Maralixibat Takes Out the Itch of Rare Liver Disease
(MedPage Today) -- WASHINGTON -- Another ileal bile acid transporter inhibitor has demonstrated in a phase III trial the ability to reduce pruritus and serum bile acids for kids with progressive familial intrahepatic cholestasis (PFIC).
In children... (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - November 9, 2022 Category: Dermatology Source Type: news
Odevixibat Scratches the Itch of Kids' Rare Liver Disease
(MedPage Today) -- Odevixibat (Bylvay) reduced intense itching and serum bile acids in children with progressive familial intrahepatic cholestasis (PFIC), as detailed in the publication of the PEDFIC 1 trial results that led to the drug's recent... (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - July 8, 2022 Category: Dermatology Source Type: news
Severe COVID-19 in Chronic Liver Disease Linked With Cholestasis and Secondary Sclerosing Cholangitis Severe COVID-19 in Chronic Liver Disease Linked With Cholestasis and Secondary Sclerosing Cholangitis
Severe COVID-19 increases the risk for cholestasis and secondary sclerosing cholangitis in patients with chronic liver disease, researchers say.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 30, 2022 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news
COVID-19 Tied to Progression of Chronic Liver Disease
TUESDAY, June 21, 2022 -- About one in five patients with chronic liver disease (CLD) develop progressive cholestasis after severe COVID-19, according to a study published online May 21 in Hepatology.
Lukas Hartl, M.D., from University of Vienna,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 21, 2022 Category: Pharmaceuticals Source Type: news
Are These Stools Acholic?
Discussion
Color can be difficult to discern and communicate. Stooling is an important part of overall health and an important harbinger of potential illness. Stooling consistency and color changes with food, environment, medication, and health conditions.
For neonates and young infants, some hepatobiliary problems may not be seen at birth but in the next few days to weeks. This includes Alagille syndrome, biliary atresia and cystic fibrosis. It is not uncommon for these patients to have prolonged jaundice and therefore the diagnosis may be delayed with some presenting with increased jaundice, acholic stool and poor feedin...
Source: PediatricEducation.org - May 23, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
Kate Mara: Actress was 'terrified' during pregnancy after cholestasis diagnosis - symptoms
ACTRESS Kate Mara starred in the first season of House of Cards and dozens of other shows and films such as Shooter, The Martian and Fantastic Four. But behind the screens, the star has had a difficult journey towards motherhood. (Source: Daily Express - Health)
Source: Daily Express - Health - March 28, 2022 Category: Consumer Health News Source Type: news
Neonatal Cholestasis: Updates on Diagnostics, Therapeutics, and Prevention
Cholestatic jaundice is a common presenting feature of hepatobiliary and/or metabolic dysfunction in the newborn and young infant. Timely detection of cholestasis, followed by rapid step-wise evaluation to determine the etiology, is crucial to identify those causes that are amenable to medical or surgical intervention and to optimize outcomes for all infants. In the past 2 decades, genetic etiologies have been elucidated for many cholestatic diseases, and next-generation sequencing, whole-exome sequencing, and whole-genome sequencing now allow for relatively rapid and cost-effective diagnosis of conditions not previously i...
Source: NeoReviews recent issues - December 1, 2021 Category: Pediatrics Source Type: news
FDA OKs Odevixibat for Pruritus Associated With Rare Liver Disease FDA OKs Odevixibat for Pruritus Associated With Rare Liver Disease
Odevixibat (Bylvay) is the first drug approved for the treatment of severe itching in children as young as 3 months with progressive familial intrahepatic cholestasis.FDA Approvals (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - July 21, 2021 Category: Drugs & Pharmacology Tags: Gastroenterology News Source Type: news
FDA Approves Bylvay (odevixibat) for the Treatment of Pruritus in Patients with Progressive Familial Intrahepatic Cholestasis (PFIC)
BOSTON, July 20, 2021 (GLOBE NEWSWIRE) -- Albireo Pharma, Inc. (Nasdaq: ALBO), a rare liver disease company developing novel bile acid modulators, today announced U.S. Food& Drug Administration (FDA) approval of... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - July 20, 2021 Category: Drugs & Pharmacology Source Type: news
Albireo gets FDA, European approval for pediatric liver disease drug
Albireo Pharma, a rare liver disease-focused biopharma spun out of AstraZeneca in 2008, has its first regulatory approval for a drug for a pediatric liver disease called progressive familial intrahepatic cholestasis (PFIC). (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - July 20, 2021 Category: Biotechnology Authors: Rowan Walrath Source Type: news
Albireo gets FDA, European approval for pediatric liver disease drug
Albireo Pharma, a rare liver disease-focused biopharma spun out of AstraZeneca in 2008, has its first regulatory approval for a drug for a pediatric liver disease called progressive familial intrahepatic cholestasis (PFIC). (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - July 20, 2021 Category: Pharmaceuticals Authors: Rowan Walrath Source Type: news
Epistane, an anabolic steroid used for recreational purposes, causes cholestasis with elevated levels of cholic acid conjugates, by upregulating bile acid synthesis (CYP8B1) and cross-talking with nuclear receptors in human hepatocytes - Petrov PD, Fern ández-Murga L, Conde I, Martínez-Sena T, Guzmán C, Castell JV, Jover R.
Anabolic-androgenic steroids are testosterone derivatives, used by body-builders to increase muscle mass. Epistane (EPI) is an orally administered 17 α-alkylated testosterone derivative with 2a-3a epithio ring. We identified four individuals who, after EPI... (Source: SafetyLit)
Source: SafetyLit - January 4, 2020 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
She was pregnant and terribly itchy. Something was going very wrong.
The ailment was intrahepatic cholestasis of pregnancy, which causes a toxic womb environment and can lead to stillbirths. (Source: Washington Post: To Your Health)
Source: Washington Post: To Your Health - December 8, 2019 Category: Consumer Health News Authors: Claire Marie Porter Source Type: news
Ursodeoxycholic Acid Ineffective for Liver Disorder of Pregnancy Ursodeoxycholic Acid Ineffective for Liver Disorder of Pregnancy
Ursodeoxycholic acid, the currently recommended treatment for intrahepatic cholestasis of pregnancy (ICP), does not reduce adverse perinatal outcomes and its routine use"should be reconsidered," conclude investigators in the PITCHES randomized controlled trial.Reuters Health Information (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 10, 2019 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health News Source Type: news
Common Therapy for Obstetric Cholestasis Found Ineffective
WEDNESDAY, Aug. 7, 2019 -- For women with intrahepatic cholestasis of pregnancy, treatment with ursodeoxycholic acid does not reduce adverse perinatal outcomes, according to a study published online Aug. 1 in The Lancet.
Lucy C. Chappell, Ph.D.,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - August 7, 2019 Category: Pharmaceuticals Source Type: news
