Microbiome Profile of South Korean Vector Mosquitoes
This study sheds light on the complex interactions between mosquitoes and their microbiome, revealing potential implications for vector competence, disease transmission, and vector control strategies.PMID:38608996 | DOI:10.1016/j.actatropica.2024.107213 (Source: Acta Tropica)
Source: Acta Tropica - April 12, 2024 Category: Infectious Diseases Authors: Ashraf Akintayo Akintola Ui Wook Hwang Source Type: research
Design, synthesis, and evaluation of formylpiperazine analogs of Ferrostatin-1 as novel improved ferroptosis inhibitors
In this study, a series of new formylpiperazine-derived ferroptosis inhibitors were designed and synthesized based on the structure of a known ferroptosis inhibitor, ferrostatin-1 (Fer-1). The anti-ferroptosis activity of these synthetic compounds in human umbilical vein endothelial cells (HUVECs) induced by Erastin was evaluated. It was found that some of the new compounds, especially compound 26, showed potent anti-ferroptosis activity, as evidenced by its ability to restore cell viability, reduce iron accumulation, scavenge reactive oxygen species, maintain mitochondrial membrane potential, increase GSH levels, decrease...
Source: Bioorganic and Medicinal Chemistry - April 12, 2024 Category: Chemistry Authors: Hua-Long Ji Yi-Fan Zhang Nai-Yu Zhang Kai-Ming Wang Ning Meng Juan Zhang Cheng-Shi Jiang Source Type: research
Proteomics-derived biomarker panel facilitates distinguishing primary lung adenocarcinomas with intestinal or mucinous differentiation (PAIM) from lung metastatic colorectal cancer (lmCRC)
This study aimed to explore the protein biomarkers that could distinguish between PAIM and lmCRC. To uncover differences between the two diseases, we used tandem mass tagging (TMT)-based shotgun proteomics to characterize proteomes of formalin-fixed paraffin-embedded (FFPE) tumor samples of PAIM (n = 22) and lmCRC (n = 17).Then three machine learning algorithms, namely support vector machine (SVM), random forest and the Least Absolute Shrinkage and Selection Operator (LASSO), were utilized to select protein features with diagnostic significance. These candidate proteins were further validated in an independent cohort (PAIM...
Source: Molecular and Cellular Proteomics : MCP - April 12, 2024 Category: Molecular Biology Authors: Jiaying Liu Xiaona Chang Liujia Qian Shuo Chen Zhangzhi Xue Junhua Wu Danju Luo Bo Huang Jun Fan Tiannan Guo Xiu Nie Source Type: research
Microbiome Profile of South Korean Vector Mosquitoes
This study sheds light on the complex interactions between mosquitoes and their microbiome, revealing potential implications for vector competence, disease transmission, and vector control strategies.PMID:38608996 | DOI:10.1016/j.actatropica.2024.107213 (Source: Acta Tropica)
Source: Acta Tropica - April 12, 2024 Category: Infectious Diseases Authors: Ashraf Akintayo Akintola Ui Wook Hwang Source Type: research
Proteomics-derived biomarker panel facilitates distinguishing primary lung adenocarcinomas with intestinal or mucinous differentiation (PAIM) from lung metastatic colorectal cancer (lmCRC)
This study aimed to explore the protein biomarkers that could distinguish between PAIM and lmCRC. To uncover differences between the two diseases, we used tandem mass tagging (TMT)-based shotgun proteomics to characterize proteomes of formalin-fixed paraffin-embedded (FFPE) tumor samples of PAIM (n = 22) and lmCRC (n = 17).Then three machine learning algorithms, namely support vector machine (SVM), random forest and the Least Absolute Shrinkage and Selection Operator (LASSO), were utilized to select protein features with diagnostic significance. These candidate proteins were further validated in an independent cohort (PAIM...
Source: Molecular and Cellular Proteomics : MCP - April 12, 2024 Category: Molecular Biology Authors: Jiaying Liu Xiaona Chang Liujia Qian Shuo Chen Zhangzhi Xue Junhua Wu Danju Luo Bo Huang Jun Fan Tiannan Guo Xiu Nie Source Type: research
L-Ergothioneine slows the progression of age-related hearing loss in CBA/CaJ mice
Hear Res. 2024 Apr 2;446:109004. doi: 10.1016/j.heares.2024.109004. Online ahead of print.ABSTRACTThe naturally occurring amino acid, l-ergothioneine (EGT), has immense potential as a therapeutic, having shown promise in the treatment of other disease models, including neurological disorders. EGT is naturally uptaken into cells via its specific receptor, OCTN1, to be utilized by cells as an antioxidant and anti-inflammatory. In our current study, EGT was administered over a period of 6 months to 25-26-month-old CBA/CaJ mice as a possible treatment for age-related hearing loss (ARHL), since presbycusis has been linked to hi...
Source: Hearing Research - April 12, 2024 Category: Audiology Authors: Mark A Bauer Parveen Bazard Alejandro A Acosta Nidhi Bangalore Lina Elessaway Mark Thivierge Moksheta Chellani Xiaoxia Zhu Bo Ding Joseph P Walton Robert D Frisina Source Type: research
Microbiome Profile of South Korean Vector Mosquitoes
This study sheds light on the complex interactions between mosquitoes and their microbiome, revealing potential implications for vector competence, disease transmission, and vector control strategies.PMID:38608996 | DOI:10.1016/j.actatropica.2024.107213 (Source: Acta Tropica)
Source: Acta Tropica - April 12, 2024 Category: Infectious Diseases Authors: Ashraf Akintayo Akintola Ui Wook Hwang Source Type: research
L-Ergothioneine slows the progression of age-related hearing loss in CBA/CaJ mice
Hear Res. 2024 Apr 2;446:109004. doi: 10.1016/j.heares.2024.109004. Online ahead of print.ABSTRACTThe naturally occurring amino acid, l-ergothioneine (EGT), has immense potential as a therapeutic, having shown promise in the treatment of other disease models, including neurological disorders. EGT is naturally uptaken into cells via its specific receptor, OCTN1, to be utilized by cells as an antioxidant and anti-inflammatory. In our current study, EGT was administered over a period of 6 months to 25-26-month-old CBA/CaJ mice as a possible treatment for age-related hearing loss (ARHL), since presbycusis has been linked to hi...
Source: Hearing Research - April 12, 2024 Category: Audiology Authors: Mark A Bauer Parveen Bazard Alejandro A Acosta Nidhi Bangalore Lina Elessaway Mark Thivierge Moksheta Chellani Xiaoxia Zhu Bo Ding Joseph P Walton Robert D Frisina Source Type: research
L-Ergothioneine slows the progression of age-related hearing loss in CBA/CaJ mice
Hear Res. 2024 Apr 2;446:109004. doi: 10.1016/j.heares.2024.109004. Online ahead of print.ABSTRACTThe naturally occurring amino acid, l-ergothioneine (EGT), has immense potential as a therapeutic, having shown promise in the treatment of other disease models, including neurological disorders. EGT is naturally uptaken into cells via its specific receptor, OCTN1, to be utilized by cells as an antioxidant and anti-inflammatory. In our current study, EGT was administered over a period of 6 months to 25-26-month-old CBA/CaJ mice as a possible treatment for age-related hearing loss (ARHL), since presbycusis has been linked to hi...
Source: Hearing Research - April 12, 2024 Category: Audiology Authors: Mark A Bauer Parveen Bazard Alejandro A Acosta Nidhi Bangalore Lina Elessaway Mark Thivierge Moksheta Chellani Xiaoxia Zhu Bo Ding Joseph P Walton Robert D Frisina Source Type: research
GSE260582 Mitochondrial ACSS1-K-635 acetylation mimic knock-in mice exhibit altered lipid metabolism, hepatic cell senescence, and acute non-alcoholic fatty liver [2ndSet_analysis]
Contributors : David Gius ; Guogang Xu ; Joseph Schell ; Nobuo Horikoshi ; Yidong Chen ; Zhao LaiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe generated an ACSS1-acetylation (Ac) mimic mouse, where lysine 635 was mutated to glutamine (K635Q). Male Acss1K635Q/K635Q mice were smaller with higher metabolic rate and blood acetate, and decreased liver/serum ATP and lactate levels. After a 48-hour fast, Acss1K635Q/K635Q mice presented hypothermia and liver aberrations, including enlargement, discoloration, lipid droplet accumulation, and microsteatosis – consistent with nonalco...
Source: GEO: Gene Expression Omnibus - April 12, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE260581 Mitochondrial ACSS1-K-635 acetylation mimic knock-in mice exhibit altered lipid metabolism, hepatic cell senescence, and acute non-alcoholic fatty liver [1stSet_analysis]
Contributors : David Gius ; Guogang Xu ; Joseph Schell ; Nobuo Horikoshi ; Yidong Chen ; Zhao LaiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe generated an ACSS1-acetylation (Ac) mimic mouse, where lysine 635 was mutated to glutamine (K635Q). Male Acss1K635Q/K635Q mice were smaller with higher metabolic rate and blood acetate, and decreased liver/serum ATP and lactate levels. After a 48-hour fast, Acss1K635Q/K635Q mice presented hypothermia and liver aberrations, including enlargement, discoloration, lipid droplet accumulation, and microsteatosis – consistent with nonalco...
Source: GEO: Gene Expression Omnibus - April 12, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Clinical characteristics of BRAT1-related disease: a systematic literature review
ConclusionsThis is the first comprehensive systematic review to present quantitative data about clinical characteristics of BRAT1-related disease, which helps doctors to recognize and diagnose it easier. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 12, 2024 Category: Neurology Source Type: research
Exosomal Tenascin-C Primes Macrophage Pyroptosis Amplifying Aberrant Inflammation during Sepsis-Induced Acute Lung Injury
Transl Res. 2024 Apr 9:S1931-5244(24)00078-1. doi: 10.1016/j.trsl.2024.04.001. Online ahead of print.ABSTRACTSepsis-induced acute lung injury (ALI) is a serious complication of sepsis and the predominant cause of death. Exosomes released by lung tissue cells critically influence the progression of ALI during sepsis by modulating the inflammatory microenvironment. However, the molecular mechanisms by which exosome-mediated intercellular signaling exacerbates ALI in septic infection remain undefined. Our study found increased levels of exosomal Tenascin-C (TNC) in the plasma of both patients and mice with ALI, showing a stro...
Source: Translational Research : the journal of laboratory and clinical medicine - April 11, 2024 Category: Laboratory Medicine Authors: Ting Gong Xuedi Zhang Xiaolei Liu Yinfeng Ye Zhiyuan Tian Shuang Yin Min Zhang Jing Tang Youtan Liu Source Type: research
Exosomal Tenascin-C Primes Macrophage Pyroptosis Amplifying Aberrant Inflammation during Sepsis-Induced Acute Lung Injury
Transl Res. 2024 Apr 9:S1931-5244(24)00078-1. doi: 10.1016/j.trsl.2024.04.001. Online ahead of print.ABSTRACTSepsis-induced acute lung injury (ALI) is a serious complication of sepsis and the predominant cause of death. Exosomes released by lung tissue cells critically influence the progression of ALI during sepsis by modulating the inflammatory microenvironment. However, the molecular mechanisms by which exosome-mediated intercellular signaling exacerbates ALI in septic infection remain undefined. Our study found increased levels of exosomal Tenascin-C (TNC) in the plasma of both patients and mice with ALI, showing a stro...
Source: Cell Research - April 11, 2024 Category: Cytology Authors: Ting Gong Xuedi Zhang Xiaolei Liu Yinfeng Ye Zhiyuan Tian Shuang Yin Min Zhang Jing Tang Youtan Liu Source Type: research
