Protective effect of kavain in meristematic cells of Allium cepa L
An Acad Bras Cienc. 2022 Jun 13;94(2):e20200520. doi: 10.1590/0001-3765202220200520. eCollection 2022.ABSTRACTKavain is one of the main kavalactones of Piper methysticum (Piperaceae) with anxiolytic, analgesic, and antioxidant activities. Therefore, the aim of the study was to evaluate the cytotoxic, mutagenic, and antimutagenic potential of kavain in Allium cepa cells. Roots of A. cepa were transferred to the negative (2% acetone) and positive (10 µg/mL of Methylmethanesulfonate, MMS) controls and to the concentrations of kavain (32, 64 and 128 µg/mL) for 48 h. A total of 5,000 meristematic cells were analyzed under an ...
Source: An Acad Bras Cienc - June 15, 2022 Category: Science Authors: Erasmo P DO Vale Junior Marcos Vitor R Ferreira Bianca Cristina S Fernandes Thais T DA Silva Francielle Alline Martins Pedro Marcos DE Almeida Source Type: research
Protective effect of kavain in meristematic cells of Allium cepa L
An Acad Bras Cienc. 2022 Jun 13;94(2):e20200520. doi: 10.1590/0001-3765202220200520. eCollection 2022.ABSTRACTKavain is one of the main kavalactones of Piper methysticum (Piperaceae) with anxiolytic, analgesic, and antioxidant activities. Therefore, the aim of the study was to evaluate the cytotoxic, mutagenic, and antimutagenic potential of kavain in Allium cepa cells. Roots of A. cepa were transferred to the negative (2% acetone) and positive (10 µg/mL of Methylmethanesulfonate, MMS) controls and to the concentrations of kavain (32, 64 and 128 µg/mL) for 48 h. A total of 5,000 meristematic cells were analyzed under an ...
Source: An Acad Bras Cienc - June 15, 2022 Category: Science Authors: Erasmo P DO Vale Junior Marcos Vitor R Ferreira Bianca Cristina S Fernandes Thais T DA Silva Francielle Alline Martins Pedro Marcos DE Almeida Source Type: research
Protective effect of kavain in meristematic cells of Allium cepa L
An Acad Bras Cienc. 2022 Jun 13;94(2):e20200520. doi: 10.1590/0001-3765202220200520. eCollection 2022.ABSTRACTKavain is one of the main kavalactones of Piper methysticum (Piperaceae) with anxiolytic, analgesic, and antioxidant activities. Therefore, the aim of the study was to evaluate the cytotoxic, mutagenic, and antimutagenic potential of kavain in Allium cepa cells. Roots of A. cepa were transferred to the negative (2% acetone) and positive (10 µg/mL of Methylmethanesulfonate, MMS) controls and to the concentrations of kavain (32, 64 and 128 µg/mL) for 48 h. A total of 5,000 meristematic cells were analyzed under an ...
Source: An Acad Bras Cienc - June 15, 2022 Category: Science Authors: Erasmo P DO Vale Junior Marcos Vitor R Ferreira Bianca Cristina S Fernandes Thais T DA Silva Francielle Alline Martins Pedro Marcos DE Almeida Source Type: research
Protective effect of kavain in meristematic cells of Allium cepa L
An Acad Bras Cienc. 2022 Jun 13;94(2):e20200520. doi: 10.1590/0001-3765202220200520. eCollection 2022.ABSTRACTKavain is one of the main kavalactones of Piper methysticum (Piperaceae) with anxiolytic, analgesic, and antioxidant activities. Therefore, the aim of the study was to evaluate the cytotoxic, mutagenic, and antimutagenic potential of kavain in Allium cepa cells. Roots of A. cepa were transferred to the negative (2% acetone) and positive (10 µg/mL of Methylmethanesulfonate, MMS) controls and to the concentrations of kavain (32, 64 and 128 µg/mL) for 48 h. A total of 5,000 meristematic cells were analyzed under an ...
Source: An Acad Bras Cienc - June 15, 2022 Category: Science Authors: Erasmo P DO Vale Junior Marcos Vitor R Ferreira Bianca Cristina S Fernandes Thais T DA Silva Francielle Alline Martins Pedro Marcos DE Almeida Source Type: research
Cardiac crises: Cardiac arrhythmias and cardiomyopathy during TANGO2 deficiency related metabolic crises
TANGO2 deficiency disorder (TDD) is an autosomal recessive disease associated with metabolic crisis, lethal cardiac arrhythmias, and cardiomyopathy. Data regarding treatment, management, and outcomes of cardiac manifestations of TDD are lacking. (Source: Heart Rhythm)
Source: Heart Rhythm - May 11, 2022 Category: Cardiology Authors: Christina Y. Miyake, Erica J. Lay, Cheyenne M. Beach, Scott R. Ceresnak, Caridad M. Delauz, Taylor S. Howard, Christopher M. Janson, Kate Jardine, Prince J. Kannankeril, Maina Kava, Jeffrey J. Kim, Leonardo Liberman, Scott L. Macicek, Tam Dam Pham, Terry Source Type: research
Cardiac Crises: Cardiac Arrhythmias and Cardiomyopathy during TANGO2-deficiency related Metabolic Crises
TANGO2 deficiency disorder (TDD) is an autosomal recessive disease associated with metabolic crisis, lethal cardiac arrhythmias, and cardiomyopathy1-7. Data regarding treatment, management, and outcomes of cardiac manifestations of TDD are lacking. (Source: Heart Rhythm)
Source: Heart Rhythm - May 11, 2022 Category: Cardiology Authors: Christina Y. Miyake, Erica J. Lay, Cheyenne M. Beach, Scott R. Ceresnak, Caridad M. Delauz, Taylor S. Howard, Christopher M. Janson, Kate Jardine, Prince J. Kannankeril, Maina Kava, Jeffrey J. Kim, Leonardo Liberman, Scott L. Macicek, Tam Dam Pham, Terry Source Type: research
Patient Identification of Lung Cancer Screening Follow-Up Recommendations and the Association with Adherence
Annals of the American Thoracic Society,Volume 19, Issue 5, Page 799-806, May 2022. (Source: Annals of the American Thoracic Society)
Source: Annals of the American Thoracic Society - April 29, 2022 Category: Respiratory Medicine Authors: Matthew Triplette David S. Wenger Shahida Shahrir Erin K. Kross Christine Kava Amanda Phipps Stephen E. Hawes Allison Cole Madison Snidarich Kristina Crothers Source Type: research
Exploring the self-reported motivations of kratom ( < em > Mitragyna speciosa < /em > Korth.) use: a cross-sectional investigation
CONCLUSIONS: Kratom was primarily used as a harm-reduction agent for SUDs and self-treatment of chronic conditions. Healthcare professionals need better information about kratom, its potential adverse effects, and clinically significant drug interactions.PMID:35389321 | DOI:10.1080/00952990.2022.2041026 (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - April 7, 2022 Category: Addiction Authors: Oliver Grundmann Charles A Veltri Diana Morcos David Knightes Kirsten E Smith Darshan Singh Ornella Corazza Eduardo Cinosi Giovanni Martinotti Zach Walsh Marc T Swogger Source Type: research
Exploring the self-reported motivations of kratom ( < em > Mitragyna speciosa < /em > Korth.) use: a cross-sectional investigation
CONCLUSIONS: Kratom was primarily used as a harm-reduction agent for SUDs and self-treatment of chronic conditions. Healthcare professionals need better information about kratom, its potential adverse effects, and clinically significant drug interactions.PMID:35389321 | DOI:10.1080/00952990.2022.2041026 (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - April 7, 2022 Category: Addiction Authors: Oliver Grundmann Charles A Veltri Diana Morcos David Knightes Kirsten E Smith Darshan Singh Ornella Corazza Eduardo Cinosi Giovanni Martinotti Zach Walsh Marc T Swogger Source Type: research
Exploring the self-reported motivations of kratom ( < em > Mitragyna speciosa < /em > Korth.) use: a cross-sectional investigation
CONCLUSIONS: Kratom was primarily used as a harm-reduction agent for SUDs and self-treatment of chronic conditions. Healthcare professionals need better information about kratom, its potential adverse effects, and clinically significant drug interactions.PMID:35389321 | DOI:10.1080/00952990.2022.2041026 (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - April 7, 2022 Category: Addiction Authors: Oliver Grundmann Charles A Veltri Diana Morcos David Knightes Kirsten E Smith Darshan Singh Ornella Corazza Eduardo Cinosi Giovanni Martinotti Zach Walsh Marc T Swogger Source Type: research
Exploring the self-reported motivations of kratom ( < em > Mitragyna speciosa < /em > Korth.) use: a cross-sectional investigation
CONCLUSIONS: Kratom was primarily used as a harm-reduction agent for SUDs and self-treatment of chronic conditions. Healthcare professionals need better information about kratom, its potential adverse effects, and clinically significant drug interactions.PMID:35389321 | DOI:10.1080/00952990.2022.2041026 (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - April 7, 2022 Category: Addiction Authors: Oliver Grundmann Charles A Veltri Diana Morcos David Knightes Kirsten E Smith Darshan Singh Ornella Corazza Eduardo Cinosi Giovanni Martinotti Zach Walsh Marc T Swogger Source Type: research
Chemoprevention of Urothelial Cell Carcinoma Tumorigenesis by Dietary Flavokawain A in UPII-Mutant Ha-ras Transgenic Mice
Pharmaceutics. 2022 Feb 24;14(3):496. doi: 10.3390/pharmaceutics14030496.ABSTRACTNon-muscle-invasive bladder cancer (NMIBC) has one of the highest recurrence rates among all solid cancers and the highest lifetime treatment cost per patient. Therefore, the development of chemoprevention strategies for reducing the occurrence and recurrence of NMIBC as well as its burdens on the healthcare system is valuable. Our aim was to determine whether flavokawain A (FKA), a kava chalcone isolated from the kava plant, can target the in vivo activated Ha-ras pathway for prevention and treatment of NMIBC. UPII-mutant Ha-ras transgenic mi...
Source: Cancer Control - March 26, 2022 Category: Cancer & Oncology Authors: Zhongbo Liu Liankun Song Jun Xie Anne R Simoneau Edward Uchio Xiaolin Zi Source Type: research
Exploration of plant transcriptomes reveals five putative novel poleroviruses and an enamovirus
AbstractTranscriptome datasets available in public domain serve as valuable resource for identification and characterization of novel viral genomes. Poleroviruses are economically important plant-infecting RNA viruses belonging to the familySolemoviridae. In the present study, we explored the plant transcriptomes available in public domain and identified five putative novel poleroviruses tentatively named as Foeniculum vulgare polerovirus (FvPV), Kalanchoe marnieriana polerovirus (KmPV), Paspalum notatum polerovirus (PnPV), Piper methysticum polerovirus (PmPV), Trachyspermum ammi polerovirus (TaPV) and a novel enamovirus n...
Source: Virus Genes - March 26, 2022 Category: Genetics & Stem Cells Source Type: research
Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce
CONCLUSIONS: Based on the current data and clinician input, a range of nutraceuticals and phytoceuticals were given either a supportive recommendation or a provisional recommendation across a range of various psychiatric disorders. However several had only a weak endorsement for potential use; for a few it was not possible to reach a clear recommendation direction, largely due to mixed study findings; while some other agents showed no obvious therapeutic benefit and were clearly not recommended for use. It is the intention of these guidelines to inform psychiatric/medical, and health professional practice globally.PMID:353...
Source: The World Journal of Biological Psychiatry - March 21, 2022 Category: Psychiatry Authors: Jerome Sarris Arun Ravindran Lakshmi N Yatham Wolfgang Marx Julia J Rucklidge Roger S McIntyre Shahin Akhondzadeh Francesco Benedetti Constanza Caneo Holger Cramer Lachlan Cribb Michael de Manincor Olivia Dean Andrea Camaz Deslandes Marlene P Freeman Bang Source Type: research
Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce
CONCLUSIONS: Based on the current data and clinician input, a range of nutraceuticals and phytoceuticals were given either a supportive recommendation or a provisional recommendation across a range of various psychiatric disorders. However several had only a weak endorsement for potential use; for a few it was not possible to reach a clear recommendation direction, largely due to mixed study findings; while some other agents showed no obvious therapeutic benefit and were clearly not recommended for use. It is the intention of these guidelines to inform psychiatric/medical, and health professional practice globally.PMID:353...
Source: The World Journal of Biological Psychiatry - March 21, 2022 Category: Psychiatry Authors: Jerome Sarris Arun Ravindran Lakshmi N Yatham Wolfgang Marx Julia J Rucklidge Roger S McIntyre Shahin Akhondzadeh Francesco Benedetti Constanza Caneo Holger Cramer Lachlan Cribb Michael de Manincor Olivia Dean Andrea Camaz Deslandes Marlene P Freeman Bang Source Type: research
