Log in to search using one of your social media accounts:

 

Statin use is associated with a reduced risk of hepatocellular carcinoma recurrence after initial liver resection.
Authors: Kawaguchi Y, Sakamoto Y, Ito D, Ito K, Arita J, Akamatsu N, Kaneko J, Hasegawa K, Moriya K, Kokudo N Abstract Effective adjuvant therapies have not been established for hepatocellular carcinoma (HCC). The study aimed to determine prognostic influence of statin against HCC recurrence after initial resection. From 2003 to 2013, 734 patients underwent initial HCC resection. Exposure to statins was defined as the use at the recommended daily dosage for> 90 days after surgery. Outcomes were compared between patients who did and did not receive statins. Of 734 patients, 31 (4.2%) received statins for dyslipid...
Source: BioScience Trends - October 31, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

PCSK9 rs7552841 is associated with plasma lipids profiles in female Chinese adolescents without posttraumatic stress disorder.
Authors: Guo Q, Si Y, Su M, Fan M, Lin J, Memon NH, Fang D Abstract To explain the inconsistent relationship between proprotein convertase subtilisin/kexin type 9 (PCSK9) rs7552841 and plasma lipids profiles, we hypothesized that interplays might occur among gender, PCSK9 rs7552841 and posttraumatic stress disorder (PTSD) on plasma lipids levels. To test this hypothesis, a population of 704 Chinese Han high school students was used, which had been recruited after the 2008 Wenchuan Earthquake. In this population, the plasma levels of glucose, triglyceride (TG), total cholesterol (TC), high-density lipoprotein choles...
Source: BioScience Trends - October 31, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Total bilirubin amount in drainage fluid can be an early predictor for severe biliary fistula after hepatobiliary surgery.
In conclusion, TBA may be a more reliable predictor of sBF than the conventionally used d-Bil/s-Bil ratio. Early prediction of sBF may be useful for early removal of unnecessary prophylactic drainage tubes after hepatobiliary surgery. PMID: 29070759 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - October 29, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Induction of apoptosis by ethanol extract of Citrus unshiu Markovich peel in human bladder cancer T24 cells through ROS-mediated inactivation of the PI3K/Akt pathway.
In this study, the inhibitory effect of ethanol extract of C. unshiu peel (EECU) on the growth of human bladder cancer T24 cells was evaluated and the underlying mechanism was investigated. The present study demonstrated that the suppression of T24 cell viability by EECU is associated with apoptosis induction. EECU-induced apoptosis was found to correlate with an activation of caspase-8, -9, and -3 in concomitance with a decrease in the expression of the inhibitor of apoptosis family of proteins and an increase in the Bax:Bcl-2 ratio accompanied by the proteolytic degradation of poly(ADP-ribose) polymerase. EECU also incre...
Source: BioScience Trends - October 29, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Price adjustment for traditional Chinese medicine procedures: Based on a standardized value parity model.
This study has examined incorporating value indicators and data on basic manpower expended, time spent, technical difficulty, and the degree of risk in the latest standards for the price of medical procedures in China, and this study also offers a price adjustment model with the relative price ratio as a key index. This study examined 144 TCM procedures and found that prices of TCM procedures were mainly based on the value of medical care provided; on average, medical care provided accounted for 89% of the price. Current price levels were generally low and the current price accounted for 56% of the standardized value of a ...
Source: BioScience Trends - October 29, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

A comparative study on predicting influenza outbreaks.
Authors: Zhang J, Nawata K Abstract Worldwide, influenza is estimated to result in approximately 3 to 5 million annual cases of severe illness and approximately 250,000 to 500,000 deaths. We need an accurate time-series model to predict the number of influenza patients. Although time-series models with different time lags as feature spaces could lead to varied accuracy, past studies simply adopted a time lag in their models without comparing or selecting an appropriate number of time lags. We investigated the performance of adopting 6 different time lags in 6 different models: Auto-Regressive Integrated Moving Aver...
Source: BioScience Trends - October 29, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Protective effects of luteolin-7-O-glucoside against starvation-induced injury through upregulation of autophagy in H9c2 Cells.
In this study, cardioprotection and mechanisms of LUTG against starvation-induced injury were investigated in vitro. 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2-tetrazolium bromide (MTT) assay showed starvation-induced autophagy is a homeostatic and protective response for H9c2 cell survival. LUTG could protect against injury induced by starvation in H9c2 cells. Acridine orange (AO) staining showed that pretreatment with LUTG enhanced lysosomal autophagy. Western blotting indicated that LUTG enhanced autophagy by down-regulating the expression of phospho-extracellular signal regulated kinase1/2 (p-ERK), phospho-protein kin...
Source: BioScience Trends - October 17, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Construction of C35 gene bait recombinants and T47D cell cDNA library.
Authors: Yin K, Xu C, Zhao GH, Liu Y, Xiao T, Zhu S, Yan G Abstract C35 is a novel tumor biomarker associated with metastasis progression. To investigate the interaction factors of C35 in its high expressed breast cancer cell lines, we constructed bait recombinant plasmids of C35 gene and T47D cell cDNA library for yeast two-hybrid screening. Full length C35 sequences were subcloned using RT-PCR from cDNA template extracted from T47D cells. Based on functional domain analysis, the full-length C351-348bp was also truncated into two fragments C351-153bp and C35154-348bp to avoid auto-activation. The three kinds of C3...
Source: BioScience Trends - October 17, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

5-aminolevulinic acid (5-ALA) fluorescence-guided Mohs surgery resection of penile-scrotal extramammary Paget's disease.
In conclusion, 5-ALA fluorescence-guided minimum range can be completely removed in penile-scrotal Paget's lesions, and it is able to detect distant scattered lesions. PMID: 29033402 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - October 17, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Relationships between neighborhood attributes and subjective well-being among the Chinese elderly: Data from Shanghai.
In conclusion, both social and physical attributes of neighborhoods were associated with SWB among Chinese elderly. These findings suggest that creating aesthetic and cohesive neighborhoods may encourage Chinese elders to participate in social activities and promote their SWB. PMID: 29021420 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - October 16, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Indication for surgical resection in patients with hepatocellular carcinoma with major vascular invasion.
Authors: Higaki T, Yamazaki S, Moriguchi M, Nakayama H, Kurokawa T, Takayama T Abstract Major portal vein invasion (MVI) by hepatocellular carcinoma (HCC) carries an extremely poor prognosis. Our aim was to clarify the indications of hepatic resection in the presence of MVI by HCC. Between 2001 and 2015, 1,306 patients undergoing primary treatment for HCC were analyzed (866 hepatic resections and 440 transarterial therapies). Significant prognostic factors were identified by retrospectively analyzing tumor status, liver function and treatment. Overall survival was compared in terms of the degree of vascular invasio...
Source: BioScience Trends - October 16, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Non-linear association between alcohol and incident frailty among community-dwelling older people: A dose-response meta-analysis.
Authors: Kojima G, Iliffe S, Liljas A, Walters K Abstract A recent systematic review and meta-analysis study suggested that higher alcohol consumption is associated with lower risks for frailty. However the apparent protective effect may not be true because of some limitations. Therefore we further explored potential linear and non-linear associations using a two-stage dose-response meta-analysis. Restricted cubic splines were applied with three fixed knots at percentiles (10%, 50%, and 90%). A two-stage dose-response meta-analysis showed a significant non-linear association (p for non-linearity
Source: BioScience Trends - October 16, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

New medical education reform in China: Towards healthy China 2030.
Authors: Song P, Jin C, Tang W Abstract On July 11, 2017, the State Council of China issued a bold plan to revolutionize medical education and promote collaboration between medical education and practice. The cornerstone of the plan is training more qualified medical professionals to improve public healthcare on the path to Healthy China 2030. According to this plan, a "5+3" training system will be instituted to train medical professionals in China, and top medical colleges will be encouraged to recruit more students. However, given the less-than-ideal professional status of Chinese doctors, the frequent ...
Source: BioScience Trends - September 16, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Intravenous polymyxins: Revival with puzzle.
In conclusion, there're still controversies in combination regimens, dosing strategies and so on. Prospective trials of lager sample size are needed. PMID: 28904326 [PubMed - in process] (Source: BioScience Trends)
Source: BioScience Trends - September 16, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

The clinical management of hepatocellular carcinoma worldwide: A concise review and comparison of current guidelines from 2001 to 2017.
Authors: Song P, Cai Y, Tang H, Li C, Huang J Abstract Hepatocellular carcinoma (HCC) is the fifth most common malignancy and the second leading cause of cancer-related mortality worldwide. In this review, we made a review on current guidelines published from January 2001 to June 2017 worldwide with a focus on the clinical management of HCC. The electronic databases MEDLINE, the Chinese SinoMed, and the Japanese CiNii were systematically searched. A total of 18 characteristic guidelines for HCC management were finally included, including 8 guidelines from Asia, 5 from Europe, and 5 from the United States of America...
Source: BioScience Trends - September 16, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

A narrative review of non-operative treatment, especially traditional Chinese medicine therapy, for lumbar intervertebral disc herniation.
Authors: Zhang B, Xu H, Wang J, Liu B, Sun G Abstract Lumbar intervertebral disc herniation (LIDH), as the main contributor to low back pain and sciatica, imposes a heavy burden on both the individual and society. Non-operative treatment or conservative treatment has proven effective in alleviation of the symptoms of LIDH and are considered to be a first-line choice for most cases. Active lifestyle, physical therapy, complementary and alternative medicine therapy or Traditional Chinese medicine (TCM) therapy, and pharmacotherapy are routinely used as effective non-operative treatment for LIDH patients. However, how...
Source: BioScience Trends - September 16, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Latest advances in the efficacy, tolerability, and monotherapy of integrase inhibitors.
Authors: Tang Q, Lu H Abstract More than 30 drugs for antiretroviral therapy (ART), including integrase inhibitors (INIs), have been approved by the U.S. Food and Drug Administration (FDA) as of 2017. Integrase is the third essential enzyme in the cycle of human immunodeficiency virus (HIV) replication. INIs can effectively inhibit the replication of HIV and HIV is less prone to develop resistance to INIs clinically. Previous studies based on 7 phase III clinic trials indicate that INIs have satisfactory efficacy and tolerability in patients infected with HIV. The latest advances in INIs indicate that: i) dolutegra...
Source: BioScience Trends - September 16, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

A comparison of liquid chromatography-tandem mass spectrometry (LC-MS/MS) and enzyme-multiplied immunoassay technique (EMIT) for the determination of the cyclosporin A concentration in whole blood from Chinese patients.
The objectives of this study were to compare the correlation of liquid chromatography-tandem mass spectrometry (LC-MS/MS) and enzyme-multiplied immunoassay technique (EMIT) for the determination of the CyA concentration in human blood and to provide evidence for the rational usage of EMIT in clinical practice. Blood samples collected from 132 patients undergoing a liver or kidney transplant or patients with aplastic anemia at Qilu Hospital of Shandong University were tested using the two methods. The calibration curve was linear from 25-500 ng·mL(-1) for LC-MS/MS and from 50-450 ng·mL(-1) for EMIT. The inter-...
Source: BioScience Trends - August 30, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Organ-preserving surgery for locally advanced duodenal gastrointestinal stromal tumor after neoadjuvant treatment.
In conclusion, in patients with locally advanced duodenal GISTs, neoadjuvant IM administration followed by OPS is a feasible treatment strategy which leads to favorable short- and long-term outcomes. PMID: 28845017 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - August 30, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Blockage of cytosolic phospholipase A2 alpha by monoclonal antibody attenuates focal ischemic brain damage in mice.
This study evaluated whether the use of anti-cPLA2α mAb could reduce stroke injury in a mouse model of cerebral IR injury. The expression/activity of cPLA2α and cPLA2α- derived proinflammatory lipid mediators such as prostaglandin E2 (PGE2), leukotriene B4 (LTB4), lysophosphatidylcholine (LPC), and free fatty acids (FFA) was assessed. This study also evaluated neurological deficits, motor function, pathological changes, apoptosis, and the area of infarction in the injured mice. Mice treated with anti-cPLA2α mAb recovered neurological function and their condition improved, apoptosis in the brain decr...
Source: BioScience Trends - August 23, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Surgical management for bile duct injury.
Authors: Feng X, Dong J Abstract The management of bile duct injury (BDI) remains a considerable challenge in hepatobiliary surgery. BDI is mainly iatrogenic, and mostly occurs in cholecystectomy. Laparoscopic cholecystectomy (LC) has been performed widely, however, the incidence of BDI associated with LC increases 2-3 times compared to that in open cholecystectomy (OC). BDI also occurs in robotic cholecystectomy. In China, the evidence-based Practice Guideline for Diagnosis and Treatment of BDI was published by the Biliary Surgery Group of Surgery Branch of Chinese Medical Association, with the purpose of reducing...
Source: BioScience Trends - August 23, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Coagulopathy associated with poor prognosis in intrahepatic cholangiocarcinoma patients after curative resection.
Authors: Wang H, Liu W, Tian M, Tang Z, Jiang X, Zhou P, Ding Z, Peng Y, Dai Z, Qiu S, Zhou J, Fan J, Shi Y Abstract As a rare type of liver cancer, intrahepatic cholangiocarcinoma (ICC) has become an increasingly important malignancy and continues to present significant therapeutic challenges. Since coagulopathy is associated with poor prognosis in hepatocellular carcinoma (HCC), and prognostic factors of ICC after curative resection were still not clear, we aim to analyze the characteristics of ICC patients with coagulopathy and its correlation to prognosis. From January 2000 to June 2011, 541 ICC patients, after...
Source: BioScience Trends - August 8, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Prevalence of metabolically obese but normal weight (MONW) and metabolically healthy but obese (MHO) in Chinese Beijing urban subjects.
Authors: Zhang Y, Fu J, Yang S, Yang M, Liu A, Wang L, Cao S, Sun X, Wang F, Liu D Abstract The aim of this study was to assess the prevalence of metabolic syndrome (MetS) in non-obese adults (body mass index (BMI)
Source: BioScience Trends - July 26, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Clinical data analysis of genotypes and phenotypes of deafness gene mutations in newborns: A retrospective study.
Authors: Du Y, Huang L, Wang X, Cui Q, Cheng X, Zhao L, Ni T Abstract We retrospectively analyzed newborns with deafness gene mutations and summarized the relationship between genotype and phenotype to provide a basis for genetic counseling. We studied 582 subjects positive for deafness gene mutations that were treated in the otology outpatient department of Beijing Tongren Hospital, Capital Medical University, between April 2012 and April 2016. The subjects were divided into 3 categories: a diagnosed group (group A), which was further subdivided into subgroups A1 (homozygous and compound heterozygous GJB2 mutation...
Source: BioScience Trends - July 21, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

APOBEC-mediated genomic alterations link immunity and viral infection during human papillomavirus-driven cervical carcinogenesis.
Authors: Chen L, Qiu X, Zhang N, Wang Y, Wang M, Li D, Wang L, Du Y Abstract Cervical cancer is one of the most frequently diagnosed cancers and is a major cause of death from gynecologic cancers worldwide; the cancer burden from cervical cancer is especially heavy in less developed countries. Most cases of cervical cancer are caused by persistent infection with carcinogenic human papillomavirus (HPV) genotypes 16 and 18. Non-resolving inflammation caused by HPV infection provides a microenvironment that facilitates cancer development. Molecular alterations during the process of HPV-induced carcinogenesis are chara...
Source: BioScience Trends - July 21, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

The effect of DHEA on apoptosis and cohesin levels in oocytes in aged mice.
Authors: Chu N, Gui Y, Qiu X, Zhang N, Li L, Li D, Tang W, Gober HJ, Zhang B, Wang L Abstract Female fertility declines with age as the number of ovarian follicles decreases and aneuploidy increases. Degradation of the cohesin complex might be responsible for age-related aneuploidy. Dehydroepiandrosterone (DHEA) can improve the ovarian reserve and reduce the rate of aneuploidy, but the relationship between DHEA and cohesin levels in oocytes is still unknown. The aim of the current study was to evaluate the effect of the supplement DHEA on ovarian function, including the number of follicles and cohesin levels in ooc...
Source: BioScience Trends - July 21, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Poly(U) and CpG ameliorate the unbalanced T cell immunity and pneumonia of mice with RSV vaccine-enhanced disease.
Authors: Jia R, Lu L, Liang X, Sun Z, Tan L, Xu M, Su L, Xu J Abstract Respiratory Syncycial Virus (RSV) is the most important pathogen responsible for children's severe lower respiratory tract infection. So far no RSV vaccine has yet been authorized for clinical use. The main impediment that blocked development of RSV vaccine is that inactivated RSV vaccine could cause RSV vaccine-enhanced disease (RVED). The mechanism of RVED remains unclear. Recently some researchers found that insufficient activation of innate immunity, including Toll-like receptors (TLRs), might be associated with the onset of RVED. Based on t...
Source: BioScience Trends - June 29, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Posttraumatic stress disorder eliminates association of TrkB rs1187327 with HDL-C in Chinese Han adolescents.
This study was to investigate the interplays of PTSD and TrkB rs1187327 on serum lipid profiles. Variants of TrkB rs1187327 of 709 high school students were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analyses and verified by DNA sequencing. The PTSD Checklist Civilian Version (PCL-C) was used to assess PTSD. Colorimetric methods were used to determine the serum levels of triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and glucose. The results show that the GG homozygotes had a significantly ...
Source: BioScience Trends - June 21, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Paeoniflorin prevents TLR2/4-mediated inflammation in type 2 diabetic nephropathy.
Authors: Zhang T, Zhu Q, Shao Y, Wang K, Wu Y Abstract Paeoniflorin is an effective Chinese traditional medicine with anti-inflammatory and immune-regulatory effects. The aim of this study was to investigate the underlying renoprotective mechanism of Paeoniflorin. In vivo, db/db mice were intraperitoneally injected with Paeoniflorin at a dose of 15, 30, or 60 mg/kg respectively. The immunostaining of TLR2, TLR4, CD68, NF-kB p65 and the mRNA level of inflammatory factors, together with the protein expression of TLR2/4 signaling were evaluated. Our data demonstrated that Paeoniflorin could decrease the urinary albumi...
Source: BioScience Trends - June 21, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Clinical correspondence to hepatocellular carcinoma-related lesions with atypical radiological pattern.
Authors: Higaki T, Midorikawa Y, Nakashima Y, Nakayama H, Matsuoka S, Moriyama M, Sugitani M, Takayama T Abstract In patients at risk of hepatocarcinogenesis, tumors are frequently detected with atypical radiological patterns related to hepatocellular carcinoma (HCC) on imaging studies. Despite their high potential for malignancy, whether to resect such lesions immediately is controversial. Based on histological findings, patients with non-enhanced tumors or enhanced tumors without washout were divided into two groups: those with tumors that should be treated containing well, moderately, and poorly differentiated H...
Source: BioScience Trends - June 21, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Once malaria is eliminated, more attention should be paid to imported malaria: Data from five years of surveillance in the City of Yiwu in eastern China.
This study reviewed and analyzed data on malaria cases in Yiwu from 2012 to 2016 via a webbased system for managing and reporting information on infectious diseases. A total of 161 cases were diagnosed (77.02% due to Plasmodium falciparum, 18.01% due to P. vivax, 4.35% due to P. ovale, and 0.62% due to P. malariae). One case was imported from Yunnan Province in China and the others were imported from overseas. The ratio of male to female patients was 7.47:1. The average age was 36.34 years (SD: 9.63). Most cases (87.58%) were imported from 1 of 30 countries in Africa. As malaria is gradually being eliminated in China, the ...
Source: BioScience Trends - June 21, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Unique Trichomonas vaginalis gene sequences identified in multinational regions of Northwest China.
This study determined the sequence of the 18S ribosomal RNA gene of T. vaginalis infecting both females and males in Xinjiang, China. Samples from 73 females and 28 males were collected and confirmed for infection with T. vaginalis, a total of 110 sequences were identified when the T. vaginalis 18S ribosomal RNA gene was sequenced. These sequences were used to prepare a phylogenetic network. The rooted network comprised three large clades and several independent branches. Most of the Xinjiang sequences were in one group. Preliminary results suggest that Xinjiang T. vaginalis isolates might be genetically unique, as indicat...
Source: BioScience Trends - June 14, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

The T-Box transcription factor 3 in development and cancer.
Authors: Willmer T, Cooper A, Peres J, Omar R, Prince S Abstract T-box factors comprise an archaic family of evolutionary conserved transcription factors that regulate patterns of gene expression essential for embryonic development. The T-box transcription factor 3 (TBX3), a member of this family, is expressed in several tissues and plays critical roles in, among other structures, the heart, mammary gland and limbs and haploinsufficiency of the human TBX3 gene is the genetic basis for the autosomal dominant disorder, ulnar-mammary syndrome. Overexpression of TBX3 on the other hand has been linked to several cancers...
Source: BioScience Trends - June 6, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Sustained release vancomycin-coated titanium alloy using a novel electrostatic dry powder coating technique may be a potential strategy to reduce implant-related infection.
Authors: Han J, Yang Y, Lu J, Wang C, Xie Y, Zheng X, Yao Z, Zhang C Abstract In order to tackle the implant-related infection, a novel way was developed in this study to coat vancomycin particles mixed with controlled release coating materials onto the surface of titanium alloy by using an electrostatic dry powder coating technique. To characterize this sustained release antibacterial coating, surface morphology, in vitro and in vivo drug release were sequentially evaluated. In vitro cytotoxicity was tested by Cell Counting Kit-8 (CCK-8) assay and cytological changes were observed by inverted microscope. The antib...
Source: BioScience Trends - May 30, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Comparative transcriptomic analysis identifies reprogramming and differentiation genes differentially expressed in UiPSCs and ESCs.
Authors: Shi L, Cui Y, Zhou X, Luan J, Wang L, Han J Abstract Embryonic stem cells (ESCs) technology has garnered worldwide attention for its therapeutic applications in vivo. Researchers have previously shown that non-viral induced pluripotent stem cells (iPSCs) can be generated from urine. As a potential alternative, Urinary iPSCs (UiPSCs) are highly similar to embryonic stem cells (ESCs) in many aspects such as morphology, expression of pluripotency markers and the capacity to develop into three germ layers in vitro and in vivo. However, the degree of gene expression similarity between iPSCs and ESCs has not bee...
Source: BioScience Trends - May 23, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Preoperative biliary drainage versus direct surgery for perihilar cholangiocarcinoma: A retrospective study at a single center.
This study also sought to find an optimal value of total bilirubin (TB) to indicate performing PBD. Between 2009 and 2014, after excluding patients with acute cholangitis and PVE, patients who had undergone hepatectomy for pCC were enrolled in this study. First, the surgical outcomes and postoperative outcomes were compared between PBD group and direct surgery group. Second, ROC curve analysis of a subgroup of patients was performed to find the best cut off value of TB for indicating the PBD. Third, the costs for patients, including the total charges and the charges per day were compared between the two groups. Subjects we...
Source: BioScience Trends - May 23, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Traditional Chinese medicine for human papillomavirus (HPV) infections: A systematic review.
Authors: Lin J, Chen L, Qiu X, Zhang N, Guo Q, Wang Y, Wang M, Gober HJ, Li D, Wang L Abstract Human papillomavirus (HPV) infections are common and generally harmless, but persistent infections can bring health problems like cancer and genital warts. For the uninfected group, HPV vaccines provide safe and effective protection, but they're type-restricted and expensive. For those infected, so far there have been a handful of treatments for HPV-associated benign or malignant diseases, traditional Chinese medicine being one of them. This systematic review focuses on the application of traditional Chinese medicine in H...
Source: BioScience Trends - May 10, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Liver fibrosis after antiretroviral therapy in a longitudinal cohort of sexually infected HIV patients in eastern China.
Authors: Wei Q, Lin H, Ding Y, Liu X, Wu Q, Shen W, Gao M, He N Abstract We assessed the factors that influenced improvement or progression in human immunodeficiency virus (HIV)-infected patients who were receiving combination antiretroviral therapy (cART). This was a retrospective cohort study of HIV-infected patients receiving cART in Taizhou, Zhejiang, China, 2009-2015. Liver fibrosis was assessed by Fibrosis-4 (FIB-4) score. Improvement of liver fibrosis was defined as having> 30% decrease in FIB-4 from baseline, whereas progression of liver fibrosis was defined as having> 30% increase in FIB-4 score from...
Source: BioScience Trends - May 10, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Index of convexity: A novel method for assessing liver functional reserve using technetium-99m-galactosyl human serum albumin liver scintigraphy.
Authors: Sato T, Arita J, Inoue Y, Koga R, Takahashi Y, Saiura A Abstract Preoperative evaluation of liver functional reserve is important in hepatobiliary surgery. Although the indocyanine green retention rate at 15 minutes (ICG-R15) is the gold standard for this purpose, a new method without technical complexity would be preferable. We assessed the usefulness of the previously established index of convexity (IOC). In total, 159 consecutive patients who underwent both technetium-99m-galactosyl human serum albumin ((99m)Tc-GSA) scintigraphy and the ICG-R15 were included. Correlation coefficients between indices fro...
Source: BioScience Trends - May 10, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Time series analysis of weekly influenza-like illness rate using a one-year period of factors in random forest regression.
In this study, a random forest regression constructed with a one-year period of factors was adopted to forecast the weekly ILI rate using the clinical data from Shenzhen Health Information Center. The following conclusions were drawn based on this method: i) Compared to the predication with 52 (one-year) history observations, the accuracy of the predication was improved by adding another 52 first-order difference variables: mean absolute percentage error (MAPE) decreased from 5.04% to 4.35% and mean squared error (MSE) decreased from 2.85E-04 to 1.97E-04. ii) The variables with the first-order difference seemed more signif...
Source: BioScience Trends - May 10, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

C-to-U editing and site-directed RNA editing for the correction of genetic mutations.
Authors: Vu LT, Tsukahara T Abstract Cytidine to uridine (C-to-U) editing is one type of substitutional RNA editing. It occurs in both mammals and plants. The molecular mechanism of C-to-U editing involves the hydrolytic deamination of a cytosine to a uracil base. C-to-U editing is mediated by RNA-specific cytidine deaminases and several complementation factors, which have not been completely identified. Here, we review recent findings related to the regulation and enzymatic basis of C-to-U RNA editing. More importantly, when C-to-U editing occurs in coding regions, it has the power to reprogram genetic information...
Source: BioScience Trends - May 10, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Perfusion and drainage difference in the liver parenchyma: Regional plane in segment 6.
Authors: Abe H, Yamazaki S, Moriguchi M, Higaki T, Takayama T Abstract The differences between the perfusion areas of portal vein and the drainage areas of hepatic vein result in the occurrence of either ischemic or congested areas after liver resection. To elucidate which factors are related to the differences between these areas of segment (S) 6 were therefore investigated. The portal-vein-based and hepatic-vein-based regional planes of S6 were defined using the region-growing and Voronoi tessellation methods in 103 consecutive patients who undergo liver resection. Finally, factors related to the difference betwe...
Source: BioScience Trends - May 10, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Preliminary thoughts on research in medical humanities.
Authors: Yun X, Guo J, Qian H Abstract Medical humanities (MH) is an interdisciplinary field of medicine which includes the humanities (literature, philosophy, ethics, history, and religion), social sciences (anthropology, cultural studies, psychology, sociology, and health geography), and the arts (literature, theater, film, and visual arts) and their application to medical education and practice. Studies of MH should not be limited to theoretical discussions. Research results must be translated into use of methodologies to formulate medical policies, guide clinical practices, and help resolve physical or mental p...
Source: BioScience Trends - May 3, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Medical humanities play an important role in improving the doctor-patient relationship.
Authors: Wang F, Song Z, Zhang W, Xiao Y Abstract Doctors in China have been wounded or even killed in frequent violence as conflict between doctors and patients has intensified. China has had a massive dearth of medical students over the past decade and doctors are dissatisfied with conditions in their profession. Conditions in medicine are not conducive to medical reform. This paper notes that the main factors affecting the doctor-patient relationship are a lack of humanity in medicine, the predominance of techniques and technologies, and inappropriate administration of hospitals. These factors are related to a l...
Source: BioScience Trends - May 3, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Emphasizing humanities in medical education: Promoting the integration of medical scientific spirit and medical humanistic spirit.
Authors: Song P, Tang W Abstract In the era of the biological-psychological-social medicine model, an ideal of modern medicine is to enhance the humanities in medical education, to foster medical talents with humanistic spirit, and to promote the integration of scientific spirit and humanistic spirit in medicine. Throughout the United States (US), United Kingdom (UK), other Western countries, and some Asian countries like Japan, many medical universities have already integrated the learning of medical humanities in their curricula and recognized their value. While in China, although medical education reform over th...
Source: BioScience Trends - May 3, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

An upcoming program for medical humanities education in Fudan University's School of Basic Medical Sciences.
Authors: Liu Y, Cheng X PMID: 28458334 [PubMed - as supplied by publisher] (Source: BioScience Trends)
Source: BioScience Trends - May 3, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Communication skills training: Adapting to the trends and moving forward.
Authors: Liu Y, Huang Y, Gao H, Cheng X Abstract Communication ability is one of the core requirements of doctors' competency. Teaching communication to medical students and junior doctors has attracted much attention. With the challenge of escalating demands, the status of training communication skills has been promoted in the past several decades. The training content was integrated with other courses and various pedagogic approaches have been applied and proved to be effective. Practical strategies and mixed types were highly recommended. However, there are still many problems, including the fragmentation of the...
Source: BioScience Trends - May 3, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Using films and television shows with a medical theme as a medium to accelerate the spread of medical humanities.
Authors: Chen W, Qian H Abstract People have more visual experiences than ever before, and the same is true for situations in medicine. More mature films and television shows with a medical theme have been available over the past 20 years. In mainland China, the TV series "Angel Heart" has generated a wave of universal concern since it truly depicts the work of health care workers and it reflects the sharp distinction between doctors and patients to a certain extent. Riding this wave, many medical documentaries like The Human World have also been launched in China and have garnered sizable audiences. Such...
Source: BioScience Trends - May 3, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Propelling medical humanities in China.
Authors: Tang W Abstract Advances in the study of the medical humanities and medical humanities education have been made over the past few decades. Many influential journals have published articles examining the role of medical humanities and medical humanities education, the development and evaluation of medical humanities, and the design of a curriculum for medical humanities education in Western countries. However, most articles related to medical humanities in China were published in Chinese, moreover, researchers have worked in relative isolation and published in disparate journals, so their work has not been ...
Source: BioScience Trends - May 3, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Re-entry and related predictors among HIV-infected clients receiving methadone maintenance treatment in Guangdong province, China.
This study examined the re-entry characteristics and related predictors among HIV-infected methadone maintenance treatment (MMT) clients in Guangdong, China. Data on HIV-infected MMT clients was obtained from the clinic MMT registration system in Guangdong. Of the 653 participants, only 9.0% remained in the MMT program until the end of the study. For the drop-outs, 70.0% returned to MMT at least once by the end of the study. Re-entry was independently associated with marital status (ORnever married = 2.24, 95% CI: 1.02-4.93; ORmarried currently = 2.34, 95% CI: 1.05-5.22), being unemployed (OR = 1.92, 95% CI: 1.12-3.27), lo...
Source: BioScience Trends - April 20, 2017 Category: Biomedical Science Tags: Biosci Trends Source Type: research