Coronavirus Disease-2019 (COVID-19): An Updated Review

Drug Res (Stuttg) DOI: 10.1055/a-1217-2397The current outbreak of novel Coronavirus Disease-2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major pandemic situation and a catastrophe for humans. COVID-19 is a severe infectious disease particularly of the respiratory system characterized by fatal complications such as severe acute respiratory distress syndrome (SARS), pneumonia, cardiac arrhythmia, kidney failure/ multiple organ failure and even death. Since its discovery, the SARS-CoV-2 has spread across 213 countries or territories, causing more than 8.5 million people with a rising death toll over 5.5 million people (as of June 2020, WHO). In fact, the current looming crisis of COVID-19 has become an increasingly serious concern to public health. It has affected lives of millions of people with severe impact on health systems and economies globally. Since there are no specific drugs and/or vaccines available so far, combating COVID-19 remains to be a major challenging task. Therefore, development of potential and effective treatment regimens (prophylactic/therapeutic) is urgently required which could resolve the issue. In this review, we summarize the current knowledge about the coronavirus, disease epidemiology, clinical manifestations and risk factors, replication of the virus, pathophysiology and host immune responses of SARS-CoV-2 infection. ...
Source: Drug Research - Category: Drugs & Pharmacology Authors: Tags: Review Source Type: research

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Publication date: Available online 26 September 2020Source: CytotherapyAuthor(s): C. Iglesias-Lopez
Source: Cytotherapy - Category: Cytology Source Type: research
Authors: Carbonell-Estrany X, Rodgers-Gray BS, Paes B Abstract INTRODUCTION: Respiratory syncytial virus (RSV) causes approximately 120,000 deaths annually in children
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
CONCLUSIONS: Retinal circulation should be considered as a potential site for thromboembolic complications from COVID-19. PMID: 32976055 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Authors: Agrawal R PMID: 32976047 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Authors: Miserocchi E, Giuffrè C, Modorati GM, Cimaz R Abstract Italy was the first European country to be affected by the SARS-CoV-2 pandemic. In this scenario, we had to face a new clinical approach in our Pediatric Rheumatology Unit for the management of patients affected by juvenile idiopathic arthritis (JIA)-associated uveitis. During the lockdown (phase 1), the weekly outpatient clinic was discontinued and telephone consultations were set up. A toll-free telephone number was instituted for emergencies. None of our children with JIA-associated uveitis was advised to stop the ongoing immunosuppressant sy...
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Neath Port Talbot, Torfaen and the Vale of Glamorgan face further measures; Le Monde reports32% of outbreaks in France found in schools or universitiesRegular ‘circuit breaker’ lockdowns ‘could help control Covid’Minister refuses to guarantee students will be home for ChristmasBoris Johnson faces revolt over forcing through Covid measuresAustralia: ‘We should not pretend everybody is suffering equally’See all our coronavirus coverage2.50pmBSTInMarseille,a coronavirus hotspot, the city ’s top flight football team has been given a government order to play behind closed doors. InGerma...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak France UK news Europe Infectious diseases Science World news Saudi Arabia Japan South Korea Australia news Source Type: news
Authors: Yan C, Hu Y, Qiu G, Gong X, Elda D Abstract Flexible bronchoscopy (FB), developed in the 1960s, is widely used in the clinical practice of pediatrics and has demonstrated fundamental value in clinical diagnoses and treatment. However, as an invasive procedure, the use of FB is limited due to concerns regarding the tolerance of the procedure and the possible complications in neonatal units. Thus, the present study aimed to investigate the clinical safety and efficacy of flexible bronchoscopy (FB) in a neonatal intensive care unit (NICU). Neonates (n=54) who received FB in the NICU of Shanghai Children's Hos...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
The originally published article: The surname and given name of authors, M. Pawlak and A.C. de Beaux has been incorrectly published.
Source: Hernia - Category: Sports Medicine Source Type: research
ConclusionsThe use of taxis in emergency inguinal hernia is a useful first line of treatment in areas or situations where surgical care is not immediately available, including the COVID-19 pandemic. Emergency surgery remains the mainstay of management in the strangulated hernia setting.
Source: Hernia - Category: Sports Medicine Source Type: research
Despite now having evidence that test and trace is the only way to fight the virus, the UK has lost control at the crucial moment• Dr William Hanage is professor of the evolution and epidemiology of infectious disease at HarvardBritain is in the grip of an extraordinarily dangerous outbreak of forgetfulness. During the spring, more than50,000 people died – far more than the yearly total for any flu outbreak in living memory. Deaths are, sadly, an expected outcome of any pandemic. But this experience is also an opportunity to learn – assuming governments are willing to do so.Since the first outbreaks of Cov...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak Infectious diseases Health policy Science US news UK news Boris Johnson Politics Source Type: news
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