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FDA Drug Safety Communication: FDA strengthens warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) can cause heart attacks or strokes
[FDA strengthens warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) can cause heart attacks or strokes (FDA Drug Safety Communication). Based on FDA ’s comprehensive review of new safety information, the agency is requiring updates to the drug labels of all prescription NSAIDs. Widely used to treat pain and fever from many different long- and short-term medical conditions such as arthritis, menstrual cramps, headaches, colds, and the flu, NSAI Ds are available by prescription and OTC. Examples of NSAIDs include ibuprofen, naproxen, diclofenac, and celecoxib. (Source: FDA Center for Drug Evaluation...
Source: FDA Center for Drug Evaluation and Research - What's New - November 16, 2017 Category: Drugs & Pharmacology Source Type: news

Symptomatic treatment of uncomplicated lower urinary tract infections in the ambulatory setting: randomised, double blind trial
This research article concludes that diclofenac is inferior to norfloxacin for symptom relief of Urinary Tract Infections at day three. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 10, 2017 Category: Consumer Health News Source Type: news

Nuvo Pharmaceuticals(TM) Inc. Announces Topline Results from European Ankle Sprain Study with Pennsaid(R) 2%
Pennsaid 2% Already Approved for Marketing in the United States and Russia MISSISSAUGA, ON, May 15, 2017 -- (Healthcare Sales & Marketing Network) - Nuvo Pharmaceuticals Inc. (Nuvo or the Company) (TSX:NRI), a commercial healthcare company with a portf... Biopharmaceuticals Nuvo Pharmaceuticals, Pennsaid, diclofenac, ankle, sprain (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - May 15, 2017 Category: Pharmaceuticals Source Type: news

Ibuprofen linked to increased risk of heart attacks
Conclusion This study is a useful addition to our knowledge about the links between NSAIDs and heart attack risk. The study suggests all commonly-used NSAIDs are linked to a similarly-raised risk of heart attacks, that the risk generally rises with the dose, and that it is highest in the first month of treatment. The researchers did a good job at taking account of potential confounding factors that could have affected the results. Even so, we don't know for sure that the NSAIDs were the direct cause of the problem. For example, if you are prescribed NSAIDs for a painful condition, and have a heart attack two weeks later, i...
Source: NHS News Feed - May 10, 2017 Category: Consumer Health News Tags: Heart/lungs Medication Source Type: news

Class 2 medicines recall (action within 48 hours): Diclo-SR 75 Tablets (Diclofenac Sodium)
The Medicines and Healthcare Products Regulatory Agency (MHRA) has issued a class 2 medicines recall (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - March 29, 2017 Category: Drugs & Pharmacology Source Type: news

Ibuprofen claimed to raise cardiac arrest risk by a third
Conclusion This study showed an association between taking ibuprofen or diclofenac and an increased risk of a cardiac arrest in the following 30 days, but no association was found with the other NSAIDs investigated. But this study does have its limitations: Although the researchers used the same people to avoid confounding variables, the same person will differ in certain aspects over time – for example, certain diseases may get better or worse, which might have affected the results. The study only looked at prescribed drugs and not over-the-counter drugs. In Denmark, ibuprofen was the only over-the-counter drug ...
Source: NHS News Feed - March 16, 2017 Category: Consumer Health News Tags: Medication Heart/lungs Source Type: news

Calls for ibuprofen sale restrictions after study finds cardiac arrest risk
Over-the-counter drug linked to 31% increased cardiac arrest risk, with the figure rising to 50% for diclofenac, says researchThere have been fresh calls for restrictions on the sale of the painkilleribuprofen after another study found it heightens the risk of cardiac arrest.Taking the over-the-counter drug was associated with a 31% increased risk,researchers in Denmark found.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - March 15, 2017 Category: Science Authors: Matthew Weaver Tags: Health Heart attack Drugs Healthcare industry Science Business Society Source Type: news

NSAID use linked with increased risk of cardiac arrest
Researchers advise avoiding diclofenac and limiting ibuprofen to 1200 mg per day Related items fromOnMedica Taking antidepressants with painkillers could increase risk of haemorrhage GPs urged not to over prescribe painkillers Long use of pain relievers associated with hearing loss Some common painkillers can raise heart risks NSAIDs and COX 2s linked to heart failure admission (Source: OnMedica Latest News)
Source: OnMedica Latest News - March 14, 2017 Category: UK Health Source Type: news

Voltaren XR (Diclofenac Sodium Extended-Release Tablets) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - January 25, 2017 Category: Drugs & Pharmacology Source Type: news

Lupin gets USFDA nod for Diclofenac capsules' generic version
Lupin has 139 product filings pending approval with the USFDA. Cumulative filings with the USFDA now stand at 341 with the company having received approvals for 202 products. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - December 6, 2016 Category: Pharmaceuticals Source Type: news

Submicron diclofenac reduces AEs, potentially cost saving
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - October 31, 2016 Category: Drugs & Pharmacology Source Type: news

Certain painkillers 'could increase risk of heart failure'
Arthritis patients who take common painkillers such as ibuprofen could be at a greater risk of heart failure, according to a new large-scale study.The research, led by the University of Milano-Bicocca in Italy and utilising data from more than eight million patients, has offered evidence that non-steroidal anti-inflammatory drugs (NSAIDs) may lead to an elevated risk of a person being hospitalised with heart problems, meaning caution may need to be employed when using them.The heart health risks of NSAIDsPublished in the British Medical Journal, the study aimed to investigate the cardiovascular safety of NSAIDs and to...
Source: Arthritis Research UK - September 29, 2016 Category: Rheumatology Source Type: news

Ibuprofen-like painkillers linked to an increased risk of heart failure
Conclusion This useful and well-conducted study isn't the first to say NSAIDs may raise the risk of heart failure. We've known for some time that NSAIDs can have side effects, especially when used at high doses and for long periods. What this study does help show is the different levels of risk between different NSAIDs, and confirms that the risk depends partly on the dose. It's important to remember that the study only included people who were prescribed NSAIDs and not people who'd bought them over the counter. The information is most useful to older people taking prescribed NSAIDs long-term for conditions&...
Source: NHS News Feed - September 29, 2016 Category: Consumer Health News Tags: Medication Heart/lungs Source Type: news

Voltaren (Diclofenac Sodium) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - July 18, 2016 Category: Drugs & Pharmacology Source Type: news

Arthrotec (Diclofenac Sodium, Misoprostol) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - June 20, 2016 Category: Drugs & Pharmacology Source Type: news

Cataflam (Diclofenac Potassium Immediate-Release Tablets) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - June 7, 2016 Category: Drugs & Pharmacology Source Type: news

Flector Patch (Diclofenac Epolamine Topical Patch) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - June 7, 2016 Category: Drugs & Pharmacology Source Type: news

Voltaren Gel (Diclofenac Sodium Gel) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - June 7, 2016 Category: Drugs & Pharmacology Source Type: news

Cambia (Diclofenac Potassium for Oral Solution) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - May 23, 2016 Category: Drugs & Pharmacology Source Type: news

Zorvolex (Diclofenac Capsules) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - May 23, 2016 Category: Drugs & Pharmacology Source Type: news

PENNSAID (Diclofenac Sodium Topical Solution) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - May 23, 2016 Category: Drugs & Pharmacology Source Type: news

Dyloject (Diclofenac Sodium for Injection) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - May 23, 2016 Category: Drugs & Pharmacology Source Type: news

Solaraze (Diclofenac Sodium) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - May 23, 2016 Category: Drugs & Pharmacology Source Type: news

Zipsor (Diclofenac Potassium Liquid Filled Capsules) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - May 19, 2016 Category: Drugs & Pharmacology Source Type: news

Researchers determine the best strategy for preventing ulcers when taking NSAIDs
(Wiley) Non-steroidal anti-inflammatory drugs (NSAIDs) -- including ibuprofen, diclofenac, naproxen and others -- are commonly used pain medications that are generally safe but may increase the risk of developing stomach and intestinal ulcers. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 13, 2016 Category: Global & Universal Source Type: news

[Perspective] Living sentinels for climate change effects
Humans have long used animals as sentinels for threats to their own well-being. Canaries in coal mines are a classic example. On a global scale, studies of birds were key to detecting environmental problems caused by the excessive use of pesticides (1, 2). The recent loss of up to 98% of some vulture populations highlights the widespread dangerous effects of diclofenac use in cattle (3). Bee populations, sentinels for global insect losses, are also declining owing to the combined stress from pesticides and other environmental changes caused by humans, resulting in a widespread loss of pollination services (4). On page 819 ...
Source: ScienceNOW - May 12, 2016 Category: Science Authors: Martin Wikelski Tags: Ecology Source Type: news

GSK Healthcare shifts focus from Horlicks, banks on Sensodyne, Crocin to drive growth in India
In India, the power brands will be Sensodyne, Panadol (called Crocin in India), nasal decongestant Otrivin and Voltaren pain relieving gels and rubs. (Source: The Economic Times)
Source: The Economic Times - April 5, 2016 Category: Consumer Health News Source Type: news

GSK Healthcare banks on Sensodyne, Crocin to drive growth in India
In India, the power brands will be Sensodyne, Panadol (called Crocin in India), nasal decongestant Otrivin and Voltaren pain relieving gels and rubs. (Source: The Economic Times)
Source: The Economic Times - April 5, 2016 Category: Consumer Health News Source Type: news

Acetaminophen Won't Help Arthritis Pain, Study Finds
Prescription diclofenac a more effective choice for short-term pain relief, researchers say Source: HealthDay Related MedlinePlus Pages: Osteoarthritis, Pain, Pain Relievers (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - March 18, 2016 Category: Consumer Health News Source Type: news

Acetaminophen Won't Help Arthritis Pain, Study Finds
Prescription diclofenac a more effective choice for short-term pain relief, researchers say (Source: U.S. News - Health)
Source: U.S. News - Health - March 18, 2016 Category: Consumer Health News Source Type: news

Paracetamol 'useless' in treating osteoarthritis pain
Conclusion This Swiss study reviewed drugs commonly used and recommended to help pain associated with osteoarthritis. Through indirect comparison, it identified those likely to be most effective (diclofenac 150 mg/day) and those that are pretty likely to be useless (paracetamol any dose). The study looked at a large number of good-sized RCTs – all with more than 100 people – and covered a useful range of NSAIDS. The quality of the RCTs was also assessed and was generally not highly biased, although variable. However, the review included many indirect comparisons of the drugs, which is less accurate and reliable...
Source: NHS News Feed - March 18, 2016 Category: Consumer Health News Tags: Medication Older people Source Type: news

Acetaminophen Won't Help Arthritis Pain, Study Finds
Prescription diclofenac a more effective choice for short-term pain relief, researchers say (Source: WebMD Health)
Source: WebMD Health - March 18, 2016 Category: Consumer Health News Source Type: news

Which Drugs Are Best for Osteoarthritis Pain? (FREE)
By Kelly Young Edited by André Sofair, MD, MPH, and William E. Chavey, MD, MS The nonsteroidal anti-inflammatory drugs diclofenac, etoricoxib, and rofecoxib were associated with the greatest pain reduction for patients with knee or hip osteoarthritis, while acetaminophen was not superior … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - March 18, 2016 Category: Primary Care Source Type: news

For Arthritis Pain: Diclofenac Best, Acetaminophen WorstFor Arthritis Pain: Diclofenac Best, Acetaminophen Worst
Diclofenac was most effective and acetaminophen least effective for relieving pain in knee or hip osteoarthritis. Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - March 17, 2016 Category: Neurology Tags: Rheumatology News Source Type: news

Cambia (Diclofenac Potassium for Oral Solution) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 9, 2016 Category: Drugs & Pharmacology Source Type: news

Common painkiller may also be powerful cancer killer
Stephen FellerWASHINGTON, Jan. 12 (UPI) -- The common painkiller diclofenac may be a powerful cancer killer, researchers said of the widely used non-steroidal anti-inflammatory drug. (Source: Health News - UPI.com)
Source: Health News - UPI.com - January 12, 2016 Category: Consumer Health News Source Type: news

Painkiller tapped to become future cancer-killer
Diclofenac, a common painkiller, has significant anti-cancer properties, according to researchers. Like other drugs examined by the ReDO project, diclofenac is cheap and readily accessible -- and as it's already present in many medicine cabinets, it has been carefully tested. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 11, 2016 Category: Science Source Type: news

Painkiller tapped to become future cancer-killer
(ecancermedicalscience) Diclofenac, a common painkiller, has significant anti-cancer properties, according to researchers from the Repurposing Drugs in Oncology project. Like other drugs examined by the ReDO project, diclofenac is cheap and readily accessible -- and as it's already present in many medicine cabinets, it has been carefully tested. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 11, 2016 Category: Cancer & Oncology Source Type: news

Lucy's Weight Loss System Issues Voluntary Nationwide Recall of Pink Bikini Dietary Supplement Due to Undeclared Diclofenac
Lucy's Weight Loss System is voluntarily recalling all lots of Pink Bikini White powder Capsules, 30 white (750MG per capsule) to the consumer level. Pink Bikini has been found positive for diclofenac after FDA sampling and testing.Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID). (Source: Food and Drug Administration)
Source: Food and Drug Administration - December 9, 2015 Category: Food Science Source Type: news

Lipo Escultura Corp. Issues Nationwide Recall of Lipo Escultura Due to Undeclared Sibutramine and Diclofenac
Lipo Escultura Corp. of Brooklyn, NY dba JAT Productos Naturales Corp., and JAT Natural Products Corp. are voluntarily recalling all Lipo Escultura within expiry to the consumer level. The Lipo Escultura capsules were tested by the U.S. Food and Drug Administration and have been found to contain two potentially harmful ingredients--sibutramine and diclofenac. (Source: Food and Drug Administration)
Source: Food and Drug Administration - December 4, 2015 Category: Food Science Source Type: news

Novartis: Alcon reorg on tap for 2016
(Reuters) — Novartis (NYSE:NVS) has agreed in principle to pay $390 million to settle U.S. allegations that it used kickbacks to speciality pharmacies to push sales of some drugs, the Swiss company said today, hitting 3rd-quarter earnings. The U.S. Justice Dept. had sued Novartis in a Manhattan federal court, saying the world’s biggest seller of prescription drugs sought illegally to boost sales of drugs covered by Medicare and Medicaid. The $390 million settlement, still pending approval, pushed Novartis’s 3rd-quarter net income down 42% to $1.8 billion. Novartis’s underlying re...
Source: Mass Device - October 27, 2015 Category: Medical Equipment Authors: Brad Perriello Tags: Legal News MassDevice Earnings Roundup Optical/Ophthalmic Source Type: news

UK Study Indicates That The Cardiovascular Risk Of Celebrex No Different From Other Pain Drugs
But for those free of cardiovascular disease, Celebrex appears to offer no increased cardiovascular risk compared to traditional NSAIDs like ibuprofen and diclofenac. Many would have bet against such an outcome 10 years ago. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - September 3, 2015 Category: Pharmaceuticals Authors: John LaMattina Source Type: news

Zipsor (Diclofenac Potassium Liquid Filled Capsules) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - August 19, 2015 Category: Drugs & Pharmacology Source Type: news

Diclofenac On-Demand Equals Continuous for Slowing AS (CME/CE)
(MedPage Today) -- Upends accepted theories about bone metabolism in ankylosing spondylitis (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - August 14, 2015 Category: Rheumatology Source Type: news

FDA strengthens warning that NSAIDs increase heart attack and stroke risk
Back in 2005, the FDA warned that taking nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen increased the risk of having a heart attack or stroke. Last week it took the unusual step of further strengthening this warning. This was done on the advice of an expert panel that reviewed new information about NSAIDs and their risks. Because NSAIDs are widely used, it’s important to be aware of downsides of taking an NSAID and to take steps to limit the risk. Many people take NSAIDs to relieve mild to moderate pain. These medications may be particularly effective in conditions in which pain results pri...
Source: New Harvard Health Information - July 13, 2015 Category: Consumer Health News Authors: Gregory Curfman, MD Tags: Heart Health heart attack heart disease NSAIDS Stroke Source Type: news

FDA strengthens warning on prescription anti-inflammatory medications
A decade's worth of research on nonsteroidal anti-inflammatory drugs, or NSAIDs,  has prompted the Food and Drug Administration to demand stiffer warnings on the labels of such prescription medications as celecoxib (marketed commercially as Celebrex) and diclofenac (Voltaren) about the increased... (Source: Los Angeles Times - Science)
Source: Los Angeles Times - Science - July 9, 2015 Category: Science Authors: Melissa Healy Source Type: news

G&C Natural Nutrition, Inc. Issues Voluntary Nationwide Recall of Pyrola Due to Undeclared Drug Ingredients
G&C Natural Nutrition, Inc. is voluntarily recalling all lots of Pyrola, 430mg/capsule. Advanced Joint Formula capsules may contain undeclared diclofenac and chlorpheniramine. (Source: NCCAM Featured Content)
Source: NCCAM Featured Content - June 16, 2015 Category: Complementary Medicine Authors: NCCAM Source Type: news

Are back pain drugs like Naproxen and diclofenac making you INFERTILE?
Non-steroidal anti-inflammatory drugs, which also include ibuprofen and aspirin, could be studied as possible contraceptives in light of the findings, University of Baghdad researchers said. (Source: the Mail online | Health)
Source: the Mail online | Health - June 15, 2015 Category: Consumer Health News Source Type: news

Are back pain drugs making you INFERTILE? Naproxen and diclofenac 'significantly inhibit ovulation in just 10 days', scientists warn
Non-steroidal anti-inflammatory drugs, which also include ibuprofen and aspirin, could be studied as possible contraceptives in light of the findings, University of Baghdad researchers said. (Source: the Mail online | Health)
Source: the Mail online | Health - June 15, 2015 Category: Consumer Health News Source Type: news