The Antinociceptive Activities of Certain NSAIDS Combinations in Murine Orofacial Test
Drug Res (Stuttg) DOI: 10.1055/a-1217-6777Pain models are mostly in rodents and between them formalin orofacial test
allow discrimination among antinociception and anti-inflammation. This assay
use a formalin solution injected into the upper right lip of each mouse
which produces two periods of pain separated by an inactive period. The aims
of the present study were to evaluate, by means of the isobolographic
analysis, the antinociception and anti-inflammatory activities of the
following NSAIDs: dexketoprofen, diclofenac, piroxicam and metamizole in an
orofacial. The NSAIDs administered intraperitoneally produced a
dose-dependent activity with the following order of potency of the rubbing
behavior, in phase I:
diclofenac>dexketoprofen>piroxicam>metamizole and in
the phase II:
metamizole>diclofenac>piroxicam>dexketoprofen. The
coadministration of NSAIDs resulted in a synergistic interaction, which
according to the value of the potency of the combination (II) presents the
following range: dexketoprofen plus metamizole>dexketoprofen plus
diclofenac>dexketoprofen plus piroxicam, in phase I and
dexketoprofen plus metamizole>dexketoprofen plus
piroxicam>dexketoprofen plus diclofenac, on the phase II. Data
obtained in this work c...
Source: Drug Research - Category: Drugs & Pharmacology Authors: Miranda, Hugo F. Noriega, Viviana Sierralta, Fernando Sotomayor-Z árate, Ramón Prieto, Juan Carlos Tags: Original Article Source Type: research
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