Study of Reproductive Toxicity of the Liposomal Photosensitizer Lipophthalocyan
Conclusion When mating with intact female rats, no changes in
sexual behavior were observed, but the index of the ability to fertilize and
conceive decreased when compared to the values of the control group by
35–40% (TD index=60%) and by
75–80% (10 TD index=20%). The index of the
ability to fertilize and conceive differed from the values of the control group
by 90% (TD index=5%) and by 15% (10 TD
index=80%). There were no differences in the indicator of
embryotoxicity and teratogenicity in intact and drug-treated female rats,
compared with the control group. Lipophtalocyan has a negative effect on the
male and female reproductive function in rats and has an embryotoxic effect
according to the index of the ability to fertilize and conceive, as well as the
indices of preimplantation and post-implantation fetal death. The drug does not
have a teratogenic effect, neither it affects the physical development of
offspring or the rate of maturation of sensory-motor reflexes during
feeding. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Drug Research - Category: Drugs & Pharmacology Authors: Konyaeva, Olga Kulbachevskaya, Nataliya Chaley, Vera Ermakova, Nadezhda Varaksa, Pavel Lantsova, Anna Nikolaeva, Lyudmila Orlova, Olga Rodionova, Yuliya Bunyatyan, Natalia Tags: Original Article Source Type: research