Mitochondrial Disease Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The role and mechanism of PDZ binding kinase in hypobaric and hypoxic acute lung injury
CONCLUSIONS: Overexpression of PBK inhibits the expression of p53 and activates SIRT1-PINK1 axis mediated mitochondrial autophagy to alleviate HHALI.PMID:38617778 | PMC:PMC11009593 | DOI:10.21037/jtd-24-188 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Linao Sun Haoran Yue Hao Fang Runze Li Shicong Li Jianyao Wang Pengjie Tu Fei Meng Wang Yan Jinxia Zhang Elena Bignami Kyeongman Jeon Biniam Kidane Peng Zhang Source Type: research

Effects of Dietary Restriction on PGC-1 α Regulation in the Development of Age-associated Diseases
In conclusion, dietary interventions may delay ageing by regulating healthy mitochondria in various organs, presenting the possibility of a new primary prevention for many age-related diseases.PMID:38616758 | DOI:10.2174/0118746098301226240402051508 (Source: Current Aging Science)
Source: Current Aging Science - April 15, 2024 Category: Geriatrics Authors: Shefilyn Widjaja Radiana Dhewayani Antarianto Novi Silvia Hardiany Source Type: research

BmATAD3A mediates mitochondrial ribosomal protein expression to maintain the mitochondrial energy metabolism of the silkworm, Bombyx mori
BmATAD3A knockout could inhibit the synthesis of mitochondrial ribosomal protein, leading to mitochondrial dysfunction that affects the mitochondrial membrane potential, inhibits the expression levels of oxidative phosphorylation subunit complexes I (BmND4,BmND5), III (BmCYTB), IV (BmCOX2) and V (BmATP6), and reduces ATPase activity. AbstractATAD3A is a mitochondrial membrane protein belonging to the ATPase family that contains the AAA+ domain. It is widely involved in mitochondrial metabolism, protein transport, cell growth, development and other important life processes. It has previously been reported that the deletio...
Source: Insect Science - April 15, 2024 Category: Biology Authors: Zhanqi Dong, Nachuan Liao, Yan Luo, Ya Zhang, Liang Huang, Peng Chen, Cheng Lu, Minhui Pan Tags: ORIGINAL ARTICLE Source Type: research

Extant interspecific hybridization among trematodes within the < i > Schistosoma haematobium < /i > species complex in Nigeria
by Oluwaremilekun G. Ajakaye, Elisha E. Enabulele, Joshua B. Balogun, Oyetunde T. Oyeyemi, Michael E. Grigg BackgroundNatural interspecific hybridization between the human parasite (Schistosoma haematobium [Sh]) and bovine parasites (Schistosoma bovis [Sb],Schistosoma curassoni [Sc]) is increasingly reported in Africa. We developed a multi-locus PCR DNA-Seq strategy that amplifies two unlinked nuclear (transITS,BF) and two linked organellar genome markers (CO1,ND5) to genotypeS.haematobium eggs collected from infected people in Ile Oluji/Oke Igbo, Ondo State (an agrarian community) and Kachi, Jigawa State (a pastoral commu...
Source: PLoS Neglected Tropical Diseases - April 15, 2024 Category: Tropical Medicine Authors: Oluwaremilekun G. Ajakaye Source Type: research

Isobavachin attenuates osteoclastogenesis and periodontitis-induced bone loss by inhibiting cellular iron accumulation and mitochondrial biogenesis
Biochem Pharmacol. 2024 Apr 12:116202. doi: 10.1016/j.bcp.2024.116202. Online ahead of print.ABSTRACTAs bone-resorbing cells rich in mitochondria, osteoclasts require high iron uptake to promote mitochondrial biogenesis and maintain a high-energy metabolic state for active bone resorption. Given that abnormal osteoclast formation and activation leads to imbalanced bone remodeling and osteolytic bone loss, osteoclasts may be crucial targets for treating osteolytic diseases such as periodontitis. Isobavachin (IBA), a natural flavonoid compound, has been confirmed to be an inhibitor of receptor activator of nuclear factor κB...
Source: Biochemical Pharmacology - April 14, 2024 Category: Drugs & Pharmacology Authors: Ting Li Yangge Du Hantao Yao Boxuan Zhao Zijun Wang Rourong Chen Yaoting Ji Minquan Du Source Type: research

Mechanistic insights and emerging therapeutic stratagems for Alzheimer's disease
Ageing Res Rev. 2024 Apr 12:102309. doi: 10.1016/j.arr.2024.102309. Online ahead of print.ABSTRACTAlzheimer's disease (AD), a multi-factorial neurodegenerative disorder has affected over 30 million individuals globally and these numbers are expected to increase in the coming decades. Current therapeutic interventions are largely ineffective as they focus on a single target. Development of an effective drug therapy requires a deep understanding of the various factors influencing the onset and progression of the disease. Aging and genetic factors exert a major influence on the development of AD. Other factors like post-viral...
Source: Ageing Research Reviews - April 14, 2024 Category: Genetics & Stem Cells Authors: Kayalvizhi Rajendran Uma Maheswari Krishnan Source Type: research

RNF31 alleviates liver steatosis by promoting p53/BNIP3-related mitophagy in hepatocytes
CONCLUSIONS: The findings highlight RNF31's essential role in the regulation of mitochondrial homeostasis in hepatocytes, emphasizing its potential as a therapeutic target for NAFLD.PMID:38615890 | DOI:10.1016/j.freeradbiomed.2024.04.214 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 14, 2024 Category: Biology Authors: Yifei Chen Fuji Yang Yujie Shi Jingyu Sheng Yanjin Wang Liting Zhang Jing Zhou Yi Jin Yongmin Yan Source Type: research