An Attempt to Estimate the Noises in Homeopathic Pathogenetic Trials by Employing the Jaccard Similarity Index and Noise Index
CONCLUSION: The Jaccard similarity index and the Noise index might be considered an additional approach for analyzing the symptoms of the placebo group as a comparator, resulting in better noise segregation in homeopathic pathogenetic trials.PMID:34959246 | DOI:10.1055/s-0041-1735983 (Source: Homeopathy)
Source: Homeopathy - December 27, 2021 Category: Complementary Medicine Authors: Kurian Poruthukaren Source Type: research
Resurrecting Golgi proteins to grasp Golgi ribbon formation and self-association under stress
Int J Biol Macromol. 2021 Nov 30:S0141-8130(21)02578-2. doi: 10.1016/j.ijbiomac.2021.11.173. Online ahead of print.ABSTRACTThe Golgi complex is an essential organelle of the eukaryotic exocytic pathway. A subfamily of Golgi matrix proteins, called GRASPs, is central in stress-induced unconventional secretion, Golgi dynamics during mitosis/apoptosis, and Golgi ribbon formation. The Golgi ribbon is vertebrate-specific and correlates with the appearance of two GRASP paralogues and two Golgins (GM130/Golgin45), which form specific GRASP-Golgin pairs. The molecular details of their appearance only in Metazoans are unknown. More...
Source: International Journal of Biological Macromolecules - December 3, 2021 Category: Biochemistry Authors: Luis F S Mendes Mariana R B Batista Emanuel Kava Lucas Bleicher Mariana C Micheletto Antonio J Costa-Filho Source Type: research
Resurrecting Golgi proteins to grasp Golgi ribbon formation and self-association under stress
Int J Biol Macromol. 2021 Nov 30:S0141-8130(21)02578-2. doi: 10.1016/j.ijbiomac.2021.11.173. Online ahead of print.ABSTRACTThe Golgi complex is an essential organelle of the eukaryotic exocytic pathway. A subfamily of Golgi matrix proteins, called GRASPs, is central in stress-induced unconventional secretion, Golgi dynamics during mitosis/apoptosis, and Golgi ribbon formation. The Golgi ribbon is vertebrate-specific and correlates with the appearance of two GRASP paralogues and two Golgins (GM130/Golgin45), which form specific GRASP-Golgin pairs. The molecular details of their appearance only in Metazoans are unknown. More...
Source: International Journal of Biological Macromolecules - December 3, 2021 Category: Biochemistry Authors: Luis F S Mendes Mariana R B Batista Emanuel Kava Lucas Bleicher Mariana C Micheletto Antonio J Costa-Filho Source Type: research
Resurrecting Golgi proteins to grasp Golgi ribbon formation and self-association under stress
Int J Biol Macromol. 2021 Nov 30:S0141-8130(21)02578-2. doi: 10.1016/j.ijbiomac.2021.11.173. Online ahead of print.ABSTRACTThe Golgi complex is an essential organelle of the eukaryotic exocytic pathway. A subfamily of Golgi matrix proteins, called GRASPs, is central in stress-induced unconventional secretion, Golgi dynamics during mitosis/apoptosis, and Golgi ribbon formation. The Golgi ribbon is vertebrate-specific and correlates with the appearance of two GRASP paralogues and two Golgins (GM130/Golgin45), which form specific GRASP-Golgin pairs. The molecular details of their appearance only in Metazoans are unknown. More...
Source: International Journal of Biological Macromolecules - December 3, 2021 Category: Biochemistry Authors: Luis F S Mendes Mariana R B Batista Emanuel Kava Lucas Bleicher Mariana C Micheletto Antonio J Costa-Filho Source Type: research
[ASAP] Construction of an Artificial Biosynthetic Pathway for Zingerone Production in < italic toggle="yes" > Escherichia coli < /italic > Using Benzalacetone Synthase from < italic toggle="yes" > Piper methysticum < /italic >
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.1c05534 (Source: Journal of Agricultural and Food Chemistry)
Source: Journal of Agricultural and Food Chemistry - November 23, 2021 Category: Food Science Authors: Kyung Taek Heo, Kyung Won Park, Juhee Won, Byeongsan Lee, Jae-Hyuk Jang, Jung-Oh Ahn, Bang Yeon Hwang, and Young-Soo Hong Source Type: research
Prostatic Ductal Adenocarcinoma Controlled for Tumor Grade, Stage, and Margin Status Does Not Independently Influence the Likelihood of Biochemical Recurrence in Localized Prostate Cancer After Radical Prostatectomy
CONCLUSIONS.—: Advanced locoregional stage, higher tumor grade, and positive surgical margin status rather than the mere presence of PDA are more predictive of worse BCR-free survival outcomes following radical prostatectomy in men with a component of PDA.PMID:34739539 | DOI:10.5858/arpa.2021-0048-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - November 5, 2021 Category: Laboratory Medicine Authors: Oleksandr N Kryvenko Oleksii A Iakymenko Luiz P De Lima Guido Amit S Bhattu Ali Merhe Ali Mouzannar Laurence M Briski Irfan Oymagil Isabella Lugo Ivan Nemov Chad R Ritch Bruce R Kava Sanoj Punnen Merce Jorda Dipen J Parekh Mark L Gonzalgo Source Type: research
Prostatic Ductal Adenocarcinoma Controlled for Tumor Grade, Stage, and Margin Status Does Not Independently Influence the Likelihood of Biochemical Recurrence in Localized Prostate Cancer After Radical Prostatectomy
CONCLUSIONS.—: Advanced locoregional stage, higher tumor grade, and positive surgical margin status rather than the mere presence of PDA are more predictive of worse BCR-free survival outcomes following radical prostatectomy in men with a component of PDA.PMID:34739539 | DOI:10.5858/arpa.2021-0048-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - November 5, 2021 Category: Laboratory Medicine Authors: Oleksandr N Kryvenko Oleksii A Iakymenko Luiz P De Lima Guido Amit S Bhattu Ali Merhe Ali Mouzannar Laurence M Briski Irfan Oymagil Isabella Lugo Ivan Nemov Chad R Ritch Bruce R Kava Sanoj Punnen Merce Jorda Dipen J Parekh Mark L Gonzalgo Source Type: research
Prostatic Ductal Adenocarcinoma Controlled for Tumor Grade, Stage, and Margin Status Does Not Independently Influence the Likelihood of Biochemical Recurrence in Localized Prostate Cancer After Radical Prostatectomy
CONCLUSIONS.—: Advanced locoregional stage, higher tumor grade, and positive surgical margin status rather than the mere presence of PDA are more predictive of worse BCR-free survival outcomes following radical prostatectomy in men with a component of PDA.PMID:34739539 | DOI:10.5858/arpa.2021-0048-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - November 5, 2021 Category: Laboratory Medicine Authors: Oleksandr N Kryvenko Oleksii A Iakymenko Luiz P De Lima Guido Amit S Bhattu Ali Merhe Ali Mouzannar Laurence M Briski Irfan Oymagil Isabella Lugo Ivan Nemov Chad R Ritch Bruce R Kava Sanoj Punnen Merce Jorda Dipen J Parekh Mark L Gonzalgo Source Type: research
Prostatic Ductal Adenocarcinoma Controlled for Tumor Grade, Stage, and Margin Status Does Not Independently Influence the Likelihood of Biochemical Recurrence in Localized Prostate Cancer After Radical Prostatectomy
CONCLUSIONS.—: Advanced locoregional stage, higher tumor grade, and positive surgical margin status rather than the mere presence of PDA are more predictive of worse BCR-free survival outcomes following radical prostatectomy in men with a component of PDA.PMID:34739539 | DOI:10.5858/arpa.2021-0048-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - November 5, 2021 Category: Laboratory Medicine Authors: Oleksandr N Kryvenko Oleksii A Iakymenko Luiz P De Lima Guido Amit S Bhattu Ali Merhe Ali Mouzannar Laurence M Briski Irfan Oymagil Isabella Lugo Ivan Nemov Chad R Ritch Bruce R Kava Sanoj Punnen Merce Jorda Dipen J Parekh Mark L Gonzalgo Source Type: research
Rapid Detection and Structural Characterization of Methysticin Metabolites Generated from Rat and Human Liver Microsomes and Hepatocytes by Ultra-high Performance Liquid Chromatography Coupled with High-resolution Mass Spectrometry
CONCLUSIONS: For the first time, this study provides new information on the in vitro metabolic profiles of methysticin, which facilitates an understanding of the disposition of this bioactive ingredient.PMID:34606659 | DOI:10.1002/rcm.9208 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - October 4, 2021 Category: Chemistry Authors: Adila Tuerxuntayi Abudourusuli Tusun Abulikemu Tajiguli Source Type: research
Rapid Detection and Structural Characterization of Methysticin Metabolites Generated from Rat and Human Liver Microsomes and Hepatocytes by Ultra-high Performance Liquid Chromatography Coupled with High-resolution Mass Spectrometry
CONCLUSIONS: For the first time, this study provides new information on the in vitro metabolic profiles of methysticin, which facilitates an understanding of the disposition of this bioactive ingredient.PMID:34606659 | DOI:10.1002/rcm.9208 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - October 4, 2021 Category: Chemistry Authors: Adila Tuerxuntayi Abudourusuli Tusun Abulikemu Tajiguli Source Type: research
Rapid Detection and Structural Characterization of Methysticin Metabolites Generated from Rat and Human Liver Microsomes and Hepatocytes by Ultra-high Performance Liquid Chromatography Coupled with High-resolution Mass Spectrometry
CONCLUSIONS: For the first time, this study provides new information on the in vitro metabolic profiles of methysticin, which facilitates an understanding of the disposition of this bioactive ingredient.PMID:34606659 | DOI:10.1002/rcm.9208 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - October 4, 2021 Category: Chemistry Authors: Adila Tuerxuntayi Abudourusuli Tusun Abulikemu Tajiguli Source Type: research
Myristoylation and its effects on the human Golgi Reassembly and Stacking Protein 55
Biophys Chem. 2021 Sep 24;279:106690. doi: 10.1016/j.bpc.2021.106690. Online ahead of print.ABSTRACTGRASP55 is a myristoylated protein localized in the medial/trans-Golgi faces and involved in the Golgi structure maintenance and the regulation of unconventional secretion pathways. It is believed that GRASP55 achieves its main functionalities in the Golgi organization by acting as a tethering factor. When bound to the lipid bilayer, its orientation relative to the membrane surface is restricted to determine its proper trans-oligomerization. Despite the paramount role of myristoylation in GRASP function, the impact of such p...
Source: Biophysical Chemistry - October 2, 2021 Category: Chemistry Authors: Emanuel Kava Luis F S Mendes Mariana R B Batista Antonio J Costa-Filho Source Type: research
Myristoylation and its effects on the human Golgi Reassembly and Stacking Protein 55
Biophys Chem. 2021 Sep 24;279:106690. doi: 10.1016/j.bpc.2021.106690. Online ahead of print.ABSTRACTGRASP55 is a myristoylated protein localized in the medial/trans-Golgi faces and involved in the Golgi structure maintenance and the regulation of unconventional secretion pathways. It is believed that GRASP55 achieves its main functionalities in the Golgi organization by acting as a tethering factor. When bound to the lipid bilayer, its orientation relative to the membrane surface is restricted to determine its proper trans-oligomerization. Despite the paramount role of myristoylation in GRASP function, the impact of such p...
Source: Biophysical Chemistry - October 2, 2021 Category: Chemistry Authors: Emanuel Kava Luis F S Mendes Mariana R B Batista Antonio J Costa-Filho Source Type: research
Acute oral toxicity, antinociceptive and antimicrobial activities of kava dried extracts and synthetic kavain
Nat Prod Res. 2021 Sep 7:1-6. doi: 10.1080/14786419.2021.1973459. Online ahead of print.ABSTRACTPiper methysticum G. Forst, popularly known as kava, is a traditional medicinal plant widely used for the treatment of anxiety and insomnia. The aim of this study was to investigate new therapeutic applications of this plant. Nociceptive response induced by heat (hot-plate) was used as pain model. Susceptibility of different strains to kava ethanolic dried extracts was evaluated by broth microdilution method. Acute oral toxicity was performed according to Organisation for Economic Cooperation and Development (OECD) guideline. Ad...
Source: Natural Product Research - September 7, 2021 Category: Biochemistry Authors: Juliana Veloso Ferreira Isabella Campolina Pierotte Felipe Fernandes Rodrigues Larissa Camila Ribeiro de Souza Rafael Wesley Bastos Paulo Henrique Fonseca Carmo Geovanni Dantas Cassali Carlos Alberto Tagliati Renes Resende Machado Daniel Assis Santos Gers Source Type: research
