New connection found between NAFLD and rare pregnancy complication
(Digestive Disease Week) A new link has been found between a rare and serious condition that typically presents as itchy palms during pregnancy and the world's most common chronic liver disease, according to research presented at Digestive Disease Week ® (DDW) 2019. Researchers found that intrahepatic cholestasis of pregnancy (ICP), a bile acid disorder in adults that affects roughly one of every 300 pregnancies, may be associated with non-alcoholic fatty liver disease (NAFLD). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 9, 2019 Category: International Medicine & Public Health Source Type: news

What Does the Liver Do?
Discussion The liver is one of the largest organs in the body, weighing just over 3 pounds in an adult. It is found in the upper right abdomen, under the right dome of the diaphragm. Grossly, it has asymmetric lobes with the right being larger than the left. The lobes are separated by a fibrous connective tissue band that also anchors the liver in the abdominal cavity. The gallbladder is located on the inferior surface of the liver and stores bile, which is then released into the duodenum. Microscopically, the liver cells are arranged in lobules with canals carrying blood vessels and bile ducts. At any moment about 10-13% ...
Source: PediatricEducation.org - April 1, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Stillbirth Risk Up With High Serum Bile Acids in Pregnancy
TUESDAY, March 12, 2019 -- The risk of stillbirth is increased in women with intrahepatic cholestasis of pregnancy when serum bile acids concentrations are ≥100 µmol/L or more, according to a review published in the March 2 issue of The... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 12, 2019 Category: Pharmaceuticals Source Type: news

Albireo to initiate A4250 ’s Phase III clinical programme to treat PFIC
Albireo Pharma is planning to initiate a Phase III clinical programme of its product candidate A4250 in the second half of this year for the treatment of patients with progressive familial intrahepatic cholestasis (PFIC). (Source: Drug Development Technology)
Source: Drug Development Technology - May 22, 2017 Category: Pharmaceuticals Source Type: news

Discovery provides insight into life-threatening respiratory distress in newborns
St. Jude Children’s Research Hospital scientists advance understanding of intrahepatic cholestasis of pregnancy, a liver disorder that leaves infants born to affected mothers at risk for severe respiratory distress (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - September 29, 2015 Category: Science Source Type: news

Intrahepatic cholestasis of pregnancy linked with liver cancer
(University of Gothenburg) In a new study of more than 125,000 pregnant women in Sweden, researchers at the Sahlgrenska Academy found that the risk of hepatobiliary cancer and immune-mediated and cardiovascular diseases later in life is higher in women with intrahepatic cholestasis of pregnancy than in women without this condition. Their results are published in the Journal of Hepatology. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 12, 2015 Category: Cancer & Oncology Source Type: news

Research links intrahepatic cholestasis of pregnancy with liver cancer and other diseases later in life
(Elsevier Health Sciences) In a new study of more than 125,000 pregnant women in Sweden, researchers found that the risk of hepatobiliary cancer and immune-mediated and cardiovascular diseases later in life is higher in women with intrahepatic cholestasis of pregnancy than in women without this condition. Their results are published in the Journal of Hepatology. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 8, 2015 Category: Cancer & Oncology Source Type: news

Lumena doses first patients in Phase II trial of LUM001
US-based Lumena Pharmaceuticals has started dosing the first patient in the INDIGO Phase II clinical trial of its lead drug candidate, LUM001, in children with progressive familial intrahepatic cholestasis (PFIC). (Source: Drug Development Technology)
Source: Drug Development Technology - May 13, 2014 Category: Pharmaceuticals Source Type: news

Postnatal Obesity Triggered During Pregnancy
During pregnancy, the health of the mother and the intrauterine environment can have dramatic and lasting effects on the child. Intrahepatic cholestasis of pregnancy (ICP) is a liver disease that affects 0.5-2% of pregnant women and is characterized by increased bile acid levels in the maternal serum. In this issue of the Journal of Clinical Investigation, Catherine Williamson and colleagues at Imperial College London studied the long term impact of ICP in a cohort of Finnish families... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 26, 2013 Category: Consumer Health News Tags: Pregnancy / Obstetrics Source Type: news

Stillbirth And Liver Problems: New Treatment Target On The Horizon
Obstetric cholestasis (OC) is a liver condition that occurs during pregnancy in women. It affects about one in 140 pregnancies in the UK, and can result in stillbirth.1,2 Abnormally high levels of substances in the body linked with pregnancy hormones can contribute to the development of OC, by reducing the body's ability to remove bile from the liver. This results in a build up of toxic bile acids in the bloodstream, causing severe itching especially on the hands and feet, from around week 28 of pregnancy... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 5, 2013 Category: Consumer Health News Tags: Pregnancy / Obstetrics Source Type: news