Exploring The Interactions of a Natural Gamma-Oryzanol with Human
Serum Albumin: Surface Plasmon Resonance, Fluorescence, and Molecular Modeling
Studies
Drug Res (Stuttg) DOI: 10.1055/a-1533-2941γ-oryzanol (ORY) is the vital bioactive compound, which is a mixture of
ferulic acid ester and plant sterols. In the present work, the binding of ORY to
human serum albumin (HSA) was investigated at the molecular level using
fluorescence spectroscopy and surface plasmon resonance (SPR) as well as
molecular modeling studies. Based on the fluorescence data analysis, ORY can
form a non-fluorescent complex with HSA and induce static quenching of the
emission intensity of HSA. Also, the high value of K
SV
...
Source: Drug Research - July 30, 2021 Category: Drugs & Pharmacology Authors: Maleki, Somaiyeh Arabzadeh, AmirAhmad Nejati, Kazem Fathi, Farzaneh Tags: Original Article Source Type: research
Study of Reproductive Toxicity of the Liposomal Photosensitizer
Lipophthalocyan
Conclusion When mating with intact female rats, no changes in
sexual behavior were observed, but the index of the ability to fertilize and
conceive decreased when compared to the values of the control group by
35–40% (TD index=60%) and by
75–80% (10 TD index=20%). The index of the
ability to fertilize and conceive differed from the values of the control group
by 90% (TD index=5%) and by 15% (10 TD
index=80%). There were no differences in the indicator of
embryotoxicity and teratogenicity in intact and drug-treated female rats,
com...
Source: Drug Research - July 29, 2021 Category: Drugs & Pharmacology Authors: Konyaeva, Olga Kulbachevskaya, Nataliya Chaley, Vera Ermakova, Nadezhda Varaksa, Pavel Lantsova, Anna Nikolaeva, Lyudmila Orlova, Olga Rodionova, Yuliya Bunyatyan, Natalia Tags: Original Article Source Type: research
Recapitulation of Evidence of Phytochemical, Pharmacokinetic and
Biomedical Application of Silybin
Drug Res (Stuttg) DOI: 10.1055/a-1528-2721Silymarin is a standardized extract obtained from seeds of Silybum marianum (SM)
belonging to the family Asteraceae. It is a flavonolignan complex and consists
of various compounds like silybin A silybin B, isosilybin A, isosilybin B,
silydianin, silychristin and isosilychristin. Silybin is the major active
component present in 60–70% of the silymarin extract. It has
been used traditionally for the treatment of various liver disorders like
cirrhosis, jaundice, and hepatitis. Silymarin possesses antioxidant and
...
Source: Drug Research - July 27, 2021 Category: Drugs & Pharmacology Authors: Islam, Anas Mishra, Anuradha Siddiqui, Md Aftab Siddiquie, Saman Tags: Review Source Type: research
Hepcidin inhibition improves iron homeostasis in ferrous sulfate and
LPS treatment model in mice
Conclusion Ferrous sulfate-induced hyperferremia can be a valuable and
rapid screening model for assessing the efficacy of hepcidin inhibitors. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - July 26, 2021 Category: Drugs & Pharmacology Authors: Patel, Vishal Joharapurkar, Amit Kshirsagar, Samadhan Patel, Maulik Patel, Hiren Savsani, Hardikkumar Jain, Mukul Tags: Original Article Source Type: research
Synthesis, Antimicrobial Evaluation of Substituted Indole and
Nitrobenzenamine based Cr(III), Mn(III) and Fe(III) Metal
Complexes
Drug Res (Stuttg) DOI: 10.1055/a-1527-1307Schiff base ligand (E)-5-methyl-3-(1-(4-nitrophenylimino)ethyl)-1H-indol-2-amine
was synthesized by the condensation of
1-(2-amino-5-methyl-1H-indol-3-yl)ethanone and 4-nitrobenzenamine in methanol at
70 oC. The prepared Schiff base ligand doped with
Cr(III), Mn(III) and Fe(III) ion, respectively and it is denoted as
[M(C34H32N8O4)X]X2.
The complexes have been characterized with the help of elemental analysis,
conductance measurements, magnetic measurements and their structural
configuration have ...
Source: Drug Research - July 22, 2021 Category: Drugs & Pharmacology Authors: Sharma, Preeti Singh, Varun Kumar Kumar, Gajendra Tags: Original Article Source Type: research
Hepatoprotective Impact of Ghrelin against Cyclophosphamide-Induced
Toxicity in the Male Mice
Conclusion Our results reveal the hepatoprotective effect of ghrelin
against CP. Therefore, ghrelin might be useful in protecting the body against
the adverse impacts of injuries induced by chemotherapeutic drugs. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - July 19, 2021 Category: Drugs & Pharmacology Authors: Khordad, Elnaz Alipour, Fatemeh Pourabbas, Mahdieh Mansouri, Somaieh Salimnejad, Ramin Tags: Original Article Source Type: research
Allicin Reduces 5-fluorouracil-resistance in Gastric Cancer Cells
through Modulating MDR1, DKK1, and WNT5A Expression
Conclusion Our findings indicate that the combination of allicin with 5-FU
could reverse multidrug resistance in the GC cells by reducing the expression of
WNT5A, DKK1, MDR1, P-gp, and CD44 levels. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - July 14, 2021 Category: Drugs & Pharmacology Authors: Khakbaz, Parya Panahizadeh, Reza Vatankhah, Mohammad Amin Najafzadeh, Nowruz Tags: Original Article Source Type: research
Vinpocetine Effect on the Juncture of Diabetes and Aging: An
in-vitro study
Conclusion The current study showed that Vinpocetine, a derivative of
the secondary plant metabolite called Vincamine, could break this vicious
cycle of oxidative stress and aging by reducing oxidative stress and
inflammation, thus inhibiting cellular aging. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - July 12, 2021 Category: Drugs & Pharmacology Authors: Moini-Nodeh, Shermineh Rahimifard, Mahban Baeeri, Maryam Hodjat, Mahshid Haghi-Aminjan, Hamed Abdollahi, Mohammad Tags: Original Article Source Type: research
Population Pharmacokinetics Modeling of Lamotrigine in Jordanian
Epileptic Patients Using Dried Blood Spot Sampling
Conclusion Lamotrigine total clearance in the Jordanian patients is
comparable to that reported by others for Caucasian patients. Age and
concomitant therapy with carbamazepine and valproic acid significantly affected
lamotrigine clearance, and accounted for 48% of its inter-individual
variability. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - July 12, 2021 Category: Drugs & Pharmacology Authors: Dodin, Yasmeen I. Suyagh, Maysa F. Saleh, Mohammad I. Nuseir, Ziad T. Aburuz, Salah M. Al-Qudah, Abdelkarim A. Masri, Amira T. Younes, Abdallah M. Al-Ghazawi, Mutasim A. Tags: Original Article Source Type: research
Non-viral Suicide Gene Therapy: Cytosine Deaminase Gene Directed by
VEGF Promoter and 5-fluorocytosine as a Gene Directed Enzyme/prodrug
System in Breast Cancer Model
Drug Res (Stuttg) DOI: 10.1055/a-1488-6054The present study investigated the potential of vascular endothelial growth
factor (VEGF) promoter to derive cytosine deaminase (CD) transfected by
polyamidoamine (G4-PAMAM) dendrimers to 4T1 murine breast cancer cell line as
gene-directed enzyme/prodrug therapy. The VEGF promoter and cytosine
deaminase gene were cloned into the pEGFP-N1vector from the genomic DNA of 4T1
and E. coli, respectively. The frequency of transfection for
VEGF-CD-pEGFP-N1 and pEGFP-N1- CD treated groups was 35±3 and
36±4, respectively....
Source: Drug Research - June 28, 2021 Category: Drugs & Pharmacology Authors: Emamian, Manouchehr Abbaspour, Akbar Shahani, Tina Biglari, Alireza Sharafi, Ali Tags: Original Article Source Type: research
Exploring Nanoemulsions for Prostate Cancer Therapy
Drug Res (Stuttg) DOI: 10.1055/a-1518-6606Prostate carcinoma is typical cancer. It is the second most common cancer globally. The estimated new cases in 2020 was 191 930 and estimated deaths was 33 330. Age, family history, & genetic factors are major factors that drive prostate cancer. Although, for treating metastatic disease, the major therapies available are radiation,bisphosphonate, and palliative chemotherapy. But the major drawback is therapy is disease-driven and later becomes metastatic and requires treatment. The ability to revolutionize cancer treatment by major targeting vehicles via the exploration of ...
Source: Drug Research - June 22, 2021 Category: Drugs & Pharmacology Authors: Srivastava, Sushmita Haider, Md. Faheem Ahmad, Afroz Ahmad, Usama Arif, Muhammad Ali, Asad Tags: Review Source Type: research
Pain Relief by Analgesic Eardrops: Paradigm Shift in the Treatment of
Acute Otitis Media?
Drug Res (Stuttg) DOI: 10.1055/a-1494-3087Acute otitis media is a common middle ear infection in children with the
predominant symptoms of hearing impairment and pain. If antibiotics are given,
they need time to have an effect on the inflammation, so the focus is on pain
control. For pain management local anesthetics have the advantage of lesser
systemic side effects but are still subject to scrutiny. In this review the
literature between 2000 and 2020 was systematically searched for investigating
studies and recommendation in guidelines against the background of ...
Source: Drug Research - June 7, 2021 Category: Drugs & Pharmacology Authors: Michel, Olaf Tags: Review Source Type: research
Exploring Azatidinone Moiety: An Insight into its Anti-tubercular Potency
Drug Res (Stuttg) DOI: 10.1055/a-1481-7879TB is becoming a worldwide problem and it was declared since 1993 by the World Health Organization (WHO), a global health emergency. The current problem of tuberculosis therapy is the emergence of multi-drug resistant (MDR) strains, caused by the improper use of antibiotics in chemotherapy of TB patients. Azatidinones, a β-lactam cyclic amide with four atoms in a ring, has been considered as a magic moiety (wonder nucleus) which possesses almost all types of biological activities. This diversity in the biological response profile has attracted the attention of many researchers to ...
Source: Drug Research - May 25, 2021 Category: Drugs & Pharmacology Authors: Das, Rina Mehta, Dinesh Kumar Dhanawat, Meenakshi Tags: Review Source Type: research
Mechanistic Evaluation of Linalool Effect against Renal Ischemia- Reperfusion Injury in Rats
Conclusion It seems that linalool could exert a nephroprotective effect via a number of mechanisms in renal IR injury. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - May 21, 2021 Category: Drugs & Pharmacology Authors: Golmohammadi, Mohammad-Ghasem Banaei, Shokofeh Azimian, Ehsan Tags: Original Article Source Type: research
Triarylpyrazole Derivatives as Potent Cytotoxic Agents; Synthesis and Bioactivity Evaluation “Pyrazole Derivatives as Anticancer Agent”
Conclusion Concerning obtained results, it is interesting to synthesis more pyrazole derivatives as anticancer agents. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - May 19, 2021 Category: Drugs & Pharmacology Authors: Sameem, Bilqees Moghadam, Ebrahim Saeedian Darabi, Majid Shahsavari, Zahra Amini, Mohsen Tags: Original Article Source Type: research
