Silibinin Inhibit Cell Migration through Downregulation of RAC1 Gene
Expression in Highly Metastatic Breast Cancer Cell Line
Conclusion In conclusion, the results demonstrate that the silibinin
can be used as an experimental therapeutic for the management of TNBC
metastatic cancer. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - August 12, 2020 Category: Drugs & Pharmacology Authors: Lashgarian, Hamed Esmaeil Adamii, Vahid Ghorbanzadeh, Vajihe Chodari, Leila Kamali, Fayze Akbari, Soheila Dariushnejad, Hassan Tags: Original Article Source Type: research
Trends of Antimicrobial Resistance of Sepsis Pathogens at a
University Hospital in New Delhi, India
Drug Res (Stuttg) DOI: 10.1055/a-1213-2206Knowledge of the aetiological agents and its susceptibility to antimicrobial
agents enables the clinician to initiate appropriate empirical antimicrobial
therapy and guides diagnostic procedures. The aims of the study were to
identify prevalence of bacterial pathogens causing sepsis and observe their
antimicrobial resistance trends in hospitalized patients. A prospective
cohort study was conducted on patients of sepsis admitted at a university
hospital over a period of six months. Pathogens were identified by
...
Source: Drug Research - August 12, 2020 Category: Drugs & Pharmacology Authors: Alam, Md Shamshir Kapur, Prem Pillai, ParuKutty Pillai, Krishna Kolappa Tags: Original Article Source Type: research
Coronavirus Disease-2019 (COVID-19): An Updated
Review
Drug Res (Stuttg) DOI: 10.1055/a-1217-2397The current outbreak of novel Coronavirus Disease-2019 (COVID-19) caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major pandemic
situation and a catastrophe for humans. COVID-19 is a severe infectious disease
particularly of the respiratory system characterized by fatal complications such
as severe acute respiratory distress syndrome (SARS), pneumonia, cardiac
arrhythmia, kidney failure/ multiple organ failure and even death. Since
its discovery, the SARS-CoV-2 has spread across 213 countries or...
Source: Drug Research - August 2, 2020 Category: Drugs & Pharmacology Authors: Rudrapal, Mithun Khairnar, Shubham J. Borse, Laxmikant B. Jadhav, Anil G. Tags: Review Source Type: research
A Comprehensive Review on Physiological Effects of
Curcumin
Drug Res (Stuttg) DOI: 10.1055/a-1207-9469Turmeric (Curcuma longa Linn) is an herbal medicine which is traditionally
used as a spice, food colouring or flavouring agent and widely used for several
diseases such as biliary disorders, cough, hepatic disorders, rheumatism, wound
healing, sinusitis, diabetes, cardiac disorders and neurological disorder. It
belongs to the Zingiberaceae family. Turmeric is a popular domicile
remedy used in Indian food, is mainly a native of south-east Asia, is widely
cultivated in India, Sri Lanka, Indonesia, China, Jamaica , Peru, Hait...
Source: Drug Research - August 2, 2020 Category: Drugs & Pharmacology Authors: Ahsan, Rabiya Arshad, Md Khushtar, Mohammad Ahmad, Mohd Afroz Muazzam, Mohammad Akhter, Md Sohel Gupta, Gudiya Muzahid, Mohd Tags: Review Source Type: research
Analytical Method Development and Validation of UV-visible
Spectrophotometric Method for the Estimation of Vildagliptin in Gastric
Medium
Conclusion The UV method developed and validated for vildagliptin drug
was found to be linear, accurate, precise and economical which can be used for
the testing of its pharmaceutical formulations. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - August 2, 2020 Category: Drugs & Pharmacology Authors: Kumari, Beena Khansili, Aparna Tags: Original Article Source Type: research
Materiovigilance: Concept, Structure and Emerging Perspective for
Patient ’s Safety in India
Drug Res (Stuttg) DOI: 10.1055/a-1195-1945There has been an escalation in the number, diversity, and complexity of
medical devices. Regulation of these devices has also advanced due to the
requirement of better regulatory perspective induced due to elevation in the
number of adverse events associated with medical devices. All over the
globe, various measures are undertaken to provide better safety to the
patients along with attempts to improve the standard of medical devices. The
initial and ultimate objective of the concept happens to be unfailingly t...
Source: Drug Research - August 2, 2020 Category: Drugs & Pharmacology Authors: Hoda, Farazul Verma, Rishabh Arshad, Mawrah Siddiqui, Ali Nasir Khan, Mohammad Ahmed Akhtar, Mohammad Najmi, Abul Kalam Tags: Opinion Paper Source Type: research
Effects of Child-Pugh B Cirrhosis on Pharmacokinetics of
Tofogliflozin, a New Sodium-Glucose Co-Transporter (SGLT2)
Inhibitor
Conclusions Moderate hepatic impairment increased Cmax and
AUCinf of tofogliflozin by 47% and 70%,
respectively. This increase in tofogliflozin exposure did not increase UGE in
hepatically impaired subjects. A single oral dose of 40 mg tofogliflozin was
well tolerated, supporting dose adjustment is unnecessary even in moderately
hepatically impaired subjects. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - July 23, 2020 Category: Drugs & Pharmacology Authors: Yamada, Haruki Ohira, Hiromasa Ikegami, Fumiaki Nakamura, Koichi Takahashi, Atsushi Abe, Kazumichi Inano, Akihiro Shimada, Sumire Miyata, Kumiko Saito, Tomohisa Ohba, Yasuhiro Terao, Kimio Ohnishi, Akihiro Tags: Original Article Source Type: research
Design, Synthesis and Biological Evaluation of
5-amino-3-aryl-1-(6'-chloropyridazin-3'-yl)pyrazoles
and their Derivatives as Analgesic Agents
Drug Res (Stuttg) DOI: 10.1055/a-1202-9959An efficient and environmental benign solvent-free synthesis of
5-amino-3-aryl-1-(6'-chloropyridazin-3'-yl)pyrazoles
(4a-e) was accomplished by grinding 3-chloro-6-hydrazinopyridazine
(2) and β-ketonitriles (3a-e) in the presence of
p-toulenesulfonic acid as a catalyst. Subsequently, 6'-chloro
group in 4a-e was replaced with cyclic 2° amine derivatives
viz. pyrrolidine 5a, piperidine 5b and morpholine
5c to obtain 6a-e, 7a-e, 8a-e respectively. The
newly synthesized compounds were characte...
Source: Drug Research - July 23, 2020 Category: Drugs & Pharmacology Authors: Aggarwal, Ranjana Kaushik, Pawan Kumar, Ajay Saini, Deepika Tags: Original Article Source Type: research
The Antinociceptive Activities of Certain NSAIDS Combinations in
Murine Orofacial Test
Drug Res (Stuttg) DOI: 10.1055/a-1217-6777Pain models are mostly in rodents and between them formalin orofacial test
allow discrimination among antinociception and anti-inflammation. This assay
use a formalin solution injected into the upper right lip of each mouse
which produces two periods of pain separated by an inactive period. The aims
of the present study were to evaluate, by means of the isobolographic
analysis, the antinociception and anti-inflammatory activities of the
following NSAIDs: dexketoprofen, diclofenac, piroxicam and metamizole in an...
Source: Drug Research - July 23, 2020 Category: Drugs & Pharmacology Authors: Miranda, Hugo F. Noriega, Viviana Sierralta, Fernando Sotomayor-Z árate, Ramón Prieto, Juan Carlos Tags: Original Article Source Type: research
The Effect of Dihydromyricetin, a Natural Flavonoid, on
Morphine-induced Conditioned Place Preference and Physical Dependence in
Mice
Conclusion These results indicated that DHM decreased acquisition and
expression of morphine CPP and inhibited development of morphine-induced
physical dependence. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - July 16, 2020 Category: Drugs & Pharmacology Authors: Etemad, Leila Farkhari, Hadi Alavi, Mohaddeseh Sadat Roohbakhsh, Ali Tags: Original Article Source Type: research
Protective Role of EGCG Against Malathion Induced Genotoxicity Using
Human Lymphocytes
Drug Res (Stuttg) DOI: 10.1055/a-1201-2436Background: Green tea (Camellia sinensis), which is the most common drink
across the world after water, has many antioxidant properties.
Epigallocatecin-3-gallate (EGCG) is a flavonoid which accounts for
33–50% of green tea solids. It functions as a powerful
antioxidant, preventing oxidative damage in healthy cells, with antiangiogenic
and antitumor activities and as a modulator of tumor cell response to
chemotherapy. Malathion is an organophosphate pesticide which is widely used in
agriculture, veterinary and ...
Source: Drug Research - July 9, 2020 Category: Drugs & Pharmacology Authors: Taghavi, Seyed Mousa Shadboorestan, Amir Sabzevari, Samin Gholami, Maryam Keshavarz-maleki, Razieh Mozdarani, Hossein Ostad, Seyed Nasser Sabzevari, Omid Tags: Original Article Source Type: research
Combination of Lorcaserin and GLP-1/glucagon Coagonist
Improves Metabolic Dysfunction in Diet Induced-obese Mice
Conclusion These data suggest that combination of lorcaserin and
coagonist could be a better combination to induce body weight loss. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - July 8, 2020 Category: Drugs & Pharmacology Authors: Patel, Vishal Joharapurkar, Amit Kshirsagar, Samadhan Patel, Maulik Savsani, Hardikkumar Bahekar, Rajesh Jain, Mukul Tags: Original Article Source Type: research
Method Development and Validation of UV Spectrophotometric Method for
the Quantitative Estimation of Curcumin in Simulated Nasal Fluid
Conclusion The proposed method was found to be simple, sensitive and
precise. The most important this method can be used for routine quality control
analysis of curcumin with accuracy. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - June 22, 2020 Category: Drugs & Pharmacology Authors: Sharma, Sherry Sharma, Jai Bharti Bhatt, Shailendra Kumar, Manish Tags: Original Article Source Type: research
Development of Nasal Mucoadhesive Microspheres of Granisetron: A
Potential Drug
Conclusion After all the evaluation parameters and result obtained it can
be said that these results confirmed the suitability of Granisetron mucoadhesive
chitosan microspheres for nasal delivery system. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - June 18, 2020 Category: Drugs & Pharmacology Authors: Pandey, Jaideo Shankar, Ravi Kumar, Manish Shukla, Kuldeep Kumari, Beena Tags: Original Article Source Type: research
Design and Synthesis of Novel
1-substituted-3-(3-(3-nitrophenyl)-4-oxo-3,4-dihydrobenzopyrimidin-2-yl amino)
Isothioureas for their Anti-HIV, Antibacterial Activities, Graph Theoretical
Analysis, Insilico Modeling, Prediction of Toxicity and Metabolic
Studies
Drug Res (Stuttg) DOI: 10.1055/a-0991-7617In the present study, we have placed the substituted thiosemicarbazide moiety at
the C-2 position and 3-nitrophenyl group at N-3 position of benzopyrimidines and
studied their antitubercular, anti-HIV and antibacterial activities against
selected gram positive and negative bacteria. The target compounds
1-substituted-3-(3-(3-nitrophenyl)-4-oxo-3,4-dihydrobenzopyrimidin-2-ylamino)
isothioureas (PTS1 – PTS15 ) were obtained by the reaction of
2-hydrazino-3-(3-nitrophenyl) benzopyrimidin-4(3 H)-one
(5) with diff...
Source: Drug Research - June 18, 2020 Category: Drugs & Pharmacology Authors: Narendhar, Bandi Alagarsamy, Veerachamy Krishnan, Chitra Tags: Original Article Source Type: research
