Synthesis, Antimicrobial Evaluation of Substituted Indole and Nitrobenzenamine based Cr(III), Mn(III) and Fe(III) Metal Complexes

Drug Res (Stuttg) DOI: 10.1055/a-1527-1307Schiff base ligand (E)-5-methyl-3-(1-(4-nitrophenylimino)ethyl)-1H-indol-2-amine
was synthesized by the condensation of
1-(2-amino-5-methyl-1H-indol-3-yl)ethanone and 4-nitrobenzenamine in methanol at
70 oC. The prepared Schiff base ligand doped with
Cr(III), Mn(III) and Fe(III) ion, respectively and it is denoted as
[M(C34H32N8O4)X]X2.
The complexes have been characterized with the help of elemental analysis,
conductance measurements, magnetic measurements and their structural
configuration have been determined by various spectroscopic (electronic, IR,
1H NMR, 13C NMR, GCMS) techniques. Electronic and
magnetic moments of the complexes indicate that the geometry of the metal center
was five coordinate square pyramidal. These metal complexes were also tested for
their antimicrobial activities to assess their inhibiting potential against
Staphylococcus aureus, Bacillus subtilis (positive bacteria) and
Pseudomonas aeruginosa, Escherichia coli, Salmonella typhi
(negative bacteria) and fungi Rizoctonia sp., Aspergillus sp., Penicillium
sp.
[Cr(C34H32N8O4)OAc](OAc)2
shows best antimicrobial activity against all the pathogens. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |...

Source: Drug Research - July 22, 2021 Category: Drugs & Pharmacology Authors: Sharma, Preeti Singh, Varun Kumar Kumar, Gajendra Tags: Original Article Source Type: research