Meet our new editor: ProfessorFelice Petraglia
Publication date: Available online 19 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 22, 2019 Category: Reproduction Medicine Source Type: research

Dual stimulation using corifollitropin alfa in 54 Bologna criteria poor ovarian responders – a case series
ConclusionsLuteal phase stimulation results in more oocytes in poor responders compared with follicular phase stimulation. DuoStim, using corifollitropin alfa followed by individualized FSH dosing, appears to be an alternative to conventional follicular phase stimulation, decreasing the risk of cycle cancellation. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 22, 2019 Category: Reproduction Medicine Source Type: research

Regulating ART: time for a re-think in the light of increasing efficacy, safety and efficiency
Publication date: Available online 19 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): John L Yovich, Robert Casper, Michael Chapman, Jan Tesarek, Richard A Anderson (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 20, 2019 Category: Reproduction Medicine Source Type: research

Hormonal medication in medically assisted reproduction: a systematic review of assessments from patients
Publication date: Available online 19 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Kay Lankreijer, Thomas M D'Hooghe, Silke Apers, Walter Sermeus, Sjoerd Repping, Eline AF DancetAbstractSeveral hormonal fertility medications have comparable effectiveness. A literature review was conducted into patients’ assessments regarding seven medication characteristics including ‘side effects’ and ‘ease of use’. Medline, CINAHL and PsycINFO were searched for female fertility patients’ written assessments of a hormonal medication. The tools used were appraised and common (i.e. ≥10...
Source: Reproductive BioMedicine Online - January 20, 2019 Category: Reproduction Medicine Source Type: research

Meet our new editor: Professor Felice Petraglia
Publication date: Available online 19 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Felice Petraglia (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 20, 2019 Category: Reproduction Medicine Source Type: research

Meet our new editor: Professor Marinus JC Eijkemans
Publication date: Available online 19 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): René Eijkemans (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 20, 2019 Category: Reproduction Medicine Source Type: research

Meet our new editor: Professor Christopher Barratt
Publication date: Available online 19 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Christopher Barratt (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 20, 2019 Category: Reproduction Medicine Source Type: research

Overnight ovarian tissue transportation for centralized cryobanking: a feasible option
ConclusionsOvernight transportation for central cryobanking is a feasible concept that results in high reproducible success rates through standardized professional tissue freezing and storage. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 20, 2019 Category: Reproduction Medicine Source Type: research

Another new year
Publication date: January 2019Source: Reproductive BioMedicine Online, Volume 38, Issue 1Author(s): Bart Fauser, Mina Alikani, Richard Anderson, Sarah Franklin, Martin H. Johnson, Juan Garcia Velasco (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 18, 2019 Category: Reproduction Medicine Source Type: research

Thanks to our Referees
Publication date: January 2019Source: Reproductive BioMedicine Online, Volume 38, Issue 1Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 18, 2019 Category: Reproduction Medicine Source Type: research

Contents
Publication date: January 2019Source: Reproductive BioMedicine Online, Volume 38, Issue 1Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 18, 2019 Category: Reproduction Medicine Source Type: research

Editorial Board
Publication date: January 2019Source: Reproductive BioMedicine Online, Volume 38, Issue 1Author(s): (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 18, 2019 Category: Reproduction Medicine Source Type: research

Omega-3 polyunsaturated fatty acids and IVF treatment
Publication date: January 2019Source: Reproductive BioMedicine Online, Volume 38, Issue 1Author(s): Amir Lass, Andrea BelluzziAbstractOmega-3 polyunsaturated fatty acids (PUFAs) are essential fatty acids, derived mostly from fish oil, that have a significant anti-inflammatory effect. Data from animal studies support their role in the reproductive mechanism, and recent human studies suggest a positive effect on sperm quality and natural conception. Their general role in human fertility, and specifically in IVF treatment, however, is not clear. A few small, prospective cohort studies have examined the relationship between se...
Source: Reproductive BioMedicine Online - January 18, 2019 Category: Reproduction Medicine Source Type: research

Follicular fluid progesterone level associated with fertilization outcome during in vitro fertilization: a systematic review and meta-analysis
Publication date: Available online 17 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Bernadett Nagy, Laszlo Poto, Nelli Farkas, Miklos Koppan, Akos Varnagy, Kalman Kovacs, Szilard Papp, Noemi Bohonyi, Jozsef BodisAbstractFollicular fluid (FF) is a key biochemical environment for oocyte development. The potential effect of follicular progesterone level on successful fertilization is a subject of debate, therefore our aim was to give a summary on the currently available evidence on the association between FF progesterone level and fertilization outcome.To do so, a systematic review and a meta-analysis were per...
Source: Reproductive BioMedicine Online - January 18, 2019 Category: Reproduction Medicine Source Type: research

Hyperhomocysteinemia and metabolic syndrome show differences in ovulation, conception, pregnancy loss and live birth in women with PCOS: a secondary analysis of PCOSAct
ConclusionsIn PCOS patients, HHCY contributes to increased pregnancy loss and reduced ovulation, and MS was related to defects in ovulation, conception, pregnancy, pregnancy loss and live birth, indicating that the two conditions lead to defects at different reproductive stages. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 18, 2019 Category: Reproduction Medicine Source Type: research

Double stimulation in poor responders: a cause for concern?
Publication date: Available online 18 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Tarek El-Toukhy, Omar El Tokhy (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 18, 2019 Category: Reproduction Medicine Source Type: research

The IVF-LUBE trial – a randomized trial to assess Lipiodol® uterine bathing effect in women with endometriosis or repeat implantation failure undergoing IVF
ConclusionsNo evidence was found of benefit of Lipiodol prior to fresh embryo transfer in women with endometriosis or RIF. It is suggested that this treatment should not be undertaken purely as an adjuvant in IVF other than in the context of a further well-designed RCT. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 16, 2019 Category: Reproduction Medicine Source Type: research

Does the FMR1 gene affect IVF success?
Publication date: Available online 10 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Lisa M Pastore, Mindy S Christianson, Bailey McGuinness, Kamaria Cayton Vaught, Jacqueline Y Maher, William G KearnsAbstractFMR1 CCG trinucleotide repeat expansions are associated with Fragile X syndrome (full mutations) and primary ovarian insufficiency (premutation range); the effect of FMR1 on the success of fertility treatment is unclear. The effect of FMR1 CGG repeat lengths on IVF outcomes after ovarian stimulation was reviewed. PubMed was searched for studies on IVF-related outcomes reported by FMR1 trinucleotide rep...
Source: Reproductive BioMedicine Online - January 15, 2019 Category: Reproduction Medicine Source Type: research

Evaluating if ovulation suppression with progestins is cost effective compared to GnRH analogs in assisted reproduction cycles
ConclusionsOvulation inhibition in IVF using progestins requires a freeze only approach of embryos, and thus progestin use was not cost-effective compared to fresh embryo transfer cycles. However, progestins may be cost-effective compared to GnRH antagonist in planned freeze only cycles such as in PGT or fertility preservation. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 12, 2019 Category: Reproduction Medicine Source Type: research

Knowledge, attitudes and practice of physicians towards fertility and pregnancy-related issues in young BRCA-mutated breast cancer patients: results from the BCY3/BCC 2017 survey
Publication date: Available online 10 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Matteo Lambertini, Massimo Di Maio, Francesca Poggio, Olivia Pagani, Giuseppe Curigliano, Lucia Del Mastro, Shani Paluch-Shimon, Sibylle Loibl, Ann H. Partridge, Jr. Hatem A. Azim, Fedro A. Peccatori, Isabelle DemeestereABSTRACTResearch questionWe explored the knowledge, attitudes and practice of physicians towards fertility and pregnancy-related issues in young BRCA-mutated breast cancer (BC) patients.DesignPhysicians attending two international BC conferences were asked to complete a 26-item questionnaire exploring fertili...
Source: Reproductive BioMedicine Online - January 11, 2019 Category: Reproduction Medicine Source Type: research

Germ cell arrest associated with aSETX mutation in ataxia oculomotor apraxia type 2
We describe the first case of human male infertility caused by germ cell arrest in a man with AOA2. Our patient has a homozygous mutation in the SETX gene (NC_000009.11:g.135158775dup), which results in a frameshift and premature protein termination (NM_015046.6:c.6422dup, p.[Ser2142Glufs*23]). In accordance with the murine phenotype, testis histology revealed disrupted seminiferous tubules with spermatogonia and primary spermatocytes, but absent spermatids. Collectively, these data support an essential role of senataxin in human spermatogenesis, and provide a compelling case that men with AOA2 should be cou...
Source: Reproductive BioMedicine Online - January 10, 2019 Category: Reproduction Medicine Source Type: research

Live births following genome editing in human embryos: a call for clarity, self-control and regulation
Publication date: Available online 14 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Helen C O'Neill, Jacques Cohen (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 9, 2019 Category: Reproduction Medicine Source Type: research

Effect of oocyte morphology on post-warming survival and embryo development in vitrified autologous oocytes
ConclusionOocyte dysmorphisms did not seem to affect survival, fertilization and embryo development in vitrified autologous oocytes, and yielded comparable results to the morphologically normal oocytes. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 9, 2019 Category: Reproduction Medicine Source Type: research

Consultation and Treatment Behavior of Infertile Couples in China: a population-based study
ConclusionWe conclude that the prevalence of infertility in China is high, but the uptake of treatment was relatively low. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 9, 2019 Category: Reproduction Medicine Source Type: research

Evaluation of next-generation sequencing–based preimplantation genetic diagnosis for balanced reciprocal translocation carriers
ConclusionsCNV-Seq-based NGS is an efficient and reliable PGD method for balanced reciprocal translocation. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 8, 2019 Category: Reproduction Medicine Source Type: research

Maternal β-hCG levels in early IVF pregnancy: association with the embryo development stage of blastocyst
Publication date: Available online 8 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Wenyue Zhu, Queenie Yeung, David Chan, Ling Chi, Jin Huang, Qiong Wang, Jacqueline Chung, TC LiAbstractResearch QuestionDoes the development stage of the blastocyst on embryo transfer (ET) day affect the serum β-human chorionic gonadotropin (β-hCG) level 9 days and 16 days after embryo transfer in women whose pregnancy progressed to beyond 13 weeks?DesignThe retrospective study involved 204 cases whose pregnancy progressed to beyond 13 weeks of single blastocyst transfer in fresh (n=66) or frozen (n=138) cycles in a...
Source: Reproductive BioMedicine Online - January 8, 2019 Category: Reproduction Medicine Source Type: research

The high-risk human Papillomavirus continuum along the female reproductive tract and its relationship to infertility and endometriosis
ConclusionsThis study demonstrate that there is an association between hrHPV infections in the UGT with infertility, particularly with endometriosis. It also show a possible continuum hrHPV infection, from LGT to UGT. It suggest future larger studies that could fully investigate the role of hrHPV as an eventual cause of endometriosis and infertility. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 8, 2019 Category: Reproduction Medicine Source Type: research

A multicenter evaluation of the Elecsys® AMH immunoassay for prediction of antral follicle count
ConclusionThe Elecsys® AMH immunoassay provides a robust and fully automated method to measure serum AMH levels. Women with AMH values below the cut-off of 1.77 ng/mL are unlikely to have AFC>15. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 8, 2019 Category: Reproduction Medicine Source Type: research

Does Polycystic Ovary Syndrome Associate with Risk of Female Sexual Dysfunction? A Systematic Review and Meta-analysis
This study aims to evaluate whether polycystic ovary syndrome (PCOS) is a risk factor for female sexual dysfunction (FSD) through a meta-analysis. The association between PCOS and risk of FSD was performed by using the relative risk (RR) or the standard mean differences (SMD) with a 95% confidence interval (CI). The protocol for this meta-analysis is available from PROSPERO (CRD42018102247). Overall, 2626 participants (mean age: 25-36 years) were included from 10 studies (5 cross-sectional and 5 case-control studies), 1163 of whom were women with PCOS. The pooled results from 8 included studies providing the number of case...
Source: Reproductive BioMedicine Online - January 8, 2019 Category: Reproduction Medicine Source Type: research

Preconditioning of sperm with sublethal nitrosative stress: a novel approach to improve frozen–thawed sperm function
Publication date: Available online 8 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Maryam Hezavehei, Homa Mohseni Kouchesfahani, Abdolhossein Shahverdi, Mohsen Sharafi, Ghasem Hosseini Salekdeh, Poopak Eftekhari-YazdiAbstractResearch questionCan sublethal stress induced by nitric oxide on fresh human spermatozoa protect the functional properties of post–thaw human spermatozoa?DesignSemen samples were obtained from 46 donors. Twenty semen samples were used to determine toxicity level of nitric oxide by incubation of semen with different concentrations of nitric oxide (0.01 to 400 μM). Then, 26 semen...
Source: Reproductive BioMedicine Online - January 8, 2019 Category: Reproduction Medicine Source Type: research

Beneficial effects of dietary nitrate on testicular injury by improving glycemia and inhibiting apoptosis in Streptozotocin-induced diabetic male rats
ConclusionsWe demonstrated that treatment with sodium nitrate could modulate the apoptosis which is a major cause for the diabetic testicular disorder. These experiments suggest that NO plays an important role in the function of the reproductive system.Graphical abstract (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 8, 2019 Category: Reproduction Medicine Source Type: research

“Is blood thicker than water?” Donor conceived offspring subjective experiences of the donor: A systematic narrative review
Publication date: Available online 8 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Canzi Elena, Accordini Monica, Facchin FedericaAbstractThe aim of this study was to provide a systematic narrative review of the published research articles on donor conceived (DC) offspring's subjective experiences of their donor. A systematic search of electronic databases provided 29 published quantitative and qualitative studies matching our inclusion criteria. The analysis of the studies outcomes led to the identification of four main themes: a) views/representations of the donor; b) desire to contact the donor (in terms...
Source: Reproductive BioMedicine Online - January 8, 2019 Category: Reproduction Medicine Source Type: research

Three-dimensional levitation culture improves in-vitro growth of secondary follicles in bovine model
ConclusionThe three-dimensional levitation culture system improves the viability of in-vitro development of bovine secondary follicles, antrum formation and lower extrusion and degeneration rates and adequate growth rate leading to relevant oocyte viability and meiotic resumption after in-vitro maturation. This approach does not require a specific medium, and has the potential as an alternative method to in-vitro follicle culture in several species, including humans. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 5, 2019 Category: Reproduction Medicine Source Type: research

C-type natriuretic peptide regulates sperm capacitation by the cGMP/PKG signalling pathway via Ca2+ influx and tyrosine phosphorylation
Publication date: Available online 5 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Kejia Wu, Chunlei Mei, Yao Chen, Lidan Guo, Yuejin Yu, Donghui HuangAbstractResearch questionWhat is the effect of C-type natriuretic peptide (CNP) on human sperm capacitation in vitro and what is the mechanism of this effect?DesignCNP/NPR-B expression in the female rat genital tract was examined by immunohistochemistry and western blot assay, and then the role of CNP in human sperm capacitation was determined. The signal transduction pathway of CNP in the process was determined to elucidate the regulation mechanism of CNP by...
Source: Reproductive BioMedicine Online - January 5, 2019 Category: Reproduction Medicine Source Type: research

Obstetric and perinatal outcomes of pregnancies according to initial maternal serum HCG concentrations after vitrified–warmed single blastocyst transfer
ConclusionsLower initial maternal serum HCG levels indicated poorer clinical outcomes. Within the high HCG group, a lower initial maternal HCG level was found to be associated with GDM occurrence and proportion of female neonates. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 5, 2019 Category: Reproduction Medicine Source Type: research

Autologous endometrial cell co-culture improves human embryo development to high-quality blastocysts: a randomized controlled trial
ConclusionThis study demonstrated the benefits of AECC on blastocyst quality compared with conventional embryo culture medium, in a broader category of patients referred to ART as opposed to other studies that concentrated on specific causes of infertility only. However, limitations of the study design should be taken into consideration; the analysis was performed using embryos rather than patients and a follow-up of children born following the treatments could not be conducted. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - January 5, 2019 Category: Reproduction Medicine Source Type: research

Serum progesterone concentration and live birth rate in frozen–thawed embryo transfers with hormonally prepared endometrium
Publication date: Available online 5 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Isabelle Cédrin-Durnerin, Tiphaine Isnard, Sarah Mahdjoub, Charlotte Sonigo, Alice Seroka, Marjorie Comtet, Charlène Herbemont, Christophe Sifer, Michael GrynbergAbstractResearch questionIs serum progesterone measurement on the day of embryo transfer associated with outcome of frozen–thawed embryo transfer (FET) in cycles using hormonal replacement therapy (HRT) for endometrium preparation?DesignThis single-centre retrospective study assessed the relationship between serum progesterone on embryo transfer d...
Source: Reproductive BioMedicine Online - January 5, 2019 Category: Reproduction Medicine Source Type: research

Bureaucratic overheating is a parasite hampering modern clinical research – A viewpoint from the belly of the beast
Publication date: Available online 2 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Peter Humaidan, Thor HaahrAbstractClinical researchers in Europe experience an increasing amount of bureaucracy which in our eyes has now reached surrealistic heights, hampering the future of research, and thus, the development of new treatment regimens and advances in clinical research. In the long run the current approval and control processes will negatively impact patient care, education, academia, and the health economy of our countries. Thus, at this time a debate is necessary, including not only health care workers, bu...
Source: Reproductive BioMedicine Online - January 3, 2019 Category: Reproduction Medicine Source Type: research

Acupuncture performed around the time of embryo transfer: a systematic review and meta-analysis
Publication date: Available online 2 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Caroline A Smith, Mike Armour, Zewdneh Shewamene, Hsiewe Ying Tan, Robert J Norman, Neil P JohnsonAbstractThis was a systematic review and meta-analysis to examine the efficacy, effectiveness and safety of acupuncture as an adjunct to embryo transfer compared with controls to improve reproductive outcomes. The primary outcome was clinical pregnancy. Twenty trials and 5130 women were included in the review. The meta-analysis found increased pregnancies (risk ratio [RR] 1.32, 95% confidence interval [CI] 1.07–1.62, 12 tri...
Source: Reproductive BioMedicine Online - January 3, 2019 Category: Reproduction Medicine Source Type: research

Soluble LH-hCG receptor and oestradiol as predictors of pregnancy and live birth in IVF
ConclusionssLHCGR levels are negatively related to AMH when oocyte yield is high. High early cycle sLHCGR is associated with elevated day-3 oestradiol. Low sLHCGR and SOR are indicators of increased clinical pregnancy and live birth rates. Patient age and SOR, combined with EOR, might improve prediction of IVF treatment outcomes. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 29, 2018 Category: Reproduction Medicine Source Type: research

Hydrosalpinx and pregnancy loss: a systematic review and meta-analysis
Publication date: Available online 25 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): H.M. Harb, J. Ghosh, F. Al-Rshoud, B. Karunakaran, I.D. Gallos, A. CoomarasamyABSTRACTQuestionWhat is the association of hydrosalpinx with pregnancy loss and the effects of treatment of hydrosalpinx?DesignWe conducted a systematic review and meta-analysis to investigate the risk of pregnancy loss, and the benefit of treatment in women with hydrosalpinx. Searches were conducted on MEDLINE, EMBASE, Cochrane Library and Web of Science.ResultsMeta-analysis of 14 observational studies showed a 74% relative increase in the risk o...
Source: Reproductive BioMedicine Online - December 26, 2018 Category: Reproduction Medicine Source Type: research

Two- and three-dimensional transvaginal ultrasonography for diagnosis of adenomyosis of the inner myometrium
ConclusionsFor the diagnosis of adenomyosis of the inner myometrium, 3D-TVS offers a high accuracy similar to 2D-TVS. However, identification of JZ irregularity with 3D-TVS may be beneficial to diagnosis. Beyond this, a more objective diagnosis may be achieved by using a combination of ≥ two 2D features and ≥ two 3D features. These results may be useful for clinical practice and future research. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 26, 2018 Category: Reproduction Medicine Source Type: research

The effect of serum vitamin D levels in couples on embryo development and clinical outcomes
ConclusionsVitamin D levels, in neither men nor women, was associated with embryo development in cleavage (Day2 and Day3) and blastocyst (Day5/6) stage and clinical outcomes. The possible reason might be that the threshold of vitamin D affecting reproductive process is relatively low, which requires a multicenter study at high latitudes region. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 26, 2018 Category: Reproduction Medicine Source Type: research

Pituitary suppression protocol among Bologna poor responders undergoing ovarian stimulation using corifollitropin alfa: does it play any role?
Publication date: Available online 25 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): J. Errázuriz, P. Drakopoulos, D. Pening, A. Racca, A. Romito, N. De Munck, H. Tournaye, M. De Vos, C. BlockeelABSTRACTResearch questionDoes the type of of pituitary suppression protocol influence cumulative LBR in Bologna poor responders treated with CFA?DesignRetrospective cohort analysis including poor responder patients fulfilling the Bologna criteria who underwent their first ICSI cycle using a CFA-based ovarian stimulation protocol between 2011 and 2017. The starting dose of CFA was 150 μg. Our primary outcom...
Source: Reproductive BioMedicine Online - December 25, 2018 Category: Reproduction Medicine Source Type: research

Individualization of the starting dose of follitropin delta reduces the overall OHSS risk and/or the need of additional preventive interventions: Cumulative data over three stimulation cycles
ConclusionAn individualized follitropin delta dosing regimen decreased the risk of moderate/severe OHSS as well as the incidence of preventive interventions versus a conventional follitropin alfa regimen. An analysis per AMH quartile indicated that these statistically significant differences are driven mainly by patients with the highest pretreatment AMH levels. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 24, 2018 Category: Reproduction Medicine Source Type: research

Assessment of the calcium releasing machinery in oocytes that failed to fertilize after conventional ICSI and assisted oocyte activation
ConclusionsThe evaluation of spindle-chromosome normalcy and distribution of IP3R1 does not contribute to identify the presence of Ca2+ releasing deficiencies in these oocytes. However, oocyte Ca2+ analysis is of added value to identify Ca2+releasing incapacity of oocytes that failed to fertilize after ICSI or ICSI-AOA. We showed that some patients experiencing fertilization failure after ICSI-AOA present with a suspected activation deficiency downstream of the Ca2+ machinery, which cannot be overcome by ICSI-AOA based on the use of Ca2+ ionophores. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - December 24, 2018 Category: Reproduction Medicine Source Type: research

Placental volume and other first-trimester outcomes: are there differences between fresh embryo transfer, frozen-thawed embryo transfer and natural conception?
Publication date: Available online 23 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Cécile Choux, Perrine Ginod, Julie Barberet, Thierry Rousseau, Céline Bruno, Paul Sagot, Karine Astruc, Patricia FauqueABSTRACTResearch questionDoes the mode of conception influence placental volume and other first-trimester outcomes?DesignThis retrospective single-centre case-control study led in Dijon University Hospital included 252 singleton pregnancies (84 in vitro fertilization [IVF] with either fresh embryo transfer [fresh ET] or frozen-thawed embryo transfer [FET] and 168 natural conceptions). First-tr...
Source: Reproductive BioMedicine Online - December 24, 2018 Category: Reproduction Medicine Source Type: research

Evaluation of sperm telomere length in infertile men with failed fertilization after intra-cytoplasmic sperm injection
Publication date: Available online 23 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Zahra Darmishonnejad, Marziyeh Tavalaee, Tayebeh Izadi, Somayeh Tanhaei, Mohammad Hossein Nasr-EsfahaniaABSTRACTResearch QuestionTelomeres are non-coding, repetitive DNA sequences (TTAGGG repeats) that play an important role in maintaining genome integrity. Unlike in somatic cells, telomere length in sperm increases with men age and is considered as a molecular marker of sperm quality. Etiology of failed fertilization post- intracytoplasmic sperm injection (ICSI) technique is multifactorial; perhaps one of the reasons for t...
Source: Reproductive BioMedicine Online - December 24, 2018 Category: Reproduction Medicine Source Type: research

Inferring biallelism of two FSH receptor mutations associated with spontaneous ovarian hyperstimulation syndrome by evaluating FSH, LH and hCG cross-activity
Publication date: Available online 23 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Clara Lazzaretti, Laura Riccetti, Samantha Sperduti, Claudia Anzivino, Giulia Brigante, Francesco De Pascali, Francesco Potì, Valentina Rovei, Gabriella Restagno, Caterina Mari, Cristina Lussiana, Chiara Benedetto, Alberto Revelli, Livio CasariniAbstractResearch questionWhich is the cumulative effect of two FSHR mutations in sOHSS pathogenesis? Are these mutations in the mono- or biallelic state?DesignTwo follicle stimulating hormone-receptor (FSHR) mutations were found in a pregnant patient affected by spontaneous o...
Source: Reproductive BioMedicine Online - December 24, 2018 Category: Reproduction Medicine Source Type: research

Incidence and origin of meiotic whole and segmental chromosomal aneuploidies detected by karyomapping
Publication date: Available online 23 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): David Kubicek, Miroslav Hornak, Jakub Horak, Rostislav Navratil, Gabriela Tauwinklova, Jiri Rubes, Katerina VeselaAbstractResearch questionWhat is the incidence and origin of meiotic whole and segmental aneuploidies detected by karyomapping at a blastocyst stage in human-derived IVF embryos? What is the distribution of various types of errors, including rare chromosomal abnormalities?DesignThe incidence of chromosomal aneuploidies was assessed in 967 trophectoderm biopsies from 180 couples who underwent 215 cycles of IVF wi...
Source: Reproductive BioMedicine Online - December 24, 2018 Category: Reproduction Medicine Source Type: research