Nip it in the Bud: Botanicals for Anxiety — a Practical Prescriber’s Guide
AbstractPurpose of ReviewThe goal of this paper is to summarize the evidence for the use of botanical medicines for the treatment of anxiety disorders. We sought to make this review practical for psychiatrists and psychiatric prescribers.Recent FindingsIn 2018, the Natural Medicines database produced a Clinical Management of Anxiety guide that summarized the conventional and natural treatments of anxiety disorders. Based on this guide, four herbal supplements (also referred to as botanicals) were selected for deeper study including kava, lavender, lemon balm and passionflower. All four were considered possibly safe and pos...
Source: Current Psychiatry Reports - September 1, 2022 Category: Psychiatry Source Type: research
Characterization of Different Forms of Kava (Piper methysticum) Products by UPLC-MS/MS
Planta Med DOI: 10.1055/a-1708-1994There are several forms of kava (Piper methysticum) products available for human consumption, and many factors are known to influence their chemical compositions and therefore their
pharmacological properties. Because of the increased popularity of kava intake, a rigorous characterization of their content diversity is prerequisite, particularly due to its known
potential to cause hepatotoxicity. To understand the composition diversity of kavalactones and flavokavains in commercial kava products, we developed a UPLC-MS/MS-based analytical method for
the quantification of six...
Source: Planta Medica - August 22, 2022 Category: Drugs & Pharmacology Authors: Mamallapalli, Jessica Kanumuri, Siva Rama Raju Corral, Pedro Johnston, Edward Zhuang, Chunlin McCurdy, Christopher R. Mathews, Carol A. Sharma, Abhisheak Xing, Chengguo Tags: Original Papers Source Type: research
Flavokawain A Reduces Tumor-Initiating Properties and Stemness of Prostate Cancer
Front Oncol. 2022 Jul 13;12:943846. doi: 10.3389/fonc.2022.943846. eCollection 2022.ABSTRACTWe have previously demonstrated the in vivo chemopreventive efficacy of flavokawain A (FKA), a novel chalcone from the kava plant, in prostate carcinogenesis models. However, the mechanisms of the anticarcinogenic effects of FKA remain largely unknown. We evaluated the effect of FKA on prostate tumor spheroid formation by prostate cancer stem cells, which were sorted out from CD44+/CD133+ prostate cancer cells 22Rv1 and DU145. FKA treatment significantly decreased both the size and numbers of the tumor spheroids over different gener...
Source: Cancer Control - August 1, 2022 Category: Cancer & Oncology Authors: Liankun Song Merci Mino Jana Yamak Vyvyan Nguyen Derron Lopez Victor Pham Ali Fazelpour Vinh Le Dongjun Fu Matthew Tippin Edward Uchio Xiaolin Zi Source Type: research
An Updated Review on the Psychoactive, Toxic and Anticancer Properties of Kava
J Clin Med. 2022 Jul 12;11(14):4039. doi: 10.3390/jcm11144039.ABSTRACTKava (Piper methysticum) has been widely consumed for many years in the South Pacific Islands and displays psychoactive properties, especially soothing and calming effects. This plant has been used in Western countries as a natural anxiolytic in recent decades. Kava has also been used to treat symptoms associated with depression, menopause, insomnia, and convulsions, among others. Along with its putative beneficial health effects, kava has been associated with liver injury and other toxic effects, including skin toxicity in heavy consumers, possibly rela...
Source: Clinical Prostate Cancer - July 27, 2022 Category: Cancer & Oncology Authors: Rita B Soares Ricardo Jorge Dinis-Oliveira Nuno G Oliveira Source Type: research
An Updated Review on the Psychoactive, Toxic and Anticancer Properties of Kava
J Clin Med. 2022 Jul 12;11(14):4039. doi: 10.3390/jcm11144039.ABSTRACTKava (Piper methysticum) has been widely consumed for many years in the South Pacific Islands and displays psychoactive properties, especially soothing and calming effects. This plant has been used in Western countries as a natural anxiolytic in recent decades. Kava has also been used to treat symptoms associated with depression, menopause, insomnia, and convulsions, among others. Along with its putative beneficial health effects, kava has been associated with liver injury and other toxic effects, including skin toxicity in heavy consumers, possibly rela...
Source: Clinical Lung Cancer - July 27, 2022 Category: Cancer & Oncology Authors: Rita B Soares Ricardo Jorge Dinis-Oliveira Nuno G Oliveira Source Type: research
An Updated Review on the Psychoactive, Toxic and Anticancer Properties of Kava
J Clin Med. 2022 Jul 12;11(14):4039. doi: 10.3390/jcm11144039.ABSTRACTKava (Piper methysticum) has been widely consumed for many years in the South Pacific Islands and displays psychoactive properties, especially soothing and calming effects. This plant has been used in Western countries as a natural anxiolytic in recent decades. Kava has also been used to treat symptoms associated with depression, menopause, insomnia, and convulsions, among others. Along with its putative beneficial health effects, kava has been associated with liver injury and other toxic effects, including skin toxicity in heavy consumers, possibly rela...
Source: Clinical Breast Cancer - July 27, 2022 Category: Cancer & Oncology Authors: Rita B Soares Ricardo Jorge Dinis-Oliveira Nuno G Oliveira Source Type: research
An Updated Review on the Psychoactive, Toxic and Anticancer Properties of Kava
J Clin Med. 2022 Jul 12;11(14):4039. doi: 10.3390/jcm11144039.ABSTRACTKava (Piper methysticum) has been widely consumed for many years in the South Pacific Islands and displays psychoactive properties, especially soothing and calming effects. This plant has been used in Western countries as a natural anxiolytic in recent decades. Kava has also been used to treat symptoms associated with depression, menopause, insomnia, and convulsions, among others. Along with its putative beneficial health effects, kava has been associated with liver injury and other toxic effects, including skin toxicity in heavy consumers, possibly rela...
Source: Clinical Genitourinary Cancer - July 27, 2022 Category: Cancer & Oncology Authors: Rita B Soares Ricardo Jorge Dinis-Oliveira Nuno G Oliveira Source Type: research
An Updated Review on the Psychoactive, Toxic and Anticancer Properties of Kava
J Clin Med. 2022 Jul 12;11(14):4039. doi: 10.3390/jcm11144039.ABSTRACTKava (Piper methysticum) has been widely consumed for many years in the South Pacific Islands and displays psychoactive properties, especially soothing and calming effects. This plant has been used in Western countries as a natural anxiolytic in recent decades. Kava has also been used to treat symptoms associated with depression, menopause, insomnia, and convulsions, among others. Along with its putative beneficial health effects, kava has been associated with liver injury and other toxic effects, including skin toxicity in heavy consumers, possibly rela...
Source: Clinical Prostate Cancer - July 27, 2022 Category: Cancer & Oncology Authors: Rita B Soares Ricardo Jorge Dinis-Oliveira Nuno G Oliveira Source Type: research
An Updated Review on the Psychoactive, Toxic and Anticancer Properties of Kava
J Clin Med. 2022 Jul 12;11(14):4039. doi: 10.3390/jcm11144039.ABSTRACTKava (Piper methysticum) has been widely consumed for many years in the South Pacific Islands and displays psychoactive properties, especially soothing and calming effects. This plant has been used in Western countries as a natural anxiolytic in recent decades. Kava has also been used to treat symptoms associated with depression, menopause, insomnia, and convulsions, among others. Along with its putative beneficial health effects, kava has been associated with liver injury and other toxic effects, including skin toxicity in heavy consumers, possibly rela...
Source: Clinical Lung Cancer - July 27, 2022 Category: Cancer & Oncology Authors: Rita B Soares Ricardo Jorge Dinis-Oliveira Nuno G Oliveira Source Type: research
An Updated Review on the Psychoactive, Toxic and Anticancer Properties of Kava
J Clin Med. 2022 Jul 12;11(14):4039. doi: 10.3390/jcm11144039.ABSTRACTKava (Piper methysticum) has been widely consumed for many years in the South Pacific Islands and displays psychoactive properties, especially soothing and calming effects. This plant has been used in Western countries as a natural anxiolytic in recent decades. Kava has also been used to treat symptoms associated with depression, menopause, insomnia, and convulsions, among others. Along with its putative beneficial health effects, kava has been associated with liver injury and other toxic effects, including skin toxicity in heavy consumers, possibly rela...
Source: Clinical Breast Cancer - July 27, 2022 Category: Cancer & Oncology Authors: Rita B Soares Ricardo Jorge Dinis-Oliveira Nuno G Oliveira Source Type: research
An Updated Review on the Psychoactive, Toxic and Anticancer Properties of Kava
J Clin Med. 2022 Jul 12;11(14):4039. doi: 10.3390/jcm11144039.ABSTRACTKava (Piper methysticum) has been widely consumed for many years in the South Pacific Islands and displays psychoactive properties, especially soothing and calming effects. This plant has been used in Western countries as a natural anxiolytic in recent decades. Kava has also been used to treat symptoms associated with depression, menopause, insomnia, and convulsions, among others. Along with its putative beneficial health effects, kava has been associated with liver injury and other toxic effects, including skin toxicity in heavy consumers, possibly rela...
Source: Clinical Genitourinary Cancer - July 27, 2022 Category: Cancer & Oncology Authors: Rita B Soares Ricardo Jorge Dinis-Oliveira Nuno G Oliveira Source Type: research
Kava Kava Induced Acute Liver Failure
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - July 1, 2022 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research
Kalm Down With Kava: What Clinicians Need to Know
J Psychosoc Nurs Ment Health Serv. 2022 Jun 30:1-8. doi: 10.3928/02793695-20220523-02. Online ahead of print.ABSTRACTKava is a neuroactive medicinal herb that can induce pharmacological effects when ingested. As an herbal remedy, kava exhibits sedative, anesthetic, euphoriant, and entheogenic effects. Kava is used as a relaxant, pain reliever, and remedy for anxiety and insomnia. In the United States, kava is marketed as a safe dietary supplement. Kava's popularity is on the rise due to heightened awareness and interest in natural plant-based health alternatives. Although meta-analyses and systematic reviews of kava use in...
Source: Pain Physician - June 28, 2022 Category: Anesthesiology Authors: Deana Goldin Deborah Salani Source Type: research
Protective effect of kavain in meristematic cells of Allium cepa L
An Acad Bras Cienc. 2022 Jun 13;94(2):e20200520. doi: 10.1590/0001-3765202220200520. eCollection 2022.ABSTRACTKavain is one of the main kavalactones of Piper methysticum (Piperaceae) with anxiolytic, analgesic, and antioxidant activities. Therefore, the aim of the study was to evaluate the cytotoxic, mutagenic, and antimutagenic potential of kavain in Allium cepa cells. Roots of A. cepa were transferred to the negative (2% acetone) and positive (10 µg/mL of Methylmethanesulfonate, MMS) controls and to the concentrations of kavain (32, 64 and 128 µg/mL) for 48 h. A total of 5,000 meristematic cells were analyzed under an ...
Source: An Acad Bras Cienc - June 15, 2022 Category: Science Authors: Erasmo P DO Vale Junior Marcos Vitor R Ferreira Bianca Cristina S Fernandes Thais T DA Silva Francielle Alline Martins Pedro Marcos DE Almeida Source Type: research
Protective effect of kavain in meristematic cells of Allium cepa L
An Acad Bras Cienc. 2022 Jun 13;94(2):e20200520. doi: 10.1590/0001-3765202220200520. eCollection 2022.ABSTRACTKavain is one of the main kavalactones of Piper methysticum (Piperaceae) with anxiolytic, analgesic, and antioxidant activities. Therefore, the aim of the study was to evaluate the cytotoxic, mutagenic, and antimutagenic potential of kavain in Allium cepa cells. Roots of A. cepa were transferred to the negative (2% acetone) and positive (10 µg/mL of Methylmethanesulfonate, MMS) controls and to the concentrations of kavain (32, 64 and 128 µg/mL) for 48 h. A total of 5,000 meristematic cells were analyzed under an ...
Source: An Acad Bras Cienc - June 15, 2022 Category: Science Authors: Erasmo P DO Vale Junior Marcos Vitor R Ferreira Bianca Cristina S Fernandes Thais T DA Silva Francielle Alline Martins Pedro Marcos DE Almeida Source Type: research
