Flavokawain C exhibits anti-tumor effects on in vivo HCT 116 xenograft and identification of its apoptosis-linked serum biomarkers via proteomic analysis
In this study, the in vivo anti-tumor activity of flavokawain C (FKC), a naturally occurring chalcone found in Kava (Piper methysticum Forst) was evaluated in HCT 116 cells (colon carcinoma). We also attempted to identify potential biomarkers and/or molecular targets in serum with applicability in predicting treatment outcome. The anti-tumor effects and toxicity of FKC were assessed using the xenograft nude mice model. Cisplatin was used as positive control. The anti-proliferative and apoptotic activities were then evaluated in tumor tissues treated with FKC. Furthermore, two-dimensional electrophoresis (2-DE) followed by ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 25, 2021 Category: Drugs & Pharmacology Authors: Chung-Weng Phang Sri Nurestri Abd Malek Saiful Anuar Karsani Source Type: research
Flavokawain C exhibits anti-tumor effects on in vivo HCT 116 xenograft and identification of its apoptosis-linked serum biomarkers via proteomic analysis
In this study, the in vivo anti-tumor activity of flavokawain C (FKC), a naturally occurring chalcone found in Kava (Piper methysticum Forst) was evaluated in HCT 116 cells (colon carcinoma). We also attempted to identify potential biomarkers and/or molecular targets in serum with applicability in predicting treatment outcome. The anti-tumor effects and toxicity of FKC were assessed using the xenograft nude mice model. Cisplatin was used as positive control. The anti-proliferative and apoptotic activities were then evaluated in tumor tissues treated with FKC. Furthermore, two-dimensional electrophoresis (2-DE) followed by ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 25, 2021 Category: Drugs & Pharmacology Authors: Chung-Weng Phang Sri Nurestri Abd Malek Saiful Anuar Karsani Source Type: research
Molecules, Vol. 26, Pages 1397: Psychoactive Substances of Natural Origin: Toxicological Aspects, Therapeutic Properties and Analysis in Biological Samples
Duarte
The consumption of new psychoactive substances (NPSs) has been increasing, and this problem affects several countries worldwide. There is a class of NPSs of natural origin, consisting of plants and fungi, which have a wide range of alkaloids, responsible for causing relaxing, stimulating or hallucinogenic effects. The consumption of some of these substances is prompted by religious beliefs and cultural reasons, making the legislation very variable or even ambiguous. However, the abusive consumption of these substances can present an enormous risk to the health of the individuals, since their metabolism and effec...
Source: Molecules - March 5, 2021 Category: Chemistry Authors: Joana Gon çalves Ângelo Luís Eugenia Gallardo Ana Paula Duarte Tags: Review Source Type: research
Plant-based Medicines (Phytoceuticals) in the Treatment of Psychiatric Disorders: A Meta-review of Meta-analyses of Randomized Controlled Trials: Les m édicaments à base de plantes (phytoceutiques) dans le traitement des troubles psychiatriques: une méta-revue des méta-analyses d'essais randomisés contrôlés.
CONCLUSIONS: More rigorous international studies are required to validate the efficacy of these phytoceuticals before treatment recommendations can be made. In conclusion, the breadth of data tentatively supports several phytoceuticals which may be effective for mental disorders alongside pharmaceutical, psychological therapies, and standard lifestyle recommendations.
PMID: 33596697 [PubMed - as supplied by publisher] (Source: Canadian Journal of Psychiatry)
Source: Canadian Journal of Psychiatry - February 18, 2021 Category: Psychiatry Authors: Sarris J, Marx W, Ashton MM, Ng CH, Galvao-Coelho N, Ayati Z, Zhang ZJ, Kasper S, Ravindran A, Harvey BH, Lopresti A, Mischoulon D, Amsterdam J, Yatham LN, Berk M Tags: Can J Psychiatry Source Type: research
Anti-anxiety properties of selected medicinal plants.
The objective of this review is to provide information about the healing outcomes of anxiety treatment with natural products. Valeriana officinalis, Citrus aurantium, Commelina benghalensis, Achyranthes aspera, Mimosa pudica, Achillea millefolium, Nymphaea alba, Leonurus cardiac, Camellia sinensis, Turnera aphrodisiaca, Crataegus oxyacantha and Piper methysticum showed promising effects on anxiety in animal models. In clinical studies, passion flower, kava, valerian, St John's wort, and ashwagandha showed the most positive results. More studies are needed for the exploration of the anti-anxiety of medicinal plants. In drug...
Source: Current Pharmaceutical Biotechnology - January 22, 2021 Category: Biotechnology Authors: Khan A, Akram M, Thiruvengadam M, Daniyal M, Zakki SA, Munir N, Zainab R, Heydari M, Mosavat SH, Rebezov M, Shariati MA Tags: Curr Pharm Biotechnol Source Type: research
Nutraceuticals for Sleep Disorders.
Abstract
Sleep is considered as one of the most important aspect for maintaining a healthy life. For a person to function normally at least 6-8 hours of sleep daily is necessary. Sleep not only affects our mood, but also regulates the efficiency of work done. Many complications arise due to inadequacy of sleep. The unhealthy food and lifestyle choices have made us more prone to sleep disorders. The medications which are used for the treatment of sleep disorders are mainly habit forming and have tendencies of withdrawal symptoms. This inadequacy in medication has lead to search for newer, better options. Th...
Source: Combinatorial Chemistry and High Throughput Screening - January 20, 2021 Category: Chemistry Authors: Ali R, Tariq S, Kareem O, Fayaz F, Aziz T, Dinesh M, Pottoo FH, Siddiqui N Tags: Comb Chem High Throughput Screen Source Type: research
Medicinal Plants in the Treatment of Depression: Evidence from Preclinical Studies
Planta Med DOI: 10.1055/a-1338-1011Medicinal plants and their extracts are natural remedies with enormous potential for treating various diseases, including depression and anxiety. In the case of depression, hundreds of plants have traditionally been used in folk medicine for generations. Different plant extracts and natural products have been analyzed as potential antidepressant agents with validated models to test for antidepressant-like effects in animals, although other complementary studies have also been employed. Most of these studies focus on the possible mediators implicated in these potential effects, with dopami...
Source: Planta Medica - January 12, 2021 Category: Drugs & Pharmacology Authors: Moragrega, In és R íos, José Luis Tags: Reviews Source Type: research
