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Singapore scientists uncover how the liver unclogs itself
This study was published online in the Journal of Hepatology. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 30, 2017 Category: Biology Source Type: news

Albireo to initiate A4250 ’s Phase III clinical programme to treat PFIC
Albireo Pharma is planning to initiate a Phase III clinical programme of its product candidate A4250 in the second half of this year for the treatment of patients with progressive familial intrahepatic cholestasis (PFIC). (Source: Drug Development Technology)
Source: Drug Development Technology - May 21, 2017 Category: Pharmaceuticals Source Type: news

Case 2: Neonate with Cholestasis, Thrombocytopenia, and Hypoglycemia
(Source: NeoReviews recent issues)
Source: NeoReviews recent issues - June 30, 2016 Category: Pediatrics Authors: Velazquez, D. M., Ovchinsky, N., Taragin, B., Bruno, C. J. Tags: Pediatric Drug Labeling Update Index of Suspicion in the Nursery Source Type: news

Advances in IV nutrition for very low birth weight neonates
Premature neonates are at high risk for growth failure and a host of morbidities including sepsis, chronic lung disease, necrotizing enterocolitis, retinopathy of prematurity, cholestasis, and... (Source: Pediatric News)
Source: Pediatric News - April 13, 2016 Category: Journals (General) Source Type: news

Progress Noted in Treatment of Several Common Liver DiseasesProgress Noted in Treatment of Several Common Liver Diseases
Dr William Balistreri provides an overview of the latest data on such disorders as alpha-1 antitrypsin deficiency, drug-induced liver injury, and parenteral nutrition-associated cholestasis. Medscape Gastroenterology (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - April 8, 2016 Category: Transplant Surgery Tags: Gastroenterology Commentary Source Type: news

Shaping lumens by force
(National University of Singapore) Scientists from Singapore and France have revealed the underlying mechanism for the formation and growth of a fundamental type of tissue -- epithelial tubes. Defects in the architecture of epithelial tubes lead to diseases such as cholestasis, atherosclerosis and polycystic kidney disease. The study suggests that the shape and size of some types of epithelial tubes are governed by the mechanical forces that arise from the interaction of cells with the supportive extracellular matrix that surrounds them (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - February 23, 2016 Category: Biology Source Type: news

Freshwater clam extract supplement induced acute cholestasis - Yokomori H, Yamazaki H, Oda M.
[Abstract unavailable] Language: en... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - November 8, 2015 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Discovery provides insight into life-threatening respiratory distress in newborns
St. Jude Children’s Research Hospital scientists advance understanding of intrahepatic cholestasis of pregnancy, a liver disorder that leaves infants born to affected mothers at risk for severe respiratory distress (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - September 29, 2015 Category: Science Source Type: news

Intrahepatic cholestasis of pregnancy linked with liver cancer
(University of Gothenburg) In a new study of more than 125,000 pregnant women in Sweden, researchers at the Sahlgrenska Academy found that the risk of hepatobiliary cancer and immune-mediated and cardiovascular diseases later in life is higher in women with intrahepatic cholestasis of pregnancy than in women without this condition. Their results are published in the Journal of Hepatology. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 12, 2015 Category: Cancer & Oncology Source Type: news

Research links intrahepatic cholestasis of pregnancy with liver cancer and other diseases later in life
(Elsevier Health Sciences) In a new study of more than 125,000 pregnant women in Sweden, researchers found that the risk of hepatobiliary cancer and immune-mediated and cardiovascular diseases later in life is higher in women with intrahepatic cholestasis of pregnancy than in women without this condition. Their results are published in the Journal of Hepatology. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 8, 2015 Category: Cancer & Oncology Source Type: news

Blocking excessive division of cell powerhouses reduces liver cell death in cholestasis
The power plants that fuel liver cells rapidly splinter when exposed to bile salts that aid digestion, prompting cell death, but blocking this excessive fission appears to protect the liver, scientists report. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - December 22, 2014 Category: Science Source Type: news

Blocking excessive division of cell powerhouses reduces liver cell death in cholestasis
(Medical College of Georgia at Georgia Regents University) The power plants that fuel liver cells rapidly splinter when exposed to bile salts that aid digestion, prompting cell death, but blocking this excessive fission appears to protect the liver, scientists report. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 22, 2014 Category: Cancer & Oncology Source Type: news

Severe cholestasis and hepatic dysfunction in a case of fatal paraquat poisoning - Muthu V, Das A, Bal A, Agarwal R.
[Abstract unavailable] Language: en... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - September 18, 2014 Category: Global & Universal Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Lumena doses first patients in Phase II trial of LUM001
US-based Lumena Pharmaceuticals has started dosing the first patient in the INDIGO Phase II clinical trial of its lead drug candidate, LUM001, in children with progressive familial intrahepatic cholestasis (PFIC). (Source: Drug Development Technology)
Source: Drug Development Technology - May 12, 2014 Category: Pharmaceuticals Source Type: news

Case Study 5. Deconvoluting Hyperbilirubinemia: Differentiating Between Hepatotoxicity and Reversible Inhibition of UGT1A1, MRP2, or OATP1B1 in Drug Development
New molecular entities (NMEs) are evaluated using a rigorous set of in vitro and in vivo studies to assess their safety and suitability for testing in humans. Regulatory health authorities require that therapeutic and supratherapeutic doses be administered, by the intended route of administration, to two nonclinical species prior to human testing (ICH Expert Working Group. The international conference on harmonization of technical requirements for registration of pharmaceuticals for human use (ICH); Multidisciplinary guidelines; Nonclinical safety studies (M3). http://www.ich.org/fileadmin/Public_Web_Site/ICH_Pro...
Source: Springer protocols feed by Pharmacology/Toxicology - February 14, 2014 Category: Drugs & Pharmacology Source Type: news

Zinc Shortage Linked to Zinc Deficiency Disorder in Infants on Parenteral Nutrition (FREE)
By Cara Adler Nationwide shortages of injectable zinc, a component of parenteral nutrition, have led to zinc deficiency disorder in seven infants with cholestasis, according to MMWR. The shortage began in late 2012, when one of two … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - January 17, 2014 Category: Primary Care Source Type: news

Postnatal Obesity Triggered During Pregnancy
During pregnancy, the health of the mother and the intrauterine environment can have dramatic and lasting effects on the child. Intrahepatic cholestasis of pregnancy (ICP) is a liver disease that affects 0.5-2% of pregnant women and is characterized by increased bile acid levels in the maternal serum. In this issue of the Journal of Clinical Investigation, Catherine Williamson and colleagues at Imperial College London studied the long term impact of ICP in a cohort of Finnish families... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 26, 2013 Category: Consumer Health News Tags: Pregnancy / Obstetrics Source Type: news

Stillbirth And Liver Problems: New Treatment Target On The Horizon
Obstetric cholestasis (OC) is a liver condition that occurs during pregnancy in women. It affects about one in 140 pregnancies in the UK, and can result in stillbirth.1,2 Abnormally high levels of substances in the body linked with pregnancy hormones can contribute to the development of OC, by reducing the body's ability to remove bile from the liver. This results in a build up of toxic bile acids in the bloodstream, causing severe itching especially on the hands and feet, from around week 28 of pregnancy... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 5, 2013 Category: Consumer Health News Tags: Pregnancy / Obstetrics Source Type: news

Neonatal Cholestasis
Cholestatic jaundice is a common presenting feature of neonatal hepatobiliary and metabolic dysfunction. Any infant who remains jaundiced beyond age 2 to 3 weeks should have the serum bilirubin level fractionated into a conjugated (direct) and unconjugated (indirect) portion. Conjugated hyperbilirubinemia is never physiologic or normal. The differential diagnosis of cholestasis is extensive, and a step-wise approach based on the initial history and physical examination is useful to rapidly identify the underlying etiology. Early recognition of neonatal cholestasis is essential to ensure timely treatment and optimal prognos...
Source: NeoReviews recent issues - February 1, 2013 Category: Pediatrics Authors: Feldman, A. G., Sokol, R. J. Tags: Fetus and Newborn Infant Articles Source Type: news