DKK3 promotes renal fibrosis by increasing MFF-mediated mitochondrial dysfunction in Wnt/ β-catenin pathway-dependent manner

CONCLUSION: Upregulation of DKK3 caused by m6A modification activated the Wnt/β-catenin pathway to increase MFF transcriptional expression, leading to mitochondrial dysfunction and oxidative stress, thereby promoting RF progression.PMID:38682264 | DOI:10.1080/0886022X.2024.2343817

Source: Renal Failure - April 29, 2024 Category: Urology & Nephrology Authors: Jianling Song Yanxia Chen Yan Chen Minzi Qiu Wenliu Xiang Ben Ke Xiangdong Fang Source Type: research