Nanomedicines: A Focus on Nanomaterials as Drug Delivery System with
Current Trends and Future Advancement
Drug Res (Stuttg) DOI: 10.1055/a-1824-4619The rapid advancement of nanomedicine presents novel alternatives that have the
potential to transform health care. Targeted drug delivery as well as the
synthesis of nanocarriers is a growing discipline that has been intensively
researched to reduce the complexity of present medicines in a variety of
diseases and to develop new treatment and diagnostic techniques. There are
several designed nanomaterials used as a delivery system such as liposomes,
micelles, dendrimers, polymers, carbon-based materials, and many other
...
Source: Drug Research - May 30, 2022 Category: Drugs & Pharmacology Authors: Pandey, Jaya Dubey, Ragini Kate, Aditya Prasad, Bhairav Sinha, Arzoo Mishra, Mohit S Tags: Review Source Type: research
Melatonin Increases the Sensitivity of Osteosarcoma Cells to
Chemotherapy Drug Cisplatin
Drug Res (Stuttg) DOI: 10.1055/a-1830-8716Chemotherapy, which is one of the common treatments for osteosarcoma (OS), has
many side effects and in some cases has low effectiveness due to
chemoresistance, hence it is vital to study new therapies for OS. In this
regard, we combined melatonin with cisplatin and evaluate their effect on MG63
OS cells. Since melatonin has anti-cancer properties, we hypothesized that its
combination with cisplatin could increase the effectiveness of cisplatin.
Firstly, MTT assay was used to evaluate the cell viability and cytotoxicity of...
Source: Drug Research - May 30, 2022 Category: Drugs & Pharmacology Authors: Hosseini, Foroogh Shanehbandi, Dariush Soleimanpour, Jafar Yousefi, Bahman Alemi, Forough Tags: Original Article Source Type: research
Risperidone Toxicity on Human Blood Lymphocytes in Nano molar
Concentrations
This study evaluated
the toxicity effect of risperidone on human blood lymphocytes. To achieve this
aim, lymphocytes were isolated using Ficoll paque plus. The results showed that
risperidone (12, 24 and 48 nM) causes toxicity in human blood
lymphocytes by increasing the level of intracellular reactive oxygen species
(ROS), damage to lysosomal membrane, the collapse of the mitochondrial membrane
potential (MMP), and increased extracellular oxidized glutathione (GSSG). Also,
exposure of human blood lymphocytes to risperidone is associated with a decreas...
Source: Drug Research - May 23, 2022 Category: Drugs & Pharmacology Authors: Yousefsani, Bahareh Sadat Salimi, Ahmad Imani, Farnaz Ramezani, Maral Shirani, Kobra Seydi, Enayatollah Pourahmad, Jalal Tags: Original Article Source Type: research
Epidemiological Study of Acute Unintentional Poisoning Among Children
in Iran
In this study, we investigate the epidemiological
causes of acute poisoning in children.In this retrospective descriptive study, children presented with acute poisoning
during 2010–2019 to Shahid Madani Hospital were included. The Electronic
Medical Record system of the hospital was accessed to obtain the data of the
patients. The data included was demographic information, type of poisoning,
clinical findings, complications, duration of hospitalization, parents’
education status, and mortality status.Of 336 patients included in the study, the mean age of patie...
Source: Drug Research - May 23, 2022 Category: Drugs & Pharmacology Authors: Tarhani, Fariba Nezami, Alireza Heidari, Ghobad Hosseinizadeh-salavati, Nazanin Tags: Original Article Source Type: research
An Overview of Green Synthesis and Potential Pharmaceutical
Applications of Nanoparticles as Targeted Drug Delivery System in
Biomedicines
Drug Res (Stuttg) DOI: 10.1055/a-1801-6793Nanotechnology-based nanomedicine offers several benefits over conventional forms
of therapeutic agents. Moreover, nanomedicine has become a potential candidate
for targeting therapeutic agents at specific sites. However, nanomedicine
prepared by synthetic methods may produce unwanted toxic effects. Due to their
nanosize range, nanoparticles can easily reach the reticuloendothelial system
and may produce unwanted systemic effects. The nanoparticles produced by the
green chemistry approach would enhance the safety profile b...
Source: Drug Research - May 13, 2022 Category: Drugs & Pharmacology Authors: Mittal, Shweta Chakole, Chandrashekhar Mahadeo Sharma, Aman Pandey, Jaya Chauhan, Meenakshi Kanwar Tags: Review Source Type: research
Formulation, Characterization, and the Diuretic Effects of a New
Intravenous Metolazone Emulsion
Conclusion This metolazone emulsion was capable of increasing urine volume
output and demonstrated both natriuretic and kaliuretic properties. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - May 10, 2022 Category: Drugs & Pharmacology Authors: Ahlschwede, Kristen M. Ofori, Edward Andey, Terrick Osei, Anita Somberg, John S Tags: Original Article Source Type: research
Solid Lipid Nanoparticles of Lepidium Sativum L Seed Extract:
Formulation, Optimization and In vitro Cytotoxicity
Studies
Drug Res (Stuttg) DOI: 10.1055/a-1800-5956The current study focused on important bioactive compounds in plants that make
them pharmacologically valuable. Therefore, this study was aimed to develop
Lepidium sativum (L. sativum) seed extract loaded solid lipid
nanoparticles and explore its cytotoxic effect on human liver cancer cells
(HepG2 cells). The ethanolic extract of L. sativam used to develop L.
sativum seed extract loaded solid lipid nanoparticles (SLNs) was
analyzed by gas chromatography-mass spectrometry, thin-layer chromatography
(TLC) and h...
Source: Drug Research - May 3, 2022 Category: Drugs & Pharmacology Authors: Ahmad, Asad Tabassum, Heena Nabi, Rabia Mishra, Anuradha Ahmad, Iffat Zareen Tags: Original Article Source Type: research
Caveolins: Expression of Regulating Systemic Physiological Functions
in Various Predicaments
Drug Res (Stuttg) DOI: 10.1055/a-1785-4133Caveolins are membrane proteins which contains caveolae. They are present in the
plasma membrane. Many researchers found that caveolae have been associated with
expression of the caveolins in major physiological networks of mammalian cells.
Subtypes of caveolin including caveolin-1 and caveolin-2 have been found in
micro arteries of rat brain, while caveolin-3 has been found in astrocytes.
Caveolin-1 and caveolae play important roles in Alzheimer’s disease,
cancer, ischemic preconditioning-mediated cardio-protection, pos...
Source: Drug Research - April 14, 2022 Category: Drugs & Pharmacology Authors: Upadhyay, Prabhat Kumar Vishwakarma, Vishal Kumar Srivastav, Ritesh Kumar Tags: Review Source Type: research
Prazosin Treatment Protects Brain and Heart by Diminishing Oxidative
Stress and Apoptotic Pathways After Renal Ischemia Reperfusion
Drug Res (Stuttg) DOI: 10.1055/a-1806-1453Acute kidney injury (AKI) is a major medical challenge caused from renal
ischemia-reperfusion (IR) injury connected with different cellular events in
other distant organs. Renal IR-related oxidative stress and inflammation
followed by cell apoptosis play a crucial role in IR-induced distant organ
pathological damages. Prazosin has shown protective effects against IR-injuries.
Thus, the current study intended to investigate the possible protective role of
prazosin against the consequents of renal IR in the heart and brain t...
Source: Drug Research - April 14, 2022 Category: Drugs & Pharmacology Authors: Malekinejad, Zahra Aghajani, Shadi Jeddi, Mostafa Qahremani, Reihane Shahbazi, Sina Bagheri, Yasin Ahmadian, Elham Tags: Original Article Source Type: research
Anticonvulsant Effect of Minocycline on Pentylenetetrazole-Induced
Seizure in Mice: Involvement of 5-HT3 Receptor
In conclusion, our findings revealed that the
anticonvulsant effect of minocycline is mediated, at least in part, by
inhibition of 5-HT3 receptor. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - April 14, 2022 Category: Drugs & Pharmacology Authors: Entezari, Zahra Jahanabadi, Samane Tags: Original Article Source Type: research
Quercetin and Methotrexate in Combination have Anticancer Activity in
Osteosarcoma Cells and Repress Oncogenic MicroRNA-223
Conclusion Que, with the potential to boost the anticancer activity of MTX
on Saos-2 cancer cells through proliferation inhibition and apoptosis induction,
is a good candidate for combination therapy. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - April 6, 2022 Category: Drugs & Pharmacology Authors: Mohammadi, Erfan Alemi, Forough Maleki, Masomeh Malakoti, Faezeh Farsad-Akhtar, Nader Yousefi, Bahman Tags: Original Article Source Type: research
Thymoquinone Augments Methotrexate-Induced Apoptosis on Osteosarcoma
Cells
Conclusion The co-treatment of TQ and MTX is associated with the
up-regulation of apoptotic factors and down-regulation of anti-apoptotic
factors, conducting apoptosis aggravation and OS cell death. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - April 6, 2022 Category: Drugs & Pharmacology Authors: Sanapour, Narjes Malakoti, Faezeh Shanebandi, Darioush Targhazeh, Niloufar Yousefi, Bahman Soleimanpour, Jafar Majidinia, Maryam Tags: Original Article Source Type: research
Preclinical Safety Evaluation: Acute and Repeated-Dose Toxicity of a
New Intranasal Recombinant Vector Vaccine TB/FLU-04L Against
Tuberculosis
Conclusions The toxicity study in mice and rats showed that the intranasal
vector vaccine TB/FLU-04L had no toxic effect. The tests confirm no
adverse effects for laboratory animals in the studied parameters. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - April 6, 2022 Category: Drugs & Pharmacology Authors: Stosman, Kira Sivak, Konstantin Aleksandrov, Andrey Buzitskaya, Zhanna Rassokha, Tatyana Stukova, Marina Tags: Original Article Source Type: research
Administration of Orexin-A into the Rat Thalamic Paraventricular
Nucleus Enhances the Naloxone Induced Morphine Withdrawal
Conclusions These observations imply that targeting the orexin receptors
in PVT might exhibit a new therapeutic strategy for the future treatment of
dependence. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - April 6, 2022 Category: Drugs & Pharmacology Authors: Babaie, Fatemeh Kourosh-Arami, Masoumeh Farhadi, Mona Tags: Original Article Source Type: research
Therapeutic Potential of Isorhamnetin following Acetaminophen-Induced
Hepatotoxicity through Targeting
NLRP3/NF- κB/Nrf2
In this study, we
evaluated the possible effect of isorhamnetin in prevention of APAP-induced ALI
and analyzed further the involvement of oxidative stress and
inflammation-associated factors. Male C57BL/6 mice were given
isorhamnetin (25 or 100 mg/kg b.w., p.o.) three times at
48, 24, and 1 h before APAP administration (300 mg/kg
b.w., i.p.). Functional indicators of liver injury were measured as well
as analysis of oxidative stress- and inflammation-associated indices and liver
histopathology was also conducted. Isorhamnetin at the highe...
Source: Drug Research - March 31, 2022 Category: Drugs & Pharmacology Authors: Rousta, Ali-Mohammad Mirahmadi, Seyed-Mohamad-Sadegh Shahmohammadi, Alireza Mehrabi, Zhila Fallah, Soudabeh Baluchnejadmojarad, Tourandokht Roghani, Mehrdad Tags: Original Article Source Type: research
