GABA ‐modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence
Anxiety disorders are chronic and functionally disabling conditions with high psychological stress, characterised by cognitive symptoms of excessive worry and focus difficulties and physiological symptoms such as muscle tension and insomnia. Gamma‐aminobutyric acid (GABA) is an inhibitory neurotransmitter within the central nervous system and is a key target of pharmacotherapies in the treatment of anxiety. Although current pharmaceutical treatments are often efficacious, they may cause undesirable side effects including cognitive decrements and withdrawal symptoms. Plant‐based “phytomedicines” may provide novel tr...
Source: Phytotherapy Research - November 23, 2017 Category: Biochemistry Authors: Karen Savage, Joseph Firth, Con Stough, Jerome Sarris Tags: REVIEW Source Type: research
Direct and Highly Diastereoselective Synthesis of 3,4-Epoxy-2-Piperidones. Application to the Total Synthesis and Absolute Configurational Assignment of 3[small alpha],4[small alpha]-Epoxy-5[small beta]-Pipermethystine
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02700A, PaperUrbano Osorio-Nieto, Laura Y Vazquez-Amaya, Herbert Hopfl, Leticia Quintero, Fernando Sartillo-Piscil The substrate-controlled asymmetric total synthesis and absolute configurational assignment of biologically active 3 ,4-epoxy-5-pipermethystine, a minor component in the aerial parts of kava, has been achieved by featuring, as a key... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - November 21, 2017 Category: Molecular Biology Authors: Urbano Osorio-Nieto Source Type: research
Efficacy of Prostatic Artery Embolization for Catheter-Dependent Patients with Large Prostate Sizes and High Comorbidity Scores
Conclusions PAE represents a safe and effective option for management of patients with urinary retention, especially patients with large prostates who are not ideal surgical candidates. (Source: Journal of Vascular and Interventional Radiology)
Source: Journal of Vascular and Interventional Radiology - November 17, 2017 Category: Radiology Source Type: research
Efficacy of Prostatic Artery Embolization for Catheter-Dependent Patients with Large Prostate Sizes and High Comorbidity Scores
To evaluate efficacy and safety of prostate artery embolization (PAE) in urinary catheter –dependent patients with large prostate volumes and high comorbidity scores. (Source: Journal of Vascular and Interventional Radiology : JVIR)
Source: Journal of Vascular and Interventional Radiology : JVIR - November 15, 2017 Category: Radiology Authors: Shivank Bhatia, Vishal K. Sinha, Bruce R. Kava, Christopher Gomez, Sardis Harward, Sanoj Punnen, Issam Kably, Jeffrey Miller, Dipen J. Parekh Tags: Clinical Study Source Type: research
Randomized, dose ‐controlled double‐blind trial: Efficacy of an ethanolic kava (Piper methysticum rhizome) extract for the treatment of anxiety in elderly patients
Traditional&Kampo Medicine,Volume 5, Issue 1, Page 3-10, April 2018. (Source: Traditional and Kampo Medicine)
Source: Traditional and Kampo Medicine - September 26, 2017 Category: Complementary Medicine Authors: Kenny
Kuchta
,
Pietro
de Nicola
,
Mathias
Schmidt Source Type: research
Three new kavalactone dimers from Piper methysticum (kava)
. (Source: Journal of Asian Natural Products Research)
Source: Journal of Asian Natural Products Research - September 4, 2017 Category: Complementary Medicine Authors: Yao Yuan Jian-Xiang Yang Ling-Hui Nie Bai-Lin Li Xu-Bing Qin Jie-Wei Wu Sheng-Xiang Qiu Source Type: research
Reclassification Rates of Patients Eligible for Active Surveillance After the Addition of Magnetic Resonance Imaging-Ultrasound Fusion Biopsy: an Analysis of 7 Widely Used Eligibility Criteria
To evaluate the impact of adding magnetic resonance imaging-ultrasound (MRI-US) fusion biopsy cores to standard 12-core biopsy in selecting men for active surveillance (AS). (Source: Urology)
Source: Urology - August 22, 2017 Category: Urology & Nephrology Authors: Bruno Nahar, Andrew Katims, Marcelo Panizzutti Barboza, Nachiketh Soodana Prakash, Vivek Venkatramani, Bruce Kava, Ramgopal Satyanarayana, Mark L. Gonzalgo, Chad R. Ritch, Dipen J. Parekh, Sanoj Punnen Tags: Oncology Source Type: research
Reclassification Rates of Patients Eligible for Active Surveillance after the Addition of MRI-US Fusion Biopsy: an Analysis of Seven Widely Used Eligibility Criteria
To evaluate the impact of adding MRI-US fusion biopsy cores to standard 12-core biopsy in selecting men for Active Surveillance(AS). (Source: Urology)
Source: Urology - August 22, 2017 Category: Urology & Nephrology Authors: Bruno Nahar, Andrew Katims, Marcelo Panizzutti Barboza, Nachiketh Soodana Prakash, Vivek Venkatramani, Bruce Kava, Ramgopal Satyanarayana, Mark L. Gonzalgo, Chad R. Ritch, Dipen J. Parekh, Sanoj Punnen Tags: Oncology Source Type: research
Reproductive outcomes in recipients are not associated with oocyte donor body mass index up to 28 kg/m2: a cohort study of 2722 cycles
Publication date: Available online 15 August 2017 Source:Reproductive BioMedicine Online Author(s): Francisca Martínez, Alejandro Kava-Braverman, Elisabet Clúa, Ignacio Rodríguez, Sofia Gaggiotti Marre, Buenaventura Coroleu, Pedro N. Barri The effect of increasing donor body mass index (BMI) on clinical pregnancies was retrospectively analysed in a cohort of consecutive 2722 donor oocyte IVF cycles. The relationship between donor BMI and clinical pregnancies was assessed after adjusting for recipient BMI. Clinical pregnancy rates and live birth rates (LBR) were no different with increasing donor BMI (up to dono...
Source: Reproductive BioMedicine Online - August 19, 2017 Category: Reproduction Medicine Source Type: research
Reproductive outcomes in recipients are not associated with oocyte donor body mass index up to 28kg/m2: a cohort study of 2722 cycles
Publication date: Available online 15 August 2017 Source:Reproductive BioMedicine Online Author(s): Francisca Martínez, Alejandro Kava-Braverman, Elisabet Clúa, Ignacio Rodríguez, Sofia Gaggiotti Marre, Buenaventura Coroleu, Pedro N Barri The effect of increasing donor body mass index (BMI) on clinical pregnancies was retrospectively analysed in a cohort of consecutive 2722 donor oocyte IVF cycles. The relationship between donor BMI and clinical pregnancies was assessed after adjusting for recipient BMI. Clinical pregnancy rates and live birth rates (LBR) were no different with increasing donor BMI (up to donor...
Source: Reproductive BioMedicine Online - August 17, 2017 Category: Reproduction Medicine Source Type: research
The In Vitro and In Vivo Antiangiogenic Effects of Flavokawain B
Angiogenesis is implicated in the development of a variety of pathological processes, most commonly cancer. It is essential for tumor growth and metastasis, making it an important cancer therapeutic target. Naturally occurring substances have led to the discovery of anticancer agents. Flavokawain B (FKB), a chalcone isolated from the root extracts of kava‐kava plant, inhibits proliferation and causes apoptosis in vitro and in vivo of various cancer cell lines. The antimetastatic potential of FKB has also been suggested. In our study, we confirm the antiangiogenic action of FKB in vitro and, for the first time, demonstrat...
Source: Phytotherapy Research - August 1, 2017 Category: Biochemistry Authors: Mariana C. Rossette, D ébora C. Moraes, Erika K. Sacramento, Marco Aurélio Romano‐Silva, Juliana L. Carvalho, Dawidson A. Gomes, Hanna Caldas, Eitan Friedman, Luciana Bastos‐Rodrigues, Luiz De Marco Tags: Research Article Source Type: research
Kava-241 Reduced Periodontal Destruction in a Collagen Antibody Primed Porphyromonas gingivalis Model of Periodontitis.
CONCLUSION: Priming with type-II collagen antibody with oral gavage is a fast and reproducible model of periodontal destruction adequate for the evaluation of novel therapeutics. The effect of Kava-241 shows promise in the prevention and treatment of inflammation and alveolar bone loss associated with periodontitis. Further experiments are required to determine molecular pathways targeted by this therapeutic agent. This article is protected by copyright. All rights reserved.
PMID: 28746780 [PubMed - as supplied by publisher] (Source: Journal of Clinical Periodontology)
Source: Journal of Clinical Periodontology - July 26, 2017 Category: Dentistry Authors: Alshammari A, Patel J, Al-Hashemi J, Cai B, Panek J, Huck O, Amar S Tags: J Clin Periodontol Source Type: research
