A Study to Explore the Role of IDH1 (R132) Mutation on Imatinib
Toxicity and Effect of ABCG2/OCT1 Expression on N-Desmethyl Imatinib
Plasma Level in Egyptian Chronic Myeloid Leukemia Patients
This study aimed to gain more knowledge of the altered PK,
pharmacogenetic factors, and gene expression leading to variable IM levels.
Fifty patients with chronic phase-CML were enrolled in this study and divided as
25 responders and 25 non-responders (patients are directly recruited after
response assessment). HPLC/MS/MS was used to determine trough
and peak concentration of imatinib and N-desmethyl imatinib in the blood.
PCR-RFLP technique was used to detect IDH1 gene mutation (R132). The median
value of IM trough level was significantly higher, the P/...
Source: Drug Research - January 11, 2023 Category: Drugs & Pharmacology Authors: Sabri, Alaa Omran, Mervat M. Azim, S.Abdel Abdelfattah, Raafat Allam, Rasha Mahmoud Shouman, Samia A. Tags: Original Article Source Type: research
The efficacy of 2-formyl benzoic acid in reactivating diazinon
inhibited murine cholinesterase
Drug Res (Stuttg) DOI: 10.1055/a-1934-1806Oximes, as classical acetylcholinesterase (AChE) reactivators, have some
pharmacokinetics/pharmacodynamics disadvantages. During the synthesis of
non-oxime compounds, we encountered the compound 2-formylbenzoic acid (2-FBA)
with promising in vitro and in vivo cholinesterase (ChE) reactivating properties
in the acute exposure to diazinon (DZN). For in vitro experiments, the healthy
mice serum and brain homogenate were freshly prepared and exposed to DZN
(160 µg/mL). After 10 minutes, 2-FBA was added
to the po...
Source: Drug Research - January 10, 2023 Category: Drugs & Pharmacology Authors: Farhat, Humayun Zabihi, Ebrahim Alibabaei-Omran, Fatemeh Mohammadi-Khanaposhti, Maryam Tags: Original Article Source Type: research
MicroRNA-32 Suppression: its Effects on Prostate Cancer
Cells ’ Capability to Proliferate and Migrate
Conclusion These results indicate that the suppression of miR-32 might
offer an auxiliary treatment procedure for addressing the invasion, progression,
and metastasis in PCa patients by improving cell apoptosis. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - January 10, 2023 Category: Drugs & Pharmacology Authors: Al-Marzook, Farah A. Hassan, Duha Maithem Alghazal, Maha Waleed Kadheem, Rana Abd Alameer Jalil, Abduladheem Turki Saleh, Marwan Mahmood Tags: Original Article Source Type: research
Molecular Docking Studies of Rifampicin – rpoB
complex: Repurposing Drug Design Implications for against Plasmodium
falciparum Malaria through a Computational Approach
Drug Res (Stuttg) DOI: 10.1055/a-1974-9028Malaria is one of the world’s most devastating diseases, infecting well
over 300 million people annually and killing between 2 and 3 million worldwide.
Increasing parasite resistance to many existing drugs is exacerbating disease.
Resistance to commonly used malarial drugs is increasing the need to develop new
drugs urgently. Due to the slow pace and substantial costs of new drug
development, repurposing of old drugs which is recently increasingly becoming an
attractive proposition of highly efficient and effective way o...
Source: Drug Research - January 9, 2023 Category: Drugs & Pharmacology Authors: Yadav, Upasana Pandey, Jaya Tags: Original Article Source Type: research
Cysteamine Attenuate Intestinal Reperfusion Injury Induced by
Occlusion of Mesenteric Artery by Enhancing Intracellular Thiol
Activities
Conclusion Cysteamine mitigate IRI by enhancing intracellular antioxidant
defense system, inhibiting inflammatory mediators and intestinal tissue
expression of pro-apoptotic protein. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - December 27, 2022 Category: Drugs & Pharmacology Authors: Alabi, Babatunde Iwalewa, Olugbenga Omobowale, Temidayo Adedapo, Adeolu Hammed, Opeyemi Ajike, Richard Afolabi, Oladele Tags: Original Article Source Type: research
Biological Activity of a 4-Hydroxy-Furanyl-Benzamide Derivative on
Heart Failure
Conclusions All these data suggest that biological activity produced by
4-hydroxy-furanyl-benzamide derivative on left ventricular pressure is through
of both M2-muscarinic receptor and nitric oxide synthase enzyme
activation. It is important to mention that this phenomenon results as a
decrease of both infarct area and heart failure. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - December 23, 2022 Category: Drugs & Pharmacology Authors: Lauro, Figueroa-Valverde Marcela, Rosas-Nexticapa Maria, L ópez-Ramos Magdalena, Alvarez-Ramirez Virginia, Mateu-Armad Maria Francisco, D íaz-Cedillo Catalina, Cervantes-Ortega Montserrat, Melgarejo-Guutierrez Tags: Original Article Source Type: research
Effect Produced by a Cyclooctyne Derivative on Both Infarct Area and
Left Ventricular Pressure via Calcium Channel Activation
Conclusions All these data indicate that cyclooctyne derivative increase
left ventricular pressure via calcium channel activation and this phenomenon
could be translated as a decrease of infarct area. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - November 29, 2022 Category: Drugs & Pharmacology Authors: Lauro, Figueroa-Valverde Marcela, Rosas-Nexticapa Maria, L ópez-Ramos Francisco, D íaz-Cedillo Magdalena, Alvarez-Ramirez Virginia, Mateu-Armad Maria Montserrat, Melgarejo-Gutierrez Tags: Original Article Source Type: research
The Possible Protective Effects of Ondansetron and Tropisetron on
Optic Nerve Crush Injury in Rats
Conclusion Our findings indicate that cyclosporine, ondansetron, and
tropisetron protect against ONC injury in rats, possibly via the suppression of
apoptosis and modulation of calcineurin activity directly and via 5-HT3
receptors. Moreover, immunoblotting showed that tropisetron was more effective
as opposed to ondansetron. Further studies are needed to evaluate the precise
mechanism behind cyclosporine, ondansetron, and tropisetron activities. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents ...
Source: Drug Research - November 24, 2022 Category: Drugs & Pharmacology Authors: Shayan, Maryam Eslami, Faezeh Khosravi, Ayda Rashidian, Amir Jafari, Razie Mohammad Maroufi, Seyed Farzad Golroudbari, Hasti Tashak Dehpour, Ahmad Reza Tags: Original Article Source Type: research
Curcumin-Loaded Chitosan Nanoparticle Preparation and Its Protective
Effect on Celecoxib-induced Toxicity in Rat isolated Cardiomyocytes and
Mitochondria
Drug Res (Stuttg) DOI: 10.1055/a-1960-3092Curcumin has a wide range of pharmacological activities, including antioxidant,
anti-inflammatory and tissue protective. In here we hypothesized that
curcumin-loaded chitosan-coated solid lipid nanoparticles (CuCsSLN) are able to
increase its overall bioavailability and hence its antioxidant and
mitochondria;/lysosomal protective properties of curcumin. CuCsSLN were
prepared using solvent diffusion technique for formation of solid lipid
nanoparticles (SLNs) and electrostatic coating of positive-charged chitosan to
...
Source: Drug Research - November 24, 2022 Category: Drugs & Pharmacology Authors: Ebrahimi, Hossein Ali Esmaeli, Samira Khezri, Saleh Salimi, Ahmad Tags: Original Article Source Type: research
Mitochondrial Transplantation Therapy against Ifosfamide Induced
Toxicity on Rat Renal Proximal Tubular Cells
Drug Res (Stuttg) DOI: 10.1055/a-1967-2066Mitochondrial dysfunction is a basic mechanism leading to drug nephrotoxicity.
Replacement of defective mitochondria with freshly isolated mitochondria is
potentially a comprehensive tool to inhibit cytotoxicity induced by ifosfamide
on renal proximal tubular cells (RPTCs). We hypothesize that the direct exposure
of freshly isolated mitochondria into RPTCs affected by ifosfamide might restore
mitochondrial function and reduce cytotoxicity. So, the aim of this study was to
assess the protective effect of freshly isolated mi...
Source: Drug Research - November 17, 2022 Category: Drugs & Pharmacology Authors: Arjmand, Abdollah Mashhadi, Melika Kaveh, Armin Kamranfar, Farzaneh Seydi, Enayatollah Pourahmad, Jalal Tags: Original Article Source Type: research
Saliva Sampling in Therapeutic Drug Monitoring and Physiologically
Based Pharmacokinetic Modeling: Review
Drug Res (Stuttg) DOI: 10.1055/a-1956-9313Therapeutic drug monitoring investigations based on saliva samples can be
utilized as an alternative to blood sampling for many advantages. Moreover, the
development of physiologically based pharmacokinetic (PBPK) modeling tools can
further help to estimate drug exposure from saliva. This review discusses the
use of saliva samples and illustrates the applications and examples of PBPK
modeling systems for estimating drug exposure from saliva. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in T...
Source: Drug Research - November 11, 2022 Category: Drugs & Pharmacology Authors: Almukainzi, May Tags: Review Source Type: research
Aloe Vera-Containing Matrix in Transdermal Fentanyl Therapy
Improves Adhesion, Skin Tolerance and Quality of Life: Results of a German
Multicenter Study with a New Fentanyl Patch
Discussion
Aloe vera in transdermal pain treatment improves adhesion
and local tolerance of the patch. Pain control and quality of life were also
improved. Regional care data concerning cotreatment in pain therapy from this
study indicate a lack of penetration of existing guidelines in general
practitioners’ pain therapy. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - November 11, 2022 Category: Drugs & Pharmacology Authors: Dietrich, Christoph G. Kottmann, Tanja Vo ß, Hans Werner Lorenz, Roxane Tags: Original Article Source Type: research
A Double-blind, Placebo-controlled, Randomized, Single Ascending, and
Multiple Dose Phase 1 Study to Evaluate the Safety, Tolerability, and
Pharmacokinetics of Oral Dose Isomyosamine Capsules in Healthy Adult
Subjects
Conclusion Isomyosamine will continue to be investigated in phase 2
clinical trials for the treatment of sarcopenia/frailty,
hashimoto’s thyroiditis and rheumatoid arthritis. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Drug Research)
Source: Drug Research - November 11, 2022 Category: Drugs & Pharmacology Authors: Brager, Jenna Chapman, Chris Dunn, Leonard Kaplin, Adam Tags: Original Article Source Type: research
Effects of Chronic Oral Administration of Midazolam on Memory and
Circadian Rhythms in Rats
Drug Res (Stuttg) DOI: 10.1055/a-1937-9064Studies have shown the ability of benzodiazepine drugs to cause memory loss in
animals and humans. Midazolam is a benzodiazepine commonly administered
intravenously during surgical procedures because it reacts rapidly, causes
anterograde amnesia, and has few side effects. It has also been used in
palliative medicine where, among others, an oral route has been employed for
chronic administration of the drug. The current study evaluated the effects of
chronic orally administered midazolam on spatial working memory and proced...
Source: Drug Research - October 27, 2022 Category: Drugs & Pharmacology Authors: Murphy, Helen M. Kalinina, Anastasiya I. Wideman, Cyrilla H. Tags: Original Article Source Type: research
Molecular Docking Study of Isoxazole Indole Derivatives (B2A2 Series)
as Promising Selective Estrogen Receptor Modulators & Anticancer
Drugs
Drug Res (Stuttg) DOI: 10.1055/a-1958-3823A series of 7 compounds with isoxazole – indole –
γ-resorcylic acid scaffold, segregated into B2 & A2 series,
wherein, B2 comprises Compounds: 13, 14, 15 & 16 and A2 comprises
Compounds: 10, 11 & 12, on the basis of the variable substituents at the
indole, resorcinol and isoxazole end of the scaffold as in Figure: 1, were
designed and docked with human estrogen receptor: 1ERRα. The Binding
affinity (BA) and the interacting amino acids compared with reference selective
estrogen receptor modulator...
Source: Drug Research - October 27, 2022 Category: Drugs & Pharmacology Authors: Iyer, Jayashree Monikanta Khare, Aradhana Pandey, Jaya Yadav, Manish Tags: Original Article Source Type: research