Repurposing Drugs: An Empowering Approach to Drug Discovery and
Development
Drug Res (Stuttg) DOI: 10.1055/a-2095-0826Drug discovery and development is a time-consuming and costly procedure that
necessitates a substantial effort. Drug repurposing has been suggested as a
method for developing medicines that takes less time than developing brand new
medications and will be less expensive. Also known as drug repositioning or
re-profiling, this strategy has been in use from the time of serendipitous drug
discoveries to the modern computer aided drug designing and use of computational
chemistry. In the light of the COVID-19 pandemic too, drug ...
Source: Drug Research - July 21, 2023 Category: Drugs & Pharmacology Authors: Kumar, Sahil Roy, Vandana Tags: Review Source Type: research
Correction: Comparison of the efficacy of pioglitazone and metformin on
ultrasound grade and liver enzymes level in patients with non-alcoholic fatty
liver disease: A randomized controlled clinical trial
Drug Res (Stuttg) 2023; 73: e1-e1 DOI: 10.1055/a-2109-9465 Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Drug Research)
Source: Drug Research - June 27, 2023 Category: Drugs & Pharmacology Authors: Khoshbaten, Manouchehr Beheshtirouy, Samineh Shayanrad, Shahrzad Gharekhani, Afshin Rezaee, Haleh Tags: Erratum Source Type: research
Correction: Circulating Fatty Acid-binding Protein 4 Response to Acute Aerobic
Exercise in Healthy MenArtificial Intelligence for Computer-Aided Drug
Discovery
Drug Res (Stuttg) DOI: 10.1055/a-2105-9762 Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Drug Research)
Source: Drug Research - June 13, 2023 Category: Drugs & Pharmacology Authors: Kate, Aditya Seth, Ekkita Singh, Ananya Chakole, Chandrashekhar Mahadeo Chauhan, Meenakshi Kanwar Singh, Ravi Kant Maddalwar, Shrirang Mishra, Mohit Tags: Erratum Source Type: research
AGE RAGE Pathways: Cardiovascular Disease and Oxidative
Stress
Drug Res (Stuttg) DOI: 10.1055/a-2047-3896It is well established that Advanced Glycation End Products (AGEs) and their
receptor (RAGE) are primarily responsible for the development of cardiovascular
disease. As a result, diabetic therapy is very interested in therapeutic
strategies that can target the AGE-RAGE axis. The majority of the AGE-RAGE
inhibitors showed encouraging outcomes in animal experiments, but more
information is needed to completely understand their clinical effects. The main
mechanism implicated in the aetiology of cardiovascular disease in peopl...
Source: Drug Research - June 12, 2023 Category: Drugs & Pharmacology Authors: Sharma, Neeraj Kumar, Pavan Shukla, Karuna Shanker Maheshwari, Shubhrat Tags: Review Source Type: research
Phytopharmaceuticals and Herbal Approaches to Target
Neurodegenerative Disorders
Drug Res (Stuttg) DOI: 10.1055/a-2076-7939Neurodegeneration is characterized as the continuous functional and structural
loss of neurons, resulting in various clinical and pathological manifestations
and loss of functional anatomy. Medicinal plants have been oppressed from
ancient years and are highly considered throughout the world as a rich source of
therapeutic means for the prevention, treatment of various ailments.
Plant-derived medicinal products are becoming popular in India and other
nations. Further herbal therapies shows good impact on chronic long term
...
Source: Drug Research - June 12, 2023 Category: Drugs & Pharmacology Authors: Islam, Anas Mishra, Anuradha Ahsan, Rabia Fareha, Syed Tags: Review Source Type: research
Artificial Intelligence for Computer-Aided Drug
Discovery
Drug Res (Stuttg) DOI: 10.1055/a-2076-3359The continuous implementation of Artificial Intelligence (AI) in multiple
scientific domains and the rapid advancement in computer software and hardware,
along with other parameters, have rapidly fuelled this development. The
technology can contribute effectively in solving many challenges and constraints
in the traditional development of the drug. Traditionally, large-scale chemical
libraries are screened to find one promising medicine. In recent years, more
reasonable structure-based drug design approaches have avoided t...
Source: Drug Research - June 5, 2023 Category: Drugs & Pharmacology Authors: Kate, Aditya Seth, Ekkita Singh, Ananya Chakole, Chandrashekhar Mahadeo Chauhan, Meenakshi Kanwar Singh, Ravi Kant Maddalwar, Shrirang Mishra, Mohit Tags: Review Source Type: research
Effects of SGLT2 inhibitors on the intestinal bacterial flora in
Japanese patients with type 2 diabetes mellitus
In this study, we
investigated the effects of SGLT2 inhibitors on the intestinal bacterial flora.
A total of 36 Japanese patients with type 2 diabetes mellitus received a SGLT2
inhibitor (luseogliflozin or dapagliflozin) for 3 months, and the prevalences of
balance-regulating bacteria and balance-disturbing bacteria in the feces of the
patients before and after SGLT2 inhibitor treatment were determined. SGLT2
inhibitor treatment was associated with a significant increase of the overall
prevalence of the 12 types of balance-regulating bacteria. In additio...
Source: Drug Research - May 26, 2023 Category: Drugs & Pharmacology Authors: Kusunoki, Masataka Hisano, Fumiya Matsuda, Shin-ichi Kusunoki, Akiko Wakazono, Naomi Tsutsumi, Kazuhiko Miyata, Tetsuro Tags: Original Article Source Type: research
Arsenic trioxide-induced cytotoxicity in A549 cells: The role of
necroptosis
Conclusions The A549 cells, after 48 h exposure to ATO at 50 and
100 μM, induces apoptosis and necroptosis. Due to the reduced
expression of MLKL, it can be concluded that ATO is probably effective in the
metastatic stage of cancer cells. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - May 25, 2023 Category: Drugs & Pharmacology Authors: Jamil, Maryam Mohammadi-Bardbori, Afshin Safa, Omid Nikpoor, Amin Reza Bakhtari, Azizollah Mokhtarinejad, Mahnoosh Zadeh, Saghar Naybandi Shadboorestan, Amir Omidi, Mahmoud Tags: Original Article Source Type: research
Efficacy and Safety of Valproic Acid in Myelodysplastic Syndrome and
Acute Myeloid Leukemia; a Narrative Review
Drug Res (Stuttg) DOI: 10.1055/a-2088-3718Loads of new therapeutic regimes have been turned up to manage Myelodysplastic
syndrome (MDS) and acute myeloid leukemia (AML), particularly in elderly
patients who are unfit for intensive chemotherapy. Despite accumulating
research, the best MDS and AML management approach is indeterminate.
Myelodysplastic syndrome implies a group of various hematopoietic stem cell
disorders that may progress to acute myeloid leukemia. These disorders are more
frequent in older adults. To the high rate of morbidity and abundant toxicities...
Source: Drug Research - May 23, 2023 Category: Drugs & Pharmacology Authors: Omidkhoda, Navid Mahdiani, Sina Samadi, Sara Rahimi, Hossein Mohammadpour, Amir Hooshang Tags: Review Source Type: research
Ferulic Acid: Signaling Pathways in Aging
Drug Res (Stuttg) DOI: 10.1055/a-2061-7129The need for clinical remedies to the multiple age-related deficiencies in skin
function brought on by extrinsic and intrinsic causes is increased by these
demographic changes. Reactive oxygen species (ROS), mitochondrial
deoxyribonucleic acid (mtDNA) mutations, telomere shortening, as well as other
factors, contribute to the aging of the skin. In this overview, the issue of
human skin aging is introduced, along with several pathways and the protective
effects of ferulic acid in light of current patents. The complex antiox...
Source: Drug Research - May 23, 2023 Category: Drugs & Pharmacology Authors: Neopane, Deepa Ansari, Vaseem Ahamad Singh, Aditya Tags: Review Source Type: research
Interaction of Some Amino-Nitrile Derivatives with Vascular
Endothelial Growth Factor Receptor 1 (VEGFR1) Using a Theoretical
Model
Conclusions All theoretical data suggest that amino-nitrile derivatives
could produce changes in the growth of some cancer cell lines through VEGFR-1
inhibition. Therefore, these amino-nitrile derivatives could be a therapeutic
alternative to treat some types of cancer. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - May 12, 2023 Category: Drugs & Pharmacology Authors: Figueroa-Valverde, Lauro D íaz-Cedillo, Francisco Rosas-Nexticapa, Marcela Alvarez-Ramirez, Magdalena Mateu-Armad, Maria Virginia L ópez-Ramos, Maria L ópez-Gutierrez, Tomas Tags: Original Article Source Type: research
Pluronic F-68 Montmorillonite As A Drug Delivery Vehicle For Extended
Release Of Venlafaxine Hydrochloride
Drug Res (Stuttg) DOI: 10.1055/a-2024-9964Short half-life and low bioavailability of Venlafaxine hydrochloride (VF), an
antidepressant drug, necessitates the frequent administration of VF tablets in a
day in order to maintain adequate drug concentration in blood plasma. This
generates the need for the development of formulations which could prolong the
release of VF and reduce the multiple dosages. The present work explores the
combination of Montmorillonite (Mt) with Pluronic F-68 (PF-68) (OrganoMT) for
oral delivery of VF. The effect of various parameters includ...
Source: Drug Research - April 28, 2023 Category: Drugs & Pharmacology Authors: Jain, Shilpa Datta, Monika Tags: Original Article Source Type: research
Does the Ethnic Difference Affect the Pharmacokinetics of
Favipiravir? A Pharmacokinetic Study in Healthy Egyptian Volunteers and
Development of Level C In-vitro In-vivo Correlation
Drug Res (Stuttg) DOI: 10.1055/a-2061-7074Favipiravir is an antiviral drug used to treat influenza and is also being
investigated for the treatment of SARS-CoV-2. Its pharmacokinetic profile varies
depending on ethnic group. The present research examines the pharmacokinetic
features of favipiravir in healthy male Egyptian volunteers. Another goal of
this research is to determine the optimum dissolution testing conditions for
immediate release tablets. In vitro dissolution testing was investigated for
favipiravir tablets in three different pH media. The pharmacokin...
Source: Drug Research - April 24, 2023 Category: Drugs & Pharmacology Authors: Bendas, Ehab R. Rezk, Mamdouh R. Badr, Kamal A. Tags: Original Article Source Type: research
Repurposing of FDA Approved Drugs and Neuropep peptides as Anticancer
Agents Against ErbB1 and ErbB2
Drug Res (Stuttg) DOI: 10.1055/a-2030-4078ErbB1 and ErbB2 are the most important biological targets in cancer drug
discovery and development of dual inhibitors for the cancer therapy. FDA
approved drugs and Neuropep peptides were used to fit into the ATP binding site
of the tyrosine kinases; ErbB1 and ErbB2 proteins. Cytoscape, iGEMDOCK, HPEPDOCK
and DataWarrior softwares were used to study the role of these agents as
anticancer drugs. Eleven FDA approved drugs and eleven Neuropep peptides showed
the strongest 2D interactions and significant binding energy with th...
Source: Drug Research - April 17, 2023 Category: Drugs & Pharmacology Authors: Patnaik, Sunil Kumar Swaroop, Akey Krishna Naik, Mudavath Ravi Selvaraj, Jubie Chandrasekar, Moola Joghee Nanjan Tags: Original Article Source Type: research
Clinical Manifestation of AGE-RAGE Axis in Neurodegenerative and
Cognitive Impairment Disorders
Drug Res (Stuttg) DOI: 10.1055/a-2004-3591The receptor of Advanced Glycation Endproducts (RAGE) and Advanced Glycation
Endproducts (AGE) have multiple functions in our body and their restraint are
being observed in neurodegenerative and memory impairment disorders. The review
of different pathways allows an understanding of the probable mechanism of
neurodegeneration and memory impairment involving RAGE and AGE. Commonly we
observe AGE accumulation in neural cells and tissues but the extent of
accumulation increases with the presence of memory impairment disorder....
Source: Drug Research - April 11, 2023 Category: Drugs & Pharmacology Authors: Naz, Sabreena Mahmood, Tarique Gupta, Ramesh Siddiqui, Mohammed Haris Ahsan, Farogh Ansari, Vaseem Ahamad Shamim, Arshiya Rizvi, Ali Abbas Tags: Review Source Type: research
