Using a multidisciplinary team for the staged management and optimally minimally invasive treatment of severe acute pancreatitis
Biosci Trends. 2021 Apr 11. doi: 10.5582/bst.2021.01075. Online ahead of print.ABSTRACTSevere acute pancreatitis (SAP) is a common critical disease with a high mortality rate that involves a complex, rapid change in condition and multiple organ systems. Therefore, a multidisciplinary team (MDT), including staff from the emergency department, intensive care unit, pancreatic surgery, gastroenterology , and imaging, is necessary for the early diagnosis, evaluation, and treatment of patients with SAP. This involves managing the systemic inflammatory response and maintaining organ function in the early stage and managing system...
Source: BioScience Trends - April 12, 2021 Category: Biomedical Science Authors: Junxiang Yin Zhi Chen Wei Niu Lili Feng Bing Fan Longfei Zhou Bingliang Zeng Jun Zhang Hui Chen Bo Tong Lingfei Tong Xiaoliang Chen Source Type: research

Rapid SARS-CoV-2 antigen detection potentiates early diagnosis of COVID-19 disease
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01090. Online ahead of print.ABSTRACTAs the COVID-19 epidemic is still ongoing, a more rapid detection of SARS-CoV-2 infection such as viral antigen-detection needs to be evaluated for early diagnosis of COVID-19 disease. Here, we report the dynamic changes of SARS-CoV-2 viral antigens in nasopharyngeal swabs of COVID-19 patients and its association with the viral nucleic acid clearance and clinical outcomes. Eighty-five COVID-19 patients were enrolled for detection of SARS-CoV-2 viral antigens, including 57 anti-SARS-CoV-2 antibody negative cases and 28 antibody positive c...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Ying Lv Yuanyuan Ma Yanhui Si Xiaoyi Zhu Lin Zhang Haiyan Feng Di Tian Yixin Liao Tiefu Liu Hongzhou Lu Yun Ling Source Type: research

Burnout in nurses during the COVID-19 pandemic in China: New challenges for public health
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01099. Online ahead of print.ABSTRACTDuring the COVID-19 pandemic, frontline nurses have faced extraordinary personal and professional challenges. These challenges have had mental health consequences, and concerning reports of burnout have emerged globally. We conducted a cross-sectional survey at a designated COVID-19 hospital in Shanghai at the peak of the pandemic, i.e. about 2 months after the onset of the outbreak from February to April 2020. Findings revealed burnout in 6.85% of nurses. Of 336 respondents, 87 (25.89%) had a high level of emotional exhaustion, 61 (18.1...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Lin Zhang Ling Chai Yihong Zhao Lin Wang Wenxiu Sun Lingqing Lu Hongzhou Lu Jianliang Zhang Source Type: research

Trends in the treatment of pancreatic cancer in Japan
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01103. Online ahead of print.ABSTRACTPancreatic cancer is known to have the poorest prognosis among digestive cancers. With the development of new chemotherapeutic agents and introduction of multidisciplinary therapy, however, the treatment outcomes for pancreatic cancer have dramatically improved over the past two decades. The keys to successful treatment will be accurate assessment of resectability [resectable (R), borderline resectable (BR) or unresectable (UR)] at the time of diagnosis and prompt adoption of an appropriate multidisciplinary treatment strategy. Prep-02/J...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Ryota Matsuki Takaaki Arai Masaharu Kogure Yutaka Suzuki Yoshihiro Sakamoto Source Type: research

Rapid SARS-CoV-2 antigen detection potentiates early diagnosis of COVID-19 disease
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01090. Online ahead of print.ABSTRACTAs the COVID-19 epidemic is still ongoing, a more rapid detection of SARS-CoV-2 infection such as viral antigen-detection needs to be evaluated for early diagnosis of COVID-19 disease. Here, we report the dynamic changes of SARS-CoV-2 viral antigens in nasopharyngeal swabs of COVID-19 patients and its association with the viral nucleic acid clearance and clinical outcomes. Eighty-five COVID-19 patients were enrolled for detection of SARS-CoV-2 viral antigens, including 57 anti-SARS-CoV-2 antibody negative cases and 28 antibody positive c...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Ying Lv Yuanyuan Ma Yanhui Si Xiaoyi Zhu Lin Zhang Haiyan Feng Di Tian Yixin Liao Tiefu Liu Hongzhou Lu Yun Ling Source Type: research

Burnout in nurses during the COVID-19 pandemic in China: New challenges for public health
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01099. Online ahead of print.ABSTRACTDuring the COVID-19 pandemic, frontline nurses have faced extraordinary personal and professional challenges. These challenges have had mental health consequences, and concerning reports of burnout have emerged globally. We conducted a cross-sectional survey at a designated COVID-19 hospital in Shanghai at the peak of the pandemic, i.e. about 2 months after the onset of the outbreak from February to April 2020. Findings revealed burnout in 6.85% of nurses. Of 336 respondents, 87 (25.89%) had a high level of emotional exhaustion, 61 (18.1...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Lin Zhang Ling Chai Yihong Zhao Lin Wang Wenxiu Sun Lingqing Lu Hongzhou Lu Jianliang Zhang Source Type: research

Trends in the treatment of pancreatic cancer in Japan
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01103. Online ahead of print.ABSTRACTPancreatic cancer is known to have the poorest prognosis among digestive cancers. With the development of new chemotherapeutic agents and introduction of multidisciplinary therapy, however, the treatment outcomes for pancreatic cancer have dramatically improved over the past two decades. The keys to successful treatment will be accurate assessment of resectability [resectable (R), borderline resectable (BR) or unresectable (UR)] at the time of diagnosis and prompt adoption of an appropriate multidisciplinary treatment strategy. Prep-02/J...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Ryota Matsuki Takaaki Arai Masaharu Kogure Yutaka Suzuki Yoshihiro Sakamoto Source Type: research

Rapid SARS-CoV-2 antigen detection potentiates early diagnosis of COVID-19 disease
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01090. Online ahead of print.ABSTRACTAs the COVID-19 epidemic is still ongoing, a more rapid detection of SARS-CoV-2 infection such as viral antigen-detection needs to be evaluated for early diagnosis of COVID-19 disease. Here, we report the dynamic changes of SARS-CoV-2 viral antigens in nasopharyngeal swabs of COVID-19 patients and its association with the viral nucleic acid clearance and clinical outcomes. Eighty-five COVID-19 patients were enrolled for detection of SARS-CoV-2 viral antigens, including 57 anti-SARS-CoV-2 antibody negative cases and 28 antibody positive c...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Ying Lv Yuanyuan Ma Yanhui Si Xiaoyi Zhu Lin Zhang Haiyan Feng Di Tian Yixin Liao Tiefu Liu Hongzhou Lu Yun Ling Source Type: research

Burnout in nurses during the COVID-19 pandemic in China: New challenges for public health
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01099. Online ahead of print.ABSTRACTDuring the COVID-19 pandemic, frontline nurses have faced extraordinary personal and professional challenges. These challenges have had mental health consequences, and concerning reports of burnout have emerged globally. We conducted a cross-sectional survey at a designated COVID-19 hospital in Shanghai at the peak of the pandemic, i.e. about 2 months after the onset of the outbreak from February to April 2020. Findings revealed burnout in 6.85% of nurses. Of 336 respondents, 87 (25.89%) had a high level of emotional exhaustion, 61 (18.1...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Lin Zhang Ling Chai Yihong Zhao Lin Wang Wenxiu Sun Lingqing Lu Hongzhou Lu Jianliang Zhang Source Type: research

Trends in the treatment of pancreatic cancer in Japan
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01103. Online ahead of print.ABSTRACTPancreatic cancer is known to have the poorest prognosis among digestive cancers. With the development of new chemotherapeutic agents and introduction of multidisciplinary therapy, however, the treatment outcomes for pancreatic cancer have dramatically improved over the past two decades. The keys to successful treatment will be accurate assessment of resectability [resectable (R), borderline resectable (BR) or unresectable (UR)] at the time of diagnosis and prompt adoption of an appropriate multidisciplinary treatment strategy. Prep-02/J...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Ryota Matsuki Takaaki Arai Masaharu Kogure Yutaka Suzuki Yoshihiro Sakamoto Source Type: research

Rapid SARS-CoV-2 antigen detection potentiates early diagnosis of COVID-19 disease
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01090. Online ahead of print.ABSTRACTAs the COVID-19 epidemic is still ongoing, a more rapid detection of SARS-CoV-2 infection such as viral antigen-detection needs to be evaluated for early diagnosis of COVID-19 disease. Here, we report the dynamic changes of SARS-CoV-2 viral antigens in nasopharyngeal swabs of COVID-19 patients and its association with the viral nucleic acid clearance and clinical outcomes. Eighty-five COVID-19 patients were enrolled for detection of SARS-CoV-2 viral antigens, including 57 anti-SARS-CoV-2 antibody negative cases and 28 antibody positive c...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Ying Lv Yuanyuan Ma Yanhui Si Xiaoyi Zhu Lin Zhang Haiyan Feng Di Tian Yixin Liao Tiefu Liu Hongzhou Lu Yun Ling Source Type: research

Burnout in nurses during the COVID-19 pandemic in China: New challenges for public health
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01099. Online ahead of print.ABSTRACTDuring the COVID-19 pandemic, frontline nurses have faced extraordinary personal and professional challenges. These challenges have had mental health consequences, and concerning reports of burnout have emerged globally. We conducted a cross-sectional survey at a designated COVID-19 hospital in Shanghai at the peak of the pandemic, i.e. about 2 months after the onset of the outbreak from February to April 2020. Findings revealed burnout in 6.85% of nurses. Of 336 respondents, 87 (25.89%) had a high level of emotional exhaustion, 61 (18.1...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Lin Zhang Ling Chai Yihong Zhao Lin Wang Wenxiu Sun Lingqing Lu Hongzhou Lu Jianliang Zhang Source Type: research

Trends in the treatment of pancreatic cancer in Japan
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01103. Online ahead of print.ABSTRACTPancreatic cancer is known to have the poorest prognosis among digestive cancers. With the development of new chemotherapeutic agents and introduction of multidisciplinary therapy, however, the treatment outcomes for pancreatic cancer have dramatically improved over the past two decades. The keys to successful treatment will be accurate assessment of resectability [resectable (R), borderline resectable (BR) or unresectable (UR)] at the time of diagnosis and prompt adoption of an appropriate multidisciplinary treatment strategy. Prep-02/J...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Ryota Matsuki Takaaki Arai Masaharu Kogure Yutaka Suzuki Yoshihiro Sakamoto Source Type: research

Rapid SARS-CoV-2 antigen detection potentiates early diagnosis of COVID-19 disease
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01090. Online ahead of print.ABSTRACTAs the COVID-19 epidemic is still ongoing, a more rapid detection of SARS-CoV-2 infection such as viral antigen-detection needs to be evaluated for early diagnosis of COVID-19 disease. Here, we report the dynamic changes of SARS-CoV-2 viral antigens in nasopharyngeal swabs of COVID-19 patients and its association with the viral nucleic acid clearance and clinical outcomes. Eighty-five COVID-19 patients were enrolled for detection of SARS-CoV-2 viral antigens, including 57 anti-SARS-CoV-2 antibody negative cases and 28 antibody positive c...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Ying Lv Yuanyuan Ma Yanhui Si Xiaoyi Zhu Lin Zhang Haiyan Feng Di Tian Yixin Liao Tiefu Liu Hongzhou Lu Yun Ling Source Type: research

Burnout in nurses during the COVID-19 pandemic in China: New challenges for public health
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01099. Online ahead of print.ABSTRACTDuring the COVID-19 pandemic, frontline nurses have faced extraordinary personal and professional challenges. These challenges have had mental health consequences, and concerning reports of burnout have emerged globally. We conducted a cross-sectional survey at a designated COVID-19 hospital in Shanghai at the peak of the pandemic, i.e. about 2 months after the onset of the outbreak from February to April 2020. Findings revealed burnout in 6.85% of nurses. Of 336 respondents, 87 (25.89%) had a high level of emotional exhaustion, 61 (18.1...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Lin Zhang Ling Chai Yihong Zhao Lin Wang Wenxiu Sun Lingqing Lu Hongzhou Lu Jianliang Zhang Source Type: research

Trends in the treatment of pancreatic cancer in Japan
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01103. Online ahead of print.ABSTRACTPancreatic cancer is known to have the poorest prognosis among digestive cancers. With the development of new chemotherapeutic agents and introduction of multidisciplinary therapy, however, the treatment outcomes for pancreatic cancer have dramatically improved over the past two decades. The keys to successful treatment will be accurate assessment of resectability [resectable (R), borderline resectable (BR) or unresectable (UR)] at the time of diagnosis and prompt adoption of an appropriate multidisciplinary treatment strategy. Prep-02/J...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Ryota Matsuki Takaaki Arai Masaharu Kogure Yutaka Suzuki Yoshihiro Sakamoto Source Type: research

Rapid SARS-CoV-2 antigen detection potentiates early diagnosis of COVID-19 disease
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01090. Online ahead of print.ABSTRACTAs the COVID-19 epidemic is still ongoing, a more rapid detection of SARS-CoV-2 infection such as viral antigen-detection needs to be evaluated for early diagnosis of COVID-19 disease. Here, we report the dynamic changes of SARS-CoV-2 viral antigens in nasopharyngeal swabs of COVID-19 patients and its association with the viral nucleic acid clearance and clinical outcomes. Eighty-five COVID-19 patients were enrolled for detection of SARS-CoV-2 viral antigens, including 57 anti-SARS-CoV-2 antibody negative cases and 28 antibody positive c...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Ying Lv Yuanyuan Ma Yanhui Si Xiaoyi Zhu Lin Zhang Haiyan Feng Di Tian Yixin Liao Tiefu Liu Hongzhou Lu Yun Ling Source Type: research

Burnout in nurses during the COVID-19 pandemic in China: New challenges for public health
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01099. Online ahead of print.ABSTRACTDuring the COVID-19 pandemic, frontline nurses have faced extraordinary personal and professional challenges. These challenges have had mental health consequences, and concerning reports of burnout have emerged globally. We conducted a cross-sectional survey at a designated COVID-19 hospital in Shanghai at the peak of the pandemic, i.e. about 2 months after the onset of the outbreak from February to April 2020. Findings revealed burnout in 6.85% of nurses. Of 336 respondents, 87 (25.89%) had a high level of emotional exhaustion, 61 (18.1...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Lin Zhang Ling Chai Yihong Zhao Lin Wang Wenxiu Sun Lingqing Lu Hongzhou Lu Jianliang Zhang Source Type: research

Trends in the treatment of pancreatic cancer in Japan
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01103. Online ahead of print.ABSTRACTPancreatic cancer is known to have the poorest prognosis among digestive cancers. With the development of new chemotherapeutic agents and introduction of multidisciplinary therapy, however, the treatment outcomes for pancreatic cancer have dramatically improved over the past two decades. The keys to successful treatment will be accurate assessment of resectability [resectable (R), borderline resectable (BR) or unresectable (UR)] at the time of diagnosis and prompt adoption of an appropriate multidisciplinary treatment strategy. Prep-02/J...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Ryota Matsuki Takaaki Arai Masaharu Kogure Yutaka Suzuki Yoshihiro Sakamoto Source Type: research

Rapid SARS-CoV-2 antigen detection potentiates early diagnosis of COVID-19 disease
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01090. Online ahead of print.ABSTRACTAs the COVID-19 epidemic is still ongoing, a more rapid detection of SARS-CoV-2 infection such as viral antigen-detection needs to be evaluated for early diagnosis of COVID-19 disease. Here, we report the dynamic changes of SARS-CoV-2 viral antigens in nasopharyngeal swabs of COVID-19 patients and its association with the viral nucleic acid clearance and clinical outcomes. Eighty-five COVID-19 patients were enrolled for detection of SARS-CoV-2 viral antigens, including 57 anti-SARS-CoV-2 antibody negative cases and 28 antibody positive c...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Ying Lv Yuanyuan Ma Yanhui Si Xiaoyi Zhu Lin Zhang Haiyan Feng Di Tian Yixin Liao Tiefu Liu Hongzhou Lu Yun Ling Source Type: research

Burnout in nurses during the COVID-19 pandemic in China: New challenges for public health
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01099. Online ahead of print.ABSTRACTDuring the COVID-19 pandemic, frontline nurses have faced extraordinary personal and professional challenges. These challenges have had mental health consequences, and concerning reports of burnout have emerged globally. We conducted a cross-sectional survey at a designated COVID-19 hospital in Shanghai at the peak of the pandemic, i.e. about 2 months after the onset of the outbreak from February to April 2020. Findings revealed burnout in 6.85% of nurses. Of 336 respondents, 87 (25.89%) had a high level of emotional exhaustion, 61 (18.1...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Lin Zhang Ling Chai Yihong Zhao Lin Wang Wenxiu Sun Lingqing Lu Hongzhou Lu Jianliang Zhang Source Type: research

Trends in the treatment of pancreatic cancer in Japan
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01103. Online ahead of print.ABSTRACTPancreatic cancer is known to have the poorest prognosis among digestive cancers. With the development of new chemotherapeutic agents and introduction of multidisciplinary therapy, however, the treatment outcomes for pancreatic cancer have dramatically improved over the past two decades. The keys to successful treatment will be accurate assessment of resectability [resectable (R), borderline resectable (BR) or unresectable (UR)] at the time of diagnosis and prompt adoption of an appropriate multidisciplinary treatment strategy. Prep-02/J...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Ryota Matsuki Takaaki Arai Masaharu Kogure Yutaka Suzuki Yoshihiro Sakamoto Source Type: research

Rapid SARS-CoV-2 antigen detection potentiates early diagnosis of COVID-19 disease
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01090. Online ahead of print.ABSTRACTAs the COVID-19 epidemic is still ongoing, a more rapid detection of SARS-CoV-2 infection such as viral antigen-detection needs to be evaluated for early diagnosis of COVID-19 disease. Here, we report the dynamic changes of SARS-CoV-2 viral antigens in nasopharyngeal swabs of COVID-19 patients and its association with the viral nucleic acid clearance and clinical outcomes. Eighty-five COVID-19 patients were enrolled for detection of SARS-CoV-2 viral antigens, including 57 anti-SARS-CoV-2 antibody negative cases and 28 antibody positive c...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Ying Lv Yuanyuan Ma Yanhui Si Xiaoyi Zhu Lin Zhang Haiyan Feng Di Tian Yixin Liao Tiefu Liu Hongzhou Lu Yun Ling Source Type: research

Burnout in nurses during the COVID-19 pandemic in China: New challenges for public health
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01099. Online ahead of print.ABSTRACTDuring the COVID-19 pandemic, frontline nurses have faced extraordinary personal and professional challenges. These challenges have had mental health consequences, and concerning reports of burnout have emerged globally. We conducted a cross-sectional survey at a designated COVID-19 hospital in Shanghai at the peak of the pandemic, i.e. about 2 months after the onset of the outbreak from February to April 2020. Findings revealed burnout in 6.85% of nurses. Of 336 respondents, 87 (25.89%) had a high level of emotional exhaustion, 61 (18.1...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Lin Zhang Ling Chai Yihong Zhao Lin Wang Wenxiu Sun Lingqing Lu Hongzhou Lu Jianliang Zhang Source Type: research

Trends in the treatment of pancreatic cancer in Japan
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01103. Online ahead of print.ABSTRACTPancreatic cancer is known to have the poorest prognosis among digestive cancers. With the development of new chemotherapeutic agents and introduction of multidisciplinary therapy, however, the treatment outcomes for pancreatic cancer have dramatically improved over the past two decades. The keys to successful treatment will be accurate assessment of resectability [resectable (R), borderline resectable (BR) or unresectable (UR)] at the time of diagnosis and prompt adoption of an appropriate multidisciplinary treatment strategy. Prep-02/J...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Ryota Matsuki Takaaki Arai Masaharu Kogure Yutaka Suzuki Yoshihiro Sakamoto Source Type: research

Rapid SARS-CoV-2 antigen detection potentiates early diagnosis of COVID-19 disease
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01090. Online ahead of print.ABSTRACTAs the COVID-19 epidemic is still ongoing, a more rapid detection of SARS-CoV-2 infection such as viral antigen-detection needs to be evaluated for early diagnosis of COVID-19 disease. Here, we report the dynamic changes of SARS-CoV-2 viral antigens in nasopharyngeal swabs of COVID-19 patients and its association with the viral nucleic acid clearance and clinical outcomes. Eighty-five COVID-19 patients were enrolled for detection of SARS-CoV-2 viral antigens, including 57 anti-SARS-CoV-2 antibody negative cases and 28 antibody positive c...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Ying Lv Yuanyuan Ma Yanhui Si Xiaoyi Zhu Lin Zhang Haiyan Feng Di Tian Yixin Liao Tiefu Liu Hongzhou Lu Yun Ling Source Type: research

Burnout in nurses during the COVID-19 pandemic in China: New challenges for public health
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01099. Online ahead of print.ABSTRACTDuring the COVID-19 pandemic, frontline nurses have faced extraordinary personal and professional challenges. These challenges have had mental health consequences, and concerning reports of burnout have emerged globally. We conducted a cross-sectional survey at a designated COVID-19 hospital in Shanghai at the peak of the pandemic, i.e. about 2 months after the onset of the outbreak from February to April 2020. Findings revealed burnout in 6.85% of nurses. Of 336 respondents, 87 (25.89%) had a high level of emotional exhaustion, 61 (18.1...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Lin Zhang Ling Chai Yihong Zhao Lin Wang Wenxiu Sun Lingqing Lu Hongzhou Lu Jianliang Zhang Source Type: research

Trends in the treatment of pancreatic cancer in Japan
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01103. Online ahead of print.ABSTRACTPancreatic cancer is known to have the poorest prognosis among digestive cancers. With the development of new chemotherapeutic agents and introduction of multidisciplinary therapy, however, the treatment outcomes for pancreatic cancer have dramatically improved over the past two decades. The keys to successful treatment will be accurate assessment of resectability [resectable (R), borderline resectable (BR) or unresectable (UR)] at the time of diagnosis and prompt adoption of an appropriate multidisciplinary treatment strategy. Prep-02/J...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Ryota Matsuki Takaaki Arai Masaharu Kogure Yutaka Suzuki Yoshihiro Sakamoto Source Type: research

Rapid SARS-CoV-2 antigen detection potentiates early diagnosis of COVID-19 disease
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01090. Online ahead of print.ABSTRACTAs the COVID-19 epidemic is still ongoing, a more rapid detection of SARS-CoV-2 infection such as viral antigen-detection needs to be evaluated for early diagnosis of COVID-19 disease. Here, we report the dynamic changes of SARS-CoV-2 viral antigens in nasopharyngeal swabs of COVID-19 patients and its association with the viral nucleic acid clearance and clinical outcomes. Eighty-five COVID-19 patients were enrolled for detection of SARS-CoV-2 viral antigens, including 57 anti-SARS-CoV-2 antibody negative cases and 28 antibody positive c...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Ying Lv Yuanyuan Ma Yanhui Si Xiaoyi Zhu Lin Zhang Haiyan Feng Di Tian Yixin Liao Tiefu Liu Hongzhou Lu Yun Ling Source Type: research

Burnout in nurses during the COVID-19 pandemic in China: New challenges for public health
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01099. Online ahead of print.ABSTRACTDuring the COVID-19 pandemic, frontline nurses have faced extraordinary personal and professional challenges. These challenges have had mental health consequences, and concerning reports of burnout have emerged globally. We conducted a cross-sectional survey at a designated COVID-19 hospital in Shanghai at the peak of the pandemic, i.e. about 2 months after the onset of the outbreak from February to April 2020. Findings revealed burnout in 6.85% of nurses. Of 336 respondents, 87 (25.89%) had a high level of emotional exhaustion, 61 (18.1...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Lin Zhang Ling Chai Yihong Zhao Lin Wang Wenxiu Sun Lingqing Lu Hongzhou Lu Jianliang Zhang Source Type: research

Trends in the treatment of pancreatic cancer in Japan
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01103. Online ahead of print.ABSTRACTPancreatic cancer is known to have the poorest prognosis among digestive cancers. With the development of new chemotherapeutic agents and introduction of multidisciplinary therapy, however, the treatment outcomes for pancreatic cancer have dramatically improved over the past two decades. The keys to successful treatment will be accurate assessment of resectability [resectable (R), borderline resectable (BR) or unresectable (UR)] at the time of diagnosis and prompt adoption of an appropriate multidisciplinary treatment strategy. Prep-02/J...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Ryota Matsuki Takaaki Arai Masaharu Kogure Yutaka Suzuki Yoshihiro Sakamoto Source Type: research

Rapid SARS-CoV-2 antigen detection potentiates early diagnosis of COVID-19 disease
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01090. Online ahead of print.ABSTRACTAs the COVID-19 epidemic is still ongoing, a more rapid detection of SARS-CoV-2 infection such as viral antigen-detection needs to be evaluated for early diagnosis of COVID-19 disease. Here, we report the dynamic changes of SARS-CoV-2 viral antigens in nasopharyngeal swabs of COVID-19 patients and its association with the viral nucleic acid clearance and clinical outcomes. Eighty-five COVID-19 patients were enrolled for detection of SARS-CoV-2 viral antigens, including 57 anti-SARS-CoV-2 antibody negative cases and 28 antibody positive c...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Ying Lv Yuanyuan Ma Yanhui Si Xiaoyi Zhu Lin Zhang Haiyan Feng Di Tian Yixin Liao Tiefu Liu Hongzhou Lu Yun Ling Source Type: research

Burnout in nurses during the COVID-19 pandemic in China: New challenges for public health
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01099. Online ahead of print.ABSTRACTDuring the COVID-19 pandemic, frontline nurses have faced extraordinary personal and professional challenges. These challenges have had mental health consequences, and concerning reports of burnout have emerged globally. We conducted a cross-sectional survey at a designated COVID-19 hospital in Shanghai at the peak of the pandemic, i.e. about 2 months after the onset of the outbreak from February to April 2020. Findings revealed burnout in 6.85% of nurses. Of 336 respondents, 87 (25.89%) had a high level of emotional exhaustion, 61 (18.1...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Lin Zhang Ling Chai Yihong Zhao Lin Wang Wenxiu Sun Lingqing Lu Hongzhou Lu Jianliang Zhang Source Type: research

Trends in the treatment of pancreatic cancer in Japan
Biosci Trends. 2021 Mar 26. doi: 10.5582/bst.2021.01103. Online ahead of print.ABSTRACTPancreatic cancer is known to have the poorest prognosis among digestive cancers. With the development of new chemotherapeutic agents and introduction of multidisciplinary therapy, however, the treatment outcomes for pancreatic cancer have dramatically improved over the past two decades. The keys to successful treatment will be accurate assessment of resectability [resectable (R), borderline resectable (BR) or unresectable (UR)] at the time of diagnosis and prompt adoption of an appropriate multidisciplinary treatment strategy. Prep-02/J...
Source: BioScience Trends - March 29, 2021 Category: Biomedical Science Authors: Ryota Matsuki Takaaki Arai Masaharu Kogure Yutaka Suzuki Yoshihiro Sakamoto Source Type: research

Vasa previa: Perinatal outcomes in singleton and multiple pregnancies
Biosci Trends. 2021 Mar 21. doi: 10.5582/bst.2021.01052. Online ahead of print.ABSTRACTVasa previa (VP) is a rare and life-threatening condition for the fetus. It is associated with increased perinatal mortality rates. The current study sought to retrospectively analyze the perinatal outcomes of VP in singleton and multiple pregnancies between January 1, 2013 and December 31, 2019 at a tertiary hospital in west China. One hundred and fifty-seven cases of VP were identified, including 131 singletons, 23 twins and 3 triplets. VP in 20 cases was diagnosed at delivery. There were 183 live births. Neonatal mortality was signifi...
Source: BioScience Trends - March 22, 2021 Category: Biomedical Science Authors: Na Liu Qing Hu Hua Liao Xiaodong Wang Haiyan Yu Source Type: research

COVID-19 vaccine research focusses on safety, efficacy, immunoinformatics, and vaccine production and delivery: a bibliometric analysis based on VOSviewer
This study aimed to provide the current status of COVID-19 vaccine using bibliometric analysis. We searched Embase.com and MEDLINE comprehensively and included articles, articles in press, reviews, short surveys, conference abstracts and conference papers about COVID-19 vaccine. VOSviewer1.6.11 (Leiden University, Leiden, Netherlands) was applied to perform the bibliometric analysis of these papers. A total of 1,312 papers were finally included. The BMJ has been the most popular journal in this field. The United States maintained a top position worldwide and has provided a pivotal influence, followed by China, India and Un...
Source: BioScience Trends - March 22, 2021 Category: Biomedical Science Authors: Yamin Chen Luying Cheng Rongna Lian Ziwei Song Jinhui Tian Source Type: research

New challenges to fighting COVID-19: Virus variants, potential vaccines, and development of antivirals
Biosci Trends. 2021 Mar 19. doi: 10.5582/bst.2021.01092. Online ahead of print.ABSTRACTDespite strict control measures implemented worldwide, the COVID-19 pandemic continues to rage. Several drugs, including lopinavir/ritonavir, hydroxychloroquine, dexamethasone, and remdesivir, have been evaluated for the treatment of COVID-19 during the past year. While most of the drugs failed to display efficacy in treating COVID-19, scientists have encouraged herd immunity to control the pandemic. Immunity generated after natural infection with SARS-CoV-2 is precarious, as indicated by real-world evidence in the form of epidemiologica...
Source: BioScience Trends - March 22, 2021 Category: Biomedical Science Authors: Jun Chen Hongzhou Lu Source Type: research

Surgical treatment of hepatocellular carcinoma
Biosci Trends. 2021 Mar 19. doi: 10.5582/bst.2021.01094. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is one of the most common cancers in the world, and cirrhosis is a risk factor for HCC. Resection is indicated for those unilobar tumors without vascular invasion and metastases in the liver and preserved liver function. Small HCC (
Source: BioScience Trends - March 22, 2021 Category: Biomedical Science Authors: Yasuhiko Sugawara Taizo Hibi Source Type: research

Vasa previa: Perinatal outcomes in singleton and multiple pregnancies
Biosci Trends. 2021 Mar 21. doi: 10.5582/bst.2021.01052. Online ahead of print.ABSTRACTVasa previa (VP) is a rare and life-threatening condition for the fetus. It is associated with increased perinatal mortality rates. The current study sought to retrospectively analyze the perinatal outcomes of VP in singleton and multiple pregnancies between January 1, 2013 and December 31, 2019 at a tertiary hospital in west China. One hundred and fifty-seven cases of VP were identified, including 131 singletons, 23 twins and 3 triplets. VP in 20 cases was diagnosed at delivery. There were 183 live births. Neonatal mortality was signifi...
Source: BioScience Trends - March 22, 2021 Category: Biomedical Science Authors: Na Liu Qing Hu Hua Liao Xiaodong Wang Haiyan Yu Source Type: research

COVID-19 vaccine research focusses on safety, efficacy, immunoinformatics, and vaccine production and delivery: a bibliometric analysis based on VOSviewer
This study aimed to provide the current status of COVID-19 vaccine using bibliometric analysis. We searched Embase.com and MEDLINE comprehensively and included articles, articles in press, reviews, short surveys, conference abstracts and conference papers about COVID-19 vaccine. VOSviewer1.6.11 (Leiden University, Leiden, Netherlands) was applied to perform the bibliometric analysis of these papers. A total of 1,312 papers were finally included. The BMJ has been the most popular journal in this field. The United States maintained a top position worldwide and has provided a pivotal influence, followed by China, India and Un...
Source: BioScience Trends - March 22, 2021 Category: Biomedical Science Authors: Yamin Chen Luying Cheng Rongna Lian Ziwei Song Jinhui Tian Source Type: research

New challenges to fighting COVID-19: Virus variants, potential vaccines, and development of antivirals
Biosci Trends. 2021 Mar 19. doi: 10.5582/bst.2021.01092. Online ahead of print.ABSTRACTDespite strict control measures implemented worldwide, the COVID-19 pandemic continues to rage. Several drugs, including lopinavir/ritonavir, hydroxychloroquine, dexamethasone, and remdesivir, have been evaluated for the treatment of COVID-19 during the past year. While most of the drugs failed to display efficacy in treating COVID-19, scientists have encouraged herd immunity to control the pandemic. Immunity generated after natural infection with SARS-CoV-2 is precarious, as indicated by real-world evidence in the form of epidemiologica...
Source: BioScience Trends - March 22, 2021 Category: Biomedical Science Authors: Jun Chen Hongzhou Lu Source Type: research

Surgical treatment of hepatocellular carcinoma
Biosci Trends. 2021 Mar 19. doi: 10.5582/bst.2021.01094. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is one of the most common cancers in the world, and cirrhosis is a risk factor for HCC. Resection is indicated for those unilobar tumors without vascular invasion and metastases in the liver and preserved liver function. Small HCC (
Source: BioScience Trends - March 22, 2021 Category: Biomedical Science Authors: Yasuhiko Sugawara Taizo Hibi Source Type: research

Vasa previa: Perinatal outcomes in singleton and multiple pregnancies
Biosci Trends. 2021 Mar 21. doi: 10.5582/bst.2021.01052. Online ahead of print.ABSTRACTVasa previa (VP) is a rare and life-threatening condition for the fetus. It is associated with increased perinatal mortality rates. The current study sought to retrospectively analyze the perinatal outcomes of VP in singleton and multiple pregnancies between January 1, 2013 and December 31, 2019 at a tertiary hospital in west China. One hundred and fifty-seven cases of VP were identified, including 131 singletons, 23 twins and 3 triplets. VP in 20 cases was diagnosed at delivery. There were 183 live births. Neonatal mortality was signifi...
Source: BioScience Trends - March 22, 2021 Category: Biomedical Science Authors: Na Liu Qing Hu Hua Liao Xiaodong Wang Haiyan Yu Source Type: research

COVID-19 vaccine research focusses on safety, efficacy, immunoinformatics, and vaccine production and delivery: a bibliometric analysis based on VOSviewer
This study aimed to provide the current status of COVID-19 vaccine using bibliometric analysis. We searched Embase.com and MEDLINE comprehensively and included articles, articles in press, reviews, short surveys, conference abstracts and conference papers about COVID-19 vaccine. VOSviewer1.6.11 (Leiden University, Leiden, Netherlands) was applied to perform the bibliometric analysis of these papers. A total of 1,312 papers were finally included. The BMJ has been the most popular journal in this field. The United States maintained a top position worldwide and has provided a pivotal influence, followed by China, India and Un...
Source: BioScience Trends - March 22, 2021 Category: Biomedical Science Authors: Yamin Chen Luying Cheng Rongna Lian Ziwei Song Jinhui Tian Source Type: research

New challenges to fighting COVID-19: Virus variants, potential vaccines, and development of antivirals
Biosci Trends. 2021 Mar 19. doi: 10.5582/bst.2021.01092. Online ahead of print.ABSTRACTDespite strict control measures implemented worldwide, the COVID-19 pandemic continues to rage. Several drugs, including lopinavir/ritonavir, hydroxychloroquine, dexamethasone, and remdesivir, have been evaluated for the treatment of COVID-19 during the past year. While most of the drugs failed to display efficacy in treating COVID-19, scientists have encouraged herd immunity to control the pandemic. Immunity generated after natural infection with SARS-CoV-2 is precarious, as indicated by real-world evidence in the form of epidemiologica...
Source: BioScience Trends - March 22, 2021 Category: Biomedical Science Authors: Jun Chen Hongzhou Lu Source Type: research

Surgical treatment of hepatocellular carcinoma
Biosci Trends. 2021 Mar 19. doi: 10.5582/bst.2021.01094. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is one of the most common cancers in the world, and cirrhosis is a risk factor for HCC. Resection is indicated for those unilobar tumors without vascular invasion and metastases in the liver and preserved liver function. Small HCC (
Source: BioScience Trends - March 22, 2021 Category: Biomedical Science Authors: Yasuhiko Sugawara Taizo Hibi Source Type: research

Vasa previa: Perinatal outcomes in singleton and multiple pregnancies
Biosci Trends. 2021 Mar 21. doi: 10.5582/bst.2021.01052. Online ahead of print.ABSTRACTVasa previa (VP) is a rare and life-threatening condition for the fetus. It is associated with increased perinatal mortality rates. The current study sought to retrospectively analyze the perinatal outcomes of VP in singleton and multiple pregnancies between January 1, 2013 and December 31, 2019 at a tertiary hospital in west China. One hundred and fifty-seven cases of VP were identified, including 131 singletons, 23 twins and 3 triplets. VP in 20 cases was diagnosed at delivery. There were 183 live births. Neonatal mortality was signifi...
Source: BioScience Trends - March 22, 2021 Category: Biomedical Science Authors: Na Liu Qing Hu Hua Liao Xiaodong Wang Haiyan Yu Source Type: research

COVID-19 vaccine research focusses on safety, efficacy, immunoinformatics, and vaccine production and delivery: a bibliometric analysis based on VOSviewer
This study aimed to provide the current status of COVID-19 vaccine using bibliometric analysis. We searched Embase.com and MEDLINE comprehensively and included articles, articles in press, reviews, short surveys, conference abstracts and conference papers about COVID-19 vaccine. VOSviewer1.6.11 (Leiden University, Leiden, Netherlands) was applied to perform the bibliometric analysis of these papers. A total of 1,312 papers were finally included. The BMJ has been the most popular journal in this field. The United States maintained a top position worldwide and has provided a pivotal influence, followed by China, India and Un...
Source: BioScience Trends - March 22, 2021 Category: Biomedical Science Authors: Yamin Chen Luying Cheng Rongna Lian Ziwei Song Jinhui Tian Source Type: research

New challenges to fighting COVID-19: Virus variants, potential vaccines, and development of antivirals
Biosci Trends. 2021 Mar 19. doi: 10.5582/bst.2021.01092. Online ahead of print.ABSTRACTDespite strict control measures implemented worldwide, the COVID-19 pandemic continues to rage. Several drugs, including lopinavir/ritonavir, hydroxychloroquine, dexamethasone, and remdesivir, have been evaluated for the treatment of COVID-19 during the past year. While most of the drugs failed to display efficacy in treating COVID-19, scientists have encouraged herd immunity to control the pandemic. Immunity generated after natural infection with SARS-CoV-2 is precarious, as indicated by real-world evidence in the form of epidemiologica...
Source: BioScience Trends - March 22, 2021 Category: Biomedical Science Authors: Jun Chen Hongzhou Lu Source Type: research

Surgical treatment of hepatocellular carcinoma
Biosci Trends. 2021 Mar 19. doi: 10.5582/bst.2021.01094. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is one of the most common cancers in the world, and cirrhosis is a risk factor for HCC. Resection is indicated for those unilobar tumors without vascular invasion and metastases in the liver and preserved liver function. Small HCC (
Source: BioScience Trends - March 22, 2021 Category: Biomedical Science Authors: Yasuhiko Sugawara Taizo Hibi Source Type: research