Circulating versus Lipopolysaccharide-Induced Inflammatory Markers as Correlates of Subthreshold Depressive Symptoms in Older Adults.
Conclusion: LPS-induced cytokines may be more sensitive correlates of subthreshold depressive symptoms than circulating cytokines, particularly in older adults with higher systemic inflammation. Clinical Trials Registry: ClinicalTrials.gov NCT00280020. PMID: 31552779 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - September 25, 2019 Category: Psychiatry Authors: Lee SM, Te S, Breen EC, Olmstead R, Irwin MR, Cho JH Tags: World J Biol Psychiatry Source Type: research

Positive association between cerebral grey matter metabolism and dopamine D2/D3 receptor availability in healthy and schizophrenia subjects: an 18F-fluorodeoxyglucose and 18F-fallypride positron emission tomography study.
Conclusions: Dopaminergic system may be involved in modulation of grey matter metabolism and neurometabolic coupling in both healthy human brain and psychopathology. Hyperdopaminergic state in untreated schizophrenia may at least partly account for the corresponding decreases in grey matter metabolism. PMID: 31552783 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - September 25, 2019 Category: Psychiatry Authors: Mitelman SA, Buchsbaum MS, Christian BT, Merrill BM, Buchsbaum BR, Mukherjee J, Lehrer DS Tags: World J Biol Psychiatry Source Type: research

Higher fasting ghrelin serum levels in active smokers than in former and never-smokers.
Conclusions: This study provides evidence that total ghrelin serum levels are positively associated with active smoking. No association was found for former smokers. A unique feature of the study is the large sample size. PMID: 31552785 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - September 25, 2019 Category: Psychiatry Authors: Wittekind DA, Kratzsch J, Mergl R, Enzenbach C, Witte V, Villringer A, Kluge M Tags: World J Biol Psychiatry Source Type: research

Drugs Used in the Treatment of Bipolar Disorder and their Effects on Cholesterol Biosynthesis- A Possible Therapeutic Mechanism.
Conclusions: These data suggest that BD drug combination is increasing cholesterol biosynthesis and the newly synthesised cholesterol is being utilised within the cells, possibly for synthesis of new membranes to facilitate neurite outgrowth. This mechanism possibly underpins clinical efficacy in individuals with BD treated with polypharmacy. PMID: 31535581 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - September 19, 2019 Category: Psychiatry Authors: Kidnapillai S, Bortolasci CC, Panizzutti B, Spolding B, Connor T, Bonifacio K, Sanigorski A, Dean OM, Crowley T, Jamain S, Gray L, Leboyer M, Berk M, Walder K Tags: World J Biol Psychiatry Source Type: research

Dimensions of pain catastrophizing and specific structural and functional alterations in patients with chronic pain: evidence in medication-overuse headache.
Conclusion: PC dimensions are associated with a specific structural and functional neuroanatomical pattern, which is different from the pattern observed when PC is considered as a single score. The involvement of basal ganglia and cerebellum needs further investigation. PMID: 31535584 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - September 19, 2019 Category: Psychiatry Authors: Christidi F, Karavasilis E, Michels L, Riederer F, Velonakis G, Anagnostou E, Ferentinos P, Kollias S, Efstathopoulos E, Kelekis N, Kararizou E Tags: World J Biol Psychiatry Source Type: research

SIRT1 mediates improvement of cardiac surgery induced postoperative cognitive dysfunction via TLR4/NF- κB pathway.
Conclusion: SIRT1 mediates the improvement of cardiac surgery induced postoperative cognitive dysfunction via TLR4/NF-κB pathway. PMID: 31418620 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - August 16, 2019 Category: Psychiatry Authors: Shi J, Zou X, Jiang K, Wang F Tags: World J Biol Psychiatry Source Type: research

Extrapyramidal reactions following treatment with antidepressants: Results of the AMSP multinational drug surveillance program.
CONCLUSIONS: Our results highlight the possibility of EPS as an important, although uncommon, adverse effect of antidepressants. Clinicians should be aware of this adverse effect and monitor early warning signs carefully. PMID: 31347932 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - July 26, 2019 Category: Psychiatry Authors: Mörkl S, Seltenreich D, Letmaier M, Bengesser S, Wurm W, Grohmann R, Bleich S, Toto S, Stübner S, Butler MI, Kasper S Tags: World J Biol Psychiatry Source Type: research

Circulating Leptin, Cortisol and Gender Differences Associated with Anorexia or Obesity in Depression.
Conclusion: Obesity is a risk factor for depression. The shift from typical to atypical depression is due to an inhibitory effect of higher circulating leptin on HPA axis activity and subsequent decrease in the lipolytic effects of cortisol. PMID: 31347937 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - July 26, 2019 Category: Psychiatry Authors: Haleem DJ, Gul S Tags: World J Biol Psychiatry Source Type: research

Results of the European Group for the Study of Resistant Depression (GSRD) - basis for further research and clinical practice.
Conclusions: The GSRD findings offer a unique and balanced perspective on TRD representing foundation for further research elaborating on specific clinical and genetic hypotheses and treatment strategies within appropriate study-designs, especially interaction-based models and randomized controlled trials. PMID: 31340696 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - July 25, 2019 Category: Psychiatry Authors: Bartova L, Dold M, Kautzky A, Fabbri C, Spies M, Serretti A, Souery D, Mendlewicz J, Zohar J, Montgomery S, Schosser A, Kasper S Tags: World J Biol Psychiatry Source Type: research

Hypothalamic-pituitary-adrenal axis function and exposure to stress factors and cannabis use in recent-onset psychosis.
Conclusions: Our study provides evidence for the effect of cannabis exposure in cortisol secretion patterns in both healthy controls and recent-onset psychosis patients. PMID: 31244371 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - June 27, 2019 Category: Psychiatry Authors: Labad J, Ortega L, Cabezas Á, Montalvo I, Arranz S, Algora MJ, Solé M, Martorell L, Vilella E, Sánchez-Gistau V Tags: World J Biol Psychiatry Source Type: research

Increased risk of prostatitis in male patients with depression.
Conclusions: Depression can be an independent factor associated with the increased risk of prostatitis for men. The incidence of chronic prostatitis is greater than that of acute prostatitis. Close surveillance for UTI and depression treatment and lifestyle intervention should be considered for men with high risk for prostatitis. The mechanism associated with the development of prostatitis in men with depression requires further study. In addition, the mechanism of prostatitis may need comprehensive investigation. PMID: 31198079 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - June 14, 2019 Category: Psychiatry Authors: Lien CS, Chung CJ, Lin CL, Chang CH Tags: World J Biol Psychiatry Source Type: research

Correction.
Authors: PMID: 31177903 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - June 10, 2019 Category: Psychiatry Tags: World J Biol Psychiatry Source Type: research

Visual impairments in type 1 bipolar disorder.
Abstract OBJECTIVES: The present study evaluated early visual processing, in terms of the contrast sensitivity function (CSF), in bipolar disorder (BPD) patients. METHODS: Data were recorded in 17 healthy participants and 17 outpatients with type 1 BPD, from 20 to 45 years of age. The CSF was measured at spatial frequencies of .2, .6, 3.1, 8.0, 16.0, and 20.0 cycles per degree (cpd) using Gabor patches and a two-alternative, forced-choice, logarithmic staircase method. The groups were matched for gender, age, and level of education. RESULTS: The CSF differed between groups. Patients with BPD had lower di...
Source: The World Journal of Biological Psychiatry - June 6, 2019 Category: Psychiatry Authors: Fernandes TP, Silverstein SM, Almeida NL, Santos NA Tags: World J Biol Psychiatry Source Type: research

Metabolic profiling for water-soluble metabolites in patients with schizophrenia and healthy controls in a Chinese population: A case-control study.
Conclusions: This study appears to distinguish between groups of patients and controls, which should be considered as a contribution to putative potential biomarkers. The water-soluble metabolites were determined to be significantly different between the groups in the current study, and were primarily related to cellular bioenergetics, notably oxidative stress. PMID: 31161852 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - June 4, 2019 Category: Psychiatry Authors: Cao B, Wang D, Pan Z, McIntyre RS, Brietzke E, Subramanieapillai M, Nozari Y, Wang J Tags: World J Biol Psychiatry Source Type: research

Mirtazapine decreased induction and expression of cocaine  + nicotine-induced locomotor sensitization in rats.
CONCLUSION: Our results suggest that mirtazapine demonstrated efficacy in decreasing the psycho-stimulant effects of concurrent use of cocaine and nicotine. PMID: 31104538 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - May 20, 2019 Category: Psychiatry Authors: Barbosa Méndez S, Salazar-Juárez A Tags: World J Biol Psychiatry Source Type: research

A thank-you note from the Chief-Editor.
PMID: 31099703 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - May 17, 2019 Category: Psychiatry Authors: Kasper S Tags: World J Biol Psychiatry Source Type: research

Mitochondrial DNA copy number, damage, repair and degradation in depressive disorder.
CONCLUSIONS: We are the first to show that impairment in repair and degradation of mtDNA may be involved in the pathophysiology of depression. PMID: 31081430 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - May 13, 2019 Category: Psychiatry Authors: Czarny P, Wigner P, Strycharz J, Swiderska E, Synowiec E, Szatkowska M, Sliwinska A, Talarowska M, Szemraj J, Su KP, Maes M, Sliwinski T, Galecki P Tags: World J Biol Psychiatry Source Type: research

Cytokine-mediated cellular immune activation in electroconvulsive therapy: A CSF study in patients with treatment-resistant depression.
CONCLUSIONS: Although the sample size was small, we found different effects of the ECT treatment per se and of the antidepressant action induced by ECT in CSF and blood. PMID: 31081432 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - May 13, 2019 Category: Psychiatry Authors: Mindt S, Neumaier M, Hoyer C, Sartorius A, Kranaster L Tags: World J Biol Psychiatry Source Type: research

Evidence for altered excitatory and inhibitory tone in the postmortem substantia nigra in schizophrenia.
CONCLUSIONS: Synaptic density alterations and the lack of a positive correlation between GAD67 and vGLUT1 could contribute to hyperactivity in the SN. PMID: 31062628 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - May 7, 2019 Category: Psychiatry Authors: Mabry SJ, McCollum LA, Farmer CB, Bloom ES, Roberts RC Tags: World J Biol Psychiatry Source Type: research

Lowered zinc and copper levels in drug-na ïve patients with major depression: effects of antidepressants, ketoprofen and immune activation.
CONCLUSIONS: Lower zinc is a hallmark of depression, while increments in serum zinc and attenuation of the immune-inflammatory response during treatment appear to play a role in the clinical efficacy of sertraline. PMID: 31062629 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - May 7, 2019 Category: Psychiatry Authors: Twayej AJ, Al-Hakeim HK, Al-Dujaili AH, Maes M Tags: World J Biol Psychiatry Source Type: research

Psychopharmacology and ethnicity: A comparative study on Senegalese and Italian men.
Abstract OBJECTIVES: Ethnicity represents a crucial factor in influencing response to psychotropic drugs. Some data indicate that functional polymorphisms of two candidate genes of the serotonin (5-HT) transporter (SERT) may affect the response to selective 5-HT reuptake inhibitors (SSRIs). The present study aimed to compare the platelet SERT, through the specific [3H]paroxetine ([3H]Par) binding, and plasma oxytocin (OT) levels in 20 Senegalese and in 20 Italian men. METHODS: No subjects had family or personal history of any major psychiatric disorder, or had ever regularly taken psychotropic drugs, or were ...
Source: The World Journal of Biological Psychiatry - April 23, 2019 Category: Psychiatry Authors: Marazziti D, Stahl SM, Simoncini M, Baroni S, Mucci F, Palego L, Betti L, Massimetti G, Giannaccini G, Dell'Osso L Tags: World J Biol Psychiatry Source Type: research

EEG/ERP-based biomarker/neuroalgorithms in adults with ADHD: Development, reliability, and application in clinical practice.
CONCLUSIONS: Implementation of the system in clinical practice requires facilities to track affected networks, as well as expertise in neuropathophysiology. Therefore, the use of neuroalgorithms can enhance the diagnostic process by making it less subjective and more reliable and linking it to the underlying pathology. PMID: 30990349 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - April 16, 2019 Category: Psychiatry Authors: Müller A, Vetsch S, Pershin I, Candrian G, Baschera GM, Kropotov J, Kasper J, Abdel Rehim H, Eich D Tags: World J Biol Psychiatry Source Type: research

Correction.
Authors: PMID: 30973036 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - April 11, 2019 Category: Psychiatry Tags: World J Biol Psychiatry Source Type: research

The amygdala in adolescents with attention-deficit/hyperactivity disorder: Structural and functional correlates of delay aversion.
Abstract OBJECTIVES: Recent magnetic resonance imaging (MRI) studies implicate structural alterations of amygdala, a brain region responsible for processing and experiencing negative emotions, in adolescents with attention-deficit/hyperactivity disorder (ADHD). Here we examined ADHD-related structural correlates of amygdala functional activity elicited during a functional MRI task designed to test behavioural and brain responses to the imposition of delay - an event known to both elicit amygdala hyperactivation and aversity in ADHD. METHODS: Structural MRI scans from 28 right-handed male adolescents with comb...
Source: The World Journal of Biological Psychiatry - April 4, 2019 Category: Psychiatry Authors: Van Dessel J, Sonuga-Barke E, Moerkerke M, Van der Oord S, Lemiere J, Morsink S, Danckaerts M Tags: World J Biol Psychiatry Source Type: research

On the suitability of medical analogies, from hypertension to broken leg.
PMID: 30924395 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - March 29, 2019 Category: Psychiatry Authors: Kranz GS, Kasper S Tags: World J Biol Psychiatry Source Type: research

Quantitative separation of the depressive phase of Bipolar Disorder and Major Depressive Disorder using Electrovestibulography.
CONCLUSIONS: EVestG features can reliably identify depressed and partly remitted/remitted MDD and BD patients from each other. PMID: 30912461 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - March 26, 2019 Category: Psychiatry Authors: Lithgow BJ, Moussavi Z, Fitzgerald PB Tags: World J Biol Psychiatry Source Type: research

Integrated analysis of human transcriptome data for Rett syndrome finds a network of involved genes.
CONCLUSION: Integrative analysis of omics data and prior knowledge databases is a powerful approach to identify links between mutation and phenotype especially in rare disease research where little data is available. PMID: 30907210 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - March 25, 2019 Category: Psychiatry Authors: Ehrhart F, Coort SL, Eijssen L, Cirillo E, Smeets EE, Bahram Sangani N, Evelo CT, Curfs LMG Tags: World J Biol Psychiatry Source Type: research

Guidelines for the standardized collection of blood-based biomarkers in psychiatry: Steps for laboratory validity - a consensus of the Biomarkers Task Force from the WFSBP.
BT Abstract Recently, there has been a major shift in the field of psychiatry towards the exploration of complex relationships between blood-based biomarkers and the pathophysiology of psychiatric and neuropsychiatric disorders. However, issues with study reproducibility, validity and reliability have hindered progress towards the identification of clinically relevant biomarkers for psychiatry. The achievement of laboratory validity is a crucial first step for the posterior development of clinical validity. There is evidence that the variability observed in blood-based research studies may be minimised with the i...
Source: The World Journal of Biological Psychiatry - March 25, 2019 Category: Psychiatry Authors: Andreazza AC, Laksono I, Fernandes BS, Toben C, Lewczuk P, Riederer P, Kennedy SH, Kapogiannis D, Thibaut F, Gerlach M, Gallo C, Kim YK, Grünblatt E, Yatham L, Berk M, Baune BT Tags: World J Biol Psychiatry Source Type: research

Is there a link between stress and immune biomarkers and salivary opiorphin in patients with a restrictive-type of anorexia nervosa?
This study investigated a possible correlation between opiorphin and stress/immune biomarkers, respectively cortisol, alpha-amylase (sAA), secretory IgA (sIgA) in saliva of patients with restrictive-type of AN. METHODS: A case control clinical trial was conducted in 92 AN patients (+75 healthy controls). Unstimulated salivary samples were taken during the acute stage of AN, measurements of cortisol, sAA, sIgA and opiorphin were performed with a quantitative assay (Elisa, p 
Source: The World Journal of Biological Psychiatry - March 18, 2019 Category: Psychiatry Authors: Paszynska E, Roszak M, Slopien A, Boucher Y, Dutkiewicz A, Tyszkiewicz-Nwafor M, Gawriolek M, Otulakowska-Skrzynska J, Rzatowski S, Dmitrzak-Weglarz M Tags: World J Biol Psychiatry Source Type: research

Childhood emotional neglect and oxytocin receptor variants: Association with limbic brain volumes.
CONCLUSIONS: The rs2254298 A allele may increase susceptibility to the structural brain effects of EN. PMID: 30806136 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - February 26, 2019 Category: Psychiatry Authors: Womersley JS, Hemmings SMJ, Ziegler C, Gutridge A, Ahmed-Leitao F, Rosenstein D, Domschke K, Seedat S Tags: World J Biol Psychiatry Source Type: research

Neutrophil-lymphocyte ratio, monocyte-lymphocyte ratio and platelet-lymphocyte ratio in non-affective psychosis: a meta-analysis and systematic review.
Abstract Objectives Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and monocyte/lymphocyte ratio (MLR) are inexpensive and reproducible biomarkers of inflammation. This is the first meta-analysis exploring the role of NLR, MLR, and PLR in non-affective psychosis. Methods Eight studies have been identified from the main Electronic Databases. Meta-analyses based on random-effects models have been carried out generating pooled standardized mean differences (SMDs) between non-affective psychotic patients and healthy controls (HC). Results Subjects with non-affective psychosis had a significant high...
Source: The World Journal of Biological Psychiatry - February 26, 2019 Category: Psychiatry Authors: Mazza MG, Lucchi S, Rossetti A, Clerici M Tags: World J Biol Psychiatry Source Type: research

ACE activity in blood and brain axis in an animal model for schizophrenia: effects of dopaminergic manipulation with antipsychotics and psychostimulants.
CONCLUSIONS: The validity of measuring the ACE activity in animal blood to predict the activity in CNS, as well as the lack of correlation between the activity and blood pressure, before and after the treatment with antipsychotics, were confirmed here. Correlations of the present findings with data from clinical studies also strengthen the value of this animal model for studying several aspects of SCZ. PMID: 30806143 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - February 26, 2019 Category: Psychiatry Authors: Nani JV, Yonamine CM, Musial DC, Dal Mas C, Mari JJ, Hayashi MAF Tags: World J Biol Psychiatry Source Type: research

Serum interleukin 15 in anorexia nervosa - comparison to normal weight and obese girls.
CONCLUSION: Our study demonstrated that serum IL-15 concentrations in adolescent girls with anorexia nervosa and obesity are significantly elevated in comparison to normal weight controls. However, the role of IL-15 in the pathogenesis of anorexia nervosa and obesity remains still unclear. PMID: 30806157 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - February 26, 2019 Category: Psychiatry Authors: Roczniak W, Mikołajczak A, Świętochowska E, Ostrowska Z, Ziora K, Balcerowicz S, Górska-Flak K, Milan M, Oświęcimska J Tags: World J Biol Psychiatry Source Type: research

Epigenetic alterations associated with childhood trauma and adult mental health outcomes: A systematic review.
CONCLUSION: A variety of epigenetic mediators that lie on a common pathway between CT and psychiatric disorders have been identified, although longitudinal studies and consistency in methodological approach are needed to disentangle cause and effect associations. PMID: 30806160 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - February 26, 2019 Category: Psychiatry Authors: Nöthling J, Malan-Müller S, Abrahams N, Hemmings SMJ, Seedat S Tags: World J Biol Psychiatry Source Type: research

WFSBP * and IAWMH ** Guidelines for the treatment of alcohol use disorders in pregnant women.
DISCUSSION: There is no safe level of alcohol use during pregnancy. Abstinence is recommended. Ideally, women should stop alcohol use when pregnancy is planned and, in any case, as soon as pregnancy is known. Detecting patterns of alcohol maternal drinking should be systematically conducted at first antenatal visit and throughout pregnancy. Brief interventions are recommended in the case of low or moderate risk of alcohol use. Low doses of benzodiazepines, for the shortest duration, may be used to prevent alcohol withdrawal symptoms when high and chronic alcohol intake is stopped and hospitalisation is recommended. Due to ...
Source: The World Journal of Biological Psychiatry - January 11, 2019 Category: Psychiatry Authors: Thibaut F, Chagraoui A, Buckley L, Gressier F, Labad J, Lamy S, Potenza MN, Rondon M, Rossler A, Soyka M, Yonkers K Tags: World J Biol Psychiatry Source Type: research

Pharmacogenetics of tardive dyskinesia in schizophrenia: The role of CHRM1 and CHRM2 muscarinic receptors.
CONCLUSIONS: This study did identify associations between CHRM2 variations and TD; the results of logistic regression analysis with covariates suggest that the association is, however, likely to be secondary to other concomitant factors. PMID: 30623717 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - January 9, 2019 Category: Psychiatry Authors: Boiko AS, Ivanova SA, Pozhidaev IV, Freidin MB, Osmanova DZ, Fedorenko OY, Semke AV, Bokhan NA, Wilffert B, Loonen AJM Tags: World J Biol Psychiatry Source Type: research

A positive association between a polymorphism in the HTR2B gene and cocaine-crack in a French Afro-Caribbean population.
CONCLUSION: In our population, the risk effect of HTR2B rs6736017 appeared to be specific to individuals with crack use disorders rather than being driven by impulsivity or ADHD alone. PMID: 30608182 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - January 4, 2019 Category: Psychiatry Authors: Lacoste J, Lamy S, Ramoz N, Ballon N, Jehel L, Maroteaux L, Thibaut F Tags: World J Biol Psychiatry Source Type: research

The relationship between physical activity, clinical and cognitive characteristics and BDNF mRNA levels in patients with severe mental disorders.
CONCLUSIONS: Our study suggests a positive association between self-reported physical activity, cognitive function, mood and BDNF mRNA levels in severe mental disorders. PMID: 30560709 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - December 18, 2018 Category: Psychiatry Authors: Aas M, Djurovic S, Ueland T, Mørch RH, Laskemoen JF, Reponen EJ, Cattaneo A, Steen NE, Agartz I, Melle I, Andreassen OA Tags: World J Biol Psychiatry Source Type: research

WFSBP guidelines on how to grade treatment evidence for clinical guideline development.
irs Abstract This manuscript reviews sources of data typically used in guideline development, available grading systems, their pros and cons, and the methods for evaluating risks of bias in publications, and proposes a revised method for grading evidence and recommendations for use in development of clinical treatment guidelines. The new World Federation of Societies of Biological Psychiatry (WFSBP) grading system allows guideline developers to follow a multi-step approach of defining Levels of Evidence (LoE), applying criteria for grading (define the acceptability) and the Grading of Recommendations (GoR). Furthe...
Source: The World Journal of Biological Psychiatry - December 11, 2018 Category: Psychiatry Authors: Hasan A, Bandelow B, Yatham LN, Berk M, Falkai P, Möller HJ, Kasper S, WFSBP Guideline Task Force Chairs Tags: World J Biol Psychiatry Source Type: research

Cigarette smoking and heavy coffee consumption affecting response to olanzapine: the role of genetic polymorphism.
Abstract OBJECTIVES: To evaluate the effect of cigarette smoking and heavy coffee consumption on efficacy and safety of olanzapine treatment in schizophrenia patients, in relation to genetic polymorphism. METHODS: The study involved 120 patients with schizophrenia, treated with olanzapine for 30 days. Therapy efficacy was determined using three different psychiatric scales, and safety by assessing metabolic adverse effects and extrapyramidal symptoms. Genotyping included CYP1A2*1C, CYP1A2*1F and CYP1A1/1A2 intergenic polymorphism, as well as CYP2D6*3, CYP2D6*4 and CYP2D6*6. RESULTS: Cigarette smoking and...
Source: The World Journal of Biological Psychiatry - December 4, 2018 Category: Psychiatry Authors: Djordjevic N, Radmanovic B, Cukic J, Baskic D, Djukic-Dejanovic S, Milovanovic D, Aklillu E Tags: World J Biol Psychiatry Source Type: research

Changes in cortical protein markers of iron transport with gender, major depressive disorder and suicide.
CONCLUSIONS: Our data suggests that perturbation in cortical iron transport proteins is not prevalent in mood disorders. By contrast, our data suggests changes in iron transport proteins in BA 6 and BA 10 are present after suicide completion. If these changes were present before death, they could have had a role in the genesis of the contemplation and completion of suicide. PMID: 30513246 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - December 4, 2018 Category: Psychiatry Authors: Dean B, Tsatsanis A, Lam LQ, Scarr E, Duce JA Tags: World J Biol Psychiatry Source Type: research

Autoimmune encephalitis with psychosis: Warning signs, step-by-step diagnostics and treatment.
CONCLUSIONS: Guided by clinical warning signals, our qualitative review enables rapid and reliable diagnosis of definite autoimmune encephalitis. This is of high relevance for the affected individuals, since early and sufficiently intense immunotherapy often leads to a good prognosis despite severe illness. PMID: 30513253 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - December 4, 2018 Category: Psychiatry Authors: Steiner J, Prüss H, Köhler S, Frodl T, Hasan A, Falkai P Tags: World J Biol Psychiatry Source Type: research

Weighted gene co-expression network analysis identifies specific modules and hub genes related to subsyndromal symptomatic depression.
CONCLUSIONS: This first blood gene expression study in SSD observed distinct patterns between cases and controls which may provide novel insight into understanding the molecular mechanisms of SSD. PMID: 30489189 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - November 29, 2018 Category: Psychiatry Authors: Geng R, Li Z, Yu S, Yuan C, Hong W, Wang Z, Wang Q, Yi Z, Fang Y Tags: World J Biol Psychiatry Source Type: research

Schizophrenia and the Microbiome: Time to Focus on the Impact of Antipsychotic Treatment on the Gut Microbiota.
PMID: 30394174 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - November 5, 2018 Category: Psychiatry Authors: Dinan TG, Cryan JF Tags: World J Biol Psychiatry Source Type: research

Expanding the collection of neuroimaging tools in psychiatry.
PMID: 30381986 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - November 1, 2018 Category: Psychiatry Authors: Kranz GS, Zhang JJQ Tags: World J Biol Psychiatry Source Type: research

In utero Zika virus exposure and schizophrenia.
PMID: 30311817 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - October 12, 2018 Category: Psychiatry Authors: Joob B, Wiwanitkit V Tags: World J Biol Psychiatry Source Type: research

Effects of serotonin depletion and dopamine depletion on bimodal divided attention.
CONCLUSIONS: The results indicate a possible dissociation between the effects of a diminished brain 5-HT and DA synthesis on the performance in a bimodal divided attention task. The difference was exclusively observed within the RT towards auditory signals. PMID: 30295116 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - October 8, 2018 Category: Psychiatry Authors: Königschulte W, Civai C, Hildebrand P, Gaber TJ, Fink GR, Zepf FD Tags: World J Biol Psychiatry Source Type: research

Early versus late stage schizophrenia. What markers make the difference?
te;iz Martínez P, Leza JC, Bobes J Abstract OBJECTIVES: To identify the psychopathological, cognitive, functional, physical health and inflammatory markers that differentiate between early-stage schizophrenia (ESSCH) and late-stage schizophrenia (LSSCH). METHODS: Cross-sectional, naturalistic study of 104 patients with SCH. The sample was divided in two groups: 35 ESSCH (≤7 years' duration of illness) and 69 LSSCH (>10 years' duration of illness). STATISTICAL ANALYSIS: chi-square test and Student's t-test and ANCOVA (or Quade test) controlling for age, sex, BMI and number of cigarettes/day. ...
Source: The World Journal of Biological Psychiatry - October 8, 2018 Category: Psychiatry Authors: García-Álvarez L, García-Portilla MP, Caso JR, de la Fuente-Tomás L, González-Blanco L, Sáiz Martínez P, Leza JC, Bobes J Tags: World J Biol Psychiatry Source Type: research

Adiponectin and resistin in acutely ill and weight-recovered adolescent anorexia nervosa: Association with psychiatric symptoms.
CONCLUSIONS: In the acute AN, adiponectin and resistin levels are impaired and partial weight recovery fails to normalise them thus we suggest that they can be involved in the chronicity of certain symptoms. The level of adiponectin is associated with obsessive and compulsive symptoms and resistin with depressive symptoms, which indicates their potential contribution to the regulation of emotions and behaviours in AN. PMID: 30264643 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - September 28, 2018 Category: Psychiatry Authors: Tyszkiewicz-Nwafor M, Slopien A, Dmitrzak-Węglarz M, Rybakowski F Tags: World J Biol Psychiatry Source Type: research

Benzodiazepines in anxiety disorders: Reassessment of usefulness and safety.
CONCLUSION: Results of a controlled trial as proposed will go a long way in providing clinicians missing information to guide them in the appropriate use of both BZs and ADs in anxiety disorders. PMID: 30252578 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - September 25, 2018 Category: Psychiatry Authors: Rickels K, Moeller HJ Tags: World J Biol Psychiatry Source Type: research