Celecoxib has Preventive and Therapeutic Benefits against
Nephrotoxicity Caused by Gentamicin in Mice
Drug Res (Stuttg) DOI: 10.1055/a-1785-4005It’s crucial to comprehend the impact of oxidative stress and
pro-inflammatory cytokines in the gentamicin-induced kidney injury mechanism.
Celecoxib was administered orally either before or after intraperitoneal therapy
with gentamicin in mice. The serum levels of creatinine (SCr), blood urea
nitrogen (BUN), IL-6, and TNF-α were measured by ELISA test, as well as
the levels of the kidney tissue malondialdehyde (MDA), and glutathione (GSH)
were also estimated spectrophotometrically. The renal expression of nuclear
...
Source: Drug Research - March 31, 2022 Category: Drugs & Pharmacology Authors: Abd-Eldayem, Ahmed M. Dahpy, Marwa A. Badary, Dalia M. Alnasser, Sulaiman Mohammed Hareedy, Mohammad Salem Tags: Original Article Source Type: research
A New Intranasal Influenza Vector-Based Vaccine TB/FLU-04L
Against Tuberculosis: Preclinical Safety Studies
Drug Res (Stuttg) DOI: 10.1055/a-1785-3936A recombinant vector vaccine TB/FLU-04L for the prevention of
tuberculosis was developed in RIBSP CS MES RK and SRII. The vaccine is based on
the attenuated influenza strain Flu NS106/ESAT-6_Ag85A
expressing mycobacterial antigens Esat-6 and Ag85A. This research aimed to
conduct pre-clinical safety studies of the vaccine as one of the basic and
mandatory stages in the development and introduction of immunobiological
preparations. The studies were performed at the research centers of the Republic
of Kazakhstan and...
Source: Drug Research - March 22, 2022 Category: Drugs & Pharmacology Authors: Buzitskaya, Zhanna Stosman, Kira Khairullin, Berik Kassenov, Marhabat Nurpeisova, Ainur Abylai Sansyzbay, A. Shurygina, Anna-Polina Aleksandrov, Andrey Sivak, Konstantin Stukova, Marina Tags: Original Article Source Type: research
Investigating the Role of Thymoquinone in Increasing the Rate of
Cisplatin-Induced Apoptosis through Oxidative DNA Damage in Saso-2 Cancer
Cells
Conclusion In general, TQ plus Cisplatin resulted in potentiated cellular
cytotoxicity by increasing ROS level and inducing oxidative DNA damage, leading
to the potent induction of apoptosis in tumor cells. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - March 7, 2022 Category: Drugs & Pharmacology Authors: Ahmadzadeh, Homa Ahmadi, Mehran Golchin, Asal Malakoti, Faezeh Maleki, Masomeh Alemi, Forough Bazavar, Mohammadreza Yousefi, Bahman Tags: Original Article Source Type: research
Carvacrol Enhance Apoptotic Effect of 5-FU on MCF-7 Cell Line via
inhibiting P-glycoprotein: An In-silco and In-vitro Study
Conclusion These results provide important evidence that carvacrol may be
a promising agent able to overcome P-gp-mediated MDR. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - March 4, 2022 Category: Drugs & Pharmacology Authors: Ghorbanzadeh, Vajihe Aljaf, Karwan Anwar Hassan Wasman, Hunar Mustafa Pirzeh, Lale Azimi, Saleh Dariushnejad, Hassan Tags: Original Article Source Type: research
Decipher the inhibitory potential of phytocompounds from
Leptadenia reticulata
on dopamine D2 receptor to enhance
prolactin secretion
Drug Res (Stuttg) DOI: 10.1055/a-1735-2887Dopamine is secreted by the hypothalamus, which inhibits the proliferation and
effectiveness of lactotroph cells that release prolactin via dopamine D2
receptor (D2R). D2R activation inhibits lactotroph cell prolactin synthesis and
regulates prolactin gene expression. Although, commercial medications are
available for hypogalactia and agalactia, various plant sources significantly
alleviate these problems. Leptadenia reticulata (Jivanti) is one of the
important medicinal plants often consumed by nursing mothers to improve ...
Source: Drug Research - February 17, 2022 Category: Drugs & Pharmacology Authors: Sharma, Roshan Kumar Jalalpure, Sunil S Chouhan, Mahendra Kumar Deshpande, Sanjay Acharya, Rabinarayan Hegde, Satisha Tags: Original Article Source Type: research
Toxicity of Hydrogen Sulfide on Rat Brain Neurons
This study investigated the mechanisms of cytotoxicity induced by
H2S in brain neurons. thioacetamide has been used to produce
H2S in water solutions. The results of the study showed that
thioacetamide at concentrations of 116, 232 and
464 µg/ml was able to increase the level of reactive
oxygen species (ROS), collapse in mitochondrial membrane potential (MMP), damage
to the lysosomal membrane, increase in the level of oxidized glutathione (GSSG)
and decrease in the level of reduced glutathione (GSH) in brain neurons. The
results of the s...
Source: Drug Research - February 17, 2022 Category: Drugs & Pharmacology Authors: Seydi, Enayatollah Irandoost, Zahra Khansari, Mahmoud Ghazi Naserzadeh, Parvaneh Tanbakosazan, Farahnaz Pourahmad, Jalal Tags: Original Article Source Type: research
Evaluation of the Genotoxic Potential of the Selective COX-2
Inhibitor Enflicoxib in a Battery of in vitro and in vivo
Genotoxicity Assays
Conclusions The administration of enflicoxib as a therapeutic analgesic
agent would not pose a genotoxic risk to animals or humans. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Drug Research)
Source: Drug Research - January 18, 2022 Category: Drugs & Pharmacology Authors: Guzm án, Antonio Homedes, Josep Salichs, Marta Tags: Original Article Source Type: research
In silico
Investigation of Lon Protease as a Promising
Therapeutic Target
This study showed that
Lon protease may have the characteristics of a new therapeutic target. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - January 18, 2022 Category: Drugs & Pharmacology Authors: Asadollahi, Parisa Pakzad, Iraj Ghafourian, Sobhan Kazemian, Hossein Fatahi, Roohollah Sadeghifard, Nourkhoda Kalani, Behrooz Sadeghi Tags: Original Article Source Type: research
Repercussion of cAMP and EPAC in Memory and Signaling
Drug Res (Stuttg) DOI: 10.1055/a-1657-2464It is well recognized that cyclic adenosine monophosphate (cAMP) signaling within
neurons plays a key role in the foundation of long-term memories. Memory storage
is the process that demands the movement of signals, neural plasticity, and the
molecules which can transfer the signals from the sensory neuron to the dorsal
root ganglion (DRG) neurons and later into the temporal region of the brain. The
discovery of cAMP in 1958 as the second messenger also had a role in memory
formation and other neural aspects. Further, in 1...
Source: Drug Research - January 3, 2022 Category: Drugs & Pharmacology Authors: Naz, Sabreena Mahmood, Tarique Ahsan, Farogh Rizvi, Ali Abbas Shamim, Arshiya Tags: Review Source Type: research
Phytoconstituents in the Management of Covid-19: Demystifying the
Fact
Drug Res (Stuttg) DOI: 10.1055/a-1697-5365The 2019-nCoV (COVID-19; novel coronavirus disease-2019) outbreak is caused by
the coronavirus, and its continued spread is responsible for increasing deaths,
social and economic burden. COVID-19 created a chaotic situation worldwide and
claimed the lives of over 5,027,183 and 248,467,363 confirmed cases have been
reported so far as per the data published by WHO (World Health Organization)
till 5th November 2021. Scientific communities all over the world are
toiling to find a suitable therapeutic drug for this deadly disea...
Source: Drug Research - January 3, 2022 Category: Drugs & Pharmacology Authors: Barkat, Md. Abul Kaushik, Pawan Barkat, Harshita Abul Khan, Mohammad Idreesh Hadi, Hazrina Ab Tags: Review Source Type: research
Assessment of Sumatriptan on Sepsis-Induced Kidney injury in the
Cecal Ligation and Puncture Mice Model
This study was aimed to assess
the effects of sumatriptan on kidney injury, the levels of pro-inflammatory
cytokines and the percentage of survival in (CLP)-induced sepsis were
examined.Cecal ligation and puncture (CLP) model was done on adult C57BL/6 male
mice to induce Polymicrobial sepsis. Sumatriptan was injected intraperitoneally
1 h after the sepsis induction by CLP at doses of 0.1, 0.3, and
1 mg/kg in 3 treatment groups. To study the effect of
sumatriptan on short-term survival, septic animals were detected 72 h
after CLP. Serum le...
Source: Drug Research - December 1, 2021 Category: Drugs & Pharmacology Authors: Yousefi-Manesh, Hasan Shirooie, Samira Noori, Tayebeh Tavangar, Seyed Mohammad Sheibani, Mohammad Chaboki, Alireza Mohammadi, Sina Dehpour, Ahmad Reza Tags: Original Article Source Type: research
The Effect of Levosimendan on Phosphine-Induced Nephrotoxicity:
Biochemical and Histopathological Assessment
Conclusion Our findings showed that LEV can potentially improve oxidative
stress, imbalance in the redox status, necrosis, and pathological injuries in
kidney tissue following AlP-poisoning. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - November 17, 2021 Category: Drugs & Pharmacology Authors: Baeeri, Maryam Rahimifard, Mahban Armandeh, Maryam Bameri, Behnaz Khalid, Madiha Haghi-Aminjan, Hamed Farhadi, Ramtin Abdollahi, Mohammad Tags: Original Article Source Type: research
Zellmigration als therapeutischer Zielprozess
Drug Res (Stuttg) 2021; 71: S26-S27 DOI: 10.1055/a-1606-5983 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Drug Research)
Source: Drug Research - November 17, 2021 Category: Drugs & Pharmacology Authors: Zundler, Sebastian Tags: Extended Abstract Source Type: research
Virushepatitiden
Drug Res (Stuttg) 2021; 71: S24-S25 DOI: 10.1055/a-1606-5969 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Drug Research)
Source: Drug Research - November 17, 2021 Category: Drugs & Pharmacology Authors: Thimme, Robert Tags: Extended Abstract Source Type: research
Therapie des hepatozellul ären Karzinoms – eine neue Dekade?
Drug Res (Stuttg) 2021; 71: S22-S23 DOI: 10.1055/a-1606-5955 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Drug Research)
Source: Drug Research - November 17, 2021 Category: Drugs & Pharmacology Authors: Mohr, Raphael Tacke, Frank Tags: Extended Abstract Source Type: research
