Pharmacotherapy of Anxiety Disorders: Current and Emerging Treatment Options
Anxiety disorders are the most prevalent psychiatric disorders and a leading cause of disability. While there continues to be expansive research in posttraumatic stress disorder (PTSD), depression and schizophrenia, there is a relative dearth of novel medications under investigation for anxiety disorders. This review's first aim is to summarize current pharmacological treatments (both approved and off-label) for panic disorder (PD), generalized anxiety disorder (GAD), social anxiety disorder (SAD), and specific phobias (SP), including selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibi...
Source: Frontiers in Psychiatry - December 23, 2020 Category: Psychiatry Source Type: research
Kava (Piper methysticum) Extract for the Treatment of Nervous
Anxiety, Tension and Restlessness
Conclusions Overall, the study confirms the effective and safe
short-term use of kava in the Commission E-defined indication of
“nervous anxiety, tension and restlessness”, especially in
other than chronic cases. The clinical use of kava might be translated into
context-related phobias according to ICD-10 F40, or to nervous tension
(ICD10 R45.0) or restlessness and excitation (ICD-10 R45.1). [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - November 18, 2020 Category: Drugs & Pharmacology Authors: Kuchta, Kenny Hladikova, Marie Thomsen, Michael Nahrstedt, Adolf Schmidt, Mathias Tags: Original Article Source Type: research
Yangonin inhibits ethanol-induced hepatocyte senescence via miR-194/FXR axis.
Abstract
Chronic alcohol assumption has been recognized as a major cause of alcoholic liver disease (ALD), which ranges from alcoholic steatohepatitis to fibrosis and hepatocellular carcinoma. Alcoholic liver disease has become the leading cause of liver-related health problem in the world. Herewith, effective therapeutic strategy for alcoholic liver disease is necessary. Yangonin (Yan), a bioactive compound extract from Kava, has been reported to exert hepatoprotective effects via Farnesoid X receptor (FXR) activation. The present study aims to investigate whether Yan ameliorated the ethanol-stimulated li...
Source: European Journal of Pharmacology - October 15, 2020 Category: Drugs & Pharmacology Authors: Dong R, Wang X, Wang L, Wang C, Huang K, Fu T, Liu K, Wu J, Sun H, Meng Q Tags: Eur J Pharmacol Source Type: research
Benign Prostatic Hyperplasia: A Brief Overview of Pathogenesis, Diagnosis, and Current State of Therapy
As prostatic artery embolization (PAE) is assuming an increasingly important role in the management of benign prostatic hyperplasia (BPH), it is important for the practicing interventional radiologist to have a deep understanding of all aspects of the disease process and the available treatment options. This paper provides a comprehensive overview of the pathophysiology, diagnosis and management options for BPH with an emphasis on the surgical and medical treatments. (Source: Techniques in Vascular and Interventional Radiology)
Source: Techniques in Vascular and Interventional Radiology - October 4, 2020 Category: Radiology Authors: John Manov, Prasoon P. Mohan, Bruce Kava, Shivank Bhatia Source Type: research
Kava decreases the stereotyped behavior induced by amphetamine in mice
Publication date: Available online 22 August 2020Source: Journal of EthnopharmacologyAuthor(s): Bárbara Nunes Krum, Catiuscia Molz de Freitas, Ana Paula Chiapinotto Ceretta, Caroline Pilecco Barbosa, Elizete de Moraes Reis, Rahisa Scussel, Emily da Silva Córneo, Ricardo Andrez Machado-de-Ávila, Aline Augusti Boligon, Roselei Fachinetto (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 24, 2020 Category: Drugs & Pharmacology Source Type: research
The integrated use of in silico methods for the hepatotoxicity potential of Piper methysticum.
Abstract
Herbal products as supplements and therapeutic intervention have been used for centuries. However, their toxicities are not completely evaluated and the mechanisms are not clearly understood. Dried rhizome of the plant kava (Piper methysticum) is used for its anxiolytic, and sedative effects. The drug is also known for its hepatotoxicity potential. Major constituents of the plant were identified as kavalactones, alkaloids and chalcones in previous studies. Kava hepatotoxicity mechanism and the constituent that causes the toxicity have been debated for decades. In this paper, we illustrated the use...
Source: Food and Chemical Toxicology - August 18, 2020 Category: Food Science Authors: Tugcu G, Kırmızıbekmez H, Aydın A Tags: Food Chem Toxicol Source Type: research
The Workplace Support for Health Scale: Reliability and Validity of a Brief Scale to Measure Employee Perceptions of Wellness.
CONCLUSION: The WSH scale is a reliable and valid measure of perceived workplace support for health. Employers can use the scale to identify gaps in support and create a plan for improvement.
PMID: 32808553 [PubMed - as supplied by publisher] (Source: American Journal of Health Promotion : AJHP)
Source: American Journal of Health Promotion : AJHP - August 17, 2020 Category: International Medicine & Public Health Authors: Kava CM, Passey D, Harris JR, Chan KCG, Hannon PA Tags: Am J Health Promot Source Type: research
Understanding The Complex Relationship Between Androgens and SARS-CoV2
In the United States (US), 54% of hospitalizations for COVID-19 are among men.1 In Italy, men represent 70% of COVID-19-related deaths.2 Additionally, there is a relative lack of pre-pubertal infection.3 The reason for these higher rates of infection and mortality in men, and the correspondingly low rates in pre-pubertal children remains unknown. It is possible that an androgen-dependent process may help account for these epidemiological findings, which is a topic of intense focus currently.4 –6 (Source: Urology)
Source: Urology - July 7, 2020 Category: Urology & Nephrology Authors: Jesse Ory, Thiago Fernandes Nigres Lima, Maxwell Towe, Fabio Stefano Frech, Jordan C Best, Bruce R Kava, Ranjith Ramasamy Tags: Commentary Source Type: research
Therapeutic Interventions for Adjustment Disorder: A Systematic Review
Conclusions:
Psychotherapy seems indicated for mildly symptomatic adjustment disorder. Given the fact that adjustment disorder with severe symptoms is associated with a high risk of suicidal ideation and suicide attempts, clinicians must consider the potential benefit of using psychotropic agents such as benzodiazepines, antidepressants, or etifoxine. (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - July 1, 2020 Category: Drugs & Pharmacology Tags: Systematic Review and Clinical Guidelines Source Type: research
Protective effect of kava constituents in an in vitro model of oral mucositis
ConclusionThis was the first study to identify the anti-oxidative effects and safety of FKA and kavain with regard to oral keratinocytes, highlighting their potential use in the development of a preventative treatment for oral mucositis. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - May 28, 2020 Category: Cancer & Oncology Source Type: research
Molecules, Vol. 25, Pages 2004: Synthetic Kavalactone Analogues with Increased Potency and Selective Anthelmintic Activity against Larvae of Haemonchus contortus In Vitro
bs
Robin B. Gasser
Kava extract, an aqueous rhizome emulsion of the plant Piper methysticum, has been used for centuries by Pacific Islanders as a ceremonial beverage, and has been sold as an anxiolytic agent for some decades. Kavalactones are a major constituent of kava extract. In a previous investigation, we had identified three kavalactones that inhibit larval development of Haemonchus contortus in an in vitro-bioassay. In the present study, we synthesized two kavalactones, desmethoxyyangonin and yangonin, as well as 17 analogues thereof, and evaluated their anthelmintic activities using the same bioassay as empl...
Source: Molecules - April 23, 2020 Category: Chemistry Authors: H.M.P. Dilrukshi Herath Aya C. Taki Nghi Nguyen Jos é Garcia-Bustos Andreas Hofmann Tao Wang Guangxu Ma Bill C.H. Chang Abdul Jabbar Brad E. Sleebs Robin B. Gasser Tags: Article Source Type: research
The diagnostic utility of genome sequencing in a pediatric cohort with suspected mitochondrial disease
Genetics in Medicine, Published online: 21 April 2020; doi:10.1038/s41436-020-0793-6The diagnostic utility of genome sequencing in a pediatric cohort with suspected mitochondrial disease (Source: Genetics in Medicine)
Source: Genetics in Medicine - April 20, 2020 Category: Genetics & Stem Cells Authors: Lisa G. Riley Mark J. Cowley Velimir Gayevskiy Andre E. Minoche Clare Puttick David R. Thorburn Rocio Rius Alison G. Compton Minal J. Menezes Kaustuv Bhattacharya David Coman Carolyn Ellaway Ian E. Alexander Louisa Adams Maina Kava Jacqui Robinson Carolyn Source Type: research
Behavioral and physiological effects of acute and chronic kava exposure in adult zebrafish
Publication date: Available online 30 March 2020Source: Neurotoxicology and TeratologyAuthor(s): Dongmei Wang, LongEn Yang, Jingtao Wang, Guojun Hu, ZiYuan Liu, Dongni Yan, Nazar Serikuly, Erik Alpyshov, Konstantin A. Demin, David Galstyan, Tatiana Strekalova, Murilo S. de Abreu, Tamara G. Amstislavskaya, Allan V. Kalueff (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - April 1, 2020 Category: Toxicology Source Type: research
Acute rheumatic fever in children: Experience at the hospital Hassan II of Fez, Morocco
Publication date: Available online 25 March 2020Source: Clinical Epidemiology and Global HealthAuthor(s): Himri Sara, Oumokhtar Bouchra, Filankembo kava Angéla, El Fakir Samira, Nzoyikorera Nehemie, Atmani Samir (Source: Clinical Epidemiology and Global Health)
Source: Clinical Epidemiology and Global Health - March 26, 2020 Category: Epidemiology Source Type: research
Association between chronic airflow obstruction and socio-economic position in Morocco: BOLD results
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - March 5, 2020 Category: Respiratory Medicine Authors: Atassi, M. Kava, A. C. F. Nejjari, C. Benjelloun, M. C. El Biaze, M. El Kinany, K. Patel, J. Burney, P. El Rhazi, K. Tags: ORIGINAL ARTICLES Source Type: research
