Synergetic Effect of Lupeol and Naringin Against Bile Duct Ligation Induced Cardiac Injury in Rats via Modulating Nitrite Level (eNos) and NF-kB /p65 Expression
This study was concluded that oral administration of Lupeol, Naringin, and its
combination has a curative potential against BDL-induced cardiac injury in rats
by reducing oxidative stress and inflammatory reactions, resulting in reduced
heart necrosis/myocardial infarction and increased myocardial activity.
It also inhibits cardiac damage in the rat heart, these effects may be linked to
the NO level (eNOS) is increased and the inactivation of the NF-kB-p65
expression pathways.This study also provides new insights into the development
of lupeol and Naringin combination that can be used as supportive therapy for
cardiovascular diseases. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Drug Research - Category: Drugs & Pharmacology Authors: Alam, Firoj Kharya, Anil Kumar Srivastav, Ritesh Kumar Akhtar, Juber Khan, Mohammad Irfan Ahmad, Mohammad Tags: Original Article Source Type: research
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