Sexual function in women with polycystic ovary syndrome: a systematic review and meta-analysis
We present the first systematic review and meta-analysis of sexual function in women with polycystic ovary syndrome (PCOS) compared with women without PCOS. Data on this topic are limited and often contradicting. Sexual function is influenced by endocrine, mental and social factors, which are often compromised in women with PCOS. The main outcome measures were validated sexual function questionnaires and visual analogue scales (VAS). We identified and assessed 1925 original articles; 18 articles were included. Significant small effect sizes were found on sexual function subscales (total score: P = 0.006; arousal: P = 0.019...
Source: Reproductive BioMedicine Online - October 20, 2018 Category: Reproduction Medicine Source Type: research

Small-sized follicles could contribute to high-order multiple pregnancies: outcomes of 6552 intrauterine insemination cycles
Publication date: Available online 11 October 2018Source: Reproductive BioMedicine OnlineAuthor(s): J Giles, M Cruz, C González, C Caligara, N Prados, JC Martínez, V Vergara, A RequenaAbstractResearch questionCan predictors of twin and high-order multiple pregnancy among women with multiple cycles of ovarian stimulation intrauterine insemination (IUI) be identified?DesignRetrospective cohort study of IUI cycles carried out between January 2014 and December 2015 in a private clinic in Spain. The 4879 women and 6552 cycles analysed in this study include single IUI with ovarian stimulation using recombinant FSH....
Source: Reproductive BioMedicine Online - October 11, 2018 Category: Reproduction Medicine Source Type: research

Editorial Board
Publication date: September 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 3Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - October 10, 2018 Category: Reproduction Medicine Source Type: research

Contents
Publication date: September 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 3Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - October 10, 2018 Category: Reproduction Medicine Source Type: research

pH: the silent variable significantly impacting meiotic spindle assembly in mouse oocytes
Publication date: September 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 3Author(s): Harriet Swearman, George Koustas, Emily Knight, Georgios Liperis, Christopher Grupen, Cecilia SjoblomAbstractResearch questionTemperature fluctuation negatively impacts the assembly and function of the meiotic spindle, but does pH have a similar effect?DesignPolarized light microscopy was used to study the spindle in living mouse oocytes under different pH conditions. Female mice (n = 53) were superovulated, and oocytes collected, denuded and allocated to treatment groups. All experiments were performed at 37°C, and st...
Source: Reproductive BioMedicine Online - October 10, 2018 Category: Reproduction Medicine Source Type: research

Assisted reproductive techniques in Latin America: the Latin American Registry, 2015
ConclusionsGiven the effect of multiple births on prematurity, morbidity and perinatal mortality, reinforcing the existing trend of reducing the number of embryos transferred remains mandatory. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - October 8, 2018 Category: Reproduction Medicine Source Type: research

Oxygen regulation of aquaporin-4 in human placenta
ConclusionsOxygen may regulate AQP4 expression in human placenta, possibly through HIF-1α. Therefore, the decrease in AQP4 throughout pregnancy, previously reported, is consistent with changes in HIF-1α, and suggests that AQP4 might have a crucial role during placentation. Therefore, the abnormal expression of AQP4 may be involved in the cause of pre-eclampsia, but it does not seem to take part in the apoptotic events. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - October 8, 2018 Category: Reproduction Medicine Source Type: research

Assessment of anogenital distance as a diagnostic tool in polycystic ovary syndrome
Publication date: Available online 6 October 2018Source: Reproductive BioMedicine OnlineAuthor(s): Ana I Hernández-Peñalver, Maria L Sánchez-Ferrer, Jaime Mendiola, Evdochia Adoamnei, Maria T Prieto-Sánchez, Shiana Corbalán-Biyang, Ana Carmona-Barnosi, Aníbal Nieto, Alberto M Torres-CanteroAbstractResearch questionIs anogenital distance (AGD) a useful clinical tool for predicting polycystic ovarian syndrome (PCOS) and its main National Institutes of Health (NIH) phenotypes?DesignCase–control study conducted between September 2014 and May 2016 at the Department of Obstetrics a...
Source: Reproductive BioMedicine Online - October 8, 2018 Category: Reproduction Medicine Source Type: research

Cost-effectiveness modelling of IVF in couples with unexplained infertility
Publication date: Available online 6 October 2018Source: Reproductive BioMedicine OnlineAuthor(s): Clarabelle T Pham, Jonathan D Karnon, Robert J Norman, Ben W MolAbstractResearch questionDoes delaying IVF for 6 months in couples with unexplained infertility, compared with immediate IVF treatment, decrease the cost of IVF without compromising success rates?DesignDecision modelling was used to evaluate the cost and outcomes of immediate IVF versus delayed IVF for a cohort of women aged
Source: Reproductive BioMedicine Online - October 8, 2018 Category: Reproduction Medicine Source Type: research

Gynaecologists’ view on diagnostic delay and care performance in endometriosis in the Netherlands
Conclusions: Overall familiarity with, and use of, the 2014 ESHRE guidelines among Dutch gynaecologists is high. Dutch gynaecologists agree with the recommendations relating to diagnosis and adhere to them closely. Diagnostic delay, however, is still considerable; therefore, efforts to reduce diagnostic delay of endometriosis should be aimed at improving knowledge and awareness in both patients and medical professionals, as well as improving collaboration. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - October 6, 2018 Category: Reproduction Medicine Source Type: research

Oocyte developmental competence is independent of ovarian reserve in women younger than 35 years
Publication date: Available online 6 October 2018Source: Reproductive BioMedicine OnlineAuthor(s): MJ López Martín, D García, R Vassena, A RodríguezAbstractResearch questionIs higher antral follicle count (AFC) in healthy young women associated with higher oocyte developmental competence?DesignRetrospective study of 1985 first oocyte donation cycles, corresponding to 3210 fresh embryo transfers in oocyte recipients, conducted between January 2010 and May 2014.ResultsDonors with higher AFC who underwent ovarian stimulation, produced both more cumulus–oocyte complexes (COC) (B coefficient ...
Source: Reproductive BioMedicine Online - October 6, 2018 Category: Reproduction Medicine Source Type: research

Prenatal exposure to persistent organic compounds and their association with anogenital distance in infants
ConclusionsThe decreased anogenital distance associated with prenatal exposure to the persistent organic pollutants, observed consistently in different analyses, suggests an under-masculinizing effect of these environmental pollutants in boys. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - October 6, 2018 Category: Reproduction Medicine Source Type: research

Do immature and mature sibling oocytes recovered from stimulated cycles have the same reproductive potential?
ConclusionsGerminal-vesicle rescue can be considered as a complementary approach when folliculometry (expected) and number of MII (observed) are unequal. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - October 6, 2018 Category: Reproduction Medicine Source Type: research

Revisiting the association between smoking and female fertility using the oocyte donation model
Conclusions: This study suggests that smoking is not associated with compromised oocyte quality or altered uterine receptivity in oocyte donation cycles. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - October 6, 2018 Category: Reproduction Medicine Source Type: research

Optimal endometrial thickness to maximize live births and minimize pregnancy losses: analysis of 25,767 fresh embryo transfers
ConclusionsEndometrial thickness is strongly associated with pregnancy losses and live births in IVF, and the optimal endometrial thickness threshold of 10 mm or more maximized live births and minimized pregnancy losses. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - October 6, 2018 Category: Reproduction Medicine Source Type: research

Risk of non-lethal abnormalities should not prevent pregnancies in women of advanced maternal age
Publication date: Available online 6 October 2018Source: Reproductive BioMedicine OnlineAuthor(s): Iñigo De Miguel Beriain (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - October 6, 2018 Category: Reproduction Medicine Source Type: research

Progesterone levels on pregnancy test day after hormone replacement therapy-cryopreserved embryo transfer cycles and related reproductive outcomes
Publication date: Available online 6 October 2018Source: Reproductive BioMedicine OnlineAuthor(s): Birgit Alsbjerg, Lise Thomsen, Helle O Elbaek, Rita Laursen, Betina B Povlsen, Thor Haahr, Peter HumaidanAbstract Research question: Do serum progesterone levels determine ongoing pregnancy rates (OPR) in hormone replacement therapy frozen–thawed embryo transfer (HRT–FET) cycles?Design: A cohort study of 244 HRT–FET cycles from a Danish public fertility centre. Data from patients undergoing HRT–FET from January 2016 to December 2017 were extracted from a clinical database. All patients had transfer in ...
Source: Reproductive BioMedicine Online - October 6, 2018 Category: Reproduction Medicine Source Type: research

Testicular versus ejaculated spermatozoa for ICSI in patients without azoospermia: a systematic review
Publication date: Available online 6 October 2018Source: Reproductive BioMedicine OnlineAuthor(s): Hatem A Awaga, Julia K Bosdou, Dimitrios G Goulis, Katerina Chatzimeletiou, Mohamed Salem, Salah Roshdy, Grigoris Grimbizis, Basil C Tarlatzis, Efstratios M KolibianakisAbstractThe use of testicular spermatozoa in men without azoospermia has been proposed as a means to increase the chances of pregnancy following assisted reproductive treatment. The purpose of this systematic review is to assess whether clinical outcomes are better when testicular rather than ejaculated spermatozoa are used for intracytoplasmic sperm injection...
Source: Reproductive BioMedicine Online - October 6, 2018 Category: Reproduction Medicine Source Type: research

An adapted carrier for the cryopreservation of human testicular spermatozoa
ConclusionsThe adapted carrier improved the cryopreserved sperm motility compared with the effects of 2-ml cryogenic vials. The outcomes of intracytoplasmic sperm injection and frozen-thawed embryo transfer outcomes indicate that testicular spermatozoa cryopreserved using the adapted carrier is not inferior to fresh testicular spermatozoa. The use of the adapted carrier for cryopreserving human testicular spermatozoa especially from obstructive azoospermia is simple and effective. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - October 6, 2018 Category: Reproduction Medicine Source Type: research

The status of global DNA methylation in the spermatozoa of smokers and non-smokers
Publication date: Available online 6 October 2018Source: Reproductive BioMedicine OnlineAuthor(s): Mohammed F. Hamad, Wael A. Abu Dayyih, Mohammad Laqqan, Yasir AlKhaled, Mathias Montenarh, Mohammed E. HammadehAbstractResearch questionDoes regular smoking affect semen quality and the levels of DNA methylation in mature human spermatozoa?DesignSpermatozoa from 109 men were evaluated (55 smokers and 54 non-smokers). DNA was extracted from purified spermatozoa, and DNA methylation was quantified by enzyme-linked immunosorbent assay (ELISA).ResultsGlobal DNA methylation of non-smokers is significantly lower (P
Source: Reproductive BioMedicine Online - October 6, 2018 Category: Reproduction Medicine Source Type: research

Care needed in interpretation of chromosome rearrangements
Publication date: Available online 6 October 2018Source: Reproductive BioMedicine OnlineAuthor(s): Caroline Ogilvie, Susan Bint (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - October 6, 2018 Category: Reproduction Medicine Source Type: research

The use of intracytoplasmic sperm injection is associated with a shift in the secondary sex ratio
Publication date: Available online 6 October 2018Source: Reproductive BioMedicine OnlineAuthor(s): Christoph Cirkel, Inke R. König, Askan Schultze-Mosgau, Elmar Beck, Kay Neumann, Georg GriesingerAbstractResearch question: What is the association between assisted reproductive technologies and human sex ratio as a proportion of male offspring at birth.Design: A total of 59,628 singleton deliveries resulting from IVF, intracytoplasmic sperm injection (ICSI) and intrauterine insemination (IUI) or ovulation induction from 101 IVF clinics in Germany, that had been documented in a national German IVF registry, were analysed...
Source: Reproductive BioMedicine Online - October 6, 2018 Category: Reproduction Medicine Source Type: research

Response: Risk of non-lethal abnormalities should not prevent pregnancies in women of advanced maternal age
Publication date: Available online 27 September 2018Source: Reproductive BioMedicine OnlineAuthor(s): Prof. John Lui Yovich (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - October 5, 2018 Category: Reproduction Medicine Source Type: research

Storage of sperm samples from males with azoospermia
Publication date: Available online 28 September 2018Source: Reproductive BioMedicine OnlineAuthor(s): John L Yovich, Sandro C Esteves (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - October 5, 2018 Category: Reproduction Medicine Source Type: research

Oral versus transdermal oestrogen delivery for endometrial preparation before embryo transfer: a prospective, comparative, randomized clinical trial
Publication date: Available online 29 September 2018Source: Reproductive BioMedicine OnlineAuthor(s): P Ferrer Molina, C Calatayud Lliso, R Carreras Collado, M Muñoz García, M Díaz Bachiller, J Blanes Espí, M ChecaAbstractResearch questionTo determine whether the transdermal route is equal or superior to the oral route, when preparing the endometrium with oestrogens for embryo transfer.DesignProspective, randomized controlled trial; 140 patients randomized; the pills group followed a protocol with oestradiol valerate pills and the patches group followed a protocol with oestradiol hemihydrate pat...
Source: Reproductive BioMedicine Online - October 5, 2018 Category: Reproduction Medicine Source Type: research

Serum anti-Müllerian hormone concentration before and after salpingectomy for ectopic pregnancy
ConclusionsThis is the first paired study to investigate serum AMH values before and after salpingectomy in an unselected population of women presenting with an ectopic pregnancy, including both patients who conceived naturally and following fertility treatment. It was found that salpingectomy for ectopic pregnancy had no short-term effect on serum AMH levels, and changes in AMH levels were independent of age, time to follow-up, and pre-operative serum AMH level. Furthermore, the study demonstrated a 6-month biological variation of AMH of less than 30%. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - September 16, 2018 Category: Reproduction Medicine Source Type: research

The expected cumulative incidence of live birth of patients starting IVF treatment at age 41 years or older
Publication date: Available online 12 September 2018Source: Reproductive BioMedicine OnlineAuthor(s): Oshrit Lebovitz, Jigal Haas, Kaitlyn E. James, Daniel S. Seidman, Raoul Orvieto, Ariel HourvitzAbstractResearch questionWhat is the cumulative incidence of live birth (CLIB) for high-order consecutive IVF cycles, and which factors are associated with live birth of women aged ≥41 years using autologous oocytes?DesignA retrospective cohort study including 146 patients aged 41 years to
Source: Reproductive BioMedicine Online - September 12, 2018 Category: Reproduction Medicine Source Type: research

Towards international standardization of immunoassays for Müllerian inhibiting substance/anti-Müllerian hormone
Conclusions: A reference material prepared using human recombinant AMH is a promising candidate for the preparation of an international standard for AMH for immunoassays calibrated to recombinant human AMH. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - September 5, 2018 Category: Reproduction Medicine Source Type: research

Patentability of time-lapse monitoring has nothing to do with human dignity: a response to Alain Pottage
Publication date: Available online 30 August 2018Source: Reproductive BioMedicine OnlineAuthor(s): Iñigo de Miguel Beriain, Begoña SanzAbstractIn December 2017, Alain Pottage published an article denying the patentability of a technique called Time-Lapse Monitoring (TLM). His argument was that this procedure, like all other embryo selection procedures, fails to respect human dignity. Here, we argue that this statement is mistaken because assisted reproductive technologies (ART) require a scarce resource, namely a woman's uterus in the right physiological condition. Therefore, embryo selection using TLM is ent...
Source: Reproductive BioMedicine Online - August 31, 2018 Category: Reproduction Medicine Source Type: research

Is blastomere multinucleation a safeguard against embryo aneuploidy? Back to the future
Publication date: Available online 29 August 2018Source: Reproductive BioMedicine OnlineAuthor(s): Jan Tesarik (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - August 31, 2018 Category: Reproduction Medicine Source Type: research

Profiles for long non-coding RNAs in ovarian granulosa cells from women with PCOS with or without hyperandrogenism
Publication date: Available online 29 August 2018Source: Reproductive BioMedicine OnlineAuthor(s): Li Jin, Qian Yang, Chengliang Zhou, Lanxin Liu, Huihui Wang, Min Hou, Yimei Wu, Fengtao Shi, Jianzhong Sheng, Hefeng HuangAbstractResearch question: What is the expression pattern of long non-coding RNAs (lncRNA) in ovarian granulosa cells of women with polycystic ovary syndrome (PCOS) with or without hyperandrogenism?Design: Microarray screening of lncRNA was conducted in ovarian granulosa cells collected from women with PCOS with hyperandrogenism (PCOS-T) or without hyperandrogenism (PCOS-N) and control participants, with f...
Source: Reproductive BioMedicine Online - August 31, 2018 Category: Reproduction Medicine Source Type: research

Metabolic characteristics of normal weight central obesity phenotype polycystic ovary syndrome women: a large-scale national epidemiological survey
Publication date: Available online 29 August 2018Source: Reproductive BioMedicine OnlineAuthor(s): Liangshan Mu, Yue Zhao, Rong Li, Yuchen Lai, Jie QiaoAbstractResearch question: The aim was to investigate the metabolic profiles of women with normal weight but central obesity in polycystic ovary syndrome (PCOS).Design: In total, 727 women with PCOS from a large-scale epidemiological survey were included. Diagnosis of PCOS was based on Rotterdam criteria. Subjects were categorized into four subgroups: (i) normal weight non-central obesity (NWNCO): body mass index (BMI) ≤18.5 kg/m2 to
Source: Reproductive BioMedicine Online - August 31, 2018 Category: Reproduction Medicine Source Type: research

Dignity (yet) again. A rejoinder to de Miguel and Sanz
Publication date: Available online 28 August 2018Source: Reproductive BioMedicine OnlineAuthor(s): Alain Pottage (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - August 29, 2018 Category: Reproduction Medicine Source Type: research

Prevalence and authenticity of de-novo segmental aneuploidy (>16 Mb) in human blastocysts as detected by next-generation sequencing
ConclusionsDe-novo segmental aneuploidy above 16 Mb occurred in blastocysts and could be detected by NGS, while some aneuploidies existed as mosaics in both TE and ICM. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - August 29, 2018 Category: Reproduction Medicine Source Type: research

pH stability of human preimplantation embryo culture media: effects of culture and batches
Conclusions: A relevant difference in pH was found between batches of human preimplantation embryo culture media. This suggests that the CO2 level of incubators may need to be adjusted for new batches of culture medium based on measured pH, to anticipate batch variability and safely accommodate limited pH increase over time. This study was unable to identify the cause of the differences in pH between batches, and further investigation on a larger number of batches and other media seems warranted. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - August 29, 2018 Category: Reproduction Medicine Source Type: research

Endometrial thickness of less than 7.5 mm is associated with obstetric complications in fresh IVF cycles: a retrospective cohort study
ConclusionsOur results demonstrated that a thin endometrial lining was associated with obstetric complications that might be related to poor placentation. These findings should be validated in large prospective cohort studies. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - August 24, 2018 Category: Reproduction Medicine Source Type: research

Trends in anti-Müllerian hormone concentrations across different stages of pregnancy in women with polycystic ovary syndrome
Publication date: Available online 23 August 2018Source: Reproductive BioMedicine OnlineAuthor(s): Angela Köninger, Antje Kampmeier, Boerge Schmidt, Mirjam Frank, Thomas Strowitzki, Rainer Kimmig, Alexandra Gellhaus, Pawel MachAbstractResearch questionWhat are the trends in anti-Müllerian hormone (AMH) concentrations from pre-conception to the third trimester of pregnancy in women with polycystic ovary syndrome (PCOS)?DesignObservational study including cross-sectional and longitudinal data analysis. The Beckman Coulter AMH Gen II Assay was used to determine AMH levels longitudinally before pregnancy from 52 wome...
Source: Reproductive BioMedicine Online - August 24, 2018 Category: Reproduction Medicine Source Type: research

Conventional versus minimal ovarian stimulation: an intra-patient comparison of ovarian response in poor-responder women according to Bologna Criteria
ConclusionsIn poor responder patients, MOS is a good alternative when COS has failed, or even as a first-line treatment. It offered a significantly greater number of good-quality embryos as well as a higher number of oocytes, using significantly lower doses of gonadotrophins per oocyte and embryo obtained. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - August 24, 2018 Category: Reproduction Medicine Source Type: research

Sperm cryopreservation: A review on current molecular cryobiology and advanced approaches
This article reviews recent reports on molecular and cellular modifications of spermatozoa during cryopreservation in order to collate the existing understanding in this field. The aim is to discuss current freezing techniques and novel strategies that have been developed for sperm protection against cryo-damage, as well as evaluating the probable effects of sperm freezing on offspring health. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - August 23, 2018 Category: Reproduction Medicine Source Type: research

Assisted reproductive technology in Beijing, 2013–2015
ConclusionsIn Beijing over 3 years, the number of IVF–ICSI cycles has increased and the number of IUI cycles has decreased; IVF–ICSI outcomes are better and safer. Further effort should be made to lower the multiple pregnancy rates. A Chinese nationwide ART registry should be promoted. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - August 23, 2018 Category: Reproduction Medicine Source Type: research

Human mitochondrial DNA haplogroup M8a influences the penetrance of m.8684C>T in Han Chinese men with non-obstructive azoospermia
Publication date: Available online 23 August 2018Source: Reproductive BioMedicine OnlineAuthor(s): Juan Ji, Miaofei Xu, Rong Wang, Ying Wang, Yufeng Qin, Lei Li, Hongxiang Zheng, Shuping Yang, Shilin Li, Dengshun Miao, Li Jin, Lin Zhou, Xiufeng Ling, Yankai Xia, Chuncheng Lu, Xinru WangAbstractResearch question: What is the role of mitochondrial DNA (mtDNA) in the pathogenesis of non-obstructive azoospermia (NOA)?Design: mtDNA genome sequencing followed by an independent population validation were performed in 628 NOA cases and 584 healthy controls. Antioxidant capacity of serum was evaluated in 54 randomly selected cases ...
Source: Reproductive BioMedicine Online - August 23, 2018 Category: Reproduction Medicine Source Type: research

Social egg freezing: Who chooses and who uses?
Publication date: Available online 21 August 2018Source: Reproductive BioMedicine OnlineAuthor(s): Gill Lockwood, Bart CJM Fauser (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - August 21, 2018 Category: Reproduction Medicine Source Type: research

Status of preimplantation genetic testing and embryo selection
Publication date: Available online 20 August 2018Source: Reproductive BioMedicine OnlineAuthor(s): Santiago MunnéAbstractAt the recent 2018 PGDIS congress, a review of randomized controlled trials of preimplantation genetic testing for aneuploidies (PGT-A) showed improved ongoing pregnancy rates per transfer in experienced centres and in women aged 35 years and older. Young women produce 40% abnormal embryos (20–60% range), but not all centres see a selection advantage; this indicates the need for more emphasis in improving biopsy and case management. Some chromosome abnormalities are iatrogenic; PGT-A could, ...
Source: Reproductive BioMedicine Online - August 20, 2018 Category: Reproduction Medicine Source Type: research

Cocaine alters the mouse testicular epigenome with direct impact on histone acetylation and DNA methylation marks
ConclusionsCocaine intake is associated with testicular toxicity and significant reproductive function impairment. The results presented here broaden the basic knowledge of the impact of addictive stimulants on testicular pathophysiology, fertility and male reproductive health and imply that altered epigenetic homeostasis by cocaine may have potential consequences on future generations. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - August 18, 2018 Category: Reproduction Medicine Source Type: research

Ovarian tissue transplantation for hormone replacement
Publication date: Available online 16 August 2018Source: Reproductive BioMedicine OnlineAuthor(s): RA Anderson (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - August 18, 2018 Category: Reproduction Medicine Source Type: research

New strategies of ovarian stimulation based on the concept of ovarian follicular waves: from conventional to random and double stimulation
Publication date: Available online 11 August 2018Source: Reproductive BioMedicine OnlineAuthor(s): Giovanna Sighinolfi, Sesh Kamal Sunkara, Antonio La MarcaAbstractThe theory of a multicyclic development of follicles during the menstrual cycle prompted new approaches to ovarian stimulation, such as starting gonadotrophins for ovarian stimulation at any time during the menstrual cycle or using double stimulation during it, with stimulation in both the follicular and luteal phases. Because of the asynchrony between endometrial receptivity and embryo development with a ‘non-conventional start’ stimulation, all the...
Source: Reproductive BioMedicine Online - August 11, 2018 Category: Reproduction Medicine Source Type: research

Response: how PGS/PGT-A laboratories succeeded in losing all credibility
Publication date: August 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 2Author(s): Francesca Romana Grati, Gloria Gallazzi, Lara Branca, Federico Maggi, Giuseppe Simoni, Yuval Yaron (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - August 1, 2018 Category: Reproduction Medicine Source Type: research

Editorial Board
Publication date: August 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 2Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - August 1, 2018 Category: Reproduction Medicine Source Type: research

Contents
Publication date: August 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 2Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - August 1, 2018 Category: Reproduction Medicine Source Type: research

Is 45 years-of-age the cut-off for using autologous oocytes?
Publication date: August 2018Source: Reproductive BioMedicine Online, Volume 37, Issue 2Author(s): John L. Yovich, Michael J. Chapman, Kevin N. Keane, Julian Savulescu (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - August 1, 2018 Category: Reproduction Medicine Source Type: research