Allergisches Asthma – Behandlungsoptionen
Drug Res (Stuttg) 2020; 70: S6-S6 DOI: 10.1055/a-1119-2654 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Drug Research)
Source: Drug Research - November 17, 2020 Category: Drugs & Pharmacology Authors: Virchow, Johann-Christian Tags: Extended Abstract Source Type: research
Therapie allergischer Erkrankungen – Stand und Ausblick
Drug Res (Stuttg) 2020; 70: S5-S5 DOI: 10.1055/a-1119-2582 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Drug Research)
Source: Drug Research - November 17, 2020 Category: Drugs & Pharmacology Authors: Bieber, Thomas Endres, Stefan Tags: Editorial Source Type: research
Therapeutic Approach against 2019-nCoV by Inhibition of ACE-2
Receptor
Drug Res (Stuttg) DOI: 10.1055/a-1275-0228 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Drug Research)
Source: Drug Research - November 12, 2020 Category: Drugs & Pharmacology Authors: Kumar, Gajendra Kumar, Dharmendra Singh, Netra Pal Tags: Retraction Source Type: research
Therapeutic Approach against 2019-nCoV by Inhibition of ACE-2 Receptor
Drug Res (Stuttg) DOI: 10.1055/a-1275-0228The continued spread of 2019-nCoV has prompted widespread concern around the world. WHO formally named COVID-19 and International Committee on Taxonomy called it Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Due to this viral attack, the whole world is in lockdown. Presently, there is no effective way to control it, except social distancing and hygienic activity. World class scientists and researchers are trying to make vaccine and discover the medicine against the control and cure to this deadly viral disease. Our aim to presenting this article is kick-off deadly v...
Source: Drug Research - November 12, 2020 Category: Drugs & Pharmacology Authors: Kumar, Gajendra Kumar, Dharmendra Singh, Netra Pal Tags: Original Article Source Type: research
A Rapid Mercury Droplet Electrode Polarography Method for Determination of Blood Lead Level in Lead Poisoned People
Conclusion Based on the results of this study it was observed that BLL in opium addicted people needs to be measured as soon as possible. Furthermore, screening of blood lead concentrations in opium-addicted people with a rapid and accurate MDEP method is very necessary and important. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - November 12, 2020 Category: Drugs & Pharmacology Authors: Hosseini, Golriz Hanaie, Jalal Ostadi, Ali Valipor, Javad Hamidi, Aliasghar Ghanbarzadeh, Saeed Tags: Original Article Source Type: research
Favipiravir and COVID-19: A Simplified Summary
Drug Res (Stuttg) DOI: 10.1055/a-1296-7935A recent outbreak of coronavirus disease 2019 (COVID-19) caused by the novel coronavirus designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) started in Wuhan, China, at the end of 2019 and then spread rapidly all over the world. However, there are no specific antiviral therapies for COVID-19, using the agents which approved or in development for other viral infections is one of the potentially quickest ways to find treatment for this new viral infection. Favipiravir is an effective agent that acts as a nucleotide analog that selectively inhibits the viral RNA...
Source: Drug Research - November 11, 2020 Category: Drugs & Pharmacology Authors: Ghasemnejad-Berenji, Morteza Pashapour, Sarvin Tags: Opinion Paper Source Type: research
Molecular Targets and Nanoparticulate Systems Designed for the Improved Therapeutic Intervention in Glioblastoma Multiforme
Drug Res (Stuttg) DOI: 10.1055/a-1296-7870Glioblastoma multiforme (GBM) is the most aggressive and fatal CNS related tumors, which is responsible for about 4% of cancer-related deaths. Current GBM therapy includes surgery, radiation, and chemotherapy. The effective chemotherapy of GBM is compromised by two barriers, i. e., the blood-brain barrier (BBB) and the blood tumor barrier (BTB). Therefore, novel therapeutic approaches are needed. Nanoparticles are one of the highly efficient drug delivery systems for a variety of chemotherapeutics that have gained massive attention from the last three decades. Perfectly designed ...
Source: Drug Research - November 9, 2020 Category: Drugs & Pharmacology Authors: Akhter, Md. Habban Rizwanullah, Md. Ahmad, Javed Amin, Saima Ahmad, Mohammad Zaki Minhaj, Md. Akram Mujtaba, Md. Ali Ali, Javed Tags: Review Source Type: research
Assessment of the Genotoxic Potential of Cizolirtine a Substance-P and Calcitonin Gene-Related Peptide Release Modulator
Drug Res (Stuttg) DOI: 10.1055/a-1286-5358The analysis of the genotoxic potential of cizolirtine, a compound being developed as a drug for analgesia and for urinary incontinence, was carried out using a battery of in vitro and in vivo assays as recommended in the guidelines for medicinal products. Negative results were obtained in an Ames test (up to 5000 µg/plate), in a Mouse Lymphoma assay (up to 2000 µg/ml) and in a single dose mouse bone marrow micronucleus assay (up to 300 mg/kg). In a human lymphocyte chromosome aberration assay, a slight statistical increase in the frequency of cells with chromosome aberrati...
Source: Drug Research - November 4, 2020 Category: Drugs & Pharmacology Authors: Fern ández de Henestrosa, AntonioR. Mar ín, Ana-Paz Tortajada, Araceli Vila, Cristina Guzm án, Antonio Tags: Original Article Source Type: research
Soft Malleable Vesicles: versatile carriers for efficient topical delivery of fungal therapeutics
Drug Res (Stuttg) DOI: 10.1055/a-1286-5750Fungal infections have become a subject of great concern and the incidence of fungal infections is increasing, presenting an enormous challenge to healthcare professionals. Since most of the fungal infections are occurring over the skin, the treatment option of these infections always involves topical application. However, in topical delivery drug reaches into systemic circulation through different barriers of skin. Nevertheless, due to the low permeability, skin restricts the movement of many drugs. Hence, a delivery system is required, which deliver the medicament into the skin l...
Source: Drug Research - November 2, 2020 Category: Drugs & Pharmacology Authors: Gupta, Preeti Jha, Antesh Kumar Prasad, Mahesh Kushwaha, Poonam Tags: Review Source Type: research
Tutankhamun ’s Antimalarial Drug for Covid-19
Drug Res (Stuttg) DOI: 10.1055/a-1274-1264Drug repositioning is a strategy that identifies new uses of approved drugs
to treat conditions different from their original purpose. Current efforts
to treat Covid-19 are based on this strategy. The first drugs used in
patients infected with SARS-CoV-2 were antimalarial drugs. It is their
mechanism of action, i. e., rise in endosomal pH, which recommends
them against the new coronavirus. Disregarding their side effects, the study
of their antiviral activity provides valuable hints for the choice and
...
Source: Drug Research - October 30, 2020 Category: Drugs & Pharmacology Authors: Sommer, Andrei P. F örsterling, Horst-Dieter Sommer, Katlin E. Tags: Original Article Source Type: research
Remdesivir: Critical Clinical Appraisal for COVID 19 Treatment
Drug Res (Stuttg) DOI: 10.1055/a-1288-4078Remdesivir is presently been considered as ‘molecule of hope’ to curb the menace of COVID19. Non-availability of any USFDA approved drug has led to several attempt of drug-repurposing and development of new therapeutic molecules. However, Remdesivir has been found to be effective against a broad range of virus including SARS, MERS and COVID 19 through in-vitro studies. Several clinical research attempt are presently being conducted showing promising result yet not conclusive. This review summarized all such clinical trials to critically appraise the usage of Remdesivir against ...
Source: Drug Research - October 29, 2020 Category: Drugs & Pharmacology Authors: Chatterjee, Saptarshi Tags: Review Source Type: research
Transition Metal Chelation Augments the Half-life of Secnidazole: Molecular Docking and Fluorescence Spectroscopic Approaches
Drug Res (Stuttg) DOI: 10.1055/a-1252-2322This current research aimed to establish the most required pharmacodynamics parameters of two transition metal complexes of an antimicrobial drug secnidazole. The spectroscopic fluorescence quenching strategy was outlined to evaluate the binding mechanism and binding affinity of nickel (II) and chromium (III) complexes of secnidazole with bovine serum albumin (BSA). The conformational modifications and the interacting patterns of the protein due to the interaction of the parent compound of the metal complexes have been investigated by molecular docking approach. The ligand-protein ...
Source: Drug Research - October 23, 2020 Category: Drugs & Pharmacology Authors: Hossain, Md. Jamal Rashid, Mohammad A. Sultan, Md. Zakir Tags: Original Article Source Type: research
Evaluation and Docking Study of Pyrazine Containing 1, 3, 4-Oxadiazoles Clubbed with Substituted Azetidin-2-one: A New Class of Potential Antimicrobial and Antitubercular
Conclusions Derivatives 7b and 7g would be effective lead candidates for tuberculosis therapy. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - October 6, 2020 Category: Drugs & Pharmacology Authors: Das, Rina Mehta, Dinesh Kumar Tags: Original Article Source Type: research
A GLP-2 Analogue Protects SH-SY5Y and Neuro-2a Cells Against Mitochondrial Damage, Autophagy Impairments and Apoptosis in a Parkinson Model
Drug Res (Stuttg) DOI: 10.1055/a-1266-3263Glucagon-like peptide-2 (GLP-2) is a peptide hormone that belongs to the glucagon-derived peptide family. We have previously shown that analogues of the sister hormone Glucagon-like peptide-1 (GLP-1) showed neuroprotective effects. Here we investigated the effect of a GLP-2 agonist in a cell model of Parkinsonʼs disease (PD) created by treating SH-SY5Y or Neuro-2a cells with 1-Methyl-4-phenyl-pyridine ion (MPP+). Cell viability and cell cytotoxicity was detected by MTT and LDH assays, respectively. The protein expression levels of mitochondrial, autophagy and apoptotic biomarkers ...
Source: Drug Research - October 5, 2020 Category: Drugs & Pharmacology Authors: Su, Yunfang Zhang, Zijuan Li, Hao Ma, Jinlian Sun, Limin Shao, Simai Zhang, Zhenqiang H ölscher, Christian Tags: Original Article Source Type: research
In Vitro Anticancer Effects of All-trans Retinoic Acid in Combination with Dacarbazine against CD117+ Melanoma Cells
Conclusion Collectively, combined treatment with ATRA and dacarbazine induced more apoptosis and enhanced the cell cycle arrest of CD117+ melanoma cells. These results suggested that ATRA increased the sensitivity of melanoma cells to the effect of dacarbazine. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - October 5, 2020 Category: Drugs & Pharmacology Authors: Jobani, Bahareh Mohammadi Mohebi, Elham Najafzadeh, Nowruz Tags: Original Article Source Type: research
