The association between problematic alcohol use, risk perceptions, and e-cigarette use.
Conclusions: Both problematic alcohol use and perception of benefits of e-cigarettes were associated with having tried an e-cigarette. This finding is problematic as the use of e-cigarettes may influence further engagement in risky behaviors including problematic drinking or transitioning to regular cigarette use. Thus, it is important to develop interventions to help college students develop more accurate risk perceptions about e-cigarettes. PMID: 31433677 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - August 21, 2019 Category: Addiction Authors: Roys MR, Peltier MR, Stewart SA, Waters AF, Waldo KM, Copeland AL Tags: Am J Drug Alcohol Abuse Source Type: research

Associations between affect and alcohol consumption in adults: an ecological momentary assessment study.
Conclusion: In the current sample affective drinking was a within-person process (i.e. persons were sensitive to their varying levels of affect). Some support was found for the self-medication and expectancy models. People may drink for coping with NA, but may also be at risk for developing affective drinking patterns in response to PA. PMID: 31430201 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - August 20, 2019 Category: Addiction Authors: Duif M, Thewissen V, Wouters S, Lechner L, Jacobs N Tags: Am J Drug Alcohol Abuse Source Type: research

Convergent functional genomics of cocaine misuse in humans and animal models.
Conclusion: This is the first meta-analysis of GWES for cocaine misuse in humans and mouse and rat models. The analysis of convergence of multiple lines of genome-wide evidence identified novel candidate genes and pathways for cocaine misuse, which are of basic and clinical importance. PMID: 31368821 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - August 1, 2019 Category: Addiction Authors: Forero DA, González-Giraldo Y Tags: Am J Drug Alcohol Abuse Source Type: research

Alcohol-themed items in hospital gift shops.
PMID: 31365271 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - July 31, 2019 Category: Addiction Authors: Sonis J, Basch CH Tags: Am J Drug Alcohol Abuse Source Type: research

Cannabis effects on brain structure, function, and cognition: considerations for medical uses of cannabis and its derivatives.
Conclusions: The findings point to considerations for age limits and guidelines for use. PMID: 31365275 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - July 31, 2019 Category: Addiction Authors: Burggren AC, Shirazi A, Ginder N, London ED Tags: Am J Drug Alcohol Abuse Source Type: research

A role for the CD38 rs3796863 polymorphism in alcohol and monetary reward: evidence from CD38 knockout mice and alcohol self-administration, [11C]-raclopride binding, and functional MRI in humans.
Conclusion: Converging evidence suggests that CD38 rs3796863 genotype may increase DA-related reward response and alcohol consumption. PMID: 31365285 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - July 31, 2019 Category: Addiction Authors: Lee MR, Shin JH, Deschaine S, Daurio AM, Stangl BL, Yan J, Ramchandani VA, Schwandt ML, Grodin EN, Momenan R, Corral-Frias NS, Hariri AR, Bogdan R, Alvarez VA, Leggio L Tags: Am J Drug Alcohol Abuse Source Type: research

Guanfacine extended-release for cannabis use disorder: a pilot feasibility trial.
Abstract Background: Currently, there are no established pharmacotherapies for cannabis use disorders (CUDs). As a long-acting alpha-2-adrenergic receptor agonist, guanfacine extended-release (G-XR) could be useful in the treatment of CUDs by mitigating withdrawal and improving behavioral control. Objectives: To evaluate the feasibility and tolerability of G-XR as a treatment for CUDs. Methods: In an eight-week open-label outpatient pilot trial, we evaluated the safety and tolerability of G-XR in 22 cannabis dependent individuals. Using 2 different titration schedules, G-XR was gradually titrated to a dose of 4 mg...
Source: The American Journal of Drug and Alcohol Abuse - July 24, 2019 Category: Addiction Authors: Dakwar E, Mahony A, Choi CJ, Pavlicova M, Brooks D, Mariani JP, Levin FR Tags: Am J Drug Alcohol Abuse Source Type: research

Fluctuations in daily PTSD symptoms are related to proximal alcohol use: a micro-longitudinal study of women victims of intimate partner violence.
Conclusions: Findings suggest that IPV-exposed women use alcohol to alleviate their PTSD symptoms at the micro-process level and that prevention and treatment efforts targeting PTSD symptoms may be useful in reducing alcohol use in this population. Further, these efforts should consider the overall severity of PTSD symptoms experienced given the differential findings among women with higher vs. lower PTSD symptom severity. PMID: 31311330 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - July 16, 2019 Category: Addiction Authors: Sullivan TP, Armeli S, Tennen H, Weiss NH, Hansen NB Tags: Am J Drug Alcohol Abuse Source Type: research

Chronic pain and addiction: worry about the worrier.
PMID: 31298942 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - July 12, 2019 Category: Addiction Authors: Compton P Tags: Am J Drug Alcohol Abuse Source Type: research

Pulmonary effects of inhaled cannabis smoke.
Conclusions: Solid conclusions regarding the respiratory consequences of regular cannabis smoking are difficult to make due to a relative paucity of literature, confounding by concurrent tobacco smoking and reports of conflicting outcomes. Additional well-controlled clinical studies on the pulmonary consequences of habitual cannabis use are needed. PMID: 31298945 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - July 12, 2019 Category: Addiction Authors: Tashkin DP, Roth MD Tags: Am J Drug Alcohol Abuse Source Type: research

Comparing alcohol cue-reactivity in treatment-seekers versus non-treatment-seekers with alcohol use disorder.
Conclusion: These findings suggest that while treatment-seekers report higher levels of subjective craving than non-treatment-seekers, they are not more cue-reactive. Under the framework of medications development, we interpret these null findings to indicate that non-treatment seeking samples may be informative about CR and therefore, medication-induced effects on CR. PMID: 31295037 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - July 11, 2019 Category: Addiction Authors: Venegas A, Ray LA Tags: Am J Drug Alcohol Abuse Source Type: research

Incentivizing university students to quit smoking: a randomized controlled trial of a contingency management intervention in a developing country.
Abstract Background: Contingency management (CM) is an empirically supported behavioral treatment for tobacco use, but its efficacy with university student smokers in a developing country is unknown. Objectives: We evaluate a randomized controlled trial of a CM smoking cessation program conducted on a sample of treatment-seeking student smokers at the University of Cape Town. Methods: The study included a recruitment period, a 6-week intervention period, and a 6-month follow-up period. Subjects in the control group (information and monitoring; n = 47, 76% male) were given information to help them quit smoking and ...
Source: The American Journal of Drug and Alcohol Abuse - July 10, 2019 Category: Addiction Authors: Hofmeyr A, Kincaid H, Rusch O Tags: Am J Drug Alcohol Abuse Source Type: research

Striatal functional connectivity in chronic ketamine users: a pilot study.
Conclusions: These preliminary findings highlighted altered striatal connectivity in chronic ketamine users, and the potential role of putamen OFC connectivity in supporting the correlation between impulsivity and duration of ketamine use. If replicated in a larger sample, these findings may represent neural markers of ketamine misuse. PMID: 31264888 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - July 2, 2019 Category: Addiction Authors: Hung CC, Zhang S, Chen CM, Duann JR, Lin CP, Lee TS, Li CR Tags: Am J Drug Alcohol Abuse Source Type: research

How will cannabis legalization affect health, safety, and social equity outcomes? It largely depends on the 14 Ps.
Abstract Jurisdictions considering or implementing alternatives to cannabis supply prohibition will confront several decisions that will influence health, safety, and social equity outcomes. This essay highlights 14 of these design considerations, which all conveniently begin with the letter P: 1) Production, 2) Profit motive, 3) Power to regulate, 4) Promotion, 5) Prevention and treatment, 6) Policing and enforcement, 7) Penalties, 8) Prior criminal records, 9) Product types, 10) Potency, 11) Purity, 12) Price, 13) Preferences for licenses, and 14) Permanency. For each factor, the paper explains why it is importa...
Source: The American Journal of Drug and Alcohol Abuse - July 2, 2019 Category: Addiction Authors: Kilmer B Tags: Am J Drug Alcohol Abuse Source Type: research

Epidemiology of harmful use of alcohol in Nigeria: a systematic review and meta-analysis.
Conclusions: While the prevalence of the total population that drinks harmfully appears to be dropping, absolute number of individuals that would be classified as harmful drinkers is increasing. This finding highlights the complexity of identifying and advocating for substance abuse policies in rapidly changing demographic settings common in Africa, Asia, and other developing countries. PMID: 31246100 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - June 27, 2019 Category: Addiction Authors: Adeloye D, Olawole-Isaac A, Auta A, Dewan MT, Omoyele C, Ezeigwe N, Jacobs W, Mpazanje RG, Harhay MO, Alemu W, Adewole IF Tags: Am J Drug Alcohol Abuse Source Type: research

Psycho-physiological response to pain among individuals with comorbid pain and opioid use disorder: Implications for patients with prolonged abstinence.
Abstract Background: Individuals with comorbid opioid addiction and pain (COAP) relapse 3-5 times more often than patients with opioid use disorder (OUD) but without pain. However, psychophysiological responses to pain among a COAP population are unknown. Objectives: We hypothesized that those on Medications for Opioid Use Disorder (MOUD) with chronic pain, relative to opioid-naïve chronic pain individuals, would show greater psycho-physiological pain reactivity and slower recovery when exposed to acute pain. Methods: Four groups with chronic pain were recruited (N = 120; 60% Female): 1) MOUD-methadone; 2) MO...
Source: The American Journal of Drug and Alcohol Abuse - June 27, 2019 Category: Addiction Authors: Wachholtz A, Gonzalez G, Ziedonis D Tags: Am J Drug Alcohol Abuse Source Type: research

Spatial access to opioid treatment program and alcohol and cannabis outlets: analysis of missed doses of methadone during the first, second, and third 90 days of treatment.
Conclusions: Improving spatial accessibility of OTPs are essential to ensure treatment opportunities are available for individuals so affected. Exploring to what extent residing in areas that facilitate alcohol and cannabis availability can influence treatment adherence is warranted. PMID: 31237791 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - June 25, 2019 Category: Addiction Authors: Amiri S, Lutz RB, McDonell MG, Roll JM, Amram O Tags: Am J Drug Alcohol Abuse Source Type: research

Guiding industry settlements of opioid litigation.
Conclusions: Negotiated settlements must align with highly effective public health priorities. Crafting wise settlement agreements is necessary to assign responsibility for huge public harms and ensure future treatments that are prudent and efficacious. PMID: 31188024 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - June 12, 2019 Category: Addiction Authors: Hodge JG, Gostin LO Tags: Am J Drug Alcohol Abuse Source Type: research

CNR1 and FAAH variation and affective states induced by marijuana smoking.
Conclusion: These preliminary findings suggest individual differences in mood states after using marijuana depend on genetic variation. Such information might be useful in understanding either motivation for use of marijuana and/or risk for associated behaviors. PMID: 31184938 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - June 11, 2019 Category: Addiction Authors: Palmer RHC, McGeary JE, Knopik VS, Bidwell LC, Metrik JM Tags: Am J Drug Alcohol Abuse Source Type: research

The association between caffeinated alcoholic beverages and the perpetration of intimate partner violence.
Conclusion: Results from the current study suggest that there exists an independent link between CAB use and partner violence perpetration. PMID: 31170013 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - June 6, 2019 Category: Addiction Authors: Crane CA, Schlauch RC, Miller KE Tags: Am J Drug Alcohol Abuse Source Type: research

Cannabis legalization, regulation, & control: a review of key challenges for local, state, and provincial officials.
Conclusion: There is a need for data and oversight structures that ensure that public health will not lose out over time. PMID: 31135218 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - May 28, 2019 Category: Addiction Authors: Caulkins JP, Kilborn ML Tags: Am J Drug Alcohol Abuse Source Type: research

A cross-sectional examination of choice and behavior of veterans with access to free medicinal cannabis.
Conclusions: Results of the current study suggest that military Veterans with reduced barriers to access cannabis could be making both helpful and harmful choices regarding their cannabis use. These findings suggest that more guidance on the selection of cannabis-based products in this population is warranted, particularly as barriers to medicinal cannabis access are reduced. PMID: 31135227 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - May 28, 2019 Category: Addiction Authors: Loflin MJE, Babson K, Sottile J, Norman SB, Gruber S, Bonn-Miller MO Tags: Am J Drug Alcohol Abuse Source Type: research

Nonconformist tendencies related to risky choices in female methamphetamine abstainers.
Conclusion: Our findings provide the first objective evidence that female methamphetamine abstainers show peer nonconformity. This nonconformist tendency may be a potential behavioral marker to track drug addiction and help to elucidate the mechanisms of decisions made by female methamphetamine abstainers. PMID: 31120769 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - May 23, 2019 Category: Addiction Authors: Wei S, Liu Q, Harrington M, Sun J, Yu H, Han J, Hao M, Wu H, Liu X Tags: Am J Drug Alcohol Abuse Source Type: research

Adverse Consequences of Co-Occurring Opioid Use Disorder and Cannabis Use Disorder Compared to Opioid Use Disorder Only.
CONCLUSIONS: These data highlight the need to further investigate whether the complex effects of cannabis use on patients with OUD are counterbalanced by potential benefits of reduced in opioid prescribing. PMID: 31112429 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - May 21, 2019 Category: Addiction Authors: De Aquino JP, Sofuoglu M, Stefanovics E, Rosenheck R Tags: Am J Drug Alcohol Abuse Source Type: research

ELSA cohort 2014: association of age of first drink and progression from first drink to drunkenness on alcohol outcomes in Argentinean college freshmen.
CONCLUSIONS: The window between the first contact with alcohol and the first episode of drunkenness is a critical period to reduce alcohol-related problems. PMID: 31112434 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - May 21, 2019 Category: Addiction Authors: Vera BDV, Pilatti A, Pautassi RM Tags: Am J Drug Alcohol Abuse Source Type: research

Measurement errors and misestimation: their effects on drinking outcomes.
PMID: 31094572 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - May 16, 2019 Category: Addiction Authors: Arndt S Tags: Am J Drug Alcohol Abuse Source Type: research

The case for a medication first approach to the treatment of opioid use disorder.
CONCLUSION: Like the Housing First model, Medication First is designed to decrease human suffering and activate the strengths and capacities of people in need. It draws on decades of research and facilitates partnerships between psychosocial and medical treatment providers to offer effective and life-saving care to persons with OUD. PMID: 31084515 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - May 14, 2019 Category: Addiction Authors: Winograd RP, Presnall N, Stringfellow E, Wood C, Horn P, Duello A, Green L, Rudder T Tags: Am J Drug Alcohol Abuse Source Type: research

Identifying strengths in youths at Substance use treatment admission.
CONCLUSION: Highly sociable, hard-working, and smart were prominent strengths in the sample. Each day sober corresponded with more identified strengths, which may encourage those in early recovery. Identifying strengths can help clients find meaningful sober recreation and may be particularly useful tools for girls and those with low parental education. Developing standards for using identified strengths in treatment planning and consensus on the taxonomy of strengths are topics for future research. PMID: 31045452 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - May 2, 2019 Category: Addiction Authors: Pagano ME, Raj NM, Rhodes C, Krentzman AR, Little M Tags: Am J Drug Alcohol Abuse Source Type: research

Personality traits and negative consequences associated with binge drinking and marijuana use in college students.
CONCLUSIONS: Impulsivity, sensation seeking and disinhibition are significant associates of substance use patterns and the negative consequences of use in college students. PMID: 31042417 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - May 1, 2019 Category: Addiction Authors: O'Leary DS, Langbehn DR, Kramer JR, Kuperman S, Fuhrmeister LA, Vaidya JG Tags: Am J Drug Alcohol Abuse Source Type: research

Associations between pain catastrophizing and clinical characteristics in adults with substance use disorders and co-occurring chronic pain.
CONCLUSION: In patients with comorbid substance use disorder and chronic pain, pain catastrophizing may offer a potential therapeutic target to improve substance use treatment outcomes. PMID: 31021654 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - April 25, 2019 Category: Addiction Authors: Kneeland ET, Griffin ML, Taghian N, Weiss RD, McHugh RK Tags: Am J Drug Alcohol Abuse Source Type: research

Perceived prevalence of peer marijuana use: changes among college students before and after Oregon recreational marijuana legalization.
This study examined whether perceived peer use of marijuana changed more following RML for college students in Oregon than in states without RML. METHODS: Repeated cross-sectional data were collected from the National College Health Assessment-II surveys from 2008 to 2016 to assess changes in descriptive norms ("Within the last 30 days, what percent of students at your school used marijuana?") among 18-26 year-old undergraduates from two Oregon institutions and 123 institutions in non-RML states (N = 280,006; 66.23% female; 33.19% male) following Oregon RML (7/1/2015). Mixed-effects regressions were used to ...
Source: The American Journal of Drug and Alcohol Abuse - April 16, 2019 Category: Addiction Authors: Koval AL, Kerr DCR, Bae H Tags: Am J Drug Alcohol Abuse Source Type: research

Retrospective analysis of a gabapentin high dose taper compared to lorazepam in acute inpatient alcohol withdrawal.
CONCLUSIONS: Implementation of an institutional guideline and order set for alcohol withdrawal incorporating high dose gabapentin tapers was associated with a decreased median daily lorazepam use as well as hospital LOS; however, retrospective design and inherent limitations require larger prospective trials to validate results. PMID: 30990361 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - April 16, 2019 Category: Addiction Authors: Morrison M, Udeh E, Burak M Tags: Am J Drug Alcohol Abuse Source Type: research

Syringeability of morphine ARER, a novel, abuse-deterrent, extended-release morphine formulation.
CONCLUSION: The difficulty to syringe morphine ARER when manipulated suggests that morphine ARER has abuse-deterrent properties that may deter intravenous abuse. PMID: 30990363 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - April 16, 2019 Category: Addiction Authors: Kinzler ER, Pantaleon C, Iverson MS, Aigner S Tags: Am J Drug Alcohol Abuse Source Type: research

Characterization of intentional-abuse venlafaxine exposures reported to poison control centers in the United States.
CONCLUSION: The prevalence of venlafaxine abuse reported to poison control centers has decreased. Medical outcomes are usually not serious. Clinicians should be aware that non-medical use is possible but infrequently reported to poison control centers. PMID: 30973750 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - April 11, 2019 Category: Addiction Authors: Leonard JB, Klein-Schwartz W Tags: Am J Drug Alcohol Abuse Source Type: research

Empirical evidence of recruitment bias in a network study of people who inject drugs.
CONCLUSIONS: The results provide the evidence that for this study population of PWID, recruitment bias may significantly alter the sample composition, making results of RDS surveys less reliable. More broadly, RDS studies that fail to collect comprehensive network data may not be able to detect biased recruitment when it occurs. PMID: 30896982 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - March 21, 2019 Category: Addiction Authors: Zeng L, Li J, Crawford FW Tags: Am J Drug Alcohol Abuse Source Type: research

Anxiety sensitivity and opioid misuse among opioid-using adults with chronic pain.
CONCLUSION: These findings suggest that anxiety sensitivity may be an important treatment target among adults with chronic pain who misuse opioids. Future research should continue to explore the explanatory relevance of anxiety sensitivity in opioid misuse among individuals with chronic pain. PMID: 30896985 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - March 21, 2019 Category: Addiction Authors: Rogers AH, Kauffman BY, Bakhshaie J, McHugh RK, Ditre JW, Zvolensky MJ Tags: Am J Drug Alcohol Abuse Source Type: research

Time trends in US cannabis use and cannabis use disorders overall and by sociodemographic subgroups: a narrative review and new findings.
Abstract BACKGROUND: Due to significant comorbidity and impairment associated with cannabis use and cannabis use disorder, understanding time trends in cannabis use and cannabis use disorder is an important public health priority. OBJECTIVES: To identify trends in cannabis use and cannabis use disorder overall, and by sociodemographic subgroup. METHODS: Narrative review of published findings on trends in cannabis use and cannabis use disorders in data from repeated cross-sectional US general population surveys. In addition, in National Epidemiologic Survey on Alcohol and Related Conditions (NESARC; 2002-...
Source: The American Journal of Drug and Alcohol Abuse - March 14, 2019 Category: Addiction Authors: Hasin DS, Shmulewitz D, Sarvet AL Tags: Am J Drug Alcohol Abuse Source Type: research

Six policy lessons relevant to cannabis legalization.
CONCLUSION: Scientists and policymakers can learn from the successes and failures of alcohol and tobacco policy to regulate cannabis products, thereby mitigating old harms of cannabis prohibition while reducing new harms from legalization. PMID: 30870053 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - March 14, 2019 Category: Addiction Authors: Shover CL, Humphreys K Tags: Am J Drug Alcohol Abuse Source Type: research

Consumption outcomes in clinical trials of alcohol use disorder treatment: Consideration of standard drink misestimation.
CONCLUSIONS: Drink size misestimation may lead to inaccurate conclusions about drinking outcomes and the comparative effectiveness of AUD treatments, including inflated type-II error rates, particularly when treatment "success" is defined by binary outcomes such as NHDD. PMID: 30870054 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - March 14, 2019 Category: Addiction Authors: Kirouac M, Kruger E, Wilson AD, Hallgren KA, Witkiewitz K Tags: Am J Drug Alcohol Abuse Source Type: research

Gender differences in associations between pain-related anxiety and alcohol use among adults with chronic pain.
CONCLUSIONS: These findings are consistent with prior research, which has demonstrated associations between pain-related anxiety and deleterious substance use outcomes. Results provide initial evidence that pain-related anxiety may be a relevant factor to consider in the context of alcohol research and treatment among male drinkers. PMID: 30864852 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - March 13, 2019 Category: Addiction Authors: Zale EL, LaRowe LR, Boissoneault J, Maisto SA, Ditre JW Tags: Am J Drug Alcohol Abuse Source Type: research

Beneficial and deleterious effects of cannabinoids in the brain: the case of ultra-low dose THC.
This article reviews the neurocognitive advantages and drawbacks of cannabinoid substances, and discusses the possible physiological mechanisms that underlie their dual activity. The article further reviews the neurocognitive effects of ultra-low doses of ∆9-tetrahydrocannabinol (THC; 3-4 orders of magnitude lower than the conventional doses) in mice, and proposes such low doses of THC as a possible remedy for various brain injuries and for the treatment of age-related cognitive decline. PMID: 30864864 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - March 13, 2019 Category: Addiction Authors: Sarne Y Tags: Am J Drug Alcohol Abuse Source Type: research

Depression and risky alcohol use: an examination of the role of difficulties regulating positive emotions in trauma-exposed individuals.
CONCLUSION: Results suggest the importance of incorporating techniques focused on improving positive emotion regulation skills in interventions for risky alcohol use among individuals with depression. PMID: 30848960 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - March 8, 2019 Category: Addiction Authors: Schick MR, Weiss NH, Contractor A, Dixon-Gordon KL, Spillane NS Tags: Am J Drug Alcohol Abuse Source Type: research

A retrospective cohort study of mortality rates in patients with an opioid use disorder treated with implant naltrexone, oral methadone or sublingual buprenorphine.
CONCLUSIONS: Crude mortality rates are comparable in patients with an opioid use disorder treated with implant naltrexone, methadone, and buprenorphine. However, implant naltrexone may be associated benefits during the first 28 days of treatment and in female patients compared to methadone. PMID: 30848965 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - March 8, 2019 Category: Addiction Authors: Kelty E, Joyce D, Hulse G Tags: Am J Drug Alcohol Abuse Source Type: research

Opioid use disorder deaths and the effects of medication therapy.
PMID: 30849238 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - March 8, 2019 Category: Addiction Authors: Mannelli P, Wu LT Tags: Am J Drug Alcohol Abuse Source Type: research

Chronic intermittent ethanol administration differentially alters DeltaFosB immunoreactivity in cortical-limbic structures of rats with high and low alcohol preference.
CONCLUSIONS: The present results suggest that different alcohol intake patterns are associated with a specific pattern of DeltaFosB-ir in brain structures that play a key role in controlling behavior and decision making, that is the amygdala, the hippocampus and the prefrontal cortex. PMID: 30849242 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - March 8, 2019 Category: Addiction Authors: Wscieklica T, Le Sueur-Maluf L, Prearo L, Conte R, Viana MB, Céspedes IC Tags: Am J Drug Alcohol Abuse Source Type: research

Amphibious anti-depressants and other wonders.
PMID: 30836014 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - March 5, 2019 Category: Addiction Authors: Dakwar E Tags: Am J Drug Alcohol Abuse Source Type: research

5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) used in a naturalistic group setting is associated with unintended improvements in depression and anxiety.
CONCLUSIONS: Future prospective controlled clinical pharmacology studies should examine the safety and efficacy of 5-MeO-DMT administration for relieving depression and anxiety. PMID: 30822141 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - March 1, 2019 Category: Addiction Authors: Davis AK, So S, Lancelotta R, Barsuglia JP, Griffiths RR Tags: Am J Drug Alcohol Abuse Source Type: research

A quasi-experimental evaluation of marijuana policies and youth marijuana use.
CONCLUSION: As the first study to concurrently assess unique effects of multiple marijuana policies, results assuage concerns over potential detrimental effects of more liberal marijuana policies on youth use. PMID: 30764656 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - February 15, 2019 Category: Addiction Authors: Coley RL, Hawkins SS, Ghiani M, Kruzik C, Baum CF Tags: Am J Drug Alcohol Abuse Source Type: research

Development of a Cascade of Care for responding to the opioid epidemic.
Abstract Amid worsening opioid overdose death rates, the nation continues to face a persistent addiction treatment gap limiting access to quality care for opioid use disorder (OUD). Three FDA-approved medications (methadone, buprenorphine, and extended-release naltrexone) have high quality evidence demonstrating reductions in drug use and overdose events, but most individuals with OUD do not receive them. The development of a unified public health framework, such as a Cascade of Care, could improve system level practice and treatment outcomes. In response to feedback from many stakeholders over the past year, we h...
Source: The American Journal of Drug and Alcohol Abuse - January 24, 2019 Category: Addiction Authors: Williams AR, Nunes EV, Bisaga A, Levin FR, Olfson M Tags: Am J Drug Alcohol Abuse Source Type: research

Identifying research gaps in substance use disorder: A systematic methodology and prioritized list.
CONCLUSIONS: This paper describes a method to identify and prioritize research gaps relevant to military and civilian research and presents the prioritized SUD gaps. Our methodology and findings can inform policy makers, researchers, and funding agencies as they consider investments in future research. PMID: 30668154 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - January 22, 2019 Category: Addiction Authors: Kelber MS, Morgan MA, Beech EH, Workman DE, Evatt DP, Belsher BE, Garvey Wilson AL, Otto J, Campbell MS Tags: Am J Drug Alcohol Abuse Source Type: research