Curcumin Upregulates miR-148a to Increase the Chemosensitivity of
CD44-Positive Prostate Cancer Stem Cells to Paclitaxel Through Targeting the
MSK1/IRS1 axis
Conclusion Curcumin may restore paclitaxel sensitivity by raising miR-148a
expression and inhibiting its target genes. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - July 22, 2022 Category: Drugs & Pharmacology Authors: Vatankhah, Mohammad Amin Panahizadeh, Reza Nejati-Koshki, Kazem Arabzadeh, Mahsa Arabzadeh, Amir Ahmad Najafzadeh, Nowruz Tags: Original Article Source Type: research
Correction: Co-Adjuvancy of Solasodine & CoQ10 Against High Fat
Diet-Induced Insulin Resistance Rats Via Modulating IRS-I and PPAR- γ
Proteins Expression
Drug Res (Stuttg) 2022; 72: e1-e1 DOI: 10.1055/a-1893-3148 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Drug Research)
Source: Drug Research - July 18, 2022 Category: Drugs & Pharmacology Authors: Khan, Irfan Kumar, Rajesh Prasad, Mahesh Srivastav, Ritesh Kumar Vishwakarma, Vishal Kumar Akhtar, Juber Tags: Erratum Source Type: research
Buspirone Ameliorates Colon Inflammation in TNBS-Induced Rat Acute
Colitis: The Involvement of TLR4/NF-kB Pathway
Drug Res (Stuttg) DOI: 10.1055/a-1855-1491Inflammatory bowel disease (IBD) is an inflammatory situation involving the whole
digestive system. This illness includes ulcerative colitis and Crohn’s
disease. According to scientific research, the immune system plays an essential
part in developing this disease. Recently, buspirone has been discovered to have
anti-inflammatory properties. As a result, this research aims to see if
buspirone provides anti-inflammatory effects in a rat model of TNBS-induced
colitis. Control, TNBS, dexamethasone (2 mg/kg), and buspirone...
Source: Drug Research - July 12, 2022 Category: Drugs & Pharmacology Authors: Rashidian, Amir Mohammadi, Sina Hamaneh, Amirabbas Mohammadi Chaboki, Alireza Shayan, Maryam Sheibani, Mohammad Abdollahi, Alireza Yousefi-Manesh, Hasan Dehpour, Ahmad Reza Tags: Original Article Source Type: research
Investigating the Role of Quercetin in Increasing the Rate of
Cisplatin-Induced Apoptosis Via the NF- κB Pathway in MG-63 Cancer
Cells
Conclusion Our study’s findings provide an exact point in the
field of adjuvant therapy in osteosarcoma. In other words, this study could
provide new insights into a better understanding of the role of Que in elevating
cisplatin-induced apoptosis with NF-κB down-regulation. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - July 4, 2022 Category: Drugs & Pharmacology Authors: Ahmadi, Mehran Valizadeh, Amir Bazavar, Mohammadreza Yousefi, Bahman Tags: Original Article Source Type: research
Dipeptidyl Peptidase-4 Inhibitor Sitagliptin Exhibits Antioxidant
Mechanism for Abrogation of Cyclophosphamide-Induced Cardiac Damage and
Oxidative Hepatorenal Toxicity in Rats
Drug Res (Stuttg) DOI: 10.1055/a-1842-7596Cyclophosphamide (CYP) is a potent DNA-interactive anticancer drug; however, its
clinical drawbacks are chiefly associated with induction of oxidative
multi-organ toxicity. Sitagliptin (STG) is an antidiabetic dipeptidyl
peptidase-4 inhibitor drug with antioxidant efficacy. Herein, we have explored
whether STG could abrogate the CYP-induced oxidative stress-mediated cardiac and
hepatorenal toxicities in male rats. Sitagliptin (20 mg/kg, o.p)
was administered to rats for 5 consecutive days against organ toxicities induced...
Source: Drug Research - June 30, 2022 Category: Drugs & Pharmacology Authors: Famurewa, Ademola C. Aja, Patrick M. Medewase, John O. Abi, Innocent Ogbonna, Okoro C. Ofor, Casimir C. Nwonuma, Charles O. Asogwa, Nnaemeka T Erejuwa, Omotayo O. Tags: Original Article Source Type: research
Effects of Liposome-Entrapped Muramyl Tripeptide
Phosphatidylethanolamine (L-MTP-PE) on the Tumor Growth and Survival of Mice
Bearing Syngeneic Tumor in Combination with a Chemotherapeutic or
Immunomodulatory Agent
Drug Res (Stuttg) DOI: 10.1055/a-1847-7312Antitumor activities of L-MTP-PE (Liposome entrapped myuramyl tripeptide
phosphatidylethanolamine) in the combination treatment with chemo- or
immune-therapeutic antitumor agents against various syngeneic tumors were
tested.Against Meth A fibrosarcoma solid tumor system, L-MTP-PE showed slight but
statistically significant elongation of survival days against 5-FU monotherapy
in spite of its non-effect on tumor growth, when combined with 5-FU. Against
liver metastasis model of M5076 carcinoma, L-MTP-PE showed a tendency of
...
Source: Drug Research - June 29, 2022 Category: Drugs & Pharmacology Authors: Tanaka, Motoharu Abe, Shigeru Tags: Original Article Source Type: research
An in-Depth Analysis of Ovarian Cancer: Pathogenesis and Clinical
Manifestation
The objective of this
review is to highlight recent contributions to the knowledge of the
interrelations between selected ovarian tumor markers, various perception signs,
and biochemical and molecular signaling processes, as well as one’s
interpretation of much more targeted and effective treatment interventions. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - June 27, 2022 Category: Drugs & Pharmacology Authors: Mahmood, Tarique Ved, Akash Siddiqui, Mohammed Haris Ahsan, Farogh Shamim, Arshiya Ansari, Vaseem Ahamad Ahmad, Afroz Kashyap, Monu Kumar Tags: Review Source Type: research
Thymoquinone Potentiates Methotrexate Mediated-Apoptosis in Saos-2
Osteosarcoma Cell Line
Conclusion The findings of the present study highlight new insights into
understanding the role of TQ as a potential therapeutic agent in osteosarcoma by
increasing MTX-induced apoptosis. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - June 27, 2022 Category: Drugs & Pharmacology Authors: khyavi, Payam Ali Valizadeh, Amir Shanehbandi, Dariush Yousefi, Bahman Soleimanpour, Jafar Tags: Original Article Source Type: research
Therapeutic Drug Monitoring of Vancomycin in Jordanian Patients.
Development of Physiologically-Based Pharmacokinetic (PBPK) Model and Validation
of Class II Drugs of Salivary Excretion Classi fication System
(SECS)
Drug Res (Stuttg) DOI: 10.1055/a-1852-5391Vancomycin is a commonly used antibiotic for multi-drug resistant gram-positive
infections treatment, especially methicillin-resistant Staphylococcus aureus
(MRSA). Despite that, it has wide individual pharmacokinetic variability and
nephrotoxic effect. Vancomycin trough concentrations for 57 Jordanian patients
were measured in plasma and saliva through immunoassay and liquid
chromatography-mass spectrometry (LC-MS/MS), respectively. Plasma levels
were within accepted normal range, with exception of 6 patients who showed
...
Source: Drug Research - June 27, 2022 Category: Drugs & Pharmacology Authors: Arabyat, Majd Abdul-Sattar, Ahmad Al-Fararjah, Feras Al-Ghazawi, Ahmad Rabayah, Ayman Al-Hasassnah, Rakan Mohmmad, Walid Al-Adham, Ibrahim Hamadi, Salim Idkaidek, Nasir Tags: Original Article Source Type: research
Preclinical and Clinical Role of Coenzyme Q10 Supplementation in
Various Pathological States
Drug Res (Stuttg) DOI: 10.1055/a-1835-1738Coenzyme Q10 (CoQ10) is an efficient antioxidant produced endogenously in a
living organism. It acts as an important cofactor in the electron transport
system of mitochondria and reported as a safe supplement in humans and animals
with minimal adverse effect. CoQ10 is found naturally, as a trans configuration,
chemical nomenclature of which is 2,3- dimethoxy-5- methyl-6-decaprenyle
-1,4-benzoquinone. It is found in the body in two forms. In quinone form
(oxidized form), it serves as an electron transporter that transfers t...
Source: Drug Research - June 20, 2022 Category: Drugs & Pharmacology Authors: Rajesh, Kumar Khan, M I Mahesh, Prasad Kumar, Srivastav Ritesh Kumar, Srivastav Shiv Tags: Review Source Type: research
Adverse Event Following Immunization (AEFI) in Children: An Analysis
of Reporting in VigiAccess
Conclusion America has the maximum, whilst Africa has the least AEFI. Few
AEFIs were caused by the measles vaccination, while the majority were related to
the general disorder and administration site condition. Data synchronization in
VigiAccess needs to be enhanced to improve its dependability. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - June 20, 2022 Category: Drugs & Pharmacology Authors: Pandey, Diksha Mehta, Geetika Sachdeva, Monika Tripathi, Rashmi Tags: Original Article Source Type: research
Quercetin Augments Cisplatin-Induced Apoptosis, DNA Damage Response,
and MiR-22 Expression While It Prevents DNA Repair in Osteosarcoma
Cells
Conclusion The co-treatment of quercetin and Cis can accelerate DNA
damage, DNA damage response, and apoptosis while interfering with the DNA repair
process in Saos-2 cells. Moreover, this combination provokes the tumor
suppressor miR-22 expression in these cells. [...] Georg Thieme Verlag Rüdigerstraße 14,70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - June 20, 2022 Category: Drugs & Pharmacology Authors: Malakoti, Faezeh Majidinia, Maryam Ahmadi, Yasin Yousefi, Bahman Shanebandi, Darioush Tags: Original Article Source Type: research
Evaluation of Biological Activity of a Diazocine Derivative against
Heart Failure Using an Ischemia-Reperfusion Injury Model
Conclusions The results indicate that biological activity produced by
diazocine derivative on left ventricular pressure is through protein CK2
activation; this phenomenon could be translated as a decrease in both infarct
area and heart failure. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - June 20, 2022 Category: Drugs & Pharmacology Authors: Lauro, Figueroa-Valverde Marcela, Rosas-Nexticapa Maria, L ópez-Ramos Magdalena, Alvarez-Ramirez Virginia, Mateu-Armad Maria Francisco, D íaz-Cedillo Alejandra, Garcimarrero-Espino Tomas, Lopez Gutierrez Montserrat, Melgarejo-Gutierrez Tags: Original Article Source Type: research
Co-Adjuvancy of Solasodine & CoQ10 Against High Fat
Diet-Induced Insulin Resistance Rats Via Modulating IRS-I and PPAR- γ
Proteins Expression
Drug Res (Stuttg) DOI: 10.1055/a-1806-1366Insulin resistance (IR) is a condition in which target cells become insensitive
to normal insulin concentrations in order to deliver glucose. The goal of this
study was to see if solasodine combined with coenzyme Q10 could help rats with
insulin resistance caused by a high-fat diet (HFD) by regulating the expression
of IRS-I and PPAR-γ proteins.One of the six groups (n=6) got a
conventional diet for 16 weeks as a control (normal), the HFD was given to the
other five groups for 16 weeks, which further classified as-one gro...
Source: Drug Research - June 20, 2022 Category: Drugs & Pharmacology Authors: Khan, Irfan Kumar, Rajesh Prasad, Mahesh Srivastav, Ritesh Kumar Vishwakarma, Vishal Kumar Akhtar, Juber Tags: Original Article Source Type: research
Statins Increase the Bioavailability of Fixed-Dose Combination of
Sofosbuvir/Ledipasvir by Inhibition of P-glycoprotein
Conclusions Both atorvastatin and lovastatin increased AUC of sofosbuvir
and its metabolite after concurrent administration with FDCSL. Statins’
P-glycoprotein inhibition is the attributed mechanism of interaction. The
increase in sofosbuvir bioavailability was more pronounced after atorvastatin
intake. Close monitoring is needed after co-administration of atorvastatin and
FDCSL. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - June 20, 2022 Category: Drugs & Pharmacology Authors: Abdelkawy, K.S. Belal, Fathalla Abdelaziz, AbdelazizE Elmekawy, H. A. Abdelgaied, M. Y. El-Khodary, N. M. Tags: Original Article Source Type: research
