Single Ascending Dose Study to Assess Pharmacokinetic Linearity, Safety, and Tolerability of Trimetazidine - Modified Release in Healthy Human Subjects
Conclusion Substantial deviation from a dose-proportional increase in
AUC(0-inf) and AUC(0-t) suggested a non-linear PK for
TMZ-modified release. Single dose of TMZ-modified release was well tolerated and
safe. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Drug Research - Category: Drugs & Pharmacology Authors: K örnicke, Thomas Arora, Deepa Samad, Abdus Kaplan, Sigal Domahidy, M ónika de Voogd, Hanka B öhmert, Stella Ramos, Rita Silveira Jain, Shashank Tags: Original Article Source Type: research