Dendrimers: A Neuroprotective Lead in Alzheimer Disease: A Review on its Synthetic approach and Applications

Drug Res (Stuttg) DOI: 10.1055/a-1886-3208Alzheimer disease is a neurodegenerative disease that is signified by cognitive
decline, memory loss, and erratic behavior. Dendrimers are a type of polymer
that has a well-defined structure, a high degree of molecular uniformity, and a
low polydispersity which have shown to be effective intracellular drug carriers
for bring down the in numerous cases. The data reported by the clinical trials
and chemical bonds of dendrimers loading and biological properties that may be
used in the bringing out the treatment of nano formulation for Alzheimer
disease. Below-range dendrimers have an unlocked figure, but higher-range
dendrimers have a more globular and dense structure so handling is difficult.
Dendrimers are similar in size to a variety of biological structures; for
example, fifth-generation polyamidoamine (PAMAM) dendrimers are similar in size
and shape to haemoglobin (5.5 nm diameter). Each generation of dendrimer
is described in terms of size, shape, molecular weight, and the number of
surface functional groups, with increasing growth specified in terms of
'generation number.' In contrast, Hawker and Frechet were the
first to report the convergent approach. A stepwise repeating reaction strategy
is used to synthesize dendrimers radically from a central core. The value of
...

Source: Drug Research - August 5, 2022 Category: Drugs & Pharmacology Authors: Singh, Aditya Ansari, Vaseem A. Mahmood, Tarique Ahsan, Farogh Wasim, Rufaida Tags: Review Source Type: research