Development and Validation of a Stability Indicating LC-MS/MS Method for the Determination of Clenbuterol HCl
Drug Res (Stuttg) DOI: 10.1055/a-1167-0529Clenbuterol hydrochloride (CLT), β2 adrenergic agonist is used as a bronchodilator in the therapeutic treatment of asthma. It is important to know the stability behaviour of the drug in different degradation conditions as per ICH Q1A (R2) guidelines for safety and efficacy purpose. The main objective of the study is to develop and validate stability indicating LC-MS/MS method for the determination of Clenbuterol HCl. The separation was achieved using Phenomenex Gemini NX C18 (250*4.6 mm, 5 μ) column and the mobile ...
Source: Drug Research - September 16, 2020 Category: Drugs & Pharmacology Authors: Prajapati, Krunal J. Kothari, Charmy Tags: Original Article Source Type: research

Does Rabeprazole Sodium Alleviate the Anti-diabetic Activity of Linagliptin? Drug-Drug Interaction Analysis by In vitro and In vivo Methods
Drug Res (Stuttg) DOI: 10.1055/a-1233-3371Drug interaction has turned into the preeminent regarding issues for a prescriber during polypharmacy. The foremost objective of this research was to form a complex between linagliptin and rabeprazole sodium by in vitro interactions. The interactions between the drugs have been examined by monitoring some chromatographic and spectroscopic analyses viz. TLC, HPLC, FT-IR, UV, Job’s plot, conductometric titrations, and Ardon’s spectrophotometric strategy. Rabeprazole sodium formed a stable complex with linagliptin, which was ensured from ...
Source: Drug Research - September 11, 2020 Category: Drugs & Pharmacology Authors: Hossain, Md. Jamal Sultan, Md. Zakir Rashid, Mohammad A. Kuddus, Md. Ruhul Tags: Original Article Source Type: research

Induction of Cell Cycle Arrest in MKN45 Cells after Schiff Base Oxovanadium Complex Treatment Using Changes in Gene Expression of CdC25 and P53
This study aimed to evaluate the role of schiff base oxovanadium complex ([N,N'-bis(3-methoxy-salicylidene)-1,2-phenylenediamine]Vanadium(IV) Oxide Complex) on cell cycle arrest and different cell cycle phases in MKN45 cell of gastric cancer. Schiff base oxovanadium complex was used to assessthe amount of cytotoxicity via cell viability test. PI color and flow cytometry technique were applied to evaluate the effects of vanadium synthetic compounds on cell cycle phases; subsequently, we analyzed the change rates of gene expression in P53, GADD45, and CDC25 genes, which are involved in cell division phases. The findings indi...
Source: Drug Research - September 4, 2020 Category: Drugs & Pharmacology Authors: Mirjalili, Sara Dejamfekr, Maedeh Moshtaghian, Abdolvahab Salehi, Mehdi Behzad, Mahdi Khaleghian, Ali Tags: Original Article Source Type: research

Single Ascending Dose Study to Assess Pharmacokinetic Linearity, Safety, and Tolerability of Trimetazidine - Modified Release in Healthy Human Subjects
Conclusion Substantial deviation from a dose-proportional increase in AUC(0-inf) and AUC(0-t) suggested a non-linear PK for TMZ-modified release. Single dose of TMZ-modified release was well tolerated and safe. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - September 4, 2020 Category: Drugs & Pharmacology Authors: K örnicke, Thomas Arora, Deepa Samad, Abdus Kaplan, Sigal Domahidy, M ónika de Voogd, Hanka B öhmert, Stella Ramos, Rita Silveira Jain, Shashank Tags: Original Article Source Type: research

Current Pharmacological Trends on Myricetin
Drug Res (Stuttg) DOI: 10.1055/a-1224-3625Myricetin is a member of the group of flavonoids called flavonols. Myricetin is obtained from various fruit, vegetables, tea, berries and red wine. Myricetin is characterized by the pysrogallol B-ring, and the more hydroxylated structure is known to be capable for its increased biological properties compared with other flavonols. Myricetin is produced by the Myricaceae, Anacardiaceae, Polygonaceae, Pinaceae and Primulacea families. It is soluble in organic solvent such as ethanol, DMSO (dimethyl sulfoxide), and dimethyl formamide (DMF). It is s...
Source: Drug Research - September 2, 2020 Category: Drugs & Pharmacology Authors: Gupta, Gudiya Siddiqui, Mohd Aftab Khan, Mohd Muazzam Ajmal, Mohd Ahsan, Rabiya Rahaman, Md Azizur Ahmad, Md Afroz Arshad, Md Khushtar, Mohammad Tags: Review Source Type: research

Pharmacokinetics and Tissue Distribution of Loratadine, Desloratadine and Their Active Metabolites in Rat based on a Newly Developed LC-MS/MS Analytical Method
In this study, a new validated LC-MS/MS method to simultaneously quantify LOR, DL, 6-OH-DL, 5-OH-DL and 3-OH-DL in plasma and tissues was established and applied to an investigation of their pharmacokinetics and target-tissue distribution tendency for the first time. Pharmacokinetics parameters in rat were measured and the results suggest that the body’s exposure to active metabolites were much higher than to the prodrug with LOR, but much lower with DL. The tissue distribution study shows that LOR, DL and their active metabolites were widely distributed in the liver, spleen, t...
Source: Drug Research - September 2, 2020 Category: Drugs & Pharmacology Authors: Zhang, Yuxin Lu, Yihua Wang, Lijuan Tian, Yuan Zhang, Zunjian Tags: Original Article Source Type: research

Saliva versus Plasma Therapeutic Drug Monitoring of Gentamicin in Jordanian Preterm Infants. Development of a Physiologically-Based Pharmacokinetic (PBPK) Model and Validation of Class II Drugs of Salivary Excretion Classification System
Drug Res (Stuttg) DOI: 10.1055/a-1233-3582Gentamicin has proven to be a very successful treatment for bacterial infection, but it also can cause adverse effects, especially ototoxicity, which is irreversible. Therapeutic drug monitoring (TDM) in saliva is a more convenient non-invasive alternative compared to plasma. A physiologically-based pharmacokinetic (PBPK) model of gentamicin was built and validated using previously-published plasma and saliva data. The validated model was then used to predict experimentally-observed plasma and saliva gentamicin TDM data in Jordanian pediatric pret...
Source: Drug Research - September 2, 2020 Category: Drugs & Pharmacology Authors: Idkaidek, Nasir Hamadi, Salim Bani-Domi, Rabab Al-Adham, Ibrahim Alsmadi, Motasem Awaysheh, Faten Aqrabawi, Hisham Al-Ghazawi, Ahmad Rabayah, Ayman Tags: Original Article Source Type: research

The Potential Therapeutic Role of Proton Pump Inhibitors in COVID-19: Hypotheses Based on Existing Evidences
Drug Res (Stuttg) DOI: 10.1055/a-1236-3041Although the major therapeutic uses of the proton pump inhibitors are in gastric-acid related diseases, evidences are suggestive of a pleiotropic nature of the compounds. We comment on the probable pathways and cellular machineries via which proton pump inhibitors could show beneficial therapeutic effects against SARS-CoV-2 based on the existing evidences. Proton pump inhibitors have shown antiviral potencies in various in vivo and in vitro studies. Some of the major possible ways through which they can act against SARS-CoV-2 are by exerting anti-...
Source: Drug Research - September 2, 2020 Category: Drugs & Pharmacology Authors: Ray, Avik Sharma, Swati Sadasivam, Balakrishnan Tags: Opinion Paper Source Type: research

Protective Effect of Grape and Apple Juices against Cadmium Intoxication in the Kidney of Rats
Conclusion Taken together, we conclude that grape and apple juices had a protective effect by means of antioxidant, antigenotoxic actions and for promoting tissue regeneration in the kidney of rats following cadmium intoxication. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - August 20, 2020 Category: Drugs & Pharmacology Authors: Handan, Bianca Andrade De Moura, Carolina Foot Gomes Cardoso, Caroline Margonato Santamarina, Aline Boveto Pisani, Luciana Pellegrini Ribeiro, Daniel Araki Tags: Review Source Type: research

Evaluation of Stable Doses of Warfarin in a Patient Cohort
Conclusion We observed similar stable doses between the definitions except for one. Hence, IWPC algorithm may not have any bias associated with inclusion of any studies with variable definitions for stable warfarin dose. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - August 20, 2020 Category: Drugs & Pharmacology Authors: Sridharan, Kannan Banny, Rashed Al Husain, Aysha Tags: Original Article Source Type: research

Silibinin Inhibit Cell Migration through Downregulation of RAC1 Gene Expression in Highly Metastatic Breast Cancer Cell Line
Conclusion In conclusion, the results demonstrate that the silibinin can be used as an experimental therapeutic for the management of TNBC metastatic cancer. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - August 13, 2020 Category: Drugs & Pharmacology Authors: Lashgarian, Hamed Esmaeil Adamii, Vahid Ghorbanzadeh, Vajihe Chodari, Leila Kamali, Fayze Akbari, Soheila Dariushnejad, Hassan Tags: Original Article Source Type: research

Trends of Antimicrobial Resistance of Sepsis Pathogens at a University Hospital in New Delhi, India
Drug Res (Stuttg) DOI: 10.1055/a-1213-2206Knowledge of the aetiological agents and its susceptibility to antimicrobial agents enables the clinician to initiate appropriate empirical antimicrobial therapy and guides diagnostic procedures. The aims of the study were to identify prevalence of bacterial pathogens causing sepsis and observe their antimicrobial resistance trends in hospitalized patients. A prospective cohort study was conducted on patients of sepsis admitted at a university hospital over a period of six months. Pathogens were identified by morphological, biochemical and ...
Source: Drug Research - August 13, 2020 Category: Drugs & Pharmacology Authors: Alam, Md Shamshir Kapur, Prem Pillai, ParuKutty Pillai, Krishna Kolappa Tags: Original Article Source Type: research

Coronavirus Disease-2019 (COVID-19): An Updated Review
Drug Res (Stuttg) DOI: 10.1055/a-1217-2397The current outbreak of novel Coronavirus Disease-2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major pandemic situation and a catastrophe for humans. COVID-19 is a severe infectious disease particularly of the respiratory system characterized by fatal complications such as severe acute respiratory distress syndrome (SARS), pneumonia, cardiac arrhythmia, kidney failure/ multiple organ failure and even death. Since its discovery, the SARS-CoV-2 has spread across 213 countries or territories, causing mor...
Source: Drug Research - August 3, 2020 Category: Drugs & Pharmacology Authors: Rudrapal, Mithun Khairnar, Shubham J. Borse, Laxmikant B. Jadhav, Anil G. Tags: Review Source Type: research

A Comprehensive Review on Physiological Effects of Curcumin
Drug Res (Stuttg) DOI: 10.1055/a-1207-9469Turmeric (Curcuma longa Linn) is an herbal medicine which is traditionally used as a spice, food colouring or flavouring agent and widely used for several diseases such as biliary disorders, cough, hepatic disorders, rheumatism, wound healing, sinusitis, diabetes, cardiac disorders and neurological disorder. It belongs to the Zingiberaceae family. Turmeric is a popular domicile remedy used in Indian food, is mainly a native of south-east Asia, is widely cultivated in India, Sri Lanka, Indonesia, China, Jamaica , Peru, Haiti and Taiwan and it is ve...
Source: Drug Research - August 3, 2020 Category: Drugs & Pharmacology Authors: Ahsan, Rabiya Arshad, Md Khushtar, Mohammad Ahmad, Mohd Afroz Muazzam, Mohammad Akhter, Md Sohel Gupta, Gudiya Muzahid, Mohd Tags: Review Source Type: research

Analytical Method Development and Validation of UV-visible Spectrophotometric Method for the Estimation of Vildagliptin in Gastric Medium
Conclusion The UV method developed and validated for vildagliptin drug was found to be linear, accurate, precise and economical which can be used for the testing of its pharmaceutical formulations. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - August 3, 2020 Category: Drugs & Pharmacology Authors: Kumari, Beena Khansili, Aparna Tags: Original Article Source Type: research

Materiovigilance: Concept, Structure and Emerging Perspective for Patient ’s Safety in India
Drug Res (Stuttg) DOI: 10.1055/a-1195-1945There has been an escalation in the number, diversity, and complexity of medical devices. Regulation of these devices has also advanced due to the requirement of better regulatory perspective induced due to elevation in the number of adverse events associated with medical devices. All over the globe, various measures are undertaken to provide better safety to the patients along with attempts to improve the standard of medical devices. The initial and ultimate objective of the concept happens to be unfailingly to ensure patient safety as wel...
Source: Drug Research - August 3, 2020 Category: Drugs & Pharmacology Authors: Hoda, Farazul Verma, Rishabh Arshad, Mawrah Siddiqui, Ali Nasir Khan, Mohammad Ahmed Akhtar, Mohammad Najmi, Abul Kalam Tags: Opinion Paper Source Type: research

Effects of Child-Pugh B Cirrhosis on Pharmacokinetics of Tofogliflozin, a New Sodium-Glucose Co-Transporter (SGLT2) Inhibitor
Conclusions Moderate hepatic impairment increased Cmax and AUCinf of tofogliflozin by 47% and 70%, respectively. This increase in tofogliflozin exposure did not increase UGE in hepatically impaired subjects. A single oral dose of 40 mg tofogliflozin was well tolerated, supporting dose adjustment is unnecessary even in moderately hepatically impaired subjects. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - July 24, 2020 Category: Drugs & Pharmacology Authors: Yamada, Haruki Ohira, Hiromasa Ikegami, Fumiaki Nakamura, Koichi Takahashi, Atsushi Abe, Kazumichi Inano, Akihiro Shimada, Sumire Miyata, Kumiko Saito, Tomohisa Ohba, Yasuhiro Terao, Kimio Ohnishi, Akihiro Tags: Original Article Source Type: research

Design, Synthesis and Biological Evaluation of 5-amino-3-aryl-1-(6'-chloropyridazin-3'-yl)pyrazoles and their Derivatives as Analgesic Agents
Drug Res (Stuttg) DOI: 10.1055/a-1202-9959An efficient and environmental benign solvent-free synthesis of 5-amino-3-aryl-1-(6'-chloropyridazin-3'-yl)pyrazoles (4a-e) was accomplished by grinding 3-chloro-6-hydrazinopyridazine (2) and β-ketonitriles (3a-e) in the presence of p-toulenesulfonic acid as a catalyst. Subsequently, 6'-chloro group in 4a-e was replaced with cyclic 2° amine derivatives viz. pyrrolidine 5a, piperidine 5b and morpholine 5c to obtain 6a-e, 7a-e, 8a-e respectively. The newly synthesized compounds were characterized by using IR, NMR (1H and 13C...
Source: Drug Research - July 24, 2020 Category: Drugs & Pharmacology Authors: Aggarwal, Ranjana Kaushik, Pawan Kumar, Ajay Saini, Deepika Tags: Original Article Source Type: research

The Antinociceptive Activities of Certain NSAIDS Combinations in Murine Orofacial Test
Drug Res (Stuttg) DOI: 10.1055/a-1217-6777Pain models are mostly in rodents and between them formalin orofacial test allow discrimination among antinociception and anti-inflammation. This assay use a formalin solution injected into the upper right lip of each mouse which produces two periods of pain separated by an inactive period. The aims of the present study were to evaluate, by means of the isobolographic analysis, the antinociception and anti-inflammatory activities of the following NSAIDs: dexketoprofen, diclofenac, piroxicam and metamizole in an orofacial. The NSAIDs adminis...
Source: Drug Research - July 24, 2020 Category: Drugs & Pharmacology Authors: Miranda, Hugo F. Noriega, Viviana Sierralta, Fernando Sotomayor-Z árate, Ramón Prieto, Juan Carlos Tags: Original Article Source Type: research

The Effect of Dihydromyricetin, a Natural Flavonoid, on Morphine-induced Conditioned Place Preference and Physical Dependence in Mice
Conclusion These results indicated that DHM decreased acquisition and expression of morphine CPP and inhibited development of morphine-induced physical dependence. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - July 17, 2020 Category: Drugs & Pharmacology Authors: Etemad, Leila Farkhari, Hadi Alavi, Mohaddeseh Sadat Roohbakhsh, Ali Tags: Original Article Source Type: research

Protective Role of EGCG Against Malathion Induced Genotoxicity Using Human Lymphocytes
Drug Res (Stuttg) DOI: 10.1055/a-1201-2436Background: Green tea (Camellia sinensis), which is the most common drink across the world after water, has many antioxidant properties. Epigallocatecin-3-gallate (EGCG) is a flavonoid which accounts for 33–50% of green tea solids. It functions as a powerful antioxidant, preventing oxidative damage in healthy cells, with antiangiogenic and antitumor activities and as a modulator of tumor cell response to chemotherapy. Malathion is an organophosphate pesticide which is widely used in agriculture, veterinary and industries. Oxidative stress ha...
Source: Drug Research - July 10, 2020 Category: Drugs & Pharmacology Authors: Taghavi, Seyed Mousa Shadboorestan, Amir Sabzevari, Samin Gholami, Maryam Keshavarz-maleki, Razieh Mozdarani, Hossein Ostad, Seyed Nasser Sabzevari, Omid Tags: Original Article Source Type: research

Combination of Lorcaserin and GLP-1/glucagon Coagonist Improves Metabolic Dysfunction in Diet Induced-obese Mice
Conclusion These data suggest that combination of lorcaserin and coagonist could be a better combination to induce body weight loss. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - July 9, 2020 Category: Drugs & Pharmacology Authors: Patel, Vishal Joharapurkar, Amit Kshirsagar, Samadhan Patel, Maulik Savsani, Hardikkumar Bahekar, Rajesh Jain, Mukul Tags: Original Article Source Type: research

Method Development and Validation of UV Spectrophotometric Method for the Quantitative Estimation of Curcumin in Simulated Nasal Fluid
Conclusion The proposed method was found to be simple, sensitive and precise. The most important this method can be used for routine quality control analysis of curcumin with accuracy. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - June 23, 2020 Category: Drugs & Pharmacology Authors: Sharma, Sherry Sharma, Jai Bharti Bhatt, Shailendra Kumar, Manish Tags: Original Article Source Type: research

Development of Nasal Mucoadhesive Microspheres of Granisetron: A Potential Drug
Conclusion After all the evaluation parameters and result obtained it can be said that these results confirmed the suitability of Granisetron mucoadhesive chitosan microspheres for nasal delivery system. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - June 19, 2020 Category: Drugs & Pharmacology Authors: Pandey, Jaideo Shankar, Ravi Kumar, Manish Shukla, Kuldeep Kumari, Beena Tags: Original Article Source Type: research

Design and Synthesis of Novel 1-substituted-3-(3-(3-nitrophenyl)-4-oxo-3,4-dihydrobenzopyrimidin-2-yl amino) Isothioureas for their Anti-HIV, Antibacterial Activities, Graph Theoretical Analysis, Insilico Modeling, Prediction of Toxicity and Metabolic Studies
Drug Res (Stuttg) DOI: 10.1055/a-0991-7617In the present study, we have placed the substituted thiosemicarbazide moiety at the C-2 position and 3-nitrophenyl group at N-3 position of benzopyrimidines and studied their antitubercular, anti-HIV and antibacterial activities against selected gram positive and negative bacteria. The target compounds 1-substituted-3-(3-(3-nitrophenyl)-4-oxo-3,4-dihydrobenzopyrimidin-2-ylamino) isothioureas (PTS1 – PTS15 ) were obtained by the reaction of 2-hydrazino-3-(3-nitrophenyl) benzopyrimidin-4(3 H)-one (5) with different alkyl/aryl isothiocy...
Source: Drug Research - June 19, 2020 Category: Drugs & Pharmacology Authors: Narendhar, Bandi Alagarsamy, Veerachamy Krishnan, Chitra Tags: Original Article Source Type: research

Comparative Study of the Effect of Macrolide Antibiotics Erythromycin, Clarithromycin, and Azithromycin on the ERG1 Gene Expression in H9c2 Cardiomyoblast Cells
Drug Res (Stuttg) DOI: 10.1055/a-1185-8762Macrolides are clinically well-established class of antibiotics. Macrolides induce cardiotoxicity by blocking ether-a-go-go–related gene (ERG) potassium channels in cardiac myocytes. The aim of this study was to compare the effects of erythromycin, clarithromycin and azithromycin on cell viability and expression of ERG1 gene in H9c2 cells. Cell viability and ERG1 gene expression of H9c2 cells in 3 different concentrations, 1, 10 and 25 µg/ml, after 48 and 72 h were determined by MTT test and Real time-PCR method respectiv...
Source: Drug Research - June 19, 2020 Category: Drugs & Pharmacology Authors: Hajimirzaei, Nima Khalili, Nazila Pour Boroumand, Behshad Safari, Fatemeh Pourhosseini, Armin Judi-Chelan, Reza Tavakoli, Fatemeh Tags: Original Article Source Type: research

The Battle against COVID 19 Pandemic: What we Need to Know Before we “Test Fire” Ivermectin
Drug Res (Stuttg) DOI: 10.1055/a-1185-8913The world is faced with the dire challenge of finding an effective treatment against the rampaging COVID 19 pandemic. Amidst the crisis, reports of in vitro inhibitory activity of ivermectin, an approved anthelmintic, against the causative SARSCoV2 virus, have generated lot of optimism. In this article, we have fished and compiled the needed information on the drug, that will help readers and prospective investigators in having a quick overview. Though the primordial biological action of the drug is allosteric modulation of helminthic ion c...
Source: Drug Research - June 19, 2020 Category: Drugs & Pharmacology Authors: Banerjee, Kushal Nandy, Manab Dalai, Chanchal Kumar Ahmed, Shah Newaz Tags: Opinion Paper Source Type: research

The Pharmacokinetics of Fluticasone Furoate Given Intranasally in Healthy Subjects Using an Ultra-Sensitive Analytical Assay
Conclusion Using a lower LLOQ than what has been previously reported, a complete characterization of intranasal fluticasone furoate pharmacokinetics, including a clearly defined terminal elimination phase, was achieved. This method will allow for further investigations into the pharmacokinetics of fluticasone furoate. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - June 2, 2020 Category: Drugs & Pharmacology Authors: Bouhajib, Mohammed Tayab, Zia Tags: Original Article Source Type: research

Interferons in the Therapy of Severe Coronavirus Infections: A Critical Analysis and Recollection of a Forgotten Therapeutic Regimen with Interferon Beta
Drug Res (Stuttg) DOI: 10.1055/a-1170-4395The pharmacological and immunological properties of interferons, especially those of interferon beta, and the corresponding treatment strategies are described, and the results of studies with different interferons in coronavirus infections are analysed. Furthermore, the data obtained with high-dosed native interferon beta in life-threatening acute viral diseases as well as the results of clinical pilot studies with high-dosed recombinant interferon beta-1a are provided because they serve as the rationale for the proposed therapeutic regimen to be applied in acute viral infections. ...
Source: Drug Research - May 22, 2020 Category: Drugs & Pharmacology Authors: Brzoska, Josef von Eick, Harald H ündgen, Manfred Tags: Opinion Paper Source Type: research

Potential Unconventional Medicines for the Treatment of SARS-CoV-2
Drug Res (Stuttg) DOI: 10.1055/a-1170-4624 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Drug Research)
Source: Drug Research - May 19, 2020 Category: Drugs & Pharmacology Authors: Coppola, Maurizio Mondola, Raffaella Tags: Letter Source Type: research

Calcitriol Reduces Adverse Effects of Diclofenac on Mitochondrial Function in Isolated Rat Heart Mitochondria
Drug Res (Stuttg) DOI: 10.1055/a-1167-0691The safety of diclofenac (DIC) use in clinical practice has been questioned because of adverse cardiovascular effects. Previous studies have indicated that DIC cause mitochondrial dysfunction and oxidative stress in heart mitochondria. The aim of this study was to investigate the protective effect of calcitriol against the mitochondrial toxicity potency of diclofenac in heart rat mitochondria. For this purpose, rat heart mitochondria were isolated with mechanical lysis and differential centrifugation. Then isolated mitochondria were pretrea...
Source: Drug Research - May 15, 2020 Category: Drugs & Pharmacology Authors: Khezri, Saleh Atashbar, Saman Azizian, Sepideh Shaikhgermchi, Zahra Kurdpour, Peyman Salimi, Ahmad Tags: Original Article Source Type: research

Validated LC-MS/MS Method for Simultaneous Quantitation of SAFit-1 and SAFit-2 in Mice Plasma: Application to a Pharmacokinetic Study
Drug Res (Stuttg) DOI: 10.1055/a-1164-6123SAFit-1 and SAFit-2 are selective FKBP51 (FK506-binding protein 51) ligands. In this paper, we present the development and validation data of an LC-MS/MS method for the simultaneous quantitation of SAFit-1 and SAFit-2 in mice plasma as per FDA regulatory guideline. SAFit-1 and SAFit-2 along with internal standard were extracted from mice plasma using liquid-liquid extraction method. Chromatographic resolution of SAFit-1, SAFit-2 and the internal standard (warfarin) was achieved on an X-Terra phenyl column using 0.2% formic acid:acetonitrile (20:80, v/v) as an eluent, which was deli...
Source: Drug Research - May 13, 2020 Category: Drugs & Pharmacology Authors: Gabani, Bhavesh Babulal Sulochana, Suresh Ponnayyan Siddesh, Anup H.A. Kiran, Vinay Saini, Neeraj Kumar Samanta, Swapan Kumar Hallur, Mahanandeesha S. Rajagopal, Sridharan Mullangi, Ramesh Tags: Original Article Source Type: research

Exploring the Potential of Traditional Herbs in the Management of Diabetic Retinopathy: An Overview
Drug Res (Stuttg) DOI: 10.1055/a-1148-3950Diabetic retinopathy is a microvascular complication in diabetes that affects eyes and is responsible for most visual impairment in diabetic patients. Diabetic retinopathy affects up to 80% of those who have had diabetes for 20 years or more. At least 90% of new cases could be reduced with proper treatment and monitoring of the eyes. The longer a person has diabetes, the higher his or her chances of developing diabetic retinopathy. Hence, it compels need for its prevention and cure. There is an increasing interest in natural products in pha...
Source: Drug Research - May 4, 2020 Category: Drugs & Pharmacology Authors: Singh, Soumya Kushwaha, Poonam Gupta, Sujeet Kumar Tags: Review Source Type: research

Trifluoperazine an Antipsychotic Drug and Inhibitor of Mitochondrial Permeability Transition Protects Cytarabine and Ifosfamide-Induced Neurotoxicity
Drug Res (Stuttg) DOI: 10.1055/a-1154-8672The link between Ca2+ dysregulation, mitochondria damages, oxidative stress and cellular derangement is particularly evident in neurotoxicity induced by chemotherapeutic agents. In the current study, we investigated effects of trifluoperazine (TFP) as an inhibitor of calmodulin against the cytotoxicity induced by cytarabine (Ara-C) and Ifosfamide (IFOS) on isolated rat neurons and also the mechanisms involved in this toxicity. Isolated rat neurons were pretreated with TFP (100 µM) for 5 min at 37°C, then Ara-C (226 µM) and IFOS (290 &micr...
Source: Drug Research - May 4, 2020 Category: Drugs & Pharmacology Authors: Kiani, Amir Nik, Shadi Heydari Khodadoost, Adineh Salimi, Ahmad Pourahmad, Jalal Tags: Original Article Source Type: research

Synthesis and Structure Activity Relationships of Chalcone based Benzocycloalkanone Derivatives as Adenosine A1 and/or A2A Receptor Antagonists
Drug Res (Stuttg) DOI: 10.1055/a-1146-2996Adenosine A1 and/or A2A receptor antagonists hold promise for the potential treatment of neurological conditions, such as Parkinson’s disease. Herein, a total of seventeen benzocycloalkanone derivatives were synthesised and evaluated for affinity towards adenosine receptors (A1 and A2A AR). The obtained results allowed for the conclusion that affinity and/or selectivity of the 2-benzylidene-1-indanone and -tetralone derivatives toward A1 and/or A2A ARs may be modulated by the nature of the substituents (either -OH, -OCH3 or morpholine) ...
Source: Drug Research - April 29, 2020 Category: Drugs & Pharmacology Authors: Janse van Rensburg, Helena D. Legoabe, Lesetja J. Terre ’Blanche, Gisella Tags: Original Article Source Type: research

Oseltamivir and S-Adenosyl-L-Methionine Combination as Effective Therapeutic Strategy for Suppression of Oxidative Damage in Lung Caused by Influenza Virus Infection in Mice
Drug Res (Stuttg) DOI: 10.1055/a-1147-8824 Background and objectives The pathogenesis of influenza infection is associated with two general processes in the body: (a) lung damage based on virus replication; (b) overproduction of free radicals, antioxidant deficiency, and development of oxidative stress. To attack these aspects of flu pathogenesis, we explored the combined effect of the antiviral agent oseltamivir, and s-adenosyl-l-methionine (SAM) as a precursor of the endogenous antioxidant glutathione, in mice infected with influenza virus. Methods After inoculation o...
Source: Drug Research - April 21, 2020 Category: Drugs & Pharmacology Authors: Mileva, Milka Dimitrova, Adriana Krastev, Dimo Alexandrova, Albena Tsvetanova, Elina Georgieva, Almira Galabov, Angel Tags: Original Article Source Type: research

Pseudomonas Aeruginosa as the Main Causative Agent of Osteomyelitis and its Susceptibility to Antibiotics
Drug Res (Stuttg) DOI: 10.1055/a-1150-2372Surgical activity is increasing in the treatment of many types of fractures, the use of various metal structures, and the potential for infection with the development of osteomyelitis accordingly increases. The urgency of the problem is due to the fact that this disease is the most expensive medical problem, especially when it comes to prosthetics of large joints, with socially significant losses and the occurrence of disability in patients of working age, it requires long-term treatment. The aim of this study was to study one of the most complex ...
Source: Drug Research - April 17, 2020 Category: Drugs & Pharmacology Authors: Pliska, Natalya N. Tags: Original Article Source Type: research

Development and Validation of an HPLC Method for Quantification of Filgotinib, a Novel JAK-1 Inhibitor in Mice Plasma: Application to a Pharmacokinetic Study
Drug Res (Stuttg) DOI: 10.1055/a-1141-3475Filgotinib is a selective JAK1 (Janus kinase) inhibitor, filed in Japan for the treatment of rheumatoid arthritis. In this paper, we present the data of development and validation of a high-performance liquid chromatography (HPLC) method for the quantitation of filgotinib in mice plasma as per the FDA regulatory guideline. The method involves the extraction of filgotinib along with internal standard (IS, tofacitinib) from mice plasma (100 µL) using ethyl acetate as an extraction solvent. The chromatographic analysis was perform...
Source: Drug Research - April 14, 2020 Category: Drugs & Pharmacology Authors: Zakkula, Ashok Pulipati, Shobha Dittakavi, Sreekanth Bestha, Ram Murthi Zainuddin, Mohd Trivedi, Ravi Kumar Mullangi, Ramesh Tags: Original Article Source Type: research

Trigonelline Demonstrated Ameliorative Effects in Dexamethasone Induced Osteoporotic Rats
This study was carried out to investigate this estrogenic activity as a possible mechanisms involved in preventing the symptoms of osteoporosis in dexamethasone induced osteoporosis in rats. Materials and Methods Wistar rats were randomly divided into eight groups, six animals in each group. Osteoporosis was induced using dexamethasone 0.1mg/kg subcutaneously in rats for three times per week for 8 consecutive weeks and treatment with drugs up to 12 weeks as per the treatment schedule described. After 12 weeks, rats were sacrificed; blood samples were collected from each...
Source: Drug Research - April 14, 2020 Category: Drugs & Pharmacology Authors: Rathi, Akshoo Ishaq, Mohd Najmi, Abul Kalam Akhtar, Mohd Tags: Original Article Source Type: research

Use of Graph Based Descriptors for Determination of Structural Features Causing Modulation of Fructose-1,6-Bisphosphatase
Drug Res (Stuttg) DOI: 10.1055/a-1138-8725Fructose-1,6-bisphosphatase performs a significant function in regulating the blood glucose level in type 2 diabetes by controlling the process gluconeogenesis. In this research work optimal descriptor (graph) based quantitative structural activity relationship studies of a set of 203 fructose-1,6-bisphosphatase has been performed with the help of Monte Carlo optimization. Distribution of compounds into different sets such as training set, invisible training set, calibration set and validation sets resulted in formation of splits. Statistical parameters obtained from quantitative s...
Source: Drug Research - April 3, 2020 Category: Drugs & Pharmacology Authors: Kumar, Ashwani Bagri, Kiran Kumar, Parvin Tags: Original Article Source Type: research

Anti-lipidemic Effect of Fractions of Peristrophe bivalvis Leaf in NG-nitro-L-arginine Methyl Ester (L-NAME) Treated Rats
Conclusion In brief, the fractions of PB leaf increased HDL-C and NO, and decrease atherogenic indices in L-NAME treated rats. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - April 3, 2020 Category: Drugs & Pharmacology Authors: Aluko, Esther Oluwasola Omobowale, Temidayo Olutayo Oyagbemi, Ademola Adetokunbo Fasanmade, Adesoji Adedipe Tags: Original Article Source Type: research

A Phytochemical and Ethnopharmacological Recapitulation on Hamelia patens
Drug Res (Stuttg) DOI: 10.1055/a-1131-7856The world health organization reports that 80% of the population living within the developing countries depends basically on traditional medicine for his or her primary health care. Quite half the entire world's population still depends entirely on plants for medicines, and plants provides the active ingredients to the most traditional medical products. Hamelia patens that belong to the family Rubiaceae, is mainly found in tropical and sub-tropical areas. It is used in folk medicine against a wide range of diseases such as athlete’s foot, skin problems, insect sting, psychiat...
Source: Drug Research - March 30, 2020 Category: Drugs & Pharmacology Authors: Noor, Gazala Ahmad, Md.Afroz Ahsan, Farogh Mahmood, Tarique Arif, Muhammad Khushtar, Mohammad Tags: Review Source Type: research

Thymoquinone Loaded Solid Lipid Nanoparticles Demonstrated Antidepressant-Like Activity in Rats via Indoleamine 2, 3- Dioxygenase Pathway
Drug Res (Stuttg) DOI: 10.1055/a-1131-7793The World Health Organization (WHO) has ranked depression the 4th leading cause of disability worldwide. Thymoquinone (TQ), is an active constituent of Nigella sativa having various medicinal properties but has poor solubility and bioavailability. This problem was overcome by developing nanoformulation of TQ. Previously TQ reported good antioxidant and anti-inflammatory effects. Recently TQ’s anti-depressant effect was demonstrated. However, the mechanisms underlying the antidepressant effect of TQ still needs evaluation. Activation of Indoleamine-2,3-dioxygenase (IDO), (an e...
Source: Drug Research - March 20, 2020 Category: Drugs & Pharmacology Authors: Alam, Mahtab Zameer, Saima Najmi, Abul Kalam Ahmad, Farhan Jalees Imam, Syed Sarim Akhtar, Mohd Tags: Original Article Source Type: research

The Population Pharmacokinetics of Rifampicin in Japanese Pulmonary Tuberculosis Patients
The objectives of this study are to (1) identify covariate(s) that may explain the variation of rifampicin, which is the key antitubercular agent, under the steady-state by evaluating its population pharmacokinetics and (2) to propose an appropriate dosing method of rifampicin to Japanese patients. For this purpose, serum concentration–time data were obtained from 138 patients receiving rifampicin (300–450 mg) and isoniazid (300–400 mg) every day over 14 days, and analyzed using nonlinear mixed effects model. Thereby, population pharmacokinetic parameters were estimated followed by elucidati...
Source: Drug Research - March 19, 2020 Category: Drugs & Pharmacology Authors: Nishimura, Takahiro Kohno, Haruichi Nagai, Hideaki Maruoka, Daisuke Koike, Yuichi Kobayashi, Masahiro Atsuda, Koichiro Tags: Original Article Source Type: research

Dig & Delve into Protein Based Nanoformulations
Drug Res (Stuttg) DOI: 10.1055/a-1127-2960Past few decades have emerged as the era of nanotechnology worldwide leading to an extensive research in pharmaceutical science as well as other fields. Nanoformulations have shown a promising future in therapeutics and theronostics. Protein based nanoformulations attracting attention in research as it can be used as therapeutics as well as carrier. Carrier based protein nanoformulatios are capable of accommodating range of therapeutics such as dyes, drugs, contrast agents and inorganic nanoclusters makings its application vast. The nano size of formulation enables it to reach the ...
Source: Drug Research - March 16, 2020 Category: Drugs & Pharmacology Authors: Shariq, Mohammad Parveen, Saba Shamim, Arshiya Ahsan, Farogh Kushwaha, Poonam Mahmood, Tarique Tags: Review Source Type: research

Effects of Additional Administration of a Selective Inhibitor of Sodium Glucose co-transporter-2 Inhibitor on the Glycemic Control in Japanese Type 2 Diabetes Mellitus Patients Receiving Treatment with a Dipeptidyl Peptidase-4 Inhibitor
Drug Res (Stuttg) DOI: 10.1055/a-1070-8783We conducted this study to determine whether additional administration sodium-glucose co-transporter 2 (SGLT2) inhibitor might provide further improvement of glycemic control and also to explore any advantages in Japanese type 2 diabetes patients showing relatively good glycemic control under treatment dipeptidyl peptidase-4 (DPP-4) inhibitors. We divided the patients in two groups, MT group and CT group. The MT group were continued on the DPP-4 inhibitor treatment for 6-months, and CT group were additionally administered an SGLT2 inhibitor treatment for 6-months. The MT group show...
Source: Drug Research - March 12, 2020 Category: Drugs & Pharmacology Authors: Kusunoki, Masataka Sato, Daisuke Sakazaki, Takahiko Miyata, Tetsuro Tsutsumi, Kazuhiko Oshida, Yoshiharu Tags: Original Article Source Type: research

Contrasting Role of Dose Increase in Modulating Sofosbuvir-Induced Hepatocyte Toxicity
Drug Res (Stuttg) DOI: 10.1055/a-1117-3004Sofosbuvir, the oral direct-acting antiviral, is a medication, which used as the effective treatment for hepatitis C infection. Although sofosbuvir thought to have few adverse-effects, there have been some experiences of serious drug-induced hepatotoxicity. In this research, the molecular/cellular pathways that lead to sofosbuvir-induced hepatotoxicity were evaluated on isolated rat hepatocytes. Rat hepatocytes were isolated using collagenase reperfusion technique. In evaluating the different pathways of sofosbuvir-induced hepatotoxicity, ROS formation, mitochondrial membrane poten...
Source: Drug Research - March 10, 2020 Category: Drugs & Pharmacology Authors: Yousefsani, Bahare Sadat Nabavi, Nasim Pourahmad, Jalal Tags: Original Article Source Type: research

Toxicity of Atenolol and Propranolol on Rat Heart Mitochondria
Drug Res (Stuttg) DOI: 10.1055/a-1112-7032Propranolol and atenolol are known as β receptor blocker drugs. These drugs are used to treat some heart diseases. There are controversies in the relationship between the use of beta-blocker drugs and the level of reactive oxygen species (ROS). Mitochondria as one of the most important sources of ROS are considered as one of the targets of drug-induced cardiotoxicity. The aim of this study was to evaluate the effects of propranolol and atenolol on mitochondria isolated from the heart. To achieve this aim, several markers of mitochondrial and cellular toxicity were evaluated. T...
Source: Drug Research - March 2, 2020 Category: Drugs & Pharmacology Authors: Seydi, Enayatollah Tabbati, Yasaman Pourahmad, Jalal Tags: Original Article Source Type: research

Guggulipid: A Promising Multi-Purpose Herbal Medicinal Agent
Drug Res (Stuttg) DOI: 10.1055/a-1115-4669Herbal medicines therapy is appreciated by many research works because herbal drugs have relatively high therapeutic window, lower side effects and more cost effective. Guggulipid is an ethyl acetate extract of resin known as guggul from the tree Commiphora wightii / mukul (Arn.) Bhandari. Chemical analysis revealed that the compounds responsible for the major activities of gum guggul are the isomers E- and Z-guggulsterone. Guggul has been used for thousands of years in the treatment of arthritis, inflammation, obesity, cardiac protection,...
Source: Drug Research - February 28, 2020 Category: Drugs & Pharmacology Authors: Ahmad, Md Afroz Mujeeb, Mohd Akhtar, Mohd Khushtar, Mohd. Arif, Mohd. Haque, Md Rafiul Tags: Review Source Type: research

Effect of an Al/Mg Hydroxide Antacid and Food on the Pharmacokinetics of Dexibuprofen
Conclusion It is concluded that concomitant intake of Al/Mg hydroxide antacid or food with dexibuprofen has an impact to significantly alter its pharmacokinetic parameters. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Drug Research)
Source: Drug Research - February 28, 2020 Category: Drugs & Pharmacology Authors: Shaker, M. Ahsan Akhtar, Naveed Minhas, Muhammad Usman Khan, Kifayat Ullah Zangi, Muhammad Imad-ud-Din Munir, Abubakar Tags: Original Article Source Type: research