Design and Synthesis of Novel 1-substituted-3-(3-(3-nitrophenyl)-4-oxo-3,4-dihydrobenzopyrimidin-2-yl amino) Isothioureas for their Anti-HIV, Antibacterial Activities, Graph Theoretical Analysis, Insilico Modeling, Prediction of Toxicity and Metabolic Studies

Drug Res (Stuttg) DOI: 10.1055/a-0991-7617In the present study, we have placed the substituted thiosemicarbazide moiety at
the C-2 position and 3-nitrophenyl group at N-3 position of benzopyrimidines and
studied their antitubercular, anti-HIV and antibacterial activities against
selected gram positive and negative bacteria. The target compounds
1-substituted-3-(3-(3-nitrophenyl)-4-oxo-3,4-dihydrobenzopyrimidin-2-ylamino)
isothioureas (PTS1 – PTS15 ) were obtained by the reaction of
2-hydrazino-3-(3-nitrophenyl) benzopyrimidin-4(3 H)-one
(5) with different alkyl/aryl isothiocyanates followed by
methylation with dimethyl sulphate. All synthesized compounds were screened for
their antitubercular, anti-HIV and antibacterial activity against selective gram
positive and gram negative bacteria by agar dilution method. Among the series,
compound
2-methyl-3-(3-(3-nitrophenyl)-4-oxo-3,4-dihydrobenzopyrimidin-2-ylamino)-1-(3-chlorophenyl)isothiourea
(PTS14) shown most potent activity against Klebsiella pneumoniae,
Proteus vulgaris and Staphylococcus aureus;
PTS14 exhibited the antitubercular activity at the minimum microgram of
1.56 µg/mL and anti-HIV activity at
0.96 µg/mL against HIV1 and HIV2 and offers potential
for further optimization and development to new antitubercular and anti-HIV
...

Source: Drug Research - June 18, 2020 Category: Drugs & Pharmacology Authors: Narendhar, Bandi Alagarsamy, Veerachamy Krishnan, Chitra Tags: Original Article Source Type: research