The Therapeutic Role of Rho Kinase Inhibitor, Fasudil, on Pulmonary
Hypertension; a Systematic Review and Meta-Analysis
Conclusion Fasudil therapy is efficacious and probably safe in the
improvement of some hemodynamics in PH patients along short and mid-term
periods. However, long-term randomized controlled trials comparing fasudil with
placebo and other treatments are warranted for confirmation of these
benefits. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - October 10, 2022 Category: Drugs & Pharmacology Authors: Abedi, Farshad Omidkhoda, Navid Arasteh, Omid Ghavami, Vahid Hosseinzadeh, Hossein Tags: Review Source Type: research
The Novel Gabapentinoid Mirogabalin Prevents Upregulation of α2δ-1 Subunit of Voltage-Gated Calcium Channels
in Spinal Dorsal Horn in a Rat Model of Spinal Nerve Ligation
In conclusion,
the α2δ-1 subunit was upregulated in the spinal
dorsal horn of SNL model rats, and repeated administration of mirogabalin
inhibited this upregulation. The inhibitory effect of mirogabalin on
upregulation of the α2δ-1 subunit after nerve injury
is considered to contribute to its analgesic effects in peripheral neuropathic
pain. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - October 10, 2022 Category: Drugs & Pharmacology Authors: Domon, Yuki Kobayashi, Naoko Kubota, Kazufumi Kitano, Yutaka Ueki, Hideaki Shimojo, Yumiko Ishikawa, Kayoko Ofune, Yuka Tags: Original Article Source Type: research
Effect of Nigella Sativa in Improving Blood Glucose Level in
T2DM: Systematic Literature Review of Randomized Control Trials
Conclusion Different mechanisms are proposed
which contribute to the anti-diabetic activity of NS. Various outcome parameters
evaluated demonstrate a significant improvement in the management of T2DM and
its complications upon intervention with NS. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - September 27, 2022 Category: Drugs & Pharmacology Authors: Hoda, Farazul Khanam, Afifa Thareja, Mehak Arshad, Mawrah Ahtar, Mohd Najmi, Abul Kalam Tags: Review Source Type: research
Identification and Screening of Novel Anti-Cancer Compounds for
Aurora Kinase-A from Chemical Database
Drug Res (Stuttg) DOI: 10.1055/a-1877-4693Aurora kinase is a group of enzymes that belongs to a serine-threonine family and
plays a critical role in cellular division. Aurora Kinase A is overexpressed and
distributed beyond the nucleus and is involved in tumorigenesis. Flavones are a
class of flavonoids that are present in plants that show anticancer activity.
Similar compounds of 2’Fluoroflavones are retrieved from the PubChem
database. Then drug-like filters viz. REOS and PAINS were applied to remove
toxic compounds using Canvas software, resulting in 3882 com...
Source: Drug Research - September 22, 2022 Category: Drugs & Pharmacology Authors: Singh, Ipsa A. Lokhande, Kiran Bharat Swamy, K. Venkateswara Tags: Original Article Source Type: research
Development and Evaluation of Topical Ethosomal Gel for Fungal
Infections
Conclusion Based on these findings, the current study found that EBZ
possesses significant antifungal efficacy against C. albicans. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - September 22, 2022 Category: Drugs & Pharmacology Authors: Gupta, Preeti Hafeez, Abdul Kushwaha, Poonam Tags: Original Article Source Type: research
Synergetic Effect of Lupeol and Naringin Against Bile Duct Ligation
Induced Cardiac Injury in Rats via Modulating Nitrite Level (eNos) and NF-kB
/p65 Expression
This study was concluded that oral administration of Lupeol, Naringin, and its
combination has a curative potential against BDL-induced cardiac injury in rats
by reducing oxidative stress and inflammatory reactions, resulting in reduced
heart necrosis/myocardial infarction and increased myocardial activity.
It also inhibits cardiac damage in the rat heart, these effects may be linked to
the NO level (eNOS) is increased and the inactivation of the NF-kB-p65
expression pathways.This study also provides new insights into the development
of lupeol and Naring...
Source: Drug Research - September 22, 2022 Category: Drugs & Pharmacology Authors: Alam, Firoj Kharya, Anil Kumar Srivastav, Ritesh Kumar Akhtar, Juber Khan, Mohammad Irfan Ahmad, Mohammad Tags: Original Article Source Type: research
Neurodegeneration: Microglia: Nf-Kappab Signaling
Pathways
Drug Res (Stuttg) DOI: 10.1055/a-1915-4861Microglia is cells of mesodermal/mesenchymal origin that migrate into the
central nervous system (CNS) to form resident macrophages inside the special
brain microenvironment. Intact with both neuronal and non-neuronal cells,
microglia is highly active cells. Continuous process extension and retraction
allows microglia to scan the brain parenchyma for threats. They are also able to
change their morphology from ramified to amoeboid, which is a sign of cell
activity. In response to pleiotropic stimuli such as neurotransmitter...
Source: Drug Research - September 2, 2022 Category: Drugs & Pharmacology Authors: Singh, Aditya Ansari, Vaseem Ahamad Mahmood, Tarique Ahsan, Farogh Wasim, Rufaida Tags: Review Source Type: research
Genes Relating to Biological Processes of Endometriosis: Expression
Changes Common to a Mouse Model and Patients
Drug Res (Stuttg) DOI: 10.1055/a-1894-6817Endometriosis is one of the most common gynecological diseases in women of
reproductive age. Retrograde menstruation is considered a major reason for the
development of endometriosis. The syngeneic transplantation mouse model is an
endometriosis animal model that is considered to mimic retrograde menstruation.
However, it remains poorly understood which genetic signatures of endometriosis
are reflected in this model. Here, we employed an in vivo syngeneic mouse
endometriosis model and identified differentially expressed ge...
Source: Drug Research - September 2, 2022 Category: Drugs & Pharmacology Authors: Iwasaki, Shiho Kaneda, Katsuyuki Tags: Original Article Source Type: research
Dihydroartemesinin and Curcumin Based Self-Microemulsifying Drug
Delivery System for Antimalarial Activity
Drug Res (Stuttg) DOI: 10.1055/a-1879-2758Malaria is a significant global problem which still persists despite the
development of various effective antimalarial drugs. It is challenging to treat
this disease due to the parasite’s complex life cycle and high
recrudensce of antimalarial drugs. A new self-micro emulsifying drug delivery
system has been developed to improve the solubility of dihydroartemisinin and
curcumin. The prepared formulation contained Dihydroartemesinin, curcumin,
Groundnut Oil, Cremephor RH, and Tween 80. Self-micro emulsification time, zeta...
Source: Drug Research - August 11, 2022 Category: Drugs & Pharmacology Authors: Srivastava, Richa Fatima, Zeeshan Sahoo, Jagannath Joshi, Prince Tripathi, Renu Tags: Original Article Source Type: research
Pathway Analysis of Patients with Severe Acute Respiratory
Syndrome
Conclusion An enhanced understanding of the pathways and molecular targets
of SARS-CoV-1 in humans will contribute to current and future drug repurposing
strategies, which are an essential tool to combat rapidly emerging health
threats. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - August 11, 2022 Category: Drugs & Pharmacology Authors: Khaleel, Anas Zakariya, Abdullah Bassam Niazi, Mohammad Qinna, Nidal A. Dayyih, Wael Abu Tarkhan, Amneh H. Tags: Original Article Source Type: research
Insilico Docking Study of Isoxazole Indole Linked Resorcinol
Derivatives as Promising Selective Estrogen Receptor Modulators &
Anticancer Drugs
Drug Res (Stuttg) DOI: 10.1055/a-1888-4684A series of 9 compounds with isoxazole-indole-γ-resorcylic acid scaffold,
segregated into B1 & A1 series, wherein, B1 comprises compounds:1,3,4,5,
& 9 and A1comprises compounds: 2,6,7, & 8 , on the basis of
variable substituents at the indole , resorcinol and isoxazole end of the
scaffold as in Fig. 1, were designed and docked with human estrogen
receptor:1ERRα. The binding affinity (BA) and the interacting amino
acids compared with reference selective estrogen receptor modulators (SERMs)
such as Ra...
Source: Drug Research - August 11, 2022 Category: Drugs & Pharmacology Authors: Iyer, Jayashree Monikanta Khare, Aradhana Pandey, Jaya Tags: Original Article Source Type: research
Dendrimers: A Neuroprotective Lead in Alzheimer Disease: A Review on
its Synthetic approach and Applications
Drug Res (Stuttg) DOI: 10.1055/a-1886-3208Alzheimer disease is a neurodegenerative disease that is signified by cognitive
decline, memory loss, and erratic behavior. Dendrimers are a type of polymer
that has a well-defined structure, a high degree of molecular uniformity, and a
low polydispersity which have shown to be effective intracellular drug carriers
for bring down the in numerous cases. The data reported by the clinical trials
and chemical bonds of dendrimers loading and biological properties that may be
used in the bringing out the treatment of nano formul...
Source: Drug Research - August 5, 2022 Category: Drugs & Pharmacology Authors: Singh, Aditya Ansari, Vaseem A. Mahmood, Tarique Ahsan, Farogh Wasim, Rufaida Tags: Review Source Type: research
Nrf2 Mediated Heme Oxygenase-1 Activation Contributes to Diabetic
Wound Healing – an Overview
Drug Res (Stuttg) DOI: 10.1055/a-1899-8233Diabetic wound healing is a complicated procedure because hyperglycemia changes
the various stages of wound healing. In type 2 diabetes mellitus (T2DM),
oxidative stress is proven to be a critical factor in causing non-healing wounds
and aggravating the inflammatory phase, resulting in the amputation of lower
limbs in T2DM patients. This makes scientists figure out how to control
oxidative stress and chronic inflammation at the molecular level. Nuclear factor
erythroid 2- related factor 2 (Nrf2) releases antioxidant protei...
Source: Drug Research - August 5, 2022 Category: Drugs & Pharmacology Authors: Ramachandran, Vadivelan Mohanasundaram, Tharani Tiwari, Ruchi Tiwari, Gaurav Vijayakumar, Putta Bhongiri, Bhargav Xavier, Rinu Mary Tags: Review Source Type: research
Correction: An in-Depth Analysis of Ovarian Cancer: Pathogenesis and Clinical
Manifestation
Drug Res (Stuttg) DOI: 10.1055/a-1904-3222 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Drug Research)
Source: Drug Research - July 26, 2022 Category: Drugs & Pharmacology Authors: Mahmood, Tarique Ved, Akash Siddiqui, Mohammed Haris Ahsan, Farogh Shamim, Arshiya Ansari, Vaseem Ahamad Ahmad, Afroz Kashyap, Monu Kumar Tags: Erratum Source Type: research
Pleiotropic Benefits of Statins in Cardiovascular
Diseases
This article examines some of the
existing molecular explanations underlying statin pleiotropy and discusses if
they have clinical relevance in cardiovascular diseases. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - July 22, 2022 Category: Drugs & Pharmacology Authors: Wasim, Rufaida Ansari, Tarique Mahmood Ahsan, Farogh Siddiqui, Mohammad Haris Singh, Aditya Shariq, Mohammad Parveen, Saba Tags: Review Source Type: research
