Correction.
Authors: PMID: 32697128 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - July 22, 2020 Category: Psychiatry Tags: World J Biol Psychiatry Source Type: research

High mean platelet volume values may have no association with high lethality suicide attempts.
PMID: 32684092 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - July 20, 2020 Category: Psychiatry Authors: Beyan C, Beyan E Tags: World J Biol Psychiatry Source Type: research

Characterising phospholipids and free fatty acids in patients with schizophrenia: A case-control study.
CONCLUSIONS: Our findings suggest that complex lipid profile abnormalities are associated with SCZ. This study may contribute to investigating the role of phospholipid and FFA alterations in the pathoetiology of SCZ. PMID: 32677491 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - July 17, 2020 Category: Psychiatry Authors: Wang D, Sun X, Maziade M, Mao W, Zhang C, Wang J, Cao B Tags: World J Biol Psychiatry Source Type: research

Depressive symptoms are not associated with long-term integrated testosterone concentrations in hair.
Conclusions: Findings from this study add to the literature by showing no association between long-term integrated testosterone in hair and depressive symptomatology in men and women. PMID: 32657193 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - July 13, 2020 Category: Psychiatry Authors: Walther A, Wehrli S, Kische H, Penz M, Wekenborg M, Gao W, Rothe N, Beesdo-Baum K, Kirschbaum C Tags: World J Biol Psychiatry Source Type: research

Left Handedness And Response To Repetitive Transcranial Magnetic Stimulation In Major Depressive Disorder.
CONCLUSIONS: Standard forms of rTMS treatment appear to be effective in patients with MDD who are left-handed and there seems no justification for modifying the laterality of treatment application in these patients. PMID: 32657212 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - July 13, 2020 Category: Psychiatry Authors: Fitzgerald PB, Hoy KE, Daskalakis ZJ Tags: World J Biol Psychiatry Source Type: research

The Association between Prolactin Concentration and Aggression in Female Patients with Schizophrenia.
This study assessed the association between serum prolactin (PRL) concentration and aggression in female patients with schizophrenia.Methods: Female patients with schizophrenia (N = 120) were diagnosed using SCID-5 based on the DSM-5 criteria. They were sampled at the University Psychiatric Hospital Vrapce during the period from March 2017 to March 2019. Aggression was evaluated using the Positive and Negative Syndrome Scale (PANSS), and Overt Aggression Scale (OAS). Patients were subdivided into aggressive and non-aggressive groups. PRL was determined in serum using electrochemiluminescence (ECLIA) method.Re...
Source: The World Journal of Biological Psychiatry - July 13, 2020 Category: Psychiatry Authors: Puljic K, Herceg M, Tudor L, Pivac N Tags: World J Biol Psychiatry Source Type: research

Cellular and extracellular white matter alterations indicate conversion to psychosis among individuals at clinical high-risk for psychosis.
Mulert C Abstract OBJECTIVES: It is important to find biomarkers associated with transition to illness in individuals at clinical high-risk for psychosis (CHR). Here, we use free-water imaging, an advanced diffusion MRI technique, to identify white matter alterations in the brains of CHR subjects who subsequently develop psychosis (CHR-P) compared to those who do not (CHR-NP). METHODS: Twenty-four healthy controls (HC) and 30 CHR individuals, 8 of whom converted to schizophrenia after a mean follow-up of 15.16 months, received baseline MRI scans. Maps of fractional anisotropy (FA), FA of cellular tissu...
Source: The World Journal of Biological Psychiatry - July 9, 2020 Category: Psychiatry Authors: Nägele FL, Pasternak O, Bitzan LV, Mußmann M, Rauh J, Kubicki M, Leicht G, Shenton ME, Lyall AE, Mulert C Tags: World J Biol Psychiatry Source Type: research

Modulation of the prefrontal blood oxygenation response to intermittent theta-burst stimulation in depression: A sham-controlled study with functional near-infrared spectroscopy.
e;n R Abstract OBJECTIVE: To better understand the neural mechanisms behind the effect of intermittent theta-burst stimulation (iTBS), we investigated how the prefrontal blood oxygenation response measured by changes in oxygenated haemoglobin (oxy-Hb) was modulated during a sham-controlled iTBS treatment course, and whether this was related to depressive symptom change. METHODS: In this randomised, double-blind study, patients with ongoing treatment-resistant depression received either active (n = 18) or sham (n = 21) iTBS over the dorsomedial prefrontal cortex for ten to fifteen d...
Source: The World Journal of Biological Psychiatry - July 8, 2020 Category: Psychiatry Authors: Struckmann W, Persson J, Weigl W, Gingnell M, Bodén R Tags: World J Biol Psychiatry Source Type: research

MEG reveals preference specific increases of sexual-image-evoked responses in paedophilic sexual offenders and healthy controls.
Conclusions: This study uncovers the first MEG differences in automatic change detection between P + CSO and HC during the presentation of subliminal sexual images of adults and children, contributing towards a better understanding of the neurobiological processes of P + CSO. PMID: 32623929 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - July 6, 2020 Category: Psychiatry Authors: Krylova M, Ristow I, Marr V, Borchardt V, Li M, Witzel J, Drumkova K, Harris JA, Zacharias N, Schiltz K, Amelung T, Beier KM, Kruger TH, Ponseti J, Schiffer B, Walter H, Kärgel C, Walter M Tags: World J Biol Psychiatry Source Type: research

Novel treatment targets for COVID-19: Contribution from molecular psychiatry.
PMID: 32619139 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - July 3, 2020 Category: Psychiatry Authors: Schmidt U, Rein T Tags: World J Biol Psychiatry Source Type: research

An overview of the human brain myelin proteome and differences associated with schizophrenia.
CONCLUSIONS: Together these findings suggest disruptive effects on synaptic activity and therefore neural transmission and connectivity, consistent with the dysconnectivity hypothesis of schizophrenia. Further studies on these proteins may lead to the identification of potential drug targets related to the synaptic dysconnectivity in schizophrenia and other psychiatric and neurodegenerative disorders. Main PointsWe have carried out the characterization of the human brain myelinome.Many of the proteins were altered in schizophrenia, with synaptic and energy metabolism roles.These proteins might represent potential drug targ...
Source: The World Journal of Biological Psychiatry - June 30, 2020 Category: Psychiatry Authors: Martins-de-Souza D, Guest PC, Reis-de-Oliveira G, Schmitt A, Falkai P, Turck CW Tags: World J Biol Psychiatry Source Type: research

Correction.
Authors: PMID: 32588702 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - June 26, 2020 Category: Psychiatry Tags: World J Biol Psychiatry Source Type: research

Altered dynamic parahippocampus functional connectivity in patients with posttraumatic stress disorder.
Conclusions: Trauma exposure may lead to an altered dynamic FC in individuals with or without PTSD. An altered DC in the parahippocampal gyrus may be an important risk factor for PTSD development following trauma exposure. A more prominently increased DC in the parahippocampal gyrus might be a common trait in the PTSD group. PMID: 32567973 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - June 22, 2020 Category: Psychiatry Authors: Chen HJ, Qi R, Ke J, Qiu J, Xu Q, Zhang Z, Zhong Y, Lu GM, Chen F Tags: World J Biol Psychiatry Source Type: research

Circulating IGFBP-2 levels reveal atherogenic metabolic risk in schizophrenic patients using atypical antipsychotics.
Conclusions: IGFBP-2 may have a role in altering metabolic risk in schizophrenic patients using SGAs. Longitudinal studies are required to evaluate whether IGFBP-2 can predict the development of a hyperTG waist phenotype in this population. PMID: 32552257 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - June 17, 2020 Category: Psychiatry Authors: Nolin MA, Demers MF, Rauzier C, Bouchard RH, Cadrin C, Després JP, Roy MA, Alméras N, Picard F Tags: World J Biol Psychiatry Source Type: research

Association of treatment facets, severity of manic symptoms, psychomotor disturbances and psychotic features with response to electroconvulsive therapy in bipolar depression.
Abstract Objectives: Clinically useful predictors of response to electroconvulsive therapy (ECT) are warranted, especially in the case of bipolar depression. The aim of this study was to explore the associations between response and its known and putative correlates.Methods: Six hundred seventy bipolar depressive patients treated with ECT were included in the study. The association between response (CGI-I ≤ 2) and mean seizure duration, number of treatments, age, sex, bipolar subtype, episode duration, HAM-D and YMRS scores, psychomotor disturbances and psychotic symptoms assessed through BPRS-EV ...
Source: The World Journal of Biological Psychiatry - June 3, 2020 Category: Psychiatry Authors: Brancati GE, Tripodi B, Novi M, Barbuti M, Medda P, Perugi G Tags: World J Biol Psychiatry Source Type: research

Resting-state network dysconnectivity in ADHD: A system-neuroscience-based meta-analysis.
CONCLUSIONS: Our data are consistent with the hypothesis that pediatric ADHD is a DMN-dysconnectivity disorder with reduced connectivity both within the core DMN sub-system and between that system and a broad set of nodes in systems involved in cognition and motivation. PMID: 32468880 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - May 29, 2020 Category: Psychiatry Authors: Sutcubasi B, Metin B, Kurban MK, Metin ZE, Beser B, Sonuga-Barke E Tags: World J Biol Psychiatry Source Type: research

Inflammatory and metabolic markers in patients with mood disorders.
CONCLUSIONS: No metabolic nor inflammatory alterations emerged in BD patients, even if when obese. A possible explanation might be due to their geographical origin, with culinary traditions based on the Mediterranean diet. Therefore, it would be interesting to ascertain whether such a diet might improve the metabolic impairment often associated with mood disorders. Again, the routine assessment of different clinical/chemistry parameters might be helpful to improve the diagnostic stratification and the personalized treatment. PMID: 32468900 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - May 29, 2020 Category: Psychiatry Authors: Mucci F, Marazziti D, Della Vecchia A, Baroni S, Massimetti G, Morana P, Mangiapane P, Morana F, Carpita B, Morana B, Dell'Osso L Tags: World J Biol Psychiatry Source Type: research

Seasonality of plasma tryptophan and kynurenine in pregnant mothers with a history of seasonal affective disorder: Vulnerability or adaptation?
Conclusions: Pregnant women with a history of full or sub-syndromal SAD exhibited a different pattern of plasma tryptophan and kynurenine across the seasons compared to control mothers, independent of current mood state. Follow-up of the children will determine the implications of these findings for neurodevelopment and psychiatric risk. Maternal seasonality and SoC may be important considerations when studying tryptophan and its metabolites in human pregnancy and foetal brain development. PMID: 32462949 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - May 28, 2020 Category: Psychiatry Authors: Levitan RD, Sqapi M, Atkinson L, Murphy K, Levitt A, Bocking A, Post M, Knight JA, Matthews SG Tags: World J Biol Psychiatry Source Type: research

Potential bioelectrical impedance analysis (BIA) parameters in prediction muscle strength in women with anorexia nervosa.
Conclusions: PA 50kHz is the best BIA parameter to predict MS in AN patients. It could be useful for assessment before physical activity treatment application. PMID: 32462960 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - May 28, 2020 Category: Psychiatry Authors: Popiołek-Kalisz J, Teter M, Kozak G, Powrózek T, Mlak R, Sobieszek G, Karakuła-Juchnowicz H, Małecka-Massalska T Tags: World J Biol Psychiatry Source Type: research

The World Federation of Societies of Biological Psychiatry (WFSBP) 2020 guidelines for the pharmacological treatment of paraphilic disorders.
Conclusions: An algorithm is proposed with different levels of treatment for different categories of paraphilic disorders accompanied by different risk levels. PMID: 32452729 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - May 26, 2020 Category: Psychiatry Authors: Thibaut F, Cosyns P, Fedoroff JP, Briken P, Goethals K, Bradford JMW, WFSBP Task Force on Paraphilias Tags: World J Biol Psychiatry Source Type: research

Associations between depressive symptom profiles and immunometabolic characteristics in individuals with depression and their siblings.
Conclusions: The results suggest that there is a familial component for each trait, but no common familial factors for the association between DSPs and IMCs. Alternative mechanisms, such as direct causal effects or non-shared environmental risk factors, may better fit these results. PMID: 32425087 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - May 19, 2020 Category: Psychiatry Authors: de Kluiver H, Milaneschi Y, Jansen R, van Sprang ED, Giltay EJ, Hartman CA, Penninx BWJH Tags: World J Biol Psychiatry Source Type: research

Sensorimotor and sensory gating in depression, anxiety, and their comorbidity.
Conclusions. The obtained results might be useful for development of integrative neural models of comorbidity of anxiety and depression, and elaboration of diagnostic and therapeutic approaches. PMID: 32420779 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - May 18, 2020 Category: Psychiatry Authors: Storozheva ZI, Akhapkin RV, Bolotina OV, Korendrukhina A, Novototsky-Vlasov VY, Sherbakova IV, Kirenskaya AV Tags: World J Biol Psychiatry Source Type: research

Genes involved in glucocorticoid receptor signaling affect susceptibility to mood disorders.
CONCLUSIONS: Our results indicate the involvement of genes associated with GR function, SRSF5, BAG1, and FKBP4 with susceptibility to mood disorders. PMID: 32400287 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - May 13, 2020 Category: Psychiatry Authors: Szczepankiewicz D, Narożna B, Celichowski P, Sakrajda K, Kołodziejski P, Banach E, Zakowicz P, Pruszyńska-Oszmałek E, Pawlak J, Wiłkość M, Dmitrzak-Węglarz M, Skibińska M, Bejger A, Twarowska-Hauser J, Rybakowski JK, Nogowski L, Szczepankiewicz A Tags: World J Biol Psychiatry Source Type: research

Novel plasma metabolite markers of attention-deficit/hyperactivity disorder identified using high-performance chemical isotope labeling-based liquid chromatography-mass spectrometry.
Conclusions: This study is the first to use the CIL-based LC-MS to profile ADHD plasma metabolites, and we identified nine novel metabolite biomarkers of ADHD. PMID: 32351159 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - April 30, 2020 Category: Psychiatry Authors: Wang LJ, Chou WJ, Tsai CS, Lee MJ, Lee SY, Hsu CW, Hsueh PC, Wu CC Tags: World J Biol Psychiatry Source Type: research

High-lethality of suicide attempts associated with platelet to lymphocyte ratio and mean platelet volume in psychiatric inpatient setting.
Conclusions: Our findings provide a potential and useful peripheral biological marker able to help clinicians in understanding the complex phenomenon of suicide. However, further studies are needed to confirm the present findings. PMID: 32338121 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - April 27, 2020 Category: Psychiatry Authors: Aguglia A, Amerio A, Asaro P, Caprino M, Conigliaro C, Giacomini G, Parisi VM, Trabucco A, Amore M, Serafini G Tags: World J Biol Psychiatry Source Type: research

Ventricular volume, white matter alterations and outcome of major depression and their relationship to endocrine parameters - a pilot study.
We examined the potentially predictive value of Magnetic Resonance Imaging (MRI) parameters related to mineralocorticoid receptor (MR) function on the treatment outcome of depression. 16 inpatients with a major depressive episode (MDE) were studied at baseline and 14 of them approximately six weeks later. Physiological biomarkers and 3-T-structural MRI based volume measures, using FreeSurfer 6.0 software, were determined.Results: Non-responders (
Source: The World Journal of Biological Psychiatry - April 20, 2020 Category: Psychiatry Authors: Murck H, Luerweg B, Hahn J, Braunisch M, Jezova D, Zavorotnyy M, Konrad C, Jansen A, Kircher T Tags: World J Biol Psychiatry Source Type: research

Diminished levels of the chemokine fractalkine in postmortem prefrontal cortex in schizophrenia but not bipolar disorder.
Conclusions: The observed deficit in fractalkine protein levels in SCZ is consistent with impaired neuron-microglia crosstalk in this disorder. Furthermore, our data is suggestive of an aberrant association between microglial function and synaptic density in SCZ. PMID: 32295454 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - April 16, 2020 Category: Psychiatry Authors: Hill SL, Shao L, Beasley CL Tags: World J Biol Psychiatry Source Type: research

Treatment-resistant depression: neurobiological correlates and the effect of sleep deprivation with sleep phase advance for the augmentation of pharmacotherapy.
Conclusions: TRD can improve after augmentation of pharmacotherapy by TSD + SPA and some biological changes may be compatible with a decrease in allostatic load. PMID: 32295463 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - April 16, 2020 Category: Psychiatry Authors: Kurczewska E, Ferensztajn-Rochowiak E, Rybakowski F, Michalak M, Rybakowski J Tags: World J Biol Psychiatry Source Type: research

Effects of psychoactive drugs on cellular bioenergetic pathways.
Conclusions: Overall our data suggest that some drugs used to treat neuropsychiatric and affective disorders have actions on a range of cellular bioenergetic processes, which could impact their effects in patients. PMID: 32295468 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - April 16, 2020 Category: Psychiatry Authors: Bortolasci CC, Spolding B, Kidnapillai S, Richardson MF, Vasilijevic N, Martin SD, Gray L, McGee SL, Berk M, Walder K Tags: World J Biol Psychiatry Source Type: research

Investigation of the Effects of Cannabidiol on Vacuous Chewing Movements, Locomotion, Oxidative Stress and Blood Glucose in Rats Treated with Oral Haloperidol.
CONCLUSIONS: We confirmed that CBD can ameliorate motor impairments produced by haloperidol. Our data suggest that CBD can be combined with haloperidol to prevent the emergent of extrapyramidal side effects and long-term movement disorders, such as acute dystonic disorder and tardive dyskinesia. PMID: 32264772 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - April 8, 2020 Category: Psychiatry Authors: Kajero JA, Seedat S, Ohaeri J, Akindele A, Aina O Tags: World J Biol Psychiatry Source Type: research

The hypothalamic-pituitary-adrenal axis in the perinatal period: Its relationship with major depressive disorder and early life adversity.
Abstract Objectives: Effects of major depressive disorder and early life adversity (ELA) on the maternal HPA axis in the perinatal period were examined.Methods: Four groups of women (n = 127) were recruited, with the perinatal groups being compared during pregnancy (Preg) and at two months postpartum (PP) - [1] Depressed during pregnancy (Depressed-Preg/PP), [2] Prior history of depression but euthymic during pregnancy (History-Preg/PP), [3] Healthy pregnant women (Control-Preg/PP), and [4] Healthy non-pregnant women (Non-pregnant Control). Serial saliva samples were collected over the course of a da...
Source: The World Journal of Biological Psychiatry - March 27, 2020 Category: Psychiatry Authors: Jairaj C, O'Leary N, Doolin K, Farrell C, McCarthy A, McAuliffe FM, O'Grady-Walshe A, Sheehan J, O'Keane V Tags: World J Biol Psychiatry Source Type: research

Differential methylation of imprinting genes and MHC locus in 22q11.2 deletion syndrome-related schizophrenia spectrum disorders.
Abstract Objectives-22q11.2 deletion syndrome (DS) is the strongest known genetic risk for schizophrenia. Methylome screening was conducted to elucidate possible involvement of epigenetic alterations in the emergence of schizophrenia spectrum disorders (SZ-SD) in 22q11.2DS.Methods-Sixteen adult men with/without SZ-SD were recruited from a 22q11.2DS cohort and underwent genome-wide DNA methylation profile analysis. Differentially methylated probes (DMPs) and regions (DMRs) were analyzed using the ChAMP software.Results-The DMPs (p-value
Source: The World Journal of Biological Psychiatry - March 26, 2020 Category: Psychiatry Authors: Carmel M, Michaelovsky E, Weinberger R, Frisch A, Mekori-Domachevsky E, Gothelf D, Weizman A Tags: World J Biol Psychiatry Source Type: research

Therapeutic drug monitoring and pharmacogenetics of antipsychotics and antidepressants in real life settings: a 5-year single center experience.
Conclusions: These data suggest that physicians are becoming more confident with the laboratory pharmacologic tools to optimize treatments and/or that the pharmacological treatment of patients with psychiatric disorders is becoming more challenging. TDM and PGx might significantly contribute to the rational selection of the best drug and best dose in individual cases. PMID: 32212950 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - March 26, 2020 Category: Psychiatry Authors: Baldelli S, Cheli S, Montrasio C, Cattaneo D, Clementi E Tags: World J Biol Psychiatry Source Type: research

Executive functioning and emotion recognition in youth with Oppositional Defiant Disorder and/or Conduct Disorder.
Conclusions: Our findings challenge the view that neuropsychological impairments in youth with ODD/CD are driven by comorbid ADHD and suggest possible distinct neurocognitive mechanisms in CD versus ODD. PMID: 32212964 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - March 26, 2020 Category: Psychiatry Authors: Kleine Deters R, Naaijen J, Rosa M, Aggensteiner PM, Banaschewski T, Saam MC, Schulze UM, Sethi A, Craig MC, Sagar-Ouriaghli I, Santosh P, Castro-Fornieles J, Penzol MJ, Arango C, Werhahn JE, Brandeis D, Franke B, Glennon J, Buitelaar JK, Hoekstra PJ, Die Tags: World J Biol Psychiatry Source Type: research

Hippocampal functional network: The mediating role between obsession and anxiety in adult patients with obsessive-compulsive disorder.
Conclusions: The FC between the hippocampus and MTG plays a key role in the relationship between anxiety and obsession. PMID: 32174208 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - March 16, 2020 Category: Psychiatry Authors: Li K, Zhang H, Wang B, Yang Y, Zhang M, Li W, Li X, Lv L, Zhao J, Zhang H Tags: World J Biol Psychiatry Source Type: research

Association analysis of potentially functional variants within 8p12 with schizophrenia in the Han Chinese population.
Abstract Objectives: Chromosome 8p12 was first identified as a schizophrenia (SCZ) risk locus in Chinese populations and replicated in European populations. However, the underlying functional variants still need to be further explored.Aims: To identify plausible causal variants associated with increased SCZ risk within the 8p12 locus.Methods: A total of 386 potentially functional variants from 29 genes within the 8p12 locus were analysed in 2,403 SCZ cases and 2,594 control subjects in the Han Chinese population using Affymetrix customized genotyping assays. SHEsisplus was used for association analysis. A multiple...
Source: The World Journal of Biological Psychiatry - March 4, 2020 Category: Psychiatry Authors: Chen R, Chen J, Gao C, Wu C, Pan D, Zhang J, Zhou J, Wang K, Zhang Q, Yang Q, Jian X, Zhao Y, Wen Y, Wang Z, Shi Y, Li Z Tags: World J Biol Psychiatry Source Type: research

Association between Plasma Dipeptidyl Peptidase-4 Activity to Brain-derived Neurotrophic Factor Ratio and Depressive Symptoms in Middle-Aged and Older Adults with Normal Glucose Tolerance: A Cross-Sectional Study.
Abstract Objectives: Attenuation of brain-derived neurotrophic factor (BDNF) availability as well as increased dipeptidyl peptidase-4 (DPP4) activity have both been reported to link to the pathogenesis of depression. The aim of this study was to test the correlation between depressive symptoms and plasma DPP4 activity to BDNF ratio (DBR).Methods: We evaluated DPP4 activity, BDNF, oxidative stress parameters, inflammatory markers and calculated DBR in a cross-sectional sample of 1640 nondiabetic participants.Results: DPP4 activity was negatively related to BDNF in participants with and without depressive symptoms (...
Source: The World Journal of Biological Psychiatry - February 21, 2020 Category: Psychiatry Authors: Zheng T, Chen X, Ge B, Chen B, Qin L, Tian L, Gao Y, Hu X, Xiao L, Pan H, Chen Y Tags: World J Biol Psychiatry Source Type: research

Evolution of BDNF serum levels during the first six months after alcohol withdrawal.
Abstract OBJECTIVES: Brain Derived Neurotrophic Factor (BDNF) has been associated to alcohol dependence and appear to vary after withdrawal, although the link with the withdrawal outcome on the long term is unknown.We aimed to assess the evolution of BDNF levels during the six months following withdrawal, and determine the association with the status of alcohol consumption. METHODS: Serum BDNF levels of alcohol-dependent patients (n = 248) and biological and clinical parameters were determined at the time of alcohol cessation (D0), 14 days (D14), 28 days (D28), and 2, 4, and 6 months after (M2, ...
Source: The World Journal of Biological Psychiatry - February 21, 2020 Category: Psychiatry Authors: Girard M, Labrunie A, Malauzat D, Nubukpo P Tags: World J Biol Psychiatry Source Type: research

SMAD4 protein is decreased in the dorsolateral prefrontal and anterior cingulate cortices in schizophrenia.
CONCLUSIONS: Our finding of lower SMAD4 protein in the cortex suggests there are likely to be abnormalities in cortical TGFB-superfamily signalling in schizophrenia. PMID: 32081064 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - February 21, 2020 Category: Psychiatry Authors: Gibbons AS, Hoyer D, Dean B Tags: World J Biol Psychiatry Source Type: research

Repetitive transcranial magnetic stimulation (rTMS) for schizophrenia patients treated with clozapine.
Conclusions: rTMS as a treatment for persistent symptoms in clozapine-treated patients did not show a beneficial effect of active compared to sham treatment. For auditory hallucinations, the size of the NNTs indicate a possible beneficial effect of rTMS. PMID: 32081071 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - February 21, 2020 Category: Psychiatry Authors: Wagner E, Honer WG, Sommer IE, Koops S, Blumberger DM, Daskalakis ZJ, Dlabac-De Lange JJ, Bais L, Knegtering H, Aleman A, Novak T, Klirova M, Slotema C, Brunelin J, Poulet E, Kujovic M, Cordes J, Wobrock T, Siskind D, Falkai P, Schneider-Axmann T, Hasan A Tags: World J Biol Psychiatry Source Type: research

Frontal GABA in schizophrenia: a meta-analysis of 1H-MRS studies.
Conclusion: The available 1H-MRS studies suggest hypo-GABA ergia specifically in ACC and hint towards possible hypo GABA-ergic state in the FC. However, limitations of the analysis should be considered while interpreting the results. PMID: 32067569 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - February 18, 2020 Category: Psychiatry Authors: Kumar V, Vajawat B, Rao NP Tags: World J Biol Psychiatry Source Type: research

In schizophrenia, psychomotor retardation is associated with executive and memory impairments, negative and psychotic symptoms, neurotoxic immune products and lower natural IgM to malondialdehyde.
Conclusions: PMR is a key psychopathological feature of schizophrenia mainly MNP. In addition, PMR may be driven by deficits in the compensatory immune-regulatory system and increased production of neurotoxic immune products, namely TRYCATs, IgM to NO-cysteinyl, and CCL-11, an endogenous cognition deteriorating chemokine. PMID: 32031479 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - February 7, 2020 Category: Psychiatry Authors: Maes M, Sirivichayakul S, Kanchanatawan B, Carvalho AF Tags: World J Biol Psychiatry Source Type: research

Management of mild cognitive impairment (MCI): The need for national and international guidelines.
Conclusions: MCI is recognised as an important treatment target and some recent national guidelines have considered symptomatic treatment recommendations for MCI. However, more needs to be done, especially at an international level. PMID: 32019392 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - February 5, 2020 Category: Psychiatry Authors: Kasper S, Bancher C, Eckert A, Förstl H, Frölich L, Hort J, Korczyn AD, Kressig RW, Levin O, Palomo MSM Tags: World J Biol Psychiatry Source Type: research

Excitatory transmission from ventral pallidum to lateral habenula mediate depression.
Conclusions: Data from our study demonstrated an involvement of the glutamatergic VP-LHb circuit in the stress-induced depression-related behaviors. PMID: 32009492 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - February 3, 2020 Category: Psychiatry Authors: Liu B, Cao Y, Wang J, Dong J Tags: World J Biol Psychiatry Source Type: research

Affective temperaments (TEMPS-A) in panic disorder and healthy probands - genetic modulation by 5-HTT variation.
e K Abstract Objectives: Temperamental traits as ascertained by the Temperament Evaluation of Memphis, Pisa, Paris and San Diego Auto-Questionnaire (TEMPS-A) have been suggested as promising intermediate phenotypes of mental disorders. In anxiety disorders, however, TEMPS scales and their genetic underpinnings are still understudied.Methods: TEMPS-A scores in 109 patients with panic disorder (PD) were compared to a sample of 536 healthy probands. All participants were genotyped for serotonin transporter gene variation (5-HTTLPR/rs25531).Results: PD patients displayed significantly increased scores on the dysthymic...
Source: The World Journal of Biological Psychiatry - December 18, 2019 Category: Psychiatry Authors: Schiele MA, Herzog K, Kollert L, Böhnlein J, Repple J, Rosenkranz K, Leehr EJ, Ziegler C, Lueken U, Dannlowski U, Pauli P, Arolt V, Zwanzger P, Deckert J, Erfurth A, Domschke K Tags: World J Biol Psychiatry Source Type: research

Serum neurofilament light chain (NFL) remains unchanged during electroconvulsive therapy.
Conclusions: Our study confirms the safety of ECT by using a most sensitive method for the detection of NFL in peripheral blood as a biomarker of neuronal damage. PMID: 31818180 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - December 10, 2019 Category: Psychiatry Authors: Besse M, Belz M, Folsche T, Vogelgsang J, Methfessel I, Steinacker P, Otto M, Wiltfang J, Zilles D Tags: World J Biol Psychiatry Source Type: research

Evidence for an enhanced procoagulant state in remitted major depression.
Conclusions: Remitted MDD is associated with an enhanced procoagulant state. Hypercoagulablity seems more a trait than a state characteristic of depression. PMID: 31755344 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - November 22, 2019 Category: Psychiatry Authors: von Känel R, Merz F, Pfister H, Brückl T, Zimmermann P, Uhr M, Holsboer F, Höhne N, Ising M Tags: World J Biol Psychiatry Source Type: research

The impact of sample processing on inflammatory markers in serum: Lessons learned.
Conclusions: Delays in processing influence cytokine concentrations in blood samples. Given the increasing use of biobanks in research, this study highlights the need to carefully evaluate sample collection and handling methods when designing biomarker studies. PMID: 31749403 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - November 21, 2019 Category: Psychiatry Authors: Pan AY, Ryu E, Geske JR, Zhou XY, McElroy SL, Cicek MS, Frye MA, Biernacka JM, Andreazza AC Tags: World J Biol Psychiatry Source Type: research

Ketamine-induced changes in plasma brain-derived neurotrophic factor (BDNF) levels are associated with the resting-state functional connectivity of the prefrontal cortex.
Conclusions: Our findings indicate BDNF level dynamics following ketamine are related to acute and 24 h RSFC changes. Particularly when BDNF increases are observed after ketamine infusion, a disconnection from dmPFC after 24 h is seen and may reflect synaptic plasticity effects. PMID: 31680600 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - November 4, 2019 Category: Psychiatry Authors: Woelfer M, Li M, Colic L, Liebe T, Di X, Biswal B, Murrough J, Lessmann V, Brigadski T, Walter M Tags: World J Biol Psychiatry Source Type: research

A Prospective Open-Label Trial of Long-Acting Liquid Methylphenidate for the Treatment of Attention Deficit/Hyperactivity Disorder in Intellectually Capable Adults with Autism Spectrum Disorder.
Abstract Objectives: This treatment trial is aimed at assessing the short-term tolerability and efficacy of liquid-formulation extended-release methylphenidate (MPH-ER) for the treatment of ADHD in adults with high-functioning autism spectrum disorder (HF-ASD). Methods: Six-week open-label trial (ClinicalTrials.gov: NCT02096952) was conducted in 15 HF-ASD adults (mean age: 24.9 ± 4.6; male: 12 [80%]) suffering from moderate-severe ADHD. MPH-ER was administered based on a flexible titration schedule. Efficacy was assessed on clinician- and self-rated measures. Tolerability was assessed by docum...
Source: The World Journal of Biological Psychiatry - October 14, 2019 Category: Psychiatry Authors: Joshi G, DiSalvo M, Wozniak J, Ceranoglu TA, Yule A, Surman C, Fried R, Galdo M, Hoskova B, Belser A, Biederman J Tags: World J Biol Psychiatry Source Type: research