Pain Relief by Analgesic Eardrops: Paradigm Shift in the Treatment of Acute Otitis Media?
Drug Res (Stuttg) DOI: 10.1055/a-1494-3087Acute otitis media is a common middle ear infection in children with the predominant symptoms of hearing impairment and pain. If antibiotics are given, they need time to have an effect on the inflammation, so the focus is on pain control. For pain management local anesthetics have the advantage of lesser systemic side effects but are still subject to scrutiny. In this review the literature between 2000 and 2020 was systematically searched for investigating studies and recommendation in guidelines against the background of the mode of action. 11 cl...
Source: Drug Research - June 7, 2021 Category: Drugs & Pharmacology Authors: Michel, Olaf Tags: Review Source Type: research

Exploring Azatidinone Moiety: An Insight into its Anti-tubercular Potency
Drug Res (Stuttg) DOI: 10.1055/a-1481-7879TB is becoming a worldwide problem and it was declared since 1993 by the World Health Organization (WHO), a global health emergency. The current problem of tuberculosis therapy is the emergence of multi-drug resistant (MDR) strains, caused by the improper use of antibiotics in chemotherapy of TB patients. Azatidinones, a β-lactam cyclic amide with four atoms in a ring, has been considered as a magic moiety (wonder nucleus) which possesses almost all types of biological activities. This diversity in the biological response profile has attracted the attention of many researchers...
Source: Drug Research - May 25, 2021 Category: Drugs & Pharmacology Authors: Das, Rina Mehta, Dinesh Kumar Dhanawat, Meenakshi Tags: Review Source Type: research

Mechanistic Evaluation of Linalool Effect against Renal Ischemia- Reperfusion Injury in Rats
Conclusion It seems that linalool could exert a nephroprotective effect via a number of mechanisms in renal IR injury. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - May 21, 2021 Category: Drugs & Pharmacology Authors: Golmohammadi, Mohammad-Ghasem Banaei, Shokofeh Azimian, Ehsan Tags: Original Article Source Type: research

Triarylpyrazole Derivatives as Potent Cytotoxic Agents; Synthesis and Bioactivity Evaluation “Pyrazole Derivatives as Anticancer Agent”
Conclusion Concerning obtained results, it is interesting to synthesis more pyrazole derivatives as anticancer agents. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - May 19, 2021 Category: Drugs & Pharmacology Authors: Sameem, Bilqees Moghadam, Ebrahim Saeedian Darabi, Majid Shahsavari, Zahra Amini, Mohsen Tags: Original Article Source Type: research

A Concept for the Reduction of Mucosal SARS-CoV-2 Load using Hypochloric Acid Solutions
Drug Res (Stuttg) DOI: 10.1055/a-1467-5956During the next few months or years, vaccination against SARS-CoV-2 infection will significantly reduce the morbidity and mortality of COVID-19. However, additional measures are needed to protect those who are still not immunized. This is even more important in view of new viral mutations that result in increased transmission rates. We propose that the use of long-standing medicinal solutions based on hypochloric acid (HOCl) and intended for application on wounds may be effective as a gargling solution or nasal irrigation in blocking transmission of the virus. Here, we propose the ...
Source: Drug Research - April 22, 2021 Category: Drugs & Pharmacology Authors: Mueller, Christian A. Winter, Michael Renner, Bertold Tags: Short Communication Source Type: research

Synthesis of N2, N6-bis(5-methylthiazol-2-yl)pyridine-2,6-dicarboxamide fluoroscent sensor for detection of Cu2+ and Ni2+ Ions
This article reports an amide based Chemosensor used for selective detection of divalent Cu+2 and Ni+2 ions via Fluorescence turn off. The selective sensing ability of Chemosensor was investigated in presence of different metal ions Mg2+, Ag+, Fe2+, K+, Cu2+, Ni2+, Hg2+, Pb2+, Mn2+, Pd2+, Cd2+ and Mn3+ as competitive ions. The receptor i. e. Chemosensor formed complexes with metal ions in 1:1 stoichiometric ratio. The detection limit and binding constant calculated as 1.92×10–4 and 1.4×10–4 M and 2.16×103 M−1 and 3.09×103 M−1 for Cu2+ and Ni2+ions respectively. The com...
Source: Drug Research - April 22, 2021 Category: Drugs & Pharmacology Authors: Kumar, Anuroop Singh, Netrapal Kumar, Mordhwaj Agarwal, Uma Tags: Original Article Source Type: research

vHTS and 3D-QSAR for the Identification of Novel Phyto-inhibitors of Farnesyltransferase: Validation of Ascorbic Acid inhibition of Farnesyltransferase in an Animal Model of Breast Cancer
In this study, phytochemicals from Curcuma longa L., Taraxacum officinale, and Spondias mombin plants were screened for their inhibitory potentials on the human farnesyltransferase. A three-dimensional quantitative structure-activity relationship (3D-QSAR) model for the inhibition of farnesyltransferase was generated and the inhibition of farnesyltransferase by the hit, ascorbic acid was validated in an animal model of breast cancer. The lead compound, ascorbic acid makes extensive hydrogen bond interactions with key residues, lys-353, tyr-300, gly-290, leu-290 within the active site of farnesyltransferase. It downregulate...
Source: Drug Research - April 16, 2021 Category: Drugs & Pharmacology Authors: Samuel Metibemu, Damilohun Tags: Original Article Source Type: research

Famotidine Repurposing for Novel Corona Virus Disease of 2019: A Systematic Review
Conclusion Famotidine has the potential to answer the ongoing global challenge owing to its selective action on viral replication. Additionally, clinical findings in COVID-19 patients support its efficacy to reduce clinical symptoms of COVID-19.We suggest that further optimally powered randomized clinical trials should be carried out to come up with definitive conclusions. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - March 23, 2021 Category: Drugs & Pharmacology Authors: Chenchula, Santenna Ray, Avik Sadasivam, Balakrishnan Tags: Review Source Type: research

Lansoprazole a Proton Pump Inhibitor Prevents IBD by Reduction of Oxidative Stress and NO Levels in the Rat
Drug Res (Stuttg) DOI: 10.1055/a-1389-5499The inflammatory disease’s increased prevalence leads to a major concern around the world. Still, there is a lack of effective and successful therapy in the reversal of Inflammatory Bowel Disease (IBD) symptoms. Whereas, reactive oxygen species (ROS) production and muddled defense capacity of antioxidants in IBD subjects reported several times. Many proton pump inhibitors have been reported previously for their anti-inflammatory effect. The present study is aimed to assess the ameliorative effect of lansoprazole in experimentally induced IBD in rats. Thirty-six female Sprague...
Source: Drug Research - March 16, 2021 Category: Drugs & Pharmacology Authors: Gandhi, Tejal Sharma, Anish Vyas, Navdha Gupta, Parth Parikh, Mihir Shah, Hital Tags: Original Article Source Type: research

Evaluation of the Effect of Captopril and Losartan on Tacrolimus-induced Nephrotoxicity in Rats
Conclusion According to this study, tacrolimus increased the BUN and Cr levels while decreasing the ACE2 levels. However, tacrolimus in combination with losartan or captopril seemed to decrease the nephrotoxicity of the drug. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - March 12, 2021 Category: Drugs & Pharmacology Authors: Poormoosavi, Seyedeh Mahsa Behmanesh, Mohammad Amin Abeyat, Hamed Sangtarash, Ehsan Tags: Original Article Source Type: research

Thymoquinone with Metformin Decreases Fasting, Post Prandial Glucose, and HbA1c in Type 2 Diabetic Patients
Conclusion At dose levels of 50 and 100 mg of TQ combined with a daily dose of 1000 mg Metformin demonstrated a reduction in the levels of HbA1c and blood glucose compared to the standard treatment of diabetic patients with metformin alone. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - March 8, 2021 Category: Drugs & Pharmacology Authors: Ali, Shoukath M. Chen, Paul Sheikh, Saifuddin Ahmad, Ateeq Ahmad, Moghis Paithankar, Mahesh Desai, Brijesh Patel, Piyush Khan, Mujtaba Chaturvedi, Alok Patel, Ronak Panchal, Dharmendra T. Shah, Kuntal Chavda, Vipul Saboo, Banshi D. Patel, Alpesh Ahmad, Im Tags: Original Article Source Type: research

Population Pharmacokinetic Analysis of Fevipiprant in Healthy Subjects and Asthma Patients using a Tukey ’s g-and-h Distribution
Conclusion Fevipiprant PK was described by a two-compartment model with first-order absorption and first-order elimination. The TGH distribution was appropriate to describe the over-dispersed and skewed PK data as observed in the current studies. Asthma patients had approximately 37% higher exposure than healthy subjects did. Other covariates changed exposure by at most 16%. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - March 5, 2021 Category: Drugs & Pharmacology Authors: Wang, Xinting Bartels, Christian Kulkarni, Swarupa Sangana, Ramachandra Jain, Monish Zack, Julia Yu, Jing Tags: Original Article Source Type: research

Correction: In-vitro Anti-trypanosomal and Cytotoxicity Evaluation of 3-methyl-3-4-dihydroquinazolin-2(1H)-one Derivatives
Drug Res (Stuttg) DOI: 10.1055/a-1387-6035 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - February 19, 2021 Category: Drugs & Pharmacology Authors: Jesumoroti, Omobolanle J. Beteck, Richard M. Legoabe, Lesetja J. Tags: Erratum Source Type: research

In-vitro Anti-trypanosomal and Cytotoxicity Evaluation of 3-methyl-3-4-dihydroquinazolin-2(1H)-one Derivatives
Drug Res (Stuttg) DOI: 10.1055/a-1349-1256Sleeping sickness, caused by trypanosomes, is a debilitating, neglected tropical disease wherein current treatments suffer from several drawbacks such as toxicity, low activity, and poor pharmacokinetic properties, and hence the need for alternative treatment is apparent. To this effect, we screened in vitro a library of 2-quinazolinone derivatives for antitrypanosomal activity against T.b. brucei and cytotoxicity against HeLa cells. Seven compounds having no overt cytotoxicity against HeLa cells exhibited antitrypanosomal activity in th...
Source: Drug Research - February 3, 2021 Category: Drugs & Pharmacology Authors: Jesumoroti, Omobolanle J. Beteck, Richard M. Legoabe, Lesetja J. Tags: Original Article Source Type: research

Validated High-performance Liquid Chromatography Method for the Determination of JW5624, A New Class Of Hepatitis C Virus Inhibitor, in Rat Plasma and its Application in the Pharmacokinetic Study of JW5624
In this study, a sensitive and reliable method for the quantitation of JW5624 in rat plasma was developed and validated using high performance liquid chromatography. Chromatographic separation was achieved using a reversed-phase (C18) column. The mobile phase, 0.02 M ammonium acetate buffer:acetonitrile (30:70, v/v), was run at a flow rate of 1.0 mL/min, and the column eluent was monitored using an ultraviolet detector at 254 nm at room temperature. The retention times of sildenafil (an internal standard), and JW5624 were approximately 5.9 and 7.3 min, respectively. The detection limit of JW5624...
Source: Drug Research - February 3, 2021 Category: Drugs & Pharmacology Authors: Kim, Tae Kon Tags: Original Article Source Type: research

In-vitro Anti-trypanosomal and Cytotoxicity Evaluation of 3-methyl-3-4-dihydoquinazolin-2(1H)-one Derivatives
Drug Res (Stuttg) DOI: 10.1055/a-1349-1256Sleeping sickness, caused by trypanosomes, is a debilitating, neglected tropical disease wherein current treatments suffer from several drawbacks such as toxicity, low activity, and poor pharmacokinetic properties, and hence the need for alternative treatment is apparent. To this effect, we screened in vitro a library of 2-quinazolinone derivatives for antitrypanosomal activity against T.b. brucei and cytotoxicity against HeLa cells. Seven compounds having no overt cytotoxicity against HeLa cells exhibited antitrypanosomal activity in the range of 0.093–45 µM wer...
Source: Drug Research - February 3, 2021 Category: Drugs & Pharmacology Authors: Jesumoroti, Omobolanle J. Beteck, Richard M. Legoabe, Lesetja J. Tags: Original Article Source Type: research

Growth Promotion and Increased ATP-Binding Cassette Transporters Expression by Liraglutide in Triple Negative Breast Cancer Cell Line MDA-MB-231
Conclusion In conclusion, these results suggest that liraglutide should be used with caution in patients who are suffering or have the personal history of triple negative breast cancer. However, more detailed studies are required to deepen understanding of liraglutide consequences in triple negative breast cancer. ▶Graphical Abstract. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - January 21, 2021 Category: Drugs & Pharmacology Authors: Shadboorestan, Amir Tarighi, Parastoo Koosha, Mahsa Faghihi, Homa Ghahremani, Mohammad Hossein Montazeri, Hamed Tags: Original Article Source Type: research

Tadalafil Reversed H-89 – and Scopolamine – Induced Spatial Learning Impairments in Male Rats
Drug Res (Stuttg) DOI: 10.1055/a-1345-7832Accumulated evidence shows that the cAMP and cGMP signaling pathway plays an important role in memory function and neuronal plasticity. Phosphodiesterase 5 (PDE5) is a hopeful therapeutic target in AD (Alzheimer disease), and PDE5 inhibition may be a good therapeutic strategy for the treatment of AD. In the present study, the four-day bilateral intra-hippocampal infusion of H-89 as a protein kinase AII inhibitor (10 µM/side) and intra-peritoneal injections of tadalafil (20 mg/kg) and scopolamine (0.5 mg/kg) alone and also on combination on spatial learnin...
Source: Drug Research - January 15, 2021 Category: Drugs & Pharmacology Authors: Tabrizian, Kaveh Amelinia, Fatemeh Belaran, Maryam Pourheidar, Soheil Mirzaei, Hadi Fanoudi, Sahar Tags: Original Article Source Type: research

Macrophage Activation and Cytokine Release Syndrome in COVID-19: Current Updates and Analysis of Repurposed and Investigational Anti-Cytokine Drugs
Drug Res (Stuttg) DOI: 10.1055/a-1291-7692Coronavirus disease (COVID-19) emerged from Wuhan, has now become pandemic and the mortality rate is growing exponentially. Clinical complication and fatality rate is much higher for patients having co-morbid issues. Compromised immune response and hyper inflammation is hall mark of pathogenesis and major cause of mortality. Cytokine release syndrome (CRS) or cytokine storm is a term used to affiliate the situation of hyper inflammation and therefore use of anti-cytokine and anti-inflammatory drugs is used to take care of this situation. Lo...
Source: Drug Research - January 12, 2021 Category: Drugs & Pharmacology Authors: Iqubal, Ashif Hoda, Farazul Najmi, Abul Kalam Haque, Syed Ehtaishamul Tags: Review Source Type: research

Synthesis of Novel Triazolyl/Oxadiazolyl/Thiadiazolyl-Piperazine as Potential Anticonvulsant Agents
Drug Res (Stuttg) DOI: 10.1055/a-1291-7554Reaction of piperazine with chloroacetylchloride in dry acetone yield compound 1 , which on reaction with hydrazine hydrate yielded compound 2, which was further reacted with various substituted phenylisothiocyanates in absolute alcohol to afford compounds 3–8 i. e. 2-(carbazolylacetyl)-N-(substitutedphenyl)-hydrazinepiperazinothioamides. Compounds 3–8 on reaction with aqueous NaOH, ethanolic NaOH and conc. H2SO4 afford triazoles 9–14, oxadiazoles 15–20 and thiadiazoles 21–26 respectively. T...
Source: Drug Research - January 12, 2021 Category: Drugs & Pharmacology Authors: Archana, Archana Tags: Original Article Source Type: research

Efficacy and Safety of Tocilizumab for Coronavirus Disease 2019 (Covid-19) Patients: A Systematic Review and Meta-analysis
This study aims to give clear evidence regarding the potential benefit and safety of tocilizumab in improving the outcome of COVID-19 patients. Methods We systematically searched the PubMed and Europe PMC database using specific keywords related to our aims until November 1st, 2020. All articles published on COVID-19 and tocilizumab were retrieved. Statistical analysis was done using Review Manager 5.4 software. Results A total of 38 studies with a total of 13 412 COVID-19 patients were included in our analysis. Our meta-analysis showed that tocilizumab treatment is associated with reduction of mortality rate from COVID-19...
Source: Drug Research - January 5, 2021 Category: Drugs & Pharmacology Authors: Hariyanto, Timotius Ivan Hardyson, Willie Kurniawan, Andree Tags: Original Article Source Type: research

Recent Therapeutic Interventions of Fenugreek Seed: A Mechanistic Approach
Drug Res (Stuttg) DOI: 10.1055/a-1320-0479Fenugreek seeds have widespread relations with Ayurveda, Unani, and Arabic medicine. The seeds were useful for the treatment and prevention of different ailments. Fenugreek (Trigonella foenum-graecum) or methi is from the Leguminosae family and are primarily known for its anti-diabetic and hypocholesterolemic activities. The germinated fenugreek seeds were used in the treatment of E.coli infection in Germany and France. The important phytoconstituents responsible for such medicinal applications are saponins, polyunsaturated fatty acids, galactomannans, trigonelline, and 4-hydroxy i...
Source: Drug Research - December 30, 2020 Category: Drugs & Pharmacology Authors: Idris, Sahar Mishra, Anuradha Khushtar, Md Tags: Review Source Type: research

A Panoramic Review on Lepidium sativum L. Bioactives as Prospective Therapeutics
Conclusion The present article appraised that L. sativum extract has a potential therapeutic effect against liver toxicity and hepato-carcinoma. Graphical Abstract. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - December 30, 2020 Category: Drugs & Pharmacology Authors: Ahmad, Asad Nabi, Rabia Mishra, Anuradha Ahmad, Iffat Zareen Tags: Review Source Type: research

Development of a Physiologically-Based Pharmacokinetic (PBPK) Model of Nebulized Hydroxychloroquine for Pulmonary Delivery to COVID-19 Patients
Drug Res (Stuttg) DOI: 10.1055/a-1325-0248Despite inconclusive evidence, chloroquine (CQ) and hydroxychloroquine (HCQ)are commonly used for the treatment of Corona virus Disease 2019(COVID-19) in critically ill patients.It was hypothesized that HCQ as an aerosol application can reach the antiviral concentration of ~1–5 μM in the alveolar cells which has been proven effective in vitro. A physiologically-based pharmacokinetic (PBPK) model of nebulized HCQ for pulmonary delivery to COVID-19 patients using the Nasal-Pulmonary Module in GastroPlus® V9.7 simulator, in order to calculate the necessary inhalati...
Source: Drug Research - December 30, 2020 Category: Drugs & Pharmacology Authors: Idkaidek, Nasir Hawari, Feras Dodin, Yasmeen Obeidat, Nour Tags: Opinion Paper Source Type: research

Therapeutic Approach Against 2019-nCoV by Inhibition of the ACE-2 receptor
Drug Res (Stuttg) DOI: 10.1055/a-1337-4462The continued spread of the 2019 novel coronavirus (2019-nCoV) has prompted global concern. The formal name given to 2019-nCoV by the World Health Organization is COVID-19, while the International Committee on Taxonomy has named it severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Due to this viral attack, nations around the world have issued lockdown restrictions. Presently, there is no effective way to control the spread of 2019-nCoV, except through social distancing and hygienic activities. World-class scientists and researchers are trying to develop vaccines and med...
Source: Drug Research - December 23, 2020 Category: Drugs & Pharmacology Authors: Kumar, Gajendra Kumar, Dharmendra Singh, Netra Pal Tags: Original Article Source Type: research

Formulation and Characterization of Losartan Loaded Chitosan Microspheres: Effect of Crosslinking Agents
Conclusion The outcome of in vitro release and other characterizations of microspheres explicitly revealed glutaraldehyde as the best cross-linker amongst the cross-linkers used herewith. The maximum sustained effect (lasting over a period of 24 h) accompanied with higher MDT and t50% with lower%DE and Q14h values thus corroborated the objective of attaining sustained release of Losartan. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - December 21, 2020 Category: Drugs & Pharmacology Authors: Pahuja, Sonia Aggarwal, Shweta Sarup, Prerna Tags: Original Article Source Type: research

Short-term Effects of Metformin on Cardiac and Peripheral Blood Cells Following Cecal Ligation and Puncture-induced Sepsis
Conclusions Our findings suggest that in CLP induced sepsis model, metformin can improve the function of blood and cardiac cells through alleviating inflammation, improvement of anti-inflammation properties, and enhancement of blood profile, and all these effects are more pronounced after 24 h in comparison with 12 h after induction of sepsis. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - December 21, 2020 Category: Drugs & Pharmacology Authors: Didari, Tina Hassani, Shokoufeh Baeeri, Maryam Navaei-Nigjeh, Mona Rahimifard, Mahban Haghi-Aminjan, Hamed Gholami, Mahdi Nejad, Solmaz Mohammadi Hassan, Fatima Ismail Mojtahedzadeh, Mojtaba Abdollahi, Mohammad Tags: Original Article Source Type: research

Piperazine: A Promising Scaffold with Analgesic and Anti-inflammatory Potential
Drug Res (Stuttg) DOI: 10.1055/a-1323-2813Piperazine, a nitrogen-containing heterocyclic has acquired an inimitable position in medicinal chemistry because of its versatile structure, which has fascinated researchers to design novel piperazine based molecules having various biological actions. The subsistence of various compounds possessing diverse pharmacological activities in the literature further confirms this fact. Currently available analgesics and anti-inflammatory drugs are associated with side effects that limit their use. Moreover, the literature reveals the incredible anti-inflammatory and analgesic potential of...
Source: Drug Research - December 17, 2020 Category: Drugs & Pharmacology Authors: Jain, Akash Chaudhary, Jasmine Khaira, Harpreet Chopra, Bhawna Dhingra, Ashwani Tags: Review Source Type: research

Recent Advancement of Synthesis of Isatins as a Versatile Pharmacophore: A review
Drug Res (Stuttg) DOI: 10.1055/a-1238-2639Isatin (1 H-indole-2, 3-Dione) and its derivatives are versatile compounds which acts as a precursor for a large number of pharmacologically active compounds. Therefore isatins have a significant importance in the synthesis of different heterocyclic compounds. Isatins show variety of biological activities. In this review we focus on synthetic methods of isatins and their biological activities such as antimicrobial, anticonvulsant, anti-inflammatory and analgesic activity, antitubercular activity. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArti...
Source: Drug Research - December 9, 2020 Category: Drugs & Pharmacology Authors: Kumar, Gajendra Singh, Netra Pal Kumar, Kaushal Tags: Review Source Type: research

Role of Bisphosphonates in The Prevention of Postoperative Hungry Bone Syndrome in Primary Hyperparathyroidism: A Meta-Analysis and Need for Randomized Controlled Trials
Drug Res (Stuttg) DOI: 10.1055/a-1325-0351 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - December 9, 2020 Category: Drugs & Pharmacology Authors: Pal, Rimesh Gautam, Akanksha Bhadada, Sanjay Kumar Tags: Letter Source Type: research

Antimicrobial Screening, in Silico Studies and QSAR of Chalcone-based 1,4-disubstituted 1,2,3-triazole Hybrids
Drug Res (Stuttg) DOI: 10.1055/a-1296-7751The in vitro antimicrobial properties of some chalcones (1a–1c ) and chalcone tethred 1,4-disubstituted 1,2,3-triazoles (2a–2u) towards different microbial strains viz. Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Aspergillus niger and Candida albicans are reported. Compounds 2g and 2u exhibited better potency than the standard Fluconazole with MIC values of 0.0063 µmol/mL and 0.0068 µmol/mL, respectively. Furthermore, molecular docking was performed to investigate the binding modes of two potent compounds 2q and 2g wit...
Source: Drug Research - December 7, 2020 Category: Drugs & Pharmacology Authors: Yadav, Pinki Lal, Kashmiri Kumar, Ashwani Tags: Original Article Source Type: research

Synthesis, Biological Evaluation and Docking Study of New Pyrimidine Compounds as Anticancer Agents
Conclusion Altogether, with respect to obtained results, it is attractive and beneficial to further investigation on pyrimidine scaffold as antimitotic agents. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - December 7, 2020 Category: Drugs & Pharmacology Authors: Boumi, Shahin Moghimirad, Jafar Ostad, Seyed Nasser Amanlou, Massoud Tavajohi, Shohreh Amini, Mohsen Tags: Original Article Source Type: research

Stabilization of Mitochondrial Function by Ellagic Acid Prevents Celecoxib-induced Toxicity in Rat Cardiomyocytes and Isolated Mitochondria
This study was designed to explore protective effect of ellagic acid (EA) against celecoxib-induced cellular and mitochondrial toxicity in cardiomyocytes and their isolated mitochondria. In order to do this, isolated cardiomyocytes and mitochondria were pretreated with 3 different concentrations of EA (10, 50 and 100 µM), after which celecoxib (16 µg/ml) was added to promote deleterious effects on cells and mitochondria. Using flow cytometry and biochemical methods, the parameters of cellular and mitochondrial toxicity were investigated. Our results showed that celecoxib (16 µg/ml) caused a ...
Source: Drug Research - December 4, 2020 Category: Drugs & Pharmacology Authors: Atashbar, Saman Sabzalipour, Towhid Salimi, Ahmad Tags: Original Article Source Type: research

Sitagliptin as an Initial Therapy and Differential Regulations of Metabolic Parameters Depending on its Glycemic Response in Subjects with Type 2 Diabetes
Drug Res (Stuttg) DOI: 10.1055/a-1304-3430The aim of this study is to investigate whether sitagliptin can be used as an initial drug for T2DM and to evaluate its effects on metabolic parameters in relation to its glycemic efficacies. The subjects received 25−50 mg/day sitagliptin monotherapy (n=69). At 3 months, they were divided into three groups (n=23 each) according to the novel parameter called “A1c index” which is designed to assess glycemic efficacy. The metabolic parameters were compared between good-responders and poor-responders. These two groups a...
Source: Drug Research - November 25, 2020 Category: Drugs & Pharmacology Authors: Kutoh, Eiji Kuto, Alexandra N. Wada, Askuka Hayashi, Jyunka Kurihara, Rumi Tags: Original Article Source Type: research

Design, Synthesis and Enhanced BBB Penetration Studies of L-serine-Tethered Nipecotic Acid-Prodrug
Drug Res (Stuttg) DOI: 10.1055/a-1290-0119Nipecotic acid is considered to be one of the most potent inhibitors of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Due to its hydrophilic nature, nipecotic acid does not readily cross the blood-brain barrier (BBB). Large neutral amino acids (LAT1)-knotted nipecotic acid prodrug was designed and synthesized with the aim to enhance the BBB permeation by the use of carrier-mediated transport. The synthesized prodrug was tested in animal models of Pentylenetetrazole (PTZ)-induced convulsions in mice. Further pain studies were ...
Source: Drug Research - November 25, 2020 Category: Drugs & Pharmacology Authors: Dhanawat, Meenakshi Gupta, Sumeet Mehta, Dinesh Kumar Das, Rina Tags: Original Article Source Type: research

Kava (Piper methysticum) Extract for the Treatment of Nervous Anxiety, Tension and Restlessness
Conclusions Overall, the study confirms the effective and safe short-term use of kava in the Commission E-defined indication of “nervous anxiety, tension and restlessness”, especially in other than chronic cases. The clinical use of kava might be translated into context-related phobias according to ICD-10 F40, or to nervous tension (ICD10 R45.0) or restlessness and excitation (ICD-10 R45.1). [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full te...
Source: Drug Research - November 18, 2020 Category: Drugs & Pharmacology Authors: Kuchta, Kenny Hladikova, Marie Thomsen, Michael Nahrstedt, Adolf Schmidt, Mathias Tags: Original Article Source Type: research

Development of Composition and Technologies of Dental Film with Ketorolac Trometamine
Drug Res (Stuttg) DOI: 10.1055/a-1302-7701The report presents the results of the development of dental films with ketorolac trometamine based on the natural biodegradable polymers from the groups of sodium alginates and xanthan gums in combination with lightly crosslinked acrylic polymer carbopol. Physicochemical properties, such as moisture, mucoadhesion, thickness, tensile strength, disintegration in phosphate buffer were determined in obtained samples of this dosage form. A comparison of physicochemical properties of experimental samples and commercial model of dental film has a...
Source: Drug Research - November 18, 2020 Category: Drugs & Pharmacology Authors: Bakhrushina, Elena O. Demina, Natalia B. Kashperko, Alena S. Vakina, Marina G. Anurova, Maria N. Zhilyakova, Elena T. Krasnyuk, Ivan I. Tags: Original Article Source Type: research

Der lange Weg zur personalisierten Medizin in der Allergologie
Drug Res (Stuttg) 2020; 70: S30-S31 DOI: 10.1055/a-1119-2827 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 17, 2020 Category: Drugs & Pharmacology Authors: Bieber, Thomas Tags: Extended Abstract Source Type: research

Epigenetic Regulation of Allergic Disease
Drug Res (Stuttg) 2020; 70: S29-S29 DOI: 10.1055/a-1119-2816 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 17, 2020 Category: Drugs & Pharmacology Authors: Renz, Harald Tags: Extended Abstract Source Type: research

Klimawandel und Gesundheit – wird die Tsunami-Welle allergischer Erkrankungen in Zukunft noch höher?
Drug Res (Stuttg) 2020; 70: S27-S28 DOI: 10.1055/a-1119-2805 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 17, 2020 Category: Drugs & Pharmacology Authors: Traidl-Hoffmann, Claudia Tags: Extended Abstract Source Type: research

Die Allergen-Immuntherapie – State of the Art 2020
Drug Res (Stuttg) 2020; 70: S24-S26 DOI: 10.1055/a-1119-2783 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 17, 2020 Category: Drugs & Pharmacology Authors: Pfaar, Oliver Tags: Extended Abstract Source Type: research

Therapiestrategien im Alltag (Steroide, Antihistaminika)
Drug Res (Stuttg) 2020; 70: S22-S23 DOI: 10.1055/a-1119-2762 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 17, 2020 Category: Drugs & Pharmacology Authors: von Kiedrowski, Ralph Tags: Extended Abstract Source Type: research

Molekulare Allergiediagnostik
Drug Res (Stuttg) 2020; 70: S17-S21 DOI: 10.1055/a-1119-2751 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 17, 2020 Category: Drugs & Pharmacology Authors: Kleine-Tebbe, J örg Tags: Extended Abstract Source Type: research

Bedeutung von Mikrobiomen in Darm und Atemwegen f ür Therapien
Drug Res (Stuttg) 2020; 70: S16-S16 DOI: 10.1055/a-1119-2740 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 17, 2020 Category: Drugs & Pharmacology Authors: von Mutius, Erika Tags: Extended Abstract Source Type: research

Arzneimittelreaktion: Allergie vs. Intoleranz gegen über Wirkstoffen
Drug Res (Stuttg) 2020; 70: S15-S15 DOI: 10.1055/a-1119-2729 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 17, 2020 Category: Drugs & Pharmacology Authors: Zuberbier, Torsten Tags: Extended Abstract Source Type: research

Adverse Cutaneous Drug Reactions
Drug Res (Stuttg) 2020; 70: S13-S14 DOI: 10.1055/a-1119-2708 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 17, 2020 Category: Drugs & Pharmacology Authors: French, Lars E. Tags: Extended Abstract Source Type: research

Anaphylaxien nach Arzneimittelgabe
Drug Res (Stuttg) 2020; 70: S12-S12 DOI: 10.1055/a-1119-2697 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 17, 2020 Category: Drugs & Pharmacology Authors: Worm, Margitta Tags: Extended Abstract Source Type: research

Nahrungsmittelallergien – Vorkommen und Behandlungsstrategien
Drug Res (Stuttg) 2020; 70: S10-S11 DOI: 10.1055/a-1119-2676 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 17, 2020 Category: Drugs & Pharmacology Authors: Schmid-Grendelmeier, Peter Tags: Extended Abstract Source Type: research

Allergische Rhinitis – Diagnostik und Therapieoptionen
Drug Res (Stuttg) 2020; 70: S7-S9 DOI: 10.1055/a-1119-2665 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 17, 2020 Category: Drugs & Pharmacology Authors: Klimek, Ludger Tags: Extended Abstract Source Type: research

Allergisches Asthma – Behandlungsoptionen
Drug Res (Stuttg) 2020; 70: S6-S6 DOI: 10.1055/a-1119-2654 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 17, 2020 Category: Drugs & Pharmacology Authors: Virchow, Johann-Christian Tags: Extended Abstract Source Type: research