Development of the Composition of the Biopolymer Base for Nasal Gel
Conclusion The obtained data shows prospects of applying the samples for the development of nasal gel with an immunobiological substance. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - January 22, 2020 Category: Drugs & Pharmacology Authors: Bakhrushina, Elena Demina, Natalya Krasnyuk, Ivan Moiseeva, Anna Tags: Original Article Source Type: research

A Review: Prevention, Treatment and Management of Tuberculosis through Combinational Approaches of Different Indian Systems of Medicine
Drug Res (Stuttg) DOI: 10.1055/a-1078-1087Tuberculosis (TB) is one of the oldest fatal diseases of history. Multidrugresistant tuberculosis (MDRTB) is a major public health issue in the world. In India, the incidence is getting up despite the Indian revised National Tuberculosis Control Programme. India has six recognize medicine systems in this category, namely Ayurveda, Siddha, Unani and Yoga, Naturopathy and Homoeopathy. This review study was undertaken to evaluate the efficacy of different drug treatments based on Indian Systems of Traditional Medicines to the standard MDR-TB regimen. This review mainly focuses on the ...
Source: Drug Research - January 13, 2020 Category: Drugs & Pharmacology Authors: Sharma, Priyanka Goyal, Ramesh K. Nandave, Mukesh Tags: Review Source Type: research

Validated HPLC Method for Quantification of a Novel Trk Inhibitor, Larotrectinib in Mice Plasma: Application to a Pharmacokinetic Study
Drug Res (Stuttg) DOI: 10.1055/a-1071-0849Larotrectinib, is an orally active novel small molecule approved for the treatment of solid tumors in pediatrics and adult patients. It acts by inhibiting tropomyosin receptor kinase. In this paper, we report the development and validation of a high-performance liquid chromatography (HPLC) method for the quantitation of larotrectinib in mice plasma as per the FDA regulatory guideline. Plasma samples processing was accomplished through simple protein precipitation using acetonitrile enriched with internal standard (IS, enasidenib). The chromatographic analysis was performed using a ...
Source: Drug Research - January 13, 2020 Category: Drugs & Pharmacology Authors: Tripathy, Harsha K. Nair Manju, S.V. Zakkula, Ashok Bestha, Ram Murthi Dittakavi, Sreekanth Mullangi, Ramesh Tags: Original Article Source Type: research

Toxicity of Pioglitazone on Mitochondria Isolated from Brain and Heart: An Analysis for Probable Drug-Induced Neurotoxicity and Cardiotoxicity
In this study, we investigated the effect of PG on mitochondria isolated from brain and heart. Mitochondrial parameters such as succinate dehydrogenase (SDH) activity, reactive oxygen species (ROS) generation, collapse in mitochondrial membrane potential (MMP), mitochondrial swelling and cytochrome c release were evaluated. The results showed that PG at concentrations of 12.5, 25 and 50 µg/ml increased the generation of ROS, the collapse of MMP, mitochondrial swelling and the release of cytochrome c in mitochondria isolated from both brain and heart tissues. The underlying mechanisms of PG induced neuro-toxici...
Source: Drug Research - January 13, 2020 Category: Drugs & Pharmacology Authors: Seydi, Enaytollah Servati, Tina Samiei, Fatemeh Naserzadeh, Parvaneh Pourahmad, Jalal Tags: Original Article Source Type: research

Acknowledgement for Reviewers
Drug Res (Stuttg) 2020; 70: 4-5 DOI: 10.1055/a-1067-7220 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - January 3, 2020 Category: Drugs & Pharmacology Tags: Acknowledgement for Reviewers Source Type: research

Persea Americana Seeds Cause Ileal Smooth Muscle Relaxation Via Stimulation of α-1 Adrenoceptors
Drug Res (Stuttg) DOI: 10.1055/a-1076-0703The effect of methanol extract of P. americana seeds on isolated ileal smooth muscle was studied for isometric response using 10 adult rabbits of both sexes. Reactivity and agonist-antagonist responses of rabbit ileum to the extract were determined in this study. The affinity, effective concentration to give 50% response (EC50) and maximum response were calculated from the concentration response curves (CRC) obtained. The result for the reactivity study showed the seed extract of P. americana caused concentration dependent relaxation of isolated rabbit ileum with threshold response...
Source: Drug Research - January 2, 2020 Category: Drugs & Pharmacology Authors: Oridupa, Olayinka Ayotunde Oshinloye, Adedunke Omobolanle Obisesan, Ayobami Deborah Olateju, Opeyemi Mordiyah Adenuga, Victor Adedotun Tags: Original Article Source Type: research

Evaluation of Phytochemical and Pharmacological Activity of Carissa carandas L. Fruits at Three Different Stages of Maturation
Drug Res (Stuttg) DOI: 10.1055/a-0815-4832Inflammation plays an important role in various diseases with high prevalence within populations such as rheumatoid arthritis, ulcer, atherosclerosis and asthma. Many drugs are available in the market for inflammatory diseases but they exhibit several unwanted side effects. Therefore, alternative treatments with safer compounds are needed. The plant Carissa carandas L. plant is used traditionally for the treatment of various diseases. Hence to validate its traditional use, the present study has envisaged screening different solvents extract of Carissa carandas fruit for their phyto...
Source: Drug Research - December 4, 2019 Category: Drugs & Pharmacology Authors: Saher, Shabnam Narnawre, Smita Patil, Jayshree Tags: Original Article Source Type: research

Pharmacokinetic and Tolerability Comparison of Sustained and Immediate Release Oral Formulations of Nifedipine Tablet Formulations: A Single-Dose, Randomized, Open-Label, Two-Period, Two-Way Crossover Study in Healthy, Fasting Egyptian Male Volunteers
This study aimed to to compare the pharmacokinetics and safety profiles of a 20 mg SR and IR (immediate release) formulation of nifedipine after single-dose administration in healthy Egyptian subjects. Randomized, crossed open-label two- way clinical trial, in 16 healthy adult volunteers, of 24.75±5.20 years, with BMI 23.26±1.756 were assessed. Blood samples were collected at predefined times for 48 h and analyzed for Nifedipine plasma concentrations using validated reversed phase liquid chromatography method with ultraviolet detection. Pharmacokinetics was determined using non- compartmental mo...
Source: Drug Research - November 19, 2019 Category: Drugs & Pharmacology Authors: El-Masry, Soha Mahmoud El-Khodary, Noha Mahmoud Tags: Original Article Source Type: research

Behandlung der Altersdepression
Drug Res (Stuttg) 2019; 69: S31-S31 DOI: 10.1055/a-0982-5242 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 15, 2019 Category: Drugs & Pharmacology Authors: Peters, Oliver Tags: Symposium der Paul-Martini-Stiftung Source Type: research

Besonderheiten der Behandlung von Diabetikern im Alter
Drug Res (Stuttg) 2019; 69: S29-S30 DOI: 10.1055/a-0982-5231 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 15, 2019 Category: Drugs & Pharmacology Authors: Bollheimer, Cornelius Tags: Symposium der Paul-Martini-Stiftung Source Type: research

Schmerzbehandlung beim Hochbetagten
Drug Res (Stuttg) 2019; 69: S27-S28 DOI: 10.1055/a-0982-5210 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 15, 2019 Category: Drugs & Pharmacology Authors: Tafelski, Sascha Tags: Symposium der Paul-Martini-Stiftung Source Type: research

State of the Art: Osteoporose, Sarkopenie, Frailty
Drug Res (Stuttg) 2019; 69: S26-S26 DOI: 10.1055/a-0982-5198 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 15, 2019 Category: Drugs & Pharmacology Authors: Bauer, J ürgen M. Tags: Symposium der Paul-Martini-Stiftung Source Type: research

Differenzialtherapie im Alter am Beispiel der Arteriellen Hypertonie
Drug Res (Stuttg) 2019; 69: S24-S25 DOI: 10.1055/a-0982-5166 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 15, 2019 Category: Drugs & Pharmacology Authors: Denkinger, Michael Tags: Symposium der Paul-Martini-Stiftung Source Type: research

Demenz, Delir, Depression, Parkinsonsyndrom als m ögliche Arzneimittelnebenwirkung im Alter
Drug Res (Stuttg) 2019; 69: S23-S23 DOI: 10.1055/a-0982-5154 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 15, 2019 Category: Drugs & Pharmacology Authors: Fl öel, Agnes Tags: Symposium der Paul-Martini-Stiftung Source Type: research

Typische Verschreibungskaskaden beim multimorbiden Patienten
Drug Res (Stuttg) 2019; 69: S21-S22 DOI: 10.1055/a-0982-5129 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 15, 2019 Category: Drugs & Pharmacology Authors: Heppner, Hans J ürgen Tags: Symposium der Paul-Martini-Stiftung Source Type: research

Adh ärenz im Alter – Wie angehen?
Drug Res (Stuttg) 2019; 69: S19-S20 DOI: 10.1055/a-0982-5118 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 15, 2019 Category: Drugs & Pharmacology Authors: Albus, Christian Tags: Symposium der Paul-Martini-Stiftung Source Type: research

Negativlisten und Positivlisten in der Pharmakotherapie älterer Patienten
Drug Res (Stuttg) 2019; 69: S16-S18 DOI: 10.1055/a-0982-5107 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 15, 2019 Category: Drugs & Pharmacology Authors: Wehling, Martin Tags: Symposium der Paul-Martini-Stiftung Source Type: research

Aktuelle Projekte und Leitlinien zum Umgang mit Multimedikation
Drug Res (Stuttg) 2019; 69: S14-S15 DOI: 10.1055/a-0982-5096 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 15, 2019 Category: Drugs & Pharmacology Authors: Th ürmann, Petra A. Tags: Symposium der Paul-Martini-Stiftung Source Type: research

Medizinische Versorgung im Alter – welche Evidenz brauchen wir? Empfehlungen der Leopoldina
Drug Res (Stuttg) 2019; 69: S12-S13 DOI: 10.1055/a-0982-5065 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 15, 2019 Category: Drugs & Pharmacology Authors: Th ürmann, Petra A. Tags: Symposium der Paul-Martini-Stiftung Source Type: research

Vaccination in Old Age
Drug Res (Stuttg) 2019; 69: S10-S11 DOI: 10.1055/a-0982-4959 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 15, 2019 Category: Drugs & Pharmacology Authors: Weinberger, Birgit Tags: Symposium der Paul-Martini-Stiftung Source Type: research

Multimorbidit ät und geänderte Pharmakodynamik im Alter
Drug Res (Stuttg) 2019; 69: S9-S9 DOI: 10.1055/a-0982-5054 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 15, 2019 Category: Drugs & Pharmacology Authors: Burkhardt, Heinrich Tags: Symposium der Paul-Martini-Stiftung Source Type: research

Does Everything Get Slower with Age? Pharmacokinetics in the Elderly
Drug Res (Stuttg) 2019; 69: S7-S8 DOI: 10.1055/a-0982-5043 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 15, 2019 Category: Drugs & Pharmacology Authors: H öchel, Joachim Tags: Symposium der Paul-Martini-Stiftung Source Type: research

Arzneimittelsicherheit im Alter – wissen wir genug über die Arzneimitteltherapie bei älteren Patienten?
Drug Res (Stuttg) 2019; 69: S6-S6 DOI: 10.1055/a-0982-5006 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 15, 2019 Category: Drugs & Pharmacology Authors: Stingl, Julia Tags: Symposium der Paul-Martini-Stiftung Source Type: research

Einf ührung in den Altersbegriff
Drug Res (Stuttg) 2019; 69: S5-S5 DOI: 10.1055/a-0982-4993 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 15, 2019 Category: Drugs & Pharmacology Authors: M üller-Werdan, Ursula Tags: Symposium der Paul-Martini-Stiftung Source Type: research

Editorial
Drug Res (Stuttg) 2019; 69: S4-S4 DOI: 10.1055/a-0982-4982 Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - November 15, 2019 Category: Drugs & Pharmacology Authors: M üller-Werdan, Ursula Endres, Stefan Tags: Symposium der Paul-Martini-Stiftung Source Type: research

Molecular Docking Studies and Synthesis of Amino-oxy-diarylquinoline Derivatives as Potent Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors
In this study, amino-oxy-diarylquinolines were designed using structure-guided molecular hybridization strategy and fusing of the pharmacophore templates of nevirapine (NVP), efavirenz (EFV), etravirine (ETV, TMC125) and rilpivirine (RPV, TMC278). The anti-HIV-1 reverse transcriptase (RT) activity was evaluated using standard ELISA method, and the cytotoxic activity was performed using MTT and XTT assays. The primary bioassay results indicated that 2-amino-4-oxy-diarylquinolines possess moderate inhibitory properties against HIV-1 RT. Molecular docking results showed that 2-amino-4-oxy-diarylquinolines 8(a-d) interacted wi...
Source: Drug Research - November 7, 2019 Category: Drugs & Pharmacology Authors: Makarasen, Arthit Kuno, Mayuso Patnin, Suwicha Reukngam, Nanthawan Khlaychan, Panita Deeyohe, Sirinya Intachote, Pakamas Saimanee, Busakorn Sengsai, Suchada Boonsri, Pornthip Chaivisuthangkura, Apinya Sirithana, Wandee Techasakul, Supanna Tags: Original Article Source Type: research

The Nephroprotective Role of Carnosine Against Ifosfamide-Induced Renal Injury and Electrolytes Imbalance is Mediated Via the Regulation of Mitochondrial Function and Alleviation of Oxidative Stress
Conclusion Our data suggest mitochondrial dysfunction and oxidative stress as fundamental mechanisms of renal injury induced by IFO. On the other hand, carnosine supplementation protected kidneys against IFO-induced injury through regulating mitochondrial function and mitigating oxidative stress. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - October 31, 2019 Category: Drugs & Pharmacology Authors: Ommati, Mohammad Mehdi Farshad, Omid Ghanbarinejad, Vahid Mohammadi, Hamid Reza Khadijeh, Mousavi Negar, Azarpira Zahra, Mahboubi Ilkhaninasab, Farshid Moezi, Leila Heidari, Reza Tags: Original Article Source Type: research

Validated LC-MS/MS Method for Simultaneous Quantitation of Enasidenib and its Active Metabolite, AGI-16903 in Small Volume Mice Plasma: Application to a Pharmacokinetic Study
Drug Res (Stuttg) DOI: 10.1055/a-1024-3623Enasidenib is a selective mutant isocitrate dehydrogenase 2 inhibitor approved for the treatment of relapsed and refractory acute myeloid leukemia patients. A sensitive and rapid method has been developed and validated as per regulatory guideline for the simultaneous quantitation of enasidenib and its active metabolite, AGI-16903 in mice plasma using an LC-MS/MS. Enasidenib and AGI-16903 along with internal standard were extracted from mice plasma using simple protein precipitation method. Chromatographic resolution of enasidenib, AGI-16903 and the internal standard (close analogue...
Source: Drug Research - October 25, 2019 Category: Drugs & Pharmacology Authors: Dittakavi, Sreekanth Hallur, Gurulingappa Purra, Buchi Reddy Kiran, Vinay Zakkula, Ashok Mullangi, Ramesh Tags: Original Article Source Type: research

A Pharmacokinetic Evaluation of Dabigatran Etexilate, Total Dabigatran, and Unconjugated Dabigatran Following the Administration of Dabigatran Etexilate Mesylate Capsules in Healthy Male and Female Subjects
Conclusion Using validated bioanalytical methods, a complete characterization of dabigatran etexilate, total dabigatran, and unconjugated dabigatran pharmacokinetics was achieved. Advancements in the development of new more accurate, specific, and sensitive validated bioanalytical methods such as these enable for a complete understanding of the drug’s pharmacokinetics and this, in turn, can have an impact on both the drug development and the evaluation of generic formulations. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract...
Source: Drug Research - October 25, 2019 Category: Drugs & Pharmacology Authors: Bouhajib, Mohammed Tayab, Zia Tags: Original Article Source Type: research

The Potential Applications of Hyaluronic Acid Hydrogels in Biomedicine
Drug Res (Stuttg) DOI: 10.1055/a-0991-7585Hyaluronic acid (HA) is widely used in the biomedicine due to its biocompatibility, biodegradability, and nontoxic properties. It is crucial for cell signaling role during morphogenesis, inflammation, and wound repair. After hydrogel formation, HA easily is converted to elastic sheets in order to use in preclinical and clinical applications. In addition, HA-derived hydrogels are easily used as vectors for cell and medication in tissue repairing and regenerative medicine. Moreover, in comparison with other polymers, HA -based hydrogels play a key role in in cellular behavior, includ...
Source: Drug Research - September 25, 2019 Category: Drugs & Pharmacology Authors: Ahmadian, Elham Dizaj, Solmaz Maleki Eftekhari, Aziz Dalir, Elaheh Vahedi, Parviz Hasanzadeh, Amir Samiei, Mohammad Tags: Review Source Type: research

Efficacy of Gemcitabine on Intracranial Erlich Tumor and its Determinants
Drug Res (Stuttg) DOI: 10.1055/a-0824-6325Gemcitabine is quite effective in the treatment of brain tumors, although this drug has a limited ability to overcome the blood-brain barrier (BBB). Aim of study is to assess the therapeutic efficacy of gemcitabine and other drugs with different permeability of BBB in the model of intracranial tumor. The therapeutic activity of gemcitabine, carmustine, cyclophosphamide and cisplatin was studied in mice with intracranially implanted Ehrlich tumor, and also gemcitabine in various doses - with intramuscularly implanted tumor. On intracranial tumor model gemcitabine (25 mg/kg) i...
Source: Drug Research - September 25, 2019 Category: Drugs & Pharmacology Authors: Stukov, Alexander N. Bespalov, Vladimir G. Alexandrov, Valerij A. Semenov, Alexander L. Kireeva, Galina S. Semiglazova, Tatjana Y. Filatova, Larisa V. Baranenko, Denis A. Tags: Original Article Source Type: research

Enchancement of Toremifene Anti-Tumor Action by Metformin and Unusual Side Effect of Toremifene in Male Transgenic Mice with HER2-Positive Breast Tumor
Drug Res (Stuttg) DOI: 10.1055/a-0892-4118HER2-positive breast tumors are found in 25–30% of patients with breast cancer and are characterized by aggressive course and reduced sensitivity to both chemotherapy and hormone therapy. The aim of the work was to study the possibilities of enhancing the therapeutic effect of anti-estrogen drug toremifene by combining it with biguanide, metformin, on the HER2-positive breast cancer model in FVB/N HER-2/neu transgenic mouse. Male FBV/N mice with intramuscularly transplanted HER2-positive mammary gland tumor from a female mouse of the same strain have been given toremifene (30...
Source: Drug Research - September 24, 2019 Category: Drugs & Pharmacology Authors: Stukov, Alexander N. Osipov, Mikhail A. Semiglazova, Tatjana Y. Filatova, Larisa V. Alexandrov, Valerij A. Bespalov, Vladimir G. Semenov, Alexander L. Tyndyk, Margarita L. Yurova, Maria N. Panchenko, Andrey V. Baranenko, Denis A. Tags: Original Article Source Type: research

Identification, Characterization and HPLC Quantification of Process-Related Impurities in Bepotastine Besilate Bulk Drug
Drug Res (Stuttg) DOI: 10.1055/a-0831-2401Bepotastine besilate (here after referred to as BTST), chemically known as ({d(S)4[4[(4chlorophenyl) (2pyridyl) methoxy] piperidino} butyric acid monobenzene sulphonate), is a second-generation antihistamine drug. To the best of our knowledge, no studies concerning the isolation or identification of process-related impurities have been reported so far. The current study reports the development and validation of a stability-indicating RP-HPLC method for the separation and identification of 5 potential impurities in bepotastine besilate. In this experiment, the structures of 3 proces...
Source: Drug Research - September 20, 2019 Category: Drugs & Pharmacology Authors: Zhang, Chaowei Han, Chengqun Sun, Lili Yu, Jinlong Zou, Qiaogen Tags: Original Article Source Type: research

Development of a Carrier Free Dry Powder Inhalation Formulation of Ketotifen for Pulmonary Drug Delivery
Conclusion The results of this study demonstrate the potential of Ketotifen DPI formulation and pave a way to use it easily in an industrial scale. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - September 18, 2019 Category: Drugs & Pharmacology Authors: Azari, Fariba Ghanbarzadeh, Saeed Safdari, Rezvan Yaqoubi, Shadi Adibkia, Khosro Hamishehkar, Hamed Tags: Original Article Source Type: research

Study of the Acute Toxicity of a New Dosage Form of Naloxone Hydrochloride for Intranasal Administration
Drug Res (Stuttg) DOI: 10.1055/a-0899-4948The experiment was conducted on 10 Wistar rats, male and female, with initial body weight 270–280 g (males) and 250–260 g (females). The drug was administered using a spray cap in 10 doses of 0.1 mg at 45 min intervals. The average cumulative dose of the drug per naloxone hydrochloride was 36.6 mg/kg for males and 39.4 mg/kg for females. The animals were monitored for 2 weeks after the exposure and then euthanized by a gentle decapitation.We noticed that after each drug administration the animals showed a decrease in motor activ...
Source: Drug Research - September 16, 2019 Category: Drugs & Pharmacology Authors: Bariev, Eduard A. Krasnyuk, Ivan I. Anurova, Maria N. Bakhrushina, Elena O. Smirnov, Valery V. Bardakov, Alexander I. Demina, Natalya B. Krasnyuk, Ivan I. Tags: Original Article Source Type: research

Cytotoxic Activity of LCS-1 is not Only due to Inhibition of SOD1
Conclusion The results of this study is an important finding as it shows that LCS-1 has more than one cytotoxic mode of action. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - September 11, 2019 Category: Drugs & Pharmacology Authors: Steverding, Dietmar Barcelos, Yzobelle Tags: Short Communication Source Type: research

Clozapine Disrupts Endothelial Nitric Oxide Signaling and Antioxidant System for its Cardiovascular Complications
Conclusion From the experimental findings, it was concluded that clozapine could depress the eNOS regulation and thereby perhaps initiates cardiovascular complications through subsequent vascular events [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - September 9, 2019 Category: Drugs & Pharmacology Authors: Nair, Gayathri M. Skaria, Dona Sheba James, Teenu Kanthlal, S. K. Tags: Short Communication Source Type: research

Contrasting Role of Concentration in Rivaroxaban Induced Toxicity and Oxidative Stress in Isolated Kidney Mitochondria
This study was designed to figure out the evaluation effect of rivaroxaban on mitochondria obtained from rat kidneys. We isolated mitochondria from rat kidneys using gradient centrifugation. Then, the toxicity parameters including succinate dehydrogenase (SDH) activity, reactive oxygen species (ROS) formation, mitochondrial swelling, mitochondrial membrane potential (MMP) collapse and cytochrome c release were measured in kidneys mitochondria following the exposure to rivaroxaban. The results showed that rivaroxaban (1.4 and 2.8 mM) raised the reactive oxygen species (ROS) generation, swelling in the mitochondria, c...
Source: Drug Research - September 9, 2019 Category: Drugs & Pharmacology Authors: Samiei, Fatemeh Sajjadi, Hanieh Jamshidzadeh, Akram Seydi, Enayatollah Pourahmad, Jalal Tags: Original Article Source Type: research

Cytotoxic Effects of Ferula Latisecta on Human Glioma U87 Cells
This study showed that F. latisecta induced cytotoxicity and apoptosis, and mitigated metastasis of U87 GBM cells. Hence, F. latisecta could be beneficial as a promising natural herb against GBM after further studies. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - September 9, 2019 Category: Drugs & Pharmacology Authors: Jalili-Nik, Mohammad Sabri, Hamed Zamiri, Ehsan Soukhtanloo, Mohammad Roshan, Mostafa Karimi Hosseini, Azar Mollazadeh, Hamid Vahedi, Mohammad Mahdi Afshari, Amir R. Mousavi, Seyed Hadi Tags: Original Article Source Type: research

Membrane-Bound Transcription Factor Site-1 Protease in PF429242 Bound State: Computational Kinetics and Dynamics of Reversible Binding
In conclusion, PF429242 binds tightly but reversible to S1P and the details of this interaction has been presented to guide future efforts at developing novel inhibitors. Site-1-protease; PF429242; Kon/Koff; Network analysis [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - August 14, 2019 Category: Drugs & Pharmacology Authors: Olaposi, Omotuyi I. Oyekanmi, Nash Ojo, Ayodeji A. Eniafe, Gabriel O. Tags: Original Article Source Type: research

Nitric Oxide and Opioids Involvement in Isobolographic Nsaids Antinociception
Drug Res (Stuttg) DOI: 10.1055/a-0983-1402Different NSAIDs are used as antinociceptive in various analgesic assays, among which should be mentioned: ibuprofen, ketorolac , ketoprofen, meloxicam , paracetamol and others. It has been shown that NSAIDs possess antinociceptive activity by blocking cyclooxygenase enzymes (COXs). The present study was designed to evaluate the possible involvement of the nitridergic pathway due to L-NAME and the opioidergic route by NTX in the antinoception induced by NSAIDs using a murine pain model the tail flick test in an automatic tail flick algesiometer. The antinociception was evaluated by...
Source: Drug Research - August 13, 2019 Category: Drugs & Pharmacology Authors: Miranda, Hugo F. Noriega, Viviana Sierralta, Fernando Poblete, Paula Aranda, Nicol ás Prieto, Juan Carlos Tags: Original Article Source Type: research

Influence of Silybum Marianum on Morphine Addicted Rats, Biochemical Parameters and Molecular Simulation Studies on µ-Opioid Receptor
Drug Res (Stuttg) DOI: 10.1055/a-0975-9124The present study aimed to investigate effects of medicinal plant (Silybum marianum) on the animals with treatment of morphine addiction compared to chemical drug (Naloxane). Also, this study was conducted to evaluate the role of Silybum marianum on factors of serum ALT, AST activities and activity of the antioxidant enzyme:superoxide dismutase (SOD) as well as the extent of lipid peroxidation of Morphine addicted rats.High performance liquid chromatography (HPLC) has been used to measure Morphine in the serum, enzymes functions well as lipid peroxidation of Morphine addicted anima...
Source: Drug Research - August 13, 2019 Category: Drugs & Pharmacology Authors: Malekshah, Rahime Eshaghi Khaleghian, Ali Tags: Original Article Source Type: research

Overcoming the Charged Ion Competition in Triple Quad Chemical Ionization Ion Source for Estimation of Celecoxib in Biological Matrix and its Application to Bioequivalence Study
Drug Res (Stuttg) DOI: 10.1055/a-0983-1303The purpose of the study was to develop and validate a sensitive, selective and reproducible method for the estimation of Celecoxib in human plasma. During the development, ion competition phenomenon observed in electrospray ionization ion source of liquid chromatography mass spectrometer system and in order to overcome it, different approaches applied. The Celecoxib and Celecoxib D7 in plasma were extracted by liquid-liquid extraction and separated in less than 4.0 min on a reverse phase C18 column, using isocratic elution with a binary mobile phase in the ratio of 70:30&th...
Source: Drug Research - August 12, 2019 Category: Drugs & Pharmacology Authors: Dubey, Naveen Kr Haq, Kashif Ul Fozdar, Bharat I. Tags: Original Article Source Type: research

Development of New Biokinetic-Dosimetric Models for the Simulation of Iodine Blockade in the Case of Radioiodine Exposure in Man
Drug Res (Stuttg) DOI: 10.1055/a-0960-5590In the case of nuclear incidents, radioiodine may be liberated. After incorporation it accumulates in the thyroid and by internal irradiation enhances the risk of cancer occurrence. By administering a large dose of non-radioactive iodine the uptake of radioiodine into the gland can be inhibited (“iodine blockade”). Biokinetic models using first order kinetics are not suited to simulate iodine blockade, as the uptake into the gland is mediated by a saturable active transport. Therefore, we integrated an uptake mechanism described by a Michaelis-Menten kinetic into a simp...
Source: Drug Research - August 7, 2019 Category: Drugs & Pharmacology Authors: Rump, Alexis Eder, Stefan Lamkowski, Andreas Kinoshita, Manabu Yamamoto, Tetsuo Abend, Michael Shinomiya, Nariyoshi Port, Matthias Tags: Original Article Source Type: research

Mitochondrial Permeability Transition Pore Sealing Agents and Antioxidants Protect Oxidative Stress and Mitochondrial Dysfunction Induced by Naproxen, Diclofenac and Celecoxib
We reported that mitochondrial permeability transition (MPT) pore sealing agents and antioxidants have the capacity to significantly prevent mitochondrial toxicity. Therefore, the inhibition of mitochondrial oxidative stress and mitochondrial dysfunction by MPT pore sealing agents and antioxidants can double confirm NSAID-induced cardiomyocytes toxicity is resulted from induction of apoptosis signaling trough ROS-mediated mitochondrial permeability transition. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  | &nbs...
Source: Drug Research - July 23, 2019 Category: Drugs & Pharmacology Authors: Salimi, Ahmad Neshat, Mohammad Reza Naserzadeh, Parvaneh Pourahmad, Jalal Tags: Original Article Source Type: research

Effects of Nitroglycerine on Renal Ischemia-Reperfusion Injury in Adult Male Rats
Conclusions The results show NG has a protective effect on renal tissue against AKI caused by I-R. These protective effects mediated through antioxidant activity and decrease of lipid peroxidation. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - July 17, 2019 Category: Drugs & Pharmacology Authors: Ahmadi, Fatemeh Hajihashemi, Saeed Rahbari, Ali Ghanbari, Fatemeh Tags: Original Article Source Type: research

Involvement of the L-arginine/Nitric Oxide/Cyclic GMP/KATP Channel Pathway and PPAR γ Receptors in the Peripheral Antinociceptive Effect of Carbamazepine
In conclusion, carbamazepine induced a peripheral antinociceptive effect through PPARγ receptors and L-arginine/NO/cGMP/KATP channel pathway, with potential for a new topical analgesic drug. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - July 4, 2019 Category: Drugs & Pharmacology Authors: Ghorbanzadeh, Behnam Kheirandish, Vahid Mansouri, Mohammad Taghi Tags: Original Article Source Type: research

Application of Carbon Nanotubes in Breast Cancer Therapy
Drug Res (Stuttg) DOI: 10.1055/a-0945-1469Conjugated single-walled carbon nanotubes (SWNT) have been shown to be promising in cancer-targeted accumulation and is biocompatible, easily excreted, and possesses little toxicity. The present study aims at reviewing the recent advancements in carbon nanotubes especially SWNT for improving the treatment of breast cancer. Nanotube drug delivery system is a potential high efficacy therapy with minimum side effects for future tumor therapy with low doses of drug. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  ...
Source: Drug Research - June 28, 2019 Category: Drugs & Pharmacology Authors: Tajabadi, Mahdis Tags: Review Source Type: research

Non-steroidal Anti-inflammatory Drugs in Tonic, Phasic and Inflammatory Mouse Models
In conclusion, the results suggests that intraperitoneal NSAIDs administration induce antinociceptive activity depending on the type of pain. The results support that NSAIDs administration, induce a wide variety of antinociceptive effect, depending on the type of pain. This suggest the participation of different mechanisms of action that can be added to the simple inhibition of COXs controlled by NSAIDs. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - June 28, 2019 Category: Drugs & Pharmacology Authors: Miranda, Hugo F. Noriega, Viviana Sierralta, Fernando Poblete, Paula Aranda, Nicolas Prieto, Juan Carlos Tags: Original Article Source Type: research

Pyocyanin, a Metabolite of Pseudomonas Aeruginosa, Exhibits Antifungal Drug Activity Through Inhibition of a Pleiotropic Drug Resistance Subfamily FgABC3
The objectives of the present study were to determine the mechanism by which the bacterium Pseudomonas aeruginosa inhibits the growth of F. graminearum. Our results indicate that P. aeruginosa metabolites as pyocyanin has effective antifungal properties. Pyocyanin was produced by P. aeruginosa when cultured on mineral salt medium and reached a maximum concentration after 72 h. Pyocyanin significantly decreased mycotoxins of F. graminearum, a 25 mg/ml of pyocyanin for 72 h decreased DON by 68.7% and NIV by 57.7%.Real-Time PCR analysis demonstrated that the antifungal effect is mediated by downregulation...
Source: Drug Research - June 28, 2019 Category: Drugs & Pharmacology Authors: Houshaymi, Bilal Awada, Rana Kedees, Mamdouh Soayfane, Zeina Tags: Original Article Source Type: research