Comparative Study of Recombinant Human Erythropoietin (rhEPO)
Products on CKD (Chronic Kidney Disease) Patients
Conclusion This study proves that the efficacy indicated by the change
instability of Hb and safety indicated by adverse event incidence of Epodion and
the reference product on chronic kidney disease were similar. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Drug Research)
Source: Drug Research - March 27, 2023 Category: Drugs & Pharmacology Authors: Dwitanto, Kuspuji Angginy, Nova Sutandar, Widodo Tags: Original Article Source Type: research
The Effects of Quercetin on Apoptosis and Antioxidant Activity in a
Renal Ischemia/Reperfusion Injury Animal Model
Drug Res (Stuttg) DOI: 10.1055/a-1999-7600Renal ischemia-reperfusion injury (IRI) is considered as one of the most
prevalent causes of acute kidney injury (AKI), which can happen in various
clinical situations including hypovolemic shock, injury, thrombo-embolism, and
after a kidney transplant. This paper aims to evaluate the reno-protective
effects of Quercetin in induced ischemia/reperfusion injury by
regulating apoptosis-related proteins, inflammatory cytokines, MMP-2, MMP-9, and
nuclear factor kappa-light-chain-enhancer inactivated B cells (NF-kB) in rats.
...
Source: Drug Research - March 27, 2023 Category: Drugs & Pharmacology Authors: Bagheri, Amin Radman, Ghazal Aria, Negar Rezaei, Fatemeh Khajenouri, Mohammad Ghiabi, Shamim Bagheri, Yasin Tags: Original Article Source Type: research
AGEs RAGE Pathways: Alzheimer ’s Disease
The objective of this review is to compile the most
recent and intriguing data of AGEs and receptor for advanced glycation end
products (RAGE) pathways which are responsible for AD. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - March 20, 2023 Category: Drugs & Pharmacology Authors: Maheshwari, Shubhrat Tags: Review Source Type: research
Prazosin Protects the Liver Against Renal
Ischemia/Reperfusion Injury in Rats
In this study, the effect of
Prazosin, an α1-Adrenergic receptor antagonist, was investigated on the
liver injury induced by kidney ischemia-reperfusion (I/R) in rats. Male
adult Wistar rats (n=21) were divided into three groups: sham, kidney
I/R, and kidney I/R pre-treated with Prazosin
(1 mg/kg). Kidney I/R was induced by vascular clamping
of the left kidney for 45 min to reduce the blood flow. Oxidative and
antioxidant factors along with apoptotic (Bax, Bcl-2, caspase3), and
inflammatory (NF-κβ, IL-1β, and IL-6) factors were
...
Source: Drug Research - March 20, 2023 Category: Drugs & Pharmacology Authors: Khajepour, Fatemeh Mahmoodpoor, Fariba Jafari, Elmira Kakaei, Farzad Bahraminia, Farina Aghajani, Shadi Vahed, Sepideh Zununi Bagheri, Yasin Tags: Original Article Source Type: research
Receptor for Advanced Glycation End Products: Dementia and Cognitive
Impairment
Drug Res (Stuttg) DOI: 10.1055/a-2015-8041The pathophysiological processes of dementia and cognitive impairment are linked
to advanced glycation end products (AGEs) and their receptor (RAGE).The
neurofibrillary tangles (NFTs) of abnormally hyperphosphorylated tau protein and
senile plaques (SPs), which are brought on by amyloid beta (Aβ)
deposition, are the hallmarks of Alzheimer’s disease (AD), a progressive
neurodegenerative condition. Advanced glycation end products that are produced
as a result of vascular dysfunction are bound by the receptor for advanced
...
Source: Drug Research - March 8, 2023 Category: Drugs & Pharmacology Authors: Singh, Aditya Ansari, Vaseem Ahamad Mahmood, Tarique Ahsan, Farogh Wasim, Rufaida Shariq, Mohammad Parveen, Saba Maheshwari, Shubhrat Tags: Review Source Type: research
Regulation of Adipose Tissue Insulin Resistance and Diabetic
Parameters in Drug Na ïve Subjects with Type 2 Diabetes Treated with
Canagliflozin Monotherapy
The objective of this study is to investigate the link between the
baseline/changes of body weight and those of diabetic parameters during
treatment with an SGLT-2 inhibitor. Drug naïve subjects with T2DM
received canagliflozin monotherapy for 3 months. Adipo-IR was selected as the
significant factor responsible for the changes of (Δ)BMI with this drug.
While no correlations were noted between ΔBMI and ΔFBG,
ΔHbA1c, ΔHOMA-R or ΔQUICKI, significant negative
correlations were observed between ΔBMI and Δadipo-IR
(R=−0.308). The subjects...
Source: Drug Research - March 7, 2023 Category: Drugs & Pharmacology Authors: Kutoh, Eiji Kuto, Alexandra N. Ozawa, Eri Kurihara, Rumi Akiyama, Midori Tags: Original Article Source Type: research
A preliminary study to identify existing drugs for potential
repurposing in breast cancer based on side effect profile
Drug Res (Stuttg) DOI: 10.1055/a-2011-5662Breast cancer is the most commonly diagnosed cancer and the second leading cause
of cancer-related death in women after lung cancer. The present study aims to
identify potential drug candidates using the PROMISCUOUS database for breast
cancer based on side effect profile and then proceed with in silico and
in vitro studies. PROMISCUOUS database was used to construct a group
of drugs that share maximum side effects with letrozole. Based on the existing
literature, ropinirole, risperidone, pregabalin, and gabapentin were s...
Source: Drug Research - March 6, 2023 Category: Drugs & Pharmacology Authors: Rymbai, Emdormi Sugumar, Deepa Krishnamurthy, Praveen Thaggikuppe Selvaraj, Divakar Vasu, Soumya Priya, Shiva Jayaram, Saravanan Tags: Original Article Source Type: research
Evaluation of Biological Activity Exerted by
Dibenzo[b,e]Thiophene-11(6H)-One on Left Ventricular Pressure Using an Isolated
Rat Heart Model
Conclusions All these data suggest that Dibenzo[b,e]thiophene-11(6H)-one
increase left ventricular pressure through calcium channel activation. In this
way, Dibenzo[b,e]thiophene-11(6H)-one could be a good candidate as positive
inotropic agent to heart failure. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - March 1, 2023 Category: Drugs & Pharmacology Authors: Figueroa-Valverde, Lauro Rosas-Nexticapa, Marcela Alvarez-Ramirez, Magdalena L ópez-Ramos, Maria D íaz-Cedillo, Francisco Mateu-Armad, Maria Virginia Tags: Original Article Source Type: research
Protein kinases: Role of their dysregulation in carcinogenesis,
identification and inhibition
Drug Res (Stuttg) DOI: 10.1055/a-1989-1856Protein kinases belong to the phosphor-transferases superfamily of enzymes, which
“activate” enzymes via phosphorylation. The kinome of an
organism is the total set of genes in the genome, which encode for all the
protein kinases. Certain mutations in the kinome have been linked to
dysregulation of protein kinases, which in turn can lead to several diseases and
disorders including cancer. In this review, we have briefly discussed the role
of protein kinases in various biochemical processes by categorizing cancer
...
Source: Drug Research - February 23, 2023 Category: Drugs & Pharmacology Authors: Sarkar, Niloy Singh, Amit Kumar, Pankaj Kaushik, Mahima Tags: Review Source Type: research
Development and Validation of HPLC Method for Quantification of
Plumbagin in Plumbago Zeylanica L. Roots
Conclusion The developed method was accurate, specific, precise, and
reproducible. This RP-HPLC may be useful for quantitative estimation of the
chemical constituents present in the plant extract as well as the quality
assessment of the herbal product. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - February 23, 2023 Category: Drugs & Pharmacology Authors: Shukla, Babita Kushwaha, Poonam Tags: Original Article Source Type: research
Preparation, Characterization and Evaluation of a Novel Drug Carrier
for the Controlled Release of Curcumin
Drug Res (Stuttg) DOI: 10.1055/a-1995-5303The upsurge of cancer demands intense, rapid and effective intervention from the
scientific society. Even though nanoparticles helped achieving this, maintaining
its size without using toxic capping agents is challenging. Phytochemicals
having reducing properties is a proper substitute and the efficiency of such
nanoparticles could be further improved by grafting with suitable monomers. It
could be further protected from rapid biodegradation by coating with suitable
materials. This approach was utilized wherein, the green ...
Source: Drug Research - February 21, 2023 Category: Drugs & Pharmacology Authors: Kasim, Faseela Nair, Archana Somasekharan Lalitha Balachandran, Aswathy Sooraj, Moorikoval Parambil Nair, Anoop Somasekharan Tags: Original Article Source Type: research
Comparison of the efficacy of pioglitazone and metformin on
ultrasound grade and liver enzymes level in patients with non-alcoholic fatty
liver disease: A randomized controlled clinical trial
This study aimed to evaluate the effectiveness of metformin and
pioglitazone in combination with vitamin E on sonography grade and liver enzymes
level in patients with non-alcoholic fatty liver disease.
Methods A randomized controlled clinical trial was designed with 68
patients diagnosed with non-alcoholic fatty liver disease by sonography and
clinical examinations. Sixty-eight patients were randomly divided into two
groups; 34 were assigned to receive 15 mg of pioglitazone per day and 34
were assigned to receive 1000 mg of metformin per day for 6 months...
Source: Drug Research - February 15, 2023 Category: Drugs & Pharmacology Authors: Khoshbaten, Manouchehr Beheshtirouy, Samineh Shayanrad, Shahrzad Gharekhani, Afshin Rezaee, Haleh Tags: Original Article Source Type: research
Interferon- γ-Treated Mesenchymal Stem Cells Modulate the T
Cell-Related Chemokines and Chemokine Receptors in an Animal Model of
Experimental Autoimmune Encephalomyelitis
Conclusion Priming the MSC with IFN-γ can be an efficient approach
to enhance the immunomodulatory potential of MSCs. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - February 8, 2023 Category: Drugs & Pharmacology Authors: Ahmadifard, Reza Jafarzadeh, Abdollah Mahmoodi, Merat Nemati, Maryam Rahmani, Mehdi Khorramdelazad, Hossein Ayoobi, Fatemeh Tags: Original Article Source Type: research
Transethosomes: A Promising Challenge for Topical Delivery Short
Title: Transethosomes for Topical Delivery
Drug Res (Stuttg) DOI: 10.1055/a-1974-9078Skin provides an excellent barrier to molecular transport, as the stratum corneum
is the most formidable barrier to the passage of most pharmaceuticals. Various
attempts have been made to improve drug administration into the body through
intact skin. Though very few routes are as attractive as the topical route, drug
transport through the skin is challenging. To overcome the challenges,
researchers have found a system in which the drug is encapsulated into the
vesicle, penetrating deeper into the skin to hit the target sit...
Source: Drug Research - February 3, 2023 Category: Drugs & Pharmacology Authors: Adnan, Mohammad Haider, Md. Faheem Naseem, Nazish Haider, Tanweer Tags: Review Source Type: research
HPLC-UV/VIS for Determination of Ipratropium Bromide Mixed
with Salbuterol, Beclomethasone Propionate and Budesonide using Dual
Wavelength-Detection Method
Conclusion The liquid phase methodology developed in this study can be
used for the determination of compound ipratropium bromide mixed with
beclomethasone propionate and budesonide. The current methodology can also be
used to provide a reference for the determination of its content after mixing,
and further data support for its clinical medication. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - February 3, 2023 Category: Drugs & Pharmacology Authors: Haihua, Guo Rui, Zhang Liangjun, Deng Meng, Li Sha, Li Suqing, Zhao Tags: Original Article Source Type: research
