Anti-lipidemic Effect of Fractions of Peristrophe bivalvis Leaf in NG-nitro-L-arginine Methyl Ester (L-NAME) Treated Rats
Conclusion In brief, the fractions of PB leaf increased HDL-C and NO, and decrease atherogenic indices in L-NAME treated rats. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - April 2, 2020 Category: Drugs & Pharmacology Authors: Aluko, Esther Oluwasola Omobowale, Temidayo Olutayo Oyagbemi, Ademola Adetokunbo Fasanmade, Adesoji Adedipe Tags: Original Article Source Type: research
A Phytochemical and Ethnopharmacological Recapitulation on Hamelia patens
Drug Res (Stuttg) DOI: 10.1055/a-1131-7856The world health organization reports that 80% of the population living within the developing countries depends basically on traditional medicine for his or her primary health care. Quite half the entire world's population still depends entirely on plants for medicines, and plants provides the active ingredients to the most traditional medical products. Hamelia patens that belong to the family Rubiaceae, is mainly found in tropical and sub-tropical areas. It is used in folk medicine against a wide range of diseases such as athlete’s foot, skin problems, insect sting, psychiatric ...
Source: Drug Research - March 29, 2020 Category: Drugs & Pharmacology Authors: Noor, Gazala Ahmad, Md.Afroz Ahsan, Farogh Mahmood, Tarique Arif, Muhammad Khushtar, Mohammad Tags: Review Source Type: research
Thymoquinone Loaded Solid Lipid Nanoparticles Demonstrated Antidepressant-Like Activity in Rats via Indoleamine 2, 3- Dioxygenase Pathway
Drug Res (Stuttg) DOI: 10.1055/a-1131-7793The World Health Organization (WHO) has ranked depression the 4th leading cause of disability worldwide. Thymoquinone (TQ), is an active constituent of Nigella sativa having various medicinal properties but has poor solubility and bioavailability. This problem was overcome by developing nanoformulation of TQ. Previously TQ reported good antioxidant and anti-inflammatory effects. Recently TQ’s anti-depressant effect was demonstrated. However, the mechanisms underlying the antidepressant effect of TQ still needs evaluation. Activation of Indoleamine-2,3-dioxygenase (IDO), (an enzym...
Source: Drug Research - March 19, 2020 Category: Drugs & Pharmacology Authors: Alam, Mahtab Zameer, Saima Najmi, Abul Kalam Ahmad, Farhan Jalees Imam, Syed Sarim Akhtar, Mohd Tags: Original Article Source Type: research
The Population Pharmacokinetics of Rifampicin in Japanese Pulmonary Tuberculosis Patients
The objectives of this study are to (1) identify covariate(s) that may explain the variation of rifampicin, which is the key antitubercular agent, under the steady-state by evaluating its population pharmacokinetics and (2) to propose an appropriate dosing method of rifampicin to Japanese patients. For this purpose, serum concentration–time data were obtained from 138 patients receiving rifampicin (300–450 mg) and isoniazid (300–400 mg) every day over 14 days, and analyzed using nonlinear mixed effects model. Thereby, population pharmacokinetic parameters were estimated followed by elucidating relations between t...
Source: Drug Research - March 18, 2020 Category: Drugs & Pharmacology Authors: Nishimura, Takahiro Kohno, Haruichi Nagai, Hideaki Maruoka, Daisuke Koike, Yuichi Kobayashi, Masahiro Atsuda, Koichiro Tags: Original Article Source Type: research
Dig & Delve into Protein Based Nanoformulations
Drug Res (Stuttg) DOI: 10.1055/a-1127-2960Past few decades have emerged as the era of nanotechnology worldwide leading to an extensive research in pharmaceutical science as well as other fields. Nanoformulations have shown a promising future in therapeutics and theronostics. Protein based nanoformulations attracting attention in research as it can be used as therapeutics as well as carrier. Carrier based protein nanoformulatios are capable of accommodating range of therapeutics such as dyes, drugs, contrast agents and inorganic nanoclusters makings its application vast. The nano size of formulation enables it to reach the ...
Source: Drug Research - March 15, 2020 Category: Drugs & Pharmacology Authors: Shariq, Mohammad Parveen, Saba Shamim, Arshiya Ahsan, Farogh Kushwaha, Poonam Mahmood, Tarique Tags: Review Source Type: research
