Design, Synthesis and Enhanced BBB Penetration Studies of
L-serine-Tethered Nipecotic Acid-Prodrug
Drug Res (Stuttg) DOI: 10.1055/a-1290-0119Nipecotic acid is considered to be one of the most potent inhibitors of
neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Due to its
hydrophilic nature, nipecotic acid does not readily cross the blood-brain
barrier (BBB). Large neutral amino acids (LAT1)-knotted nipecotic acid
prodrug was designed and synthesized with the aim to enhance the BBB
permeation by the use of carrier-mediated transport. The synthesized prodrug
was tested in animal models of Pentylenetetrazole (PTZ)-induced convulsions
...
Source: Drug Research - November 25, 2020 Category: Drugs & Pharmacology Authors: Dhanawat, Meenakshi Gupta, Sumeet Mehta, Dinesh Kumar Das, Rina Tags: Original Article Source Type: research
Kava (Piper methysticum) Extract for the Treatment of Nervous
Anxiety, Tension and Restlessness
Conclusions Overall, the study confirms the effective and safe
short-term use of kava in the Commission E-defined indication of
“nervous anxiety, tension and restlessness”, especially in
other than chronic cases. The clinical use of kava might be translated into
context-related phobias according to ICD-10 F40, or to nervous tension
(ICD10 R45.0) or restlessness and excitation (ICD-10 R45.1). [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - November 18, 2020 Category: Drugs & Pharmacology Authors: Kuchta, Kenny Hladikova, Marie Thomsen, Michael Nahrstedt, Adolf Schmidt, Mathias Tags: Original Article Source Type: research
Development of Composition and Technologies of Dental Film with
Ketorolac Trometamine
Drug Res (Stuttg) DOI: 10.1055/a-1302-7701The report presents the results of the development of dental films with
ketorolac trometamine based on the natural biodegradable polymers from the
groups of sodium alginates and xanthan gums in combination with lightly
crosslinked acrylic polymer carbopol. Physicochemical properties, such as
moisture, mucoadhesion, thickness, tensile strength, disintegration in
phosphate buffer were determined in obtained samples of this dosage form. A
comparison of physicochemical properties of experimental samples and
...
Source: Drug Research - November 18, 2020 Category: Drugs & Pharmacology Authors: Bakhrushina, Elena O. Demina, Natalia B. Kashperko, Alena S. Vakina, Marina G. Anurova, Maria N. Zhilyakova, Elena T. Krasnyuk, Ivan I. Tags: Original Article Source Type: research
Der lange Weg zur personalisierten Medizin in der Allergologie
Drug Res (Stuttg) 2020; 70: S30-S31 DOI: 10.1055/a-1119-2827 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Drug Research)
Source: Drug Research - November 17, 2020 Category: Drugs & Pharmacology Authors: Bieber, Thomas Tags: Extended Abstract Source Type: research
Epigenetic Regulation of Allergic Disease
Drug Res (Stuttg) 2020; 70: S29-S29 DOI: 10.1055/a-1119-2816 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Drug Research)
Source: Drug Research - November 17, 2020 Category: Drugs & Pharmacology Authors: Renz, Harald Tags: Extended Abstract Source Type: research
Klimawandel und Gesundheit – wird die Tsunami-Welle allergischer Erkrankungen in Zukunft noch höher?
Drug Res (Stuttg) 2020; 70: S27-S28 DOI: 10.1055/a-1119-2805 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Drug Research)
Source: Drug Research - November 17, 2020 Category: Drugs & Pharmacology Authors: Traidl-Hoffmann, Claudia Tags: Extended Abstract Source Type: research
Die Allergen-Immuntherapie – State of the Art 2020
Drug Res (Stuttg) 2020; 70: S24-S26 DOI: 10.1055/a-1119-2783 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Drug Research)
Source: Drug Research - November 17, 2020 Category: Drugs & Pharmacology Authors: Pfaar, Oliver Tags: Extended Abstract Source Type: research
Therapiestrategien im Alltag (Steroide, Antihistaminika)
Drug Res (Stuttg) 2020; 70: S22-S23 DOI: 10.1055/a-1119-2762 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Drug Research)
Source: Drug Research - November 17, 2020 Category: Drugs & Pharmacology Authors: von Kiedrowski, Ralph Tags: Extended Abstract Source Type: research
Molekulare Allergiediagnostik
Drug Res (Stuttg) 2020; 70: S17-S21 DOI: 10.1055/a-1119-2751 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Drug Research)
Source: Drug Research - November 17, 2020 Category: Drugs & Pharmacology Authors: Kleine-Tebbe, J örg Tags: Extended Abstract Source Type: research
Bedeutung von Mikrobiomen in Darm und Atemwegen f ür Therapien
Drug Res (Stuttg) 2020; 70: S16-S16 DOI: 10.1055/a-1119-2740 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Drug Research)
Source: Drug Research - November 17, 2020 Category: Drugs & Pharmacology Authors: von Mutius, Erika Tags: Extended Abstract Source Type: research
Arzneimittelreaktion: Allergie vs. Intoleranz gegen über Wirkstoffen
Drug Res (Stuttg) 2020; 70: S15-S15 DOI: 10.1055/a-1119-2729 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Drug Research)
Source: Drug Research - November 17, 2020 Category: Drugs & Pharmacology Authors: Zuberbier, Torsten Tags: Extended Abstract Source Type: research
Adverse Cutaneous Drug Reactions
Drug Res (Stuttg) 2020; 70: S13-S14 DOI: 10.1055/a-1119-2708 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Drug Research)
Source: Drug Research - November 17, 2020 Category: Drugs & Pharmacology Authors: French, Lars E. Tags: Extended Abstract Source Type: research
Anaphylaxien nach Arzneimittelgabe
Drug Res (Stuttg) 2020; 70: S12-S12 DOI: 10.1055/a-1119-2697 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Drug Research)
Source: Drug Research - November 17, 2020 Category: Drugs & Pharmacology Authors: Worm, Margitta Tags: Extended Abstract Source Type: research
Nahrungsmittelallergien – Vorkommen und Behandlungsstrategien
Drug Res (Stuttg) 2020; 70: S10-S11 DOI: 10.1055/a-1119-2676 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Drug Research)
Source: Drug Research - November 17, 2020 Category: Drugs & Pharmacology Authors: Schmid-Grendelmeier, Peter Tags: Extended Abstract Source Type: research
Allergische Rhinitis – Diagnostik und Therapieoptionen
Drug Res (Stuttg) 2020; 70: S7-S9 DOI: 10.1055/a-1119-2665 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Drug Research)
Source: Drug Research - November 17, 2020 Category: Drugs & Pharmacology Authors: Klimek, Ludger Tags: Extended Abstract Source Type: research
