Biological Activity, Hepatotoxicity, and Structure-Activity Relationship of Kavalactones and Flavokavins, the Two Main Bioactive Components in Kava ( < em > Piper methysticum < /em > )
Evid Based Complement Alternat Med. 2021 Aug 20;2021:6851798. doi: 10.1155/2021/6851798. eCollection 2021.ABSTRACTKava (Piper methysticum Forst) is a popular and favorable edible medicinal herb which was traditionally used to prepare a nonfermented beverage with relaxant beneficial for both social and recreational purposes. Numerous studies conducted on kava have confirmed the presence of kavalactones and flavokawains, two major groups of bioactive ingredients, in this miraculous natural plant. Expectedly, both kavalactone and flavokawain components exhibited potent antianxiety and anticancer activities, and their structur...
Source: Evidence-based Complementary and Alternative Medicine - September 2, 2021 Category: Complementary Medicine Authors: Yingli Wang Chao Su Bo Zhang Yang Niu Ruru Ren Xiaojun Zhao Lingling Yang Wannian Zhang Xueqin Ma Source Type: research
Herb-drug interactions in neuropsychiatric pharmacotherapy - a review of clinically relevant findings
This study reviewed the relevant literature and identified 13 commonly used herbal products - celery, echinacea, ginkgo, ginseng, hydroxycut, kava, kratom, moringa, piperine, rhodiola, St John's wort, terminalia/commiphora ayurvedic mixture and valerian - which have shown clinically relevant interactions with prescription drugs used in the management of neuropsychiatric disorders. The clinical focus is aimed to provide easily accessible information that will be of interest to clinicians, researchers, and the drug-consuming public.PMID:34370637 | DOI:10.2174/1570159X19666210809100357 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - August 9, 2021 Category: Drugs & Pharmacology Authors: Tram T Le Sarah R McGrath Pius S Fasinu Source Type: research
Herb-drug interactions in neuropsychiatric pharmacotherapy - a review of clinically relevant findings
This study reviewed the relevant literature and identified 13 commonly used herbal products - celery, echinacea, ginkgo, ginseng, hydroxycut, kava, kratom, moringa, piperine, rhodiola, St John's wort, terminalia/commiphora ayurvedic mixture and valerian - which have shown clinically relevant interactions with prescription drugs used in the management of neuropsychiatric disorders. The clinical focus is aimed to provide easily accessible information that will be of interest to clinicians, researchers, and the drug-consuming public.PMID:34370637 | DOI:10.2174/1570159X19666210809100357 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - August 9, 2021 Category: Drugs & Pharmacology Authors: Tram T Le Sarah R McGrath Pius S Fasinu Source Type: research
Herb-drug interactions in neuropsychiatric pharmacotherapy - a review of clinically relevant findings
This study reviewed the relevant literature and identified 13 commonly used herbal products - celery, echinacea, ginkgo, ginseng, hydroxycut, kava, kratom, moringa, piperine, rhodiola, St John's wort, terminalia/commiphora ayurvedic mixture and valerian - which have shown clinically relevant interactions with prescription drugs used in the management of neuropsychiatric disorders. The clinical focus is aimed to provide easily accessible information that will be of interest to clinicians, researchers, and the drug-consuming public.PMID:34370637 | DOI:10.2174/1570159X19666210809100357 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - August 9, 2021 Category: Drugs & Pharmacology Authors: Tram T Le Sarah R McGrath Pius S Fasinu Source Type: research
Herb-drug interactions in neuropsychiatric pharmacotherapy - a review of clinically relevant findings
This study reviewed the relevant literature and identified 13 commonly used herbal products - celery, echinacea, ginkgo, ginseng, hydroxycut, kava, kratom, moringa, piperine, rhodiola, St John's wort, terminalia/commiphora ayurvedic mixture and valerian - which have shown clinically relevant interactions with prescription drugs used in the management of neuropsychiatric disorders. The clinical focus is aimed to provide easily accessible information that will be of interest to clinicians, researchers, and the drug-consuming public.PMID:34370637 | DOI:10.2174/1570159X19666210809100357 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - August 9, 2021 Category: Drugs & Pharmacology Authors: Tram T Le Sarah R McGrath Pius S Fasinu Source Type: research
Herb-drug interactions in neuropsychiatric pharmacotherapy - a review of clinically relevant findings
This study reviewed the relevant literature and identified 13 commonly used herbal products - celery, echinacea, ginkgo, ginseng, hydroxycut, kava, kratom, moringa, piperine, rhodiola, St John's wort, terminalia/commiphora ayurvedic mixture and valerian - which have shown clinically relevant interactions with prescription drugs used in the management of neuropsychiatric disorders. The clinical focus is aimed to provide easily accessible information that will be of interest to clinicians, researchers, and the drug-consuming public.PMID:34370637 | DOI:10.2174/1570159X19666210809100357 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - August 9, 2021 Category: Drugs & Pharmacology Authors: Tram T Le Sarah R McGrath Pius S Fasinu Source Type: research
Herb-drug interactions in neuropsychiatric pharmacotherapy - a review of clinically relevant findings
This study reviewed the relevant literature and identified 13 commonly used herbal products - celery, echinacea, ginkgo, ginseng, hydroxycut, kava, kratom, moringa, piperine, rhodiola, St John's wort, terminalia/commiphora ayurvedic mixture and valerian - which have shown clinically relevant interactions with prescription drugs used in the management of neuropsychiatric disorders. The clinical focus is aimed to provide easily accessible information that will be of interest to clinicians, researchers, and the drug-consuming public.PMID:34370637 | DOI:10.2174/1570159X19666210809100357 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - August 9, 2021 Category: Drugs & Pharmacology Authors: Tram T Le Sarah R McGrath Pius S Fasinu Source Type: research
Herb-drug interactions in neuropsychiatric pharmacotherapy - a review of clinically relevant findings
This study reviewed the relevant literature and identified 13 commonly used herbal products - celery, echinacea, ginkgo, ginseng, hydroxycut, kava, kratom, moringa, piperine, rhodiola, St John's wort, terminalia/commiphora ayurvedic mixture and valerian - which have shown clinically relevant interactions with prescription drugs used in the management of neuropsychiatric disorders. The clinical focus is aimed to provide easily accessible information that will be of interest to clinicians, researchers, and the drug-consuming public.PMID:34370637 | DOI:10.2174/1570159X19666210809100357 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - August 9, 2021 Category: Drugs & Pharmacology Authors: Tram T Le Sarah R McGrath Pius S Fasinu Source Type: research
Medicinal Plants in the Treatment of Depression. II: Evidence from Clinical Trials
Planta Med DOI: 10.1055/a-1517-6882Depression is a syndrome characterized by deep sadness and the inhibition of psychic functions, sometimes accompanied by neurovegetative disorders, with symptoms of anxiety almost always present. The disease produces alterations in a variety of neural networks and neurotransmission systems, along with a dysfunction of the hypothalamic-pituitary-adrenal axis, which leads to concomitant alterations in the immunological response. Generally, there is a parallel increase in proinflammatory mediators as well as oxidative and nitrosative damage caused by a reduction of antioxidant defenses. In a...
Source: Planta Medica - June 22, 2021 Category: Drugs & Pharmacology Authors: Moragrega, In és R íos, José Luis Tags: Reviews Source Type: research
The DNA binding properties of 9-aminoacridine carboxamide Pt complexes
In this study, the interaction of four 9-aminoacridine carboxamide Pt complexes with purified DNA was investigated: firstly, using a fluorescent intercalator displacement (FID) assay with ethidium bromide; and secondly, with a DNA unwinding assay. The relative capacity of these compounds to perturb the fluorescence induced by DNA-bound ethidium bromide at clinically relevant drug concentrations was assessed over a 24-h period using an FID assay. All analogues were found to reduce the level of ethidium bromide-induced fluorescence in a concentration-dependent manner from the earliest time point of 10 min onwards. Cisplatin,...
Source: Bioorganic and Medicinal Chemistry - May 9, 2021 Category: Chemistry Authors: Hieronimus W Kava Wai Y Leung Anne M Galea Vincent Murray Source Type: research
Abstract No. 58 Erectile function following prostate artery embolization: a large single-center experience in 225 patients
Prostate artery embolization (PAE) is an emerging therapy for lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). This retrospective study was conducted to assess the effect of PAE on erectile dysfunction (ED) as assessed by the Sexual Health Inventory for Men (SHIM) questionnaire at 3 months following the procedure. (Source: Journal of Vascular and Interventional Radiology : JVIR)
Source: Journal of Vascular and Interventional Radiology : JVIR - April 28, 2021 Category: Radiology Authors: V. Acharya, E. Bryant, H. Jalaeian, K. Shah, B. Kava, S. Bhatia Source Type: research
Genes, Vol. 12, Pages 607: Application of Genome Sequencing from Blood to Diagnose Mitochondrial Diseases
John Christodoulou
Mitochondrial diseases can be caused by pathogenic variants in nuclear or mitochondrial DNA-encoded genes that often lead to multisystemic symptoms and can have any mode of inheritance. Using a single test, Genome Sequencing (GS) can effectively identify variants in both genomes, but it has not yet been universally used as a first-line approach to diagnosing mitochondrial diseases due to related costs and challenges in data analysis. In this article, we report three patients with mitochondrial disease molecularly diagnosed through GS performed on DNA extracted from blood to demonstrate different dia...
Source: Genes - April 20, 2021 Category: Genetics & Stem Cells Authors: Rocio Rius Alison G. Compton Naomi L. Baker AnneMarie E. Welch David Coman Maina P. Kava Andre E. Minoche Mark J. Cowley David R. Thorburn John Christodoulou Tags: Article Source Type: research
Moroccan Arabic version of the Quality of Life Inventory in Epilepsy (QOLIE-31): translation, cultural adaptation and psychometric validation
CONCLUSIONS: The global score of QOL in Moroccan patients with epilepsy is similar to that in patients in low and middle- income countries. MA-QOLIE-31 will facilitate further studies in HRQOL in Morocco and Arabic-speaking countries.PMID:33788219 | DOI:10.26719/2021.27.3.293 (Source: Eastern Mediterranean Health Journal)
Source: Eastern Mediterranean Health Journal - March 31, 2021 Category: Middle East Health Authors: Maryam Alami Merrouni Abdelkrim Janati Idrissi Abdelazizi Lamkaddem A C Filankembo Kava Samira El Fakir Zouhayr Souirti Source Type: research
