Dihydroartemesinin and Curcumin Based Self-Microemulsifying Drug Delivery System for Antimalarial Activity
Drug Res (Stuttg) DOI: 10.1055/a-1879-2758Malaria is a significant global problem which still persists despite the
development of various effective antimalarial drugs. It is challenging to treat
this disease due to the parasite’s complex life cycle and high
recrudensce of antimalarial drugs. A new self-micro emulsifying drug delivery
system has been developed to improve the solubility of dihydroartemisinin and
curcumin. The prepared formulation contained Dihydroartemesinin, curcumin,
Groundnut Oil, Cremephor RH, and Tween 80. Self-micro emulsification time, zeta
potential, droplet size, polydispersity index, transmission electron microscopy,
drug release, and in-vivo studies were performed for characterization. The
globule size was found to be 25.59±0.40 nm and the zeta
potential was-5.75±0.18 mV. The globules prepared were spherical
in shape. The in-vitro dissolution performance of formulation of
dihydroartemisinin and curcumin self emulsifying drug delivery system showed
significantly (p<0.05, Origin Pro 8.5) higher release as compared to the
pure drugs. The results of the study suggested that the prepared self
emulsifying drug delivery system combination of Dihydroartemesinin and curcumin
has a better potential to cure parasitemia as compared to the individual
drug. [...] Georg Thieme Verlag Rü...
Source: Drug Research - Category: Drugs & Pharmacology Authors: Srivastava, Richa Fatima, Zeeshan Sahoo, Jagannath Joshi, Prince Tripathi, Renu Tags: Original Article Source Type: research