The effect of blastocyst transfer on newborn sex ratio and monozygotic twinning rate: an updated systematic review and meta-analysis
Conclusions This meta-analysis provides an update and stronger evidence to support the observation that BT is associated with a higher proportion of males and an increased risk of MZT. In clinical practice, these BT-associated neonatal outcomes should be taken into account when counselling infertility patients. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 22, 2018 Category: Reproduction Medicine Source Type: research

Time-lapse imaging algorithms rank human preimplantation embryos according to the probability of live birth
Conclusions Time-lapse imaging morphokinetic-based algorithms for blastocysts can provide objective hierarchical ranking of embryos for predicting live birth and may have greater discriminating power than conventional blastocyst morphology assessment. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 22, 2018 Category: Reproduction Medicine Source Type: research

Is 45 years-of-age the cut-off for using autologous oocytes?
Publication date: Available online 19 June 2018 Source:Reproductive BioMedicine Online Author(s): John L Yovich, Michael J Chapman, Kevin N Keane, Julian Savulescu (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 20, 2018 Category: Reproduction Medicine Source Type: research

Ovarian reserve and response to stimulation in women undergoing fertility preservation according to malignancy type
Conclusions As the type of cancer does not seem to significantly affect ovarian reserve and ovarian response to ovarian stimulation, our results do not support the relevance of integrating this parameter when establishing ovarian stimulation protocol for oocyte vitrification cycle in women with cancer. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 10, 2018 Category: Reproduction Medicine Source Type: research

The impact of music therapy on pain and stress reduction during oocyte retrieval – a randomized controlled trial
Conclusion Music is a simple, inexpensive and effective way to reduce pain score and increase satisfaction with pain control during TUGOR procedure, which may justify its routine use. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 10, 2018 Category: Reproduction Medicine Source Type: research

Cumulative live birth rates after IVF in patients with polycystic ovaries: phenotype matters
Conclusions Hyperandrogenic PCOS phenotypes confer significantly lower CLBR compared with their normoandrogenic counterparts. These findings may imply the need for adapted counselling and tailored approaches when treating PCOS patients with hyperandrogenism who require ART. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 10, 2018 Category: Reproduction Medicine Source Type: research

Gene expression changes in uterine myomas in response to ulipristal acetate treatment
Conclusion This characterization provides the first molecular distinction between myomas responsive or non-responsive to UPA treatment. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 10, 2018 Category: Reproduction Medicine Source Type: research

Light element distribution in fresh and frozen –thawed human ovarian tissues: a preliminary study
Conclusions The study demonstrates that elemental imaging techniques, particularly revealing the distribution of light elements, could be useful in establishing new cryopreservation protocols. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 10, 2018 Category: Reproduction Medicine Source Type: research

Effect of the antioxidant idebenone on maternal diabetes-induced embryo alterations during early organogenesis
Conclusion Maternal idebenone treatment ameliorates altered parameters related to the prooxidant–proinflammatory environment found in embryos from mild diabetic rats, suggesting a putative treatment to prevent diabetes-induced embryo alterations. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 10, 2018 Category: Reproduction Medicine Source Type: research

Clinical application of a protocol based on universal next-generation sequencing for the diagnosis of beta-thalassaemia and sickle cell anaemia in preimplantation embryos
Conclusions It is hoped that protocols that deliver almost universally applicable low-cost tests, without compromising diagnostic accuracy, will improve patient access to preimplantation genetic testing, especially in less affluent parts of the world. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 10, 2018 Category: Reproduction Medicine Source Type: research

Hyperhomocysteinemia in polycystic ovary syndrome: decreased betaine-homocysteine methyltransferase and cystathionine β-synthase-mediated homocysteine metabolism
Conclusions These findings indicate that decreased liver Bhmt and Cbs-mediated homocysteine metabolism might have a role in hyperhomocysteinemia in PCOS and provides further evidence for a potential role of decreased liver function in PCOS. Graphical abstract (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 10, 2018 Category: Reproduction Medicine Source Type: research

hsa-miRNA-154-5p expression in plasma of endometriosis patients is a potential diagnostic marker for the disease
Conclusions miRNA seem to be promising candidates for the non-invasive diagnosis of endometriosis. Further, other clinical parameters may help in distinguishing women suffering from endometriosis from healthy individuals. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 10, 2018 Category: Reproduction Medicine Source Type: research

Critical appraisal of the Vienna consensus: performance indicators for assisted reproductive technology laboratories
Publication date: Available online 24 May 2018 Source:Reproductive BioMedicine Online Author(s): María Luisa Lopez-Regalado, Luis Martínez-Granados, Antonio González-Utor, Nereyda Ortiz, Miriam Iglesias, Manuel Ardoy, Jose A. Castilla The Vienna consensus, based on the recommendations of an expert panel, has identified 19 performance indicators for assisted reproductive technology (ART) laboratories. Two levels of reference values are established for these performance indicators: competence and benchmark. For over 10 years, the Spanish embryology association (ASEBIR) has participated in the definition...
Source: Reproductive BioMedicine Online - June 10, 2018 Category: Reproduction Medicine Source Type: research

Older women using their own eggs? Issue framed with two oldest reported IVF pregnancies and a live birth
Conclusions Female age above 42 is widely viewed as the ultimate barrier to conception with IVF. Data reported here, although small and preliminary, demonstrate that potential outcomes are better than widely perceived, while pregnancy and live birth rates remain significantly inferior to donor egg recipient cycles. However, for selected women at very advanced ages, especially with higher egg/embryo numbers, autologous oocyte IVF offers a better option than widely acknowledged, if they are given individualized age-specific care. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 10, 2018 Category: Reproduction Medicine Source Type: research

Systematic review of the clinical efficacy of vaginal progesterone for luteal phase support in assisted reproductive technology cycles
Publication date: June 2018 Source:Reproductive BioMedicine Online, Volume 36, Issue 6 Author(s): Tim Child, Saoirse A. Leonard, Jennifer S. Evans, Amir Lass Vaginal progesterone via capsule, gel or tablet is the most common route for luteal phase support (LPS) in Europe. Although there is a wealth of data comparing products used at other stages of assisted reproductive technology cycles, there is a lack of systematically identified evidence comparing the wide range of vaginal progesterone products. This systematic review queried the MEDLINE, Embase and Cochrane Library databases on 30 June 2016 to identify head-to-head r...
Source: Reproductive BioMedicine Online - June 10, 2018 Category: Reproduction Medicine Source Type: research

Pregnancy and perinatal outcomes after transfer of binucleated or multinucleated frozen –thawed embryos: a case–control study
Publication date: June 2018 Source:Reproductive BioMedicine Online, Volume 36, Issue 6 Author(s): Jaana Seikkula, Sanna Oksjoki, Saija Hurme, Harri Mankonen, Päivi Polo-Kantola, Varpu Jokimaa Blastomere multinucleation in human embryos is a common phenomenon, but data on its effect on pregnancy outcome and the health of newborns are scarce. In this case–control study, we assessed pregnancy and perinatal outcomes from 136 binucleated and multinucleated frozen–thawed embryo transfer cycles against a control group of 136 non-binucleated and multinucleated frozen embryo transfer cycles. Clinical pregnancy and...
Source: Reproductive BioMedicine Online - June 10, 2018 Category: Reproduction Medicine Source Type: research

Defining the appropriate laboratory environment for fostering healthy embryogenesis in humans: a place for consensus
Publication date: June 2018 Source:Reproductive BioMedicine Online, Volume 36, Issue 6 Author(s): Thomas B. Pool, Bart C.J.M. Fauser (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 10, 2018 Category: Reproduction Medicine Source Type: research

Response: scoring of mosaic embryos after preimplantation genetic testing – the rollercoaster ride between fear, hope and embryo wastage
Publication date: July 2018 Source:Reproductive BioMedicine Online, Volume 37, Issue 1 Author(s): Francesca Romana Grati, Gloria Gallazzi, Lara Branca, Federico Maggi, Giuseppe Simoni, Yuval Yaron (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 10, 2018 Category: Reproduction Medicine Source Type: research

Scoring of mosaic embryos after preimplantation genetic testing: a rollercoaster ride between fear, hope and embryo wastage
Publication date: July 2018 Source:Reproductive BioMedicine Online, Volume 37, Issue 1 Author(s): Maximilian Murtinger, Barbara Wirleitner, Maximilian Schuff (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 10, 2018 Category: Reproduction Medicine Source Type: research

Blastocyst vitrification, cryostorage and warming does not affect live birth rate, infant birth weight or timing of delivery
Conclusions Vitrification and cryostorage (up to 4 years) are safe and effective practices that do not significantly affect clinical outcome after embryo transfer. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 10, 2018 Category: Reproduction Medicine Source Type: research

What is the best protocol to cryopreserve immature mouse testicular cell suspensions?
Conclusion Upon freeze–thawing or vitrification–warming, and assessment of donor-derived spermatogenesis after transplantation, Dulbecco's modified Eagle's medium supplemented with 1.5M dimethyl-sulphoxide, 10% fetal calf serum and 60 µM of Z-VAD-(OMe)-FMK in vials at a freezing rate of −1°C/min was optimal. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 10, 2018 Category: Reproduction Medicine Source Type: research

Remembering J Michael Bedford (1932 – 2018): a great thinker and scholar
Publication date: July 2018 Source:Reproductive BioMedicine Online, Volume 37, Issue 1 Author(s): Ryuzo Yanagimachi, Mina Alikani (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 10, 2018 Category: Reproduction Medicine Source Type: research

Cryostorage of human gametes and embryos: a reckoning
Publication date: July 2018 Source:Reproductive BioMedicine Online, Volume 37, Issue 1 Author(s): Mina Alikani (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - June 10, 2018 Category: Reproduction Medicine Source Type: research

Low anti-m üllerian hormone concentration is associated with increased risk of embryonic aneuploidy in women of advanced age
Conclusions These findings indicate that low AMH level was associated with increased risk of embryo aneuploidy only in women of advanced age. Maternal diminished ovarian reserve along with oocyte ageing may contribute to impaired chromosomal competence of the embryo. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - April 14, 2018 Category: Reproduction Medicine Source Type: research

Oocyte retrieval difficulties in women with ovarian endometriomas
Conclusions Oocyte retrieval in women with ovarian endometriomas is more problematic but the magnitude of these increased difficulties is modest. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - April 14, 2018 Category: Reproduction Medicine Source Type: research

Screening of miRNAs in human follicular fluid reveals an inverse relationship between microRNA-663b expression and blastocyst formation
Conclusions MIR-663B expression levels in human follicular fluid samples were significantly negatively related to viable blastocyst formation and may become an objective evaluation criterion for embryo development potential after IVF. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - April 14, 2018 Category: Reproduction Medicine Source Type: research

Clinical practice guidelines for fertility preservation in young women undergoing gonadotoxic treatment: an overview and critical appraisal of methodological quality and content
Conclusion CPG on the subject of FP care are available, but there is room for improvement in quality and content. Although written for use in daily practice, the CPG can also be used to develop quality indicators to monitor the quality of current FP care or to evaluate future improvement initiatives. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - April 14, 2018 Category: Reproduction Medicine Source Type: research

Survival of selected patients with ovarian cancer treated with fertility-sparing surgery
Conclusions This study shows that patients treated with FSS for FIGO stage I EOC do not have an impaired survival compared with patients treated with RS. Nevertheless, the conclusion must be interpreted with caution due to the limited number of patients and the retrospective nature of the study. Larger studies are needed before conclusions can be drawn. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - April 12, 2018 Category: Reproduction Medicine Source Type: research

Sperm meiotic segregation of a balanced interchromosomal reciprocal insertion resulting in recurrent spontaneous miscarriage
Conclusions This study shows the value of sperm FISH analysis in improving genetic reproductive advice for IRI carriers. Disruption of critical genes through this rearrangement and their consequent functional impairment could result in recurrent miscarriages. In this case, several genes located in the 14q11.2 region, particularly RNase 3, would be good candidates to explain the lethality of the imbalances. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - April 10, 2018 Category: Reproduction Medicine Source Type: research

Perinatal outcomes following IVF with use of donor versus partner sperm
Publication date: Available online 6 April 2018 Source:Reproductive BioMedicine Online Author(s): Mohan Shashikant Kamath, Belavendra Antonisamy, Hepsy Y. Selliah, Antonio La Marca, Sesh Kamal Sunkara It is a matter of interest whether pregnancies with the use of donor sperm are associated with a higher risk of adverse perinatal outcomes compared with partner sperm. Anonymized data were obtained from the Human Fertilization & Embryology Authority. Data from 1991 to 2011 involving a total of 95,787 singleton births (4523 with donor sperm and 91,264 with partner sperm) following fresh IVF/intracytoplasmic sperm inje...
Source: Reproductive BioMedicine Online - April 7, 2018 Category: Reproduction Medicine Source Type: research

Very low anti-m üllerian hormone concentrations are not an independent predictor of embryo quality and pregnancy rate
Conclusions Although significant differences in pregnancy rates were observed among the different AMH groups, even in the lowest AMH level group, the probability of achieving pregnancy was reasonable, especially if the patient's age is not very advanced. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - April 7, 2018 Category: Reproduction Medicine Source Type: research

Early oocyte denudation does not compromise ICSI cycle outcome: a large retrospective cohort study
In conclusion, early oocyte denudation within <2 h after retrieval does not appear to compromise ICSI cycle outcome, permitting more efficiency and flexibility in scheduling laboratory workload. As this was a retrospective observational study, further prospective studies are required to confirm the findings. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - April 5, 2018 Category: Reproduction Medicine Source Type: research

Duplication of SOX9 associated with 46,XX ovotesticular disorder of sex development
Conclusion This study is thought to be the first report regarding a duplication of SOX9 that is associated with the presence of 46,XX ovotesticular DSD, encompassing at least –581 kb upstream, the entire coding region of the gene. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - April 5, 2018 Category: Reproduction Medicine Source Type: research

Predicting live birth for poor ovarian responders: the PROsPeR concept
Conclusions This model, specific to POR receiving r-HFSH, constitutes the best compromise between precision and simplicity, and is suitable for routine practice. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - March 30, 2018 Category: Reproduction Medicine Source Type: research

Comparing 36.5 °C with 37°C for human embryo culture: a prospective randomized controlled trial
Publication date: Available online 27 March 2018 Source:Reproductive BioMedicine Online Author(s): Mohamed Fawzy, Mai Emad, Mostafa A. Gad, Mohamed Sabry, Hesham Kasem, Manar Mahmoud, Mohamed A. Bedaiwy This prospective, double-blind, randomized controlled trial was designed to evaluate the efficacy of a culture temperature of 36.5°C versus 37°C on human embryo development in vitro. A total of 412 women undergoing IVF were randomized to two groups: the oocytes and embryos of the intervention group were cultured at 36.5°C; those of the control group were cultured at 37°C. Although no significant effect of c...
Source: Reproductive BioMedicine Online - March 28, 2018 Category: Reproduction Medicine Source Type: research

Prediction of Endometriosis Fertility Index in patients with endometriosis-associated infertility after laparoscopic treatment
Publication date: Available online 27 March 2018 Source:Reproductive BioMedicine Online Author(s): Xianghui Zhang, Dong Liu, Wei Huang, Qiushi Wang, Xue Feng, Jing Tan The effect of endometriosis on fecundity is unclear. Although surgery plays a vital role in the treatment of related infertility, pregnancy outcomes after laparoscopy are poorly correlated with the currently used staging system. To address this, the Endometriosis Fertility Index (EFI) was developed. This retrospective study was designed to assess the predictive value of the EFI for patients with endometriosis-associated infertility. A total of 1325 patients...
Source: Reproductive BioMedicine Online - March 28, 2018 Category: Reproduction Medicine Source Type: research

Origins of mosaicism and criteria for the transfer of mosaic embryos
Publication date: April 2018 Source:Reproductive BioMedicine Online, Volume 36, Issue 4 Author(s): Santiago Munné (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - March 27, 2018 Category: Reproduction Medicine Source Type: research

Depression and state anxiety scores during assisted reproductive treatment are associated with outcome: a meta-analysis
Publication date: Available online 23 March 2018 Source:Reproductive BioMedicine Online Author(s): Satvinder Purewal, Sarah C.E. Chapman, Olga B.A. van den Akker This meta-analysis investigated whether state anxiety and depression scores during assisted reproductive technology (ART) treatment and changes in state anxiety and depression scores between baseline and during ART treatment are associated with treatment outcome. PubMed, PsycInfo, Embase, ScienceDirect, Web of Science and Scopus were searched and meta-analytic data analysed using random effects models to estimate standardized mean differences. Eleven studies (220...
Source: Reproductive BioMedicine Online - March 24, 2018 Category: Reproduction Medicine Source Type: research

Novel mutations in genes encoding subcortical maternal complex proteins may cause human embryonic developmental arrest
Publication date: Available online 21 March 2018 Source:Reproductive BioMedicine Online Author(s): Xueqian Wang, Di Song, Dmytro Mykytenko, Yanping Kuang, Qifeng Lv, Bin Li, Biaobang Chen, Xiaoyan Mao, Yao Xu, Valery Zukin, Pavlo Mazur, Jian Mu, Zheng Yan, Zhou Zhou, Qiaoli Li, Suying Liu, Li Jin, Lin He, Qing Sang, Zhaogui Sun, Xi Dong, Lei Wang Successful human reproduction initiates from normal gamete formation, fertilization and early embryonic development. Abnormalities in any of these steps will lead to infertility. Many infertile patients undergo several failures of IVF and intracytoplasmic sperm injection (ICSI) c...
Source: Reproductive BioMedicine Online - March 22, 2018 Category: Reproduction Medicine Source Type: research

Response: the applicable scope of dual trigger
Publication date: Available online 16 March 2018 Source:Reproductive BioMedicine Online Author(s): Jie Zhang, Yanping Kuang (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - March 17, 2018 Category: Reproduction Medicine Source Type: research

Genome-wide screening for smallest regions of overlaps in cryptorchidism
Publication date: Available online 16 March 2018 Source:Reproductive BioMedicine Online Author(s): Kristian Urh, Tanja Kunej Cryptorchidism is a urogenital abnormality associated with increased rates of testicular neoplasia and impaired spermatogenesis. The field is facing expansion of genomics data; however, it lacks protocols for biomarker prioritization. Identification of smallest regions of overlap (SRO) presents an approach for candidate gene identification but has not yet been systematically conducted in cryptorchidism. The aim of this study was to conduct a genome-wide screening for SRO (GW-SRO) associated with cry...
Source: Reproductive BioMedicine Online - March 17, 2018 Category: Reproduction Medicine Source Type: research

The applicable scope of dual trigger: which protocol shall we compare with?
Publication date: Available online 15 March 2018 Source:Reproductive BioMedicine Online Author(s): Yu Xiao (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - March 16, 2018 Category: Reproduction Medicine Source Type: research

Response: impact of androgen supplementation on the follicular endocrine milieu in women with hypoandrogenism
Publication date: Available online 15 March 2018 Source:Reproductive BioMedicine Online Author(s): M. von Wolff, P. Stute, N.A. Bersinger (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - March 16, 2018 Category: Reproduction Medicine Source Type: research

Does preimplantation genetic diagnosis improve reproductive outcome in couples with recurrent pregnancy loss owing to structural chromosomal rearrangement? a systematic review
Publication date: Available online 15 March 2018 Source:Reproductive BioMedicine Online Author(s): Mahmoud Iews, Justin Tan, Omur Taskin, Sukainah Alfaraj, Faten F. AbdelHafez, Ahmed H. Abdellah, Mohamed A. Bedaiwy Recurrent pregnancy loss (RPL) is a common, yet elusive, complication of pregnancy. Among couples at high risk of RPL, such as those carrying a structural chromosomal rearrangement, preimplantation genetic diagnosis (PGD) has been proposed as a tool to improve live birth rates and reduce the incidence of miscarriage; however, no clear consensus has been reached on its benefits in this population. This systemati...
Source: Reproductive BioMedicine Online - March 16, 2018 Category: Reproduction Medicine Source Type: research

Impact of androgen supplementation on the follicular endocrine milieu in women with hypoandrogenism
Publication date: Available online 14 March 2018 Source:Reproductive BioMedicine Online Author(s): Norbert Gleicher, Vitaly A. Kushnir, David H. Barad (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - March 15, 2018 Category: Reproduction Medicine Source Type: research

Cryostorage duration does not affect pregnancy and neonatal outcomes: a retrospective single-centre cohort study of vitrified –warmed blastocysts
Publication date: Available online 14 March 2018 Source:Reproductive BioMedicine Online Author(s): Satoshi Ueno, Kazuo Uchiyama, Tomoko Kuroda., Akiko Yabuuchi, Kenji Ezoe, Tadashi Okimura, Takashi Okuno, Tamotsu Kobayashi, Keiichi Kato A retrospective cohort study of 8736 autologous single vitrified–warmed blastocyst transfer cycles was conducted in a single centre to investigate the effect of cryostorage on clinical and neonatal outcomes. Cryostorage duration was classified into two groups: (A) 0–2 months (n = 4702); (B) 2–13 months (n = 2853) and (C) 13–97 months (n = 1181). Blastocysts were vit...
Source: Reproductive BioMedicine Online - March 15, 2018 Category: Reproduction Medicine Source Type: research

Response: artificial blastocoel collapse of human blastocysts before vitrification and its effect on re-expansion after warming
Publication date: Available online 14 March 2018 Source:Reproductive BioMedicine Online Author(s): Borut Kovačič, Marjan Taborin, Veljko Vlaisavljević (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - March 14, 2018 Category: Reproduction Medicine Source Type: research

The role of mitochondrial activity in female fertility and assisted reproductive technologies: overview and current insights
Publication date: Available online 8 March 2018 Source:Reproductive BioMedicine Online Author(s): Gustavo Nardini Cecchino, Emre Seli, Eduardo Leme Alves da Motta, Juan Antonio García Velasco Mitochondria have been implicated as key factors regulating female reproductive processes. Notable progress has been made in determining the role of mitochondria with respect to oocyte maturation, fertilization and early embryo development. In addition, mitochondrial function and dysfunction has been the subject of various studies in ovarian ageing and metabolic stress models. However, the overall mitochondrial impact on femal...
Source: Reproductive BioMedicine Online - March 9, 2018 Category: Reproduction Medicine Source Type: research

Imaging the ovary
Publication date: Available online 6 March 2018 Source:Reproductive BioMedicine Online Author(s): Yi Feng, Amin Tamadon, Aaron J.W. Hsueh During each reproductive cycle, the ovary exhibits tissue remodelling and cyclic vasculature changes associated with hormonally regulated folliculogenesis, follicle rupture, luteal formation and regression. However, the relationships among different types of follicles and corpora lutea are unclear, and the role of ovarian vasculature in folliculogenesis and luteal dynamics has not been extensively investigated. Understanding of ovarian physiology and pathophysiology relies upon elucidat...
Source: Reproductive BioMedicine Online - March 7, 2018 Category: Reproduction Medicine Source Type: research

Cairo consensus on the IVF laboratory environment and air quality: report of an expert meeting
Publication date: Available online 2 March 2018 Source:Reproductive BioMedicine Online Author(s): D. Mortimer, J. Cohen, S.T. Mortimer, M. Fawzy, D.H. McCulloh, D.E. Morbeck, X. Pollet-Villard, R.T. Mansour, D.R. Brison, A. Doshi, J.C. Harper, J.E. Swain, A.V. Gilligan This proceedings report presents the outcomes from an international Expert Meeting to establish a consensus on the recommended technical and operational requirements for air quality within modern assisted reproduction technology (ART) laboratories. Topics considered included design and construction of the facility, as well as its heating, ventilation and ai...
Source: Reproductive BioMedicine Online - March 3, 2018 Category: Reproduction Medicine Source Type: research