of apoptosis family of proteins and an increase in the Bax:Bcl-2 ratio accompanied by the proteolytic degradation of poly(ADP-ribose) polymerase. EECU also incre...
Source: BioScience Trends - October 29, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Price adjustment for traditional Chinese medicine procedures: Based on a standardized value parity model.
This study has examined incorporating value indicators and data on basic manpower expended, time spent, technical difficulty, and the degree of risk in the latest standards for the price of medical procedures in China, and this study also offers a price adjustment model with the relative price ratio as a key index. This study examined 144 TCM procedures and found that prices of TCM procedures were mainly based on the value of medical care provided; on average, medical care provided accounted for 89% of the price. Current price levels were generally low and the current price accounted for 56% of the standardized value of a ...
Source: BioScience Trends - October 29, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

A comparative study on predicting influenza outbreaks.
Authors: Zhang J, Nawata K Abstract Worldwide, influenza is estimated to result in approximately 3 to 5 million annual cases of severe illness and approximately 250,000 to 500,000 deaths. We need an accurate time-series model to predict the number of influenza patients. Although time-series models with different time lags as feature spaces could lead to varied accuracy, past studies simply adopted a time lag in their models without comparing or selecting an appropriate number of time lags. We investigated the performance of adopting 6 different time lags in 6 different models: Auto-Regressive Integrated Moving Aver...
Source: BioScience Trends - October 29, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Protective effects of luteolin-7-O-glucoside against starvation-induced injury through upregulation of autophagy in H9c2 Cells.
In this study, cardioprotection and mechanisms of LUTG against starvation-induced injury were investigated in vitro. 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2-tetrazolium bromide (MTT) assay showed starvation-induced autophagy is a homeostatic and protective response for H9c2 cell survival. LUTG could protect against injury induced by starvation in H9c2 cells. Acridine orange (AO) staining showed that pretreatment with LUTG enhanced lysosomal autophagy. Western blotting indicated that LUTG enhanced autophagy by down-regulating the expression of phospho-extracellular signal regulated kinase1/2 (p-ERK), phospho-protein kin...
Source: BioScience Trends - October 17, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Construction of C35 gene bait recombinants and T47D cell cDNA library.
Authors: Yin K, Xu C, Zhao GH, Liu Y, Xiao T, Zhu S, Yan G Abstract C35 is a novel tumor biomarker associated with metastasis progression. To investigate the interaction factors of C35 in its high expressed breast cancer cell lines, we constructed bait recombinant plasmids of C35 gene and T47D cell cDNA library for yeast two-hybrid screening. Full length C35 sequences were subcloned using RT-PCR from cDNA template extracted from T47D cells. Based on functional domain analysis, the full-length C351-348bp was also truncated into two fragments C351-153bp and C35154-348bp to avoid auto-activation. The three kinds of C3...
Source: BioScience Trends - October 17, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

5-aminolevulinic acid (5-ALA) fluorescence-guided Mohs surgery resection of penile-scrotal extramammary Paget's disease.
In conclusion, 5-ALA fluorescence-guided minimum range can be completely removed in penile-scrotal Paget's lesions, and it is able to detect distant scattered lesions. PMID: 29033402 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - October 17, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Relationships between neighborhood attributes and subjective well-being among the Chinese elderly: Data from Shanghai.
In conclusion, both social and physical attributes of neighborhoods were associated with SWB among Chinese elderly. These findings suggest that creating aesthetic and cohesive neighborhoods may encourage Chinese elders to participate in social activities and promote their SWB. PMID: 29021420 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - October 16, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Indication for surgical resection in patients with hepatocellular carcinoma with major vascular invasion.
Authors: Higaki T, Yamazaki S, Moriguchi M, Nakayama H, Kurokawa T, Takayama T Abstract Major portal vein invasion (MVI) by hepatocellular carcinoma (HCC) carries an extremely poor prognosis. Our aim was to clarify the indications of hepatic resection in the presence of MVI by HCC. Between 2001 and 2015, 1,306 patients undergoing primary treatment for HCC were analyzed (866 hepatic resections and 440 transarterial therapies). Significant prognostic factors were identified by retrospectively analyzing tumor status, liver function and treatment. Overall survival was compared in terms of the degree of vascular invasio...
Source: BioScience Trends - October 16, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Non-linear association between alcohol and incident frailty among community-dwelling older people: A dose-response meta-analysis.
Authors: Kojima G, Iliffe S, Liljas A, Walters K Abstract A recent systematic review and meta-analysis study suggested that higher alcohol consumption is associated with lower risks for frailty. However the apparent protective effect may not be true because of some limitations. Therefore we further explored potential linear and non-linear associations using a two-stage dose-response meta-analysis. Restricted cubic splines were applied with three fixed knots at percentiles (10%, 50%, and 90%). A two-stage dose-response meta-analysis showed a significant non-linear association (p for non-linearity
Source: BioScience Trends - October 16, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

New medical education reform in China: Towards healthy China 2030.
Authors: Song P, Jin C, Tang W Abstract On July 11, 2017, the State Council of China issued a bold plan to revolutionize medical education and promote collaboration between medical education and practice. The cornerstone of the plan is training more qualified medical professionals to improve public healthcare on the path to Healthy China 2030. According to this plan, a "5+3" training system will be instituted to train medical professionals in China, and top medical colleges will be encouraged to recruit more students. However, given the less-than-ideal professional status of Chinese doctors, the frequent ...
Source: BioScience Trends - September 16, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Intravenous polymyxins: Revival with puzzle.
In conclusion, there're still controversies in combination regimens, dosing strategies and so on. Prospective trials of lager sample size are needed. PMID: 28904326 [PubMed - in process] (Source: BioScience Trends)
Source: BioScience Trends - September 16, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

The clinical management of hepatocellular carcinoma worldwide: A concise review and comparison of current guidelines from 2001 to 2017.
Authors: Song P, Cai Y, Tang H, Li C, Huang J Abstract Hepatocellular carcinoma (HCC) is the fifth most common malignancy and the second leading cause of cancer-related mortality worldwide. In this review, we made a review on current guidelines published from January 2001 to June 2017 worldwide with a focus on the clinical management of HCC. The electronic databases MEDLINE, the Chinese SinoMed, and the Japanese CiNii were systematically searched. A total of 18 characteristic guidelines for HCC management were finally included, including 8 guidelines from Asia, 5 from Europe, and 5 from the United States of America...
Source: BioScience Trends - September 16, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

A narrative review of non-operative treatment, especially traditional Chinese medicine therapy, for lumbar intervertebral disc herniation.
Authors: Zhang B, Xu H, Wang J, Liu B, Sun G Abstract Lumbar intervertebral disc herniation (LIDH), as the main contributor to low back pain and sciatica, imposes a heavy burden on both the individual and society. Non-operative treatment or conservative treatment has proven effective in alleviation of the symptoms of LIDH and are considered to be a first-line choice for most cases. Active lifestyle, physical therapy, complementary and alternative medicine therapy or Traditional Chinese medicine (TCM) therapy, and pharmacotherapy are routinely used as effective non-operative treatment for LIDH patients. However, how...
Source: BioScience Trends - September 16, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Latest advances in the efficacy, tolerability, and monotherapy of integrase inhibitors.
Authors: Tang Q, Lu H Abstract More than 30 drugs for antiretroviral therapy (ART), including integrase inhibitors (INIs), have been approved by the U.S. Food and Drug Administration (FDA) as of 2017. Integrase is the third essential enzyme in the cycle of human immunodeficiency virus (HIV) replication. INIs can effectively inhibit the replication of HIV and HIV is less prone to develop resistance to INIs clinically. Previous studies based on 7 phase III clinic trials indicate that INIs have satisfactory efficacy and tolerability in patients infected with HIV. The latest advances in INIs indicate that: i) dolutegra...
Source: BioScience Trends - September 16, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

A comparison of liquid chromatography-tandem mass spectrometry (LC-MS/MS) and enzyme-multiplied immunoassay technique (EMIT) for the determination of the cyclosporin A concentration in whole blood from Chinese patients.
The objectives of this study were to compare the correlation of liquid chromatography-tandem mass spectrometry (LC-MS/MS) and enzyme-multiplied immunoassay technique (EMIT) for the determination of the CyA concentration in human blood and to provide evidence for the rational usage of EMIT in clinical practice. Blood samples collected from 132 patients undergoing a liver or kidney transplant or patients with aplastic anemia at Qilu Hospital of Shandong University were tested using the two methods. The calibration curve was linear from 25-500 ng·mL(-1) for LC-MS/MS and from 50-450 ng·mL(-1) for EMIT. The inter-...
Source: BioScience Trends - August 30, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Organ-preserving surgery for locally advanced duodenal gastrointestinal stromal tumor after neoadjuvant treatment.
In conclusion, in patients with locally advanced duodenal GISTs, neoadjuvant IM administration followed by OPS is a feasible treatment strategy which leads to favorable short- and long-term outcomes. PMID: 28845017 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - August 30, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Blockage of cytosolic phospholipase A2 alpha by monoclonal antibody attenuates focal ischemic brain damage in mice.
This study evaluated whether the use of anti-cPLA2α mAb could reduce stroke injury in a mouse model of cerebral IR injury. The expression/activity of cPLA2α and cPLA2α- derived proinflammatory lipid mediators such as prostaglandin E2 (PGE2), leukotriene B4 (LTB4), lysophosphatidylcholine (LPC), and free fatty acids (FFA) was assessed. This study also evaluated neurological deficits, motor function, pathological changes, apoptosis, and the area of infarction in the injured mice. Mice treated with anti-cPLA2α mAb recovered neurological function and their condition improved, apoptosis in the brain decr...
Source: BioScience Trends - August 23, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Surgical management for bile duct injury.
Authors: Feng X, Dong J Abstract The management of bile duct injury (BDI) remains a considerable challenge in hepatobiliary surgery. BDI is mainly iatrogenic, and mostly occurs in cholecystectomy. Laparoscopic cholecystectomy (LC) has been performed widely, however, the incidence of BDI associated with LC increases 2-3 times compared to that in open cholecystectomy (OC). BDI also occurs in robotic cholecystectomy. In China, the evidence-based Practice Guideline for Diagnosis and Treatment of BDI was published by the Biliary Surgery Group of Surgery Branch of Chinese Medical Association, with the purpose of reducing...
Source: BioScience Trends - August 23, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Coagulopathy associated with poor prognosis in intrahepatic cholangiocarcinoma patients after curative resection.
Authors: Wang H, Liu W, Tian M, Tang Z, Jiang X, Zhou P, Ding Z, Peng Y, Dai Z, Qiu S, Zhou J, Fan J, Shi Y Abstract As a rare type of liver cancer, intrahepatic cholangiocarcinoma (ICC) has become an increasingly important malignancy and continues to present significant therapeutic challenges. Since coagulopathy is associated with poor prognosis in hepatocellular carcinoma (HCC), and prognostic factors of ICC after curative resection were still not clear, we aim to analyze the characteristics of ICC patients with coagulopathy and its correlation to prognosis. From January 2000 to June 2011, 541 ICC patients, after...
Source: BioScience Trends - August 8, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Prevalence of metabolically obese but normal weight (MONW) and metabolically healthy but obese (MHO) in Chinese Beijing urban subjects.
Authors: Zhang Y, Fu J, Yang S, Yang M, Liu A, Wang L, Cao S, Sun X, Wang F, Liu D Abstract The aim of this study was to assess the prevalence of metabolic syndrome (MetS) in non-obese adults (body mass index (BMI)
Source: BioScience Trends - July 26, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Clinical data analysis of genotypes and phenotypes of deafness gene mutations in newborns: A retrospective study.
Authors: Du Y, Huang L, Wang X, Cui Q, Cheng X, Zhao L, Ni T Abstract We retrospectively analyzed newborns with deafness gene mutations and summarized the relationship between genotype and phenotype to provide a basis for genetic counseling. We studied 582 subjects positive for deafness gene mutations that were treated in the otology outpatient department of Beijing Tongren Hospital, Capital Medical University, between April 2012 and April 2016. The subjects were divided into 3 categories: a diagnosed group (group A), which was further subdivided into subgroups A1 (homozygous and compound heterozygous GJB2 mutation...
Source: BioScience Trends - July 21, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

APOBEC-mediated genomic alterations link immunity and viral infection during human papillomavirus-driven cervical carcinogenesis.
Authors: Chen L, Qiu X, Zhang N, Wang Y, Wang M, Li D, Wang L, Du Y Abstract Cervical cancer is one of the most frequently diagnosed cancers and is a major cause of death from gynecologic cancers worldwide; the cancer burden from cervical cancer is especially heavy in less developed countries. Most cases of cervical cancer are caused by persistent infection with carcinogenic human papillomavirus (HPV) genotypes 16 and 18. Non-resolving inflammation caused by HPV infection provides a microenvironment that facilitates cancer development. Molecular alterations during the process of HPV-induced carcinogenesis are chara...
Source: BioScience Trends - July 21, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

The effect of DHEA on apoptosis and cohesin levels in oocytes in aged mice.
Authors: Chu N, Gui Y, Qiu X, Zhang N, Li L, Li D, Tang W, Gober HJ, Zhang B, Wang L Abstract Female fertility declines with age as the number of ovarian follicles decreases and aneuploidy increases. Degradation of the cohesin complex might be responsible for age-related aneuploidy. Dehydroepiandrosterone (DHEA) can improve the ovarian reserve and reduce the rate of aneuploidy, but the relationship between DHEA and cohesin levels in oocytes is still unknown. The aim of the current study was to evaluate the effect of the supplement DHEA on ovarian function, including the number of follicles and cohesin levels in ooc...
Source: BioScience Trends - July 21, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Poly(U) and CpG ameliorate the unbalanced T cell immunity and pneumonia of mice with RSV vaccine-enhanced disease.
Authors: Jia R, Lu L, Liang X, Sun Z, Tan L, Xu M, Su L, Xu J Abstract Respiratory Syncycial Virus (RSV) is the most important pathogen responsible for children's severe lower respiratory tract infection. So far no RSV vaccine has yet been authorized for clinical use. The main impediment that blocked development of RSV vaccine is that inactivated RSV vaccine could cause RSV vaccine-enhanced disease (RVED). The mechanism of RVED remains unclear. Recently some researchers found that insufficient activation of innate immunity, including Toll-like receptors (TLRs), might be associated with the onset of RVED. Based on t...
Source: BioScience Trends - June 29, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Posttraumatic stress disorder eliminates association of TrkB rs1187327 with HDL-C in Chinese Han adolescents.
This study was to investigate the interplays of PTSD and TrkB rs1187327 on serum lipid profiles. Variants of TrkB rs1187327 of 709 high school students were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analyses and verified by DNA sequencing. The PTSD Checklist Civilian Version (PCL-C) was used to assess PTSD. Colorimetric methods were used to determine the serum levels of triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and glucose. The results show that the GG homozygotes had a significantly ...
Source: BioScience Trends - June 21, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Paeoniflorin prevents TLR2/4-mediated inflammation in type 2 diabetic nephropathy.
Authors: Zhang T, Zhu Q, Shao Y, Wang K, Wu Y Abstract Paeoniflorin is an effective Chinese traditional medicine with anti-inflammatory and immune-regulatory effects. The aim of this study was to investigate the underlying renoprotective mechanism of Paeoniflorin. In vivo, db/db mice were intraperitoneally injected with Paeoniflorin at a dose of 15, 30, or 60 mg/kg respectively. The immunostaining of TLR2, TLR4, CD68, NF-kB p65 and the mRNA level of inflammatory factors, together with the protein expression of TLR2/4 signaling were evaluated. Our data demonstrated that Paeoniflorin could decrease the urinary albumi...
Source: BioScience Trends - June 21, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Clinical correspondence to hepatocellular carcinoma-related lesions with atypical radiological pattern.
Authors: Higaki T, Midorikawa Y, Nakashima Y, Nakayama H, Matsuoka S, Moriyama M, Sugitani M, Takayama T Abstract In patients at risk of hepatocarcinogenesis, tumors are frequently detected with atypical radiological patterns related to hepatocellular carcinoma (HCC) on imaging studies. Despite their high potential for malignancy, whether to resect such lesions immediately is controversial. Based on histological findings, patients with non-enhanced tumors or enhanced tumors without washout were divided into two groups: those with tumors that should be treated containing well, moderately, and poorly differentiated H...
Source: BioScience Trends - June 21, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Once malaria is eliminated, more attention should be paid to imported malaria: Data from five years of surveillance in the City of Yiwu in eastern China.
This study reviewed and analyzed data on malaria cases in Yiwu from 2012 to 2016 via a webbased system for managing and reporting information on infectious diseases. A total of 161 cases were diagnosed (77.02% due to Plasmodium falciparum, 18.01% due to P. vivax, 4.35% due to P. ovale, and 0.62% due to P. malariae). One case was imported from Yunnan Province in China and the others were imported from overseas. The ratio of male to female patients was 7.47:1. The average age was 36.34 years (SD: 9.63). Most cases (87.58%) were imported from 1 of 30 countries in Africa. As malaria is gradually being eliminated in China, the ...
Source: BioScience Trends - June 21, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Unique Trichomonas vaginalis gene sequences identified in multinational regions of Northwest China.
This study determined the sequence of the 18S ribosomal RNA gene of T. vaginalis infecting both females and males in Xinjiang, China. Samples from 73 females and 28 males were collected and confirmed for infection with T. vaginalis, a total of 110 sequences were identified when the T. vaginalis 18S ribosomal RNA gene was sequenced. These sequences were used to prepare a phylogenetic network. The rooted network comprised three large clades and several independent branches. Most of the Xinjiang sequences were in one group. Preliminary results suggest that Xinjiang T. vaginalis isolates might be genetically unique, as indicat...
Source: BioScience Trends - June 14, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research