Investigating the Effect of Fresh Frozen Plasma and Albumin on DNA Damage and Oxidative Stress Biomarkers in Poisoning Cases by Organophosphates
Drug Res (Stuttg) DOI: 10.1055/a-1261-9151The efficacy of albumin and fresh frozen plasma (FFP) and their effects on biomarkers of oxidative stress has been evaluated. In a randomized clinical control trial, 33 poisoned patients by Organophosphate (OP) were enrolled in the research and divided into three groups. The first group underwent conventional treatments by atropine and pralidoxime (control group); the second and third groups, in addition to traditional treatments, received albumin and FFP. Cholinesterase (ChE) enzyme activity, total antioxidant capacity (TAC), serum thiol groups (TTG), malonyl aldehyde (MDA) and DN...
Source: Drug Research - October 5, 2020 Category: Drugs & Pharmacology Authors: Afzali, Saeed Karami, Manoochehr Kheyripour, Nejat Ranjbar, Akram Tags: Original Article Source Type: research
DBS Assay with LC-MS/MS for the Determination of Idelalisib, A Selective PI3K- δ Inhibitor in Mice Blood and Its Application to a Pharmacokinetic Study
Drug Res (Stuttg) DOI: 10.1055/a-1252-2476Idelalisib is a selective and second-generation PI3K-δ inhibitor, approved for the treatment of non-Hodgkin lymphoma and chronic lymphocytic leukemia. In this paper, we present a fully validated dried blood spot (DBS) method for the quantitation of idelalisib from mice blood using an LC-MS/MS, which was operated under multiple reaction monitoring mode. To the punched DBS discs, acidified methanol enriched with internal standard (IS; larotrectinib) was added and extracted using tert-butyl methyl ether as an extraction solvent with sonication. Chromatographic separation of idelalisi...
Source: Drug Research - September 28, 2020 Category: Drugs & Pharmacology Authors: Tripathy, Harsha K. Manju, Nair S.V. Dittakavi, Sreekanth Zakkula, Ashok Mullangi, Ramesh Tags: Original Article Source Type: research
Development and Optimization of Methscopolamine Bromide Gastroretentive Floating Tablets Using 32 Factorial Design
Conclusion Floating gastroretentive tablet of methscopolamine bromide was successfully developed using direct compression method with potential to enhance the drug absorption and effective treatment of peptic ulcer. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - September 28, 2020 Category: Drugs & Pharmacology Authors: Singh, Maninder Pal Kumar, Manish Shankar, Ravi Tags: Original Article Source Type: research
Efficacy of Metformin and Chemotherapeutic Agents on the Inhibition of Colony Formation and Shh/Gli1 Pathway: Metformin/Docetaxel Versus Metformin/5-Fluorouracil
Conclusion Overall, our data strongly support an important role for metformin as an enhancer of the efficacy of chemotherapeutic agents against gastric cancer. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - September 27, 2020 Category: Drugs & Pharmacology Authors: Fatehi-Agdam, Maryam Vatankhah, Mohammad Amin Panahizadeh, Reza Jeddi, Farhad Najafzadeh, Nowruz Tags: Original Article Source Type: research
The Inhibitory Effect of Curcumin on Hypoxia Inducer Factors (Hifs)
as a Regulatory Factor in the Growth of Tumor Cells in Breast Cancer Stem-Like
Cells
In conclusion, curcumin has inhibitory effects on MCF- 7 cells and CS- LCs and
thus may be used as an antitumor agent. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - September 21, 2020 Category: Drugs & Pharmacology Authors: Sarighieh, Mehrnaz Asadi Montazeri, Vahideh Shadboorestan, Amir Ghahremani, Mohammad Hossein Ostad, Seyed Nasser Tags: Original Article Source Type: research
Development and Validation of a Stability Indicating LC-MS/MS
Method for the Determination of Clenbuterol HCl
Drug Res (Stuttg) DOI: 10.1055/a-1167-0529Clenbuterol hydrochloride (CLT), β2 adrenergic agonist is
used as a bronchodilator in the therapeutic treatment of asthma. It is
important to know the stability behaviour of the drug in different
degradation conditions as per ICH Q1A (R2) guidelines for safety and
efficacy purpose. The main objective of the study is to develop and validate
stability indicating LC-MS/MS method for the determination of
Clenbuterol HCl. The separation was achieved using Phenomenex Gemini NX C18
(250*4.6 mm, 5 μ) ...
Source: Drug Research - September 15, 2020 Category: Drugs & Pharmacology Authors: Prajapati, Krunal J. Kothari, Charmy Tags: Original Article Source Type: research
Does Rabeprazole Sodium Alleviate the Anti-diabetic Activity of
Linagliptin? Drug-Drug Interaction Analysis by In vitro and In vivo
Methods
Drug Res (Stuttg) DOI: 10.1055/a-1233-3371Drug interaction has turned into the preeminent regarding issues for a prescriber
during polypharmacy. The foremost objective of this research was to form a
complex between linagliptin and rabeprazole sodium by in vitro
interactions. The interactions between the drugs have been examined by
monitoring some chromatographic and spectroscopic analyses viz. TLC, HPLC,
FT-IR, UV, Job’s plot, conductometric titrations, and Ardon’s
spectrophotometric strategy. Rabeprazole sodium formed a stable complex with
linaglipt...
Source: Drug Research - September 10, 2020 Category: Drugs & Pharmacology Authors: Hossain, Md. Jamal Sultan, Md. Zakir Rashid, Mohammad A. Kuddus, Md. Ruhul Tags: Original Article Source Type: research
Induction of Cell Cycle Arrest in MKN45 Cells after Schiff Base Oxovanadium Complex Treatment Using Changes in Gene Expression of CdC25 and P53
This study aimed to evaluate the role of schiff base oxovanadium complex ([N,N'-bis(3-methoxy-salicylidene)-1,2-phenylenediamine]Vanadium(IV) Oxide Complex) on cell cycle arrest and different cell cycle phases in MKN45 cell of gastric cancer. Schiff base oxovanadium complex was used to assessthe amount of cytotoxicity via cell viability test. PI color and flow cytometry technique were applied to evaluate the effects of vanadium synthetic compounds on cell cycle phases; subsequently, we analyzed the change rates of gene expression in P53, GADD45, and CDC25 genes, which are involved in cell division phases. The findings indi...
Source: Drug Research - September 3, 2020 Category: Drugs & Pharmacology Authors: Mirjalili, Sara Dejamfekr, Maedeh Moshtaghian, Abdolvahab Salehi, Mehdi Behzad, Mahdi Khaleghian, Ali Tags: Original Article Source Type: research
Single Ascending Dose Study to Assess Pharmacokinetic Linearity,
Safety, and Tolerability of Trimetazidine - Modified Release in Healthy Human
Subjects
Conclusion Substantial deviation from a dose-proportional increase in
AUC(0-inf) and AUC(0-t) suggested a non-linear PK for
TMZ-modified release. Single dose of TMZ-modified release was well tolerated and
safe. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - September 3, 2020 Category: Drugs & Pharmacology Authors: K örnicke, Thomas Arora, Deepa Samad, Abdus Kaplan, Sigal Domahidy, M ónika de Voogd, Hanka B öhmert, Stella Ramos, Rita Silveira Jain, Shashank Tags: Original Article Source Type: research
Current Pharmacological Trends on Myricetin
Drug Res (Stuttg) DOI: 10.1055/a-1224-3625Myricetin is a member of the group of flavonoids called flavonols.
Myricetin is obtained from various fruit, vegetables, tea, berries and red wine.
Myricetin is characterized by the pysrogallol B-ring, and the more hydroxylated
structure is known to be capable for its increased biological properties
compared with other flavonols. Myricetin is produced by the Myricaceae,
Anacardiaceae, Polygonaceae, Pinaceae and Primulacea families. It is soluble in
organic solvent such as ethanol, DMSO (dimethyl sulfoxide), and dimethyl...
Source: Drug Research - September 1, 2020 Category: Drugs & Pharmacology Authors: Gupta, Gudiya Siddiqui, Mohd Aftab Khan, Mohd Muazzam Ajmal, Mohd Ahsan, Rabiya Rahaman, Md Azizur Ahmad, Md Afroz Arshad, Md Khushtar, Mohammad Tags: Review Source Type: research
Pharmacokinetics and Tissue Distribution of Loratadine, Desloratadine
and Their Active Metabolites in Rat based on a Newly Developed LC-MS/MS
Analytical Method
In this study, a new validated
LC-MS/MS method to simultaneously quantify LOR, DL, 6-OH-DL, 5-OH-DL and
3-OH-DL in plasma and tissues was established and applied to an investigation of
their pharmacokinetics and target-tissue distribution tendency for the first
time. Pharmacokinetics parameters in rat were measured and the results suggest
that the body’s exposure to active metabolites were much higher than to
the prodrug with LOR, but much lower with DL. The tissue distribution study
shows that LOR, DL and their active metabolites were widely distribut...
Source: Drug Research - September 1, 2020 Category: Drugs & Pharmacology Authors: Zhang, Yuxin Lu, Yihua Wang, Lijuan Tian, Yuan Zhang, Zunjian Tags: Original Article Source Type: research
Saliva versus Plasma Therapeutic Drug Monitoring of Gentamicin in
Jordanian Preterm Infants. Development of a Physiologically-Based
Pharmacokinetic (PBPK) Model and Validation of Class II Drugs of Salivary
Excretion Classification System
Drug Res (Stuttg) DOI: 10.1055/a-1233-3582Gentamicin has proven to be a very successful treatment for bacterial infection,
but it also can cause adverse effects, especially ototoxicity, which is
irreversible. Therapeutic drug monitoring (TDM) in saliva is a more convenient
non-invasive alternative compared to plasma. A physiologically-based
pharmacokinetic (PBPK) model of gentamicin was built and validated using
previously-published plasma and saliva data. The validated model was then used
to predict experimentally-observed plasma and saliva gentamicin TDM data in...
Source: Drug Research - September 1, 2020 Category: Drugs & Pharmacology Authors: Idkaidek, Nasir Hamadi, Salim Bani-Domi, Rabab Al-Adham, Ibrahim Alsmadi, Motasem Awaysheh, Faten Aqrabawi, Hisham Al-Ghazawi, Ahmad Rabayah, Ayman Tags: Original Article Source Type: research
The Potential Therapeutic Role of Proton Pump Inhibitors in COVID-19:
Hypotheses Based on Existing Evidences
Drug Res (Stuttg) DOI: 10.1055/a-1236-3041Although the major therapeutic uses of the proton pump inhibitors are in
gastric-acid related diseases, evidences are suggestive of a pleiotropic nature
of the compounds. We comment on the probable pathways and cellular machineries
via which proton pump inhibitors could show beneficial therapeutic effects
against SARS-CoV-2 based on the existing evidences. Proton pump inhibitors have
shown antiviral potencies in various in vivo and in vitro studies. Some of the
major possible ways through which they can act against SARS-Co...
Source: Drug Research - September 1, 2020 Category: Drugs & Pharmacology Authors: Ray, Avik Sharma, Swati Sadasivam, Balakrishnan Tags: Opinion Paper Source Type: research
Protective Effect of Grape and Apple Juices against Cadmium
Intoxication in the Kidney of Rats
Conclusion Taken together, we conclude that grape and apple juices had a
protective effect by means of antioxidant, antigenotoxic actions and for
promoting tissue regeneration in the kidney of rats following cadmium
intoxication. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - August 19, 2020 Category: Drugs & Pharmacology Authors: Handan, Bianca Andrade De Moura, Carolina Foot Gomes Cardoso, Caroline Margonato Santamarina, Aline Boveto Pisani, Luciana Pellegrini Ribeiro, Daniel Araki Tags: Review Source Type: research
Evaluation of Stable Doses of Warfarin in a Patient
Cohort
Conclusion We observed similar stable doses between the definitions
except for one. Hence, IWPC algorithm may not have any bias associated with
inclusion of any studies with variable definitions for stable warfarin dose. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - August 19, 2020 Category: Drugs & Pharmacology Authors: Sridharan, Kannan Banny, Rashed Al Husain, Aysha Tags: Original Article Source Type: research
