Vitexin inhibits acrylamide-induced neuroinflammation and improves behavioral changes in zebrafish larvae
Publication date: Available online 31 May 2019Source: Neurotoxicology and TeratologyAuthor(s): Manigandan Krishnan, Sun Chul KangAbstractNeuroinflammation is crucial for the pathophysiological hallmarks of many neurodegenerative disorders. Hyperactivated microglia has long been implicated as a detrimental player in regulating unresolvable inflammatory insults which cause damage to neurons. In the context of acrylamide (ACR) neurotoxicity, microglia activation is documented to correlate with ACR-adduct formation in the presynaptic neurons. Thus, inhibition of inflammatory mediators through vital candidate is greatly warrant...
Source: Neurotoxicology and Teratology - June 2, 2019 Category: Toxicology Source Type: research

Prenatal and recent methylmercury exposure and heart rate variability in young adults: the Seychelles Child Development Study
In conclusion, prenatal and recent MeHg exposure had no consistent pattern of associations to support the hypothesis that they are adversely associated with heart rate variability in this study population that consumes large amounts of fish. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - May 25, 2019 Category: Toxicology Source Type: research

Sub-lethal effects of the triazole fungicide propiconazole on zebrafish (Danio rerio) development, oxidative respiration, and larval locomotor activity
This study demonstrates that propiconazole can induce hypopigmentation in zebrafish, disrupts mitochondrial bioenergetics, and alters locomotor activity. However, these sub-lethal responses were observed at concentrations above what is typically detected in the environment. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - May 24, 2019 Category: Toxicology Source Type: research

Paternal nicotine exposure in rats produces long-lasting neurobehavioral effects in the offspring
Publication date: Available online 16 May 2019Source: Neurotoxicology and TeratologyAuthor(s): Andrew B. Hawkey, Hannah White, Erica Pippen, Eva Greengrove, Amir H. Rezvani, Susan K. Murphy, Edward D. LevinAbstractStudies of intergenerational effects of parental chemical exposure have principally focused on maternal exposure, particularly for studies of adverse neurobehavioral consequences on the offspring. Maternal nicotine exposure has long been known to cause adverse neurobehavioral effects on the offspring. However, paternal toxicant exposure has also been found to cause neurobehavioral toxicity in their offspring. Rec...
Source: Neurotoxicology and Teratology - May 18, 2019 Category: Toxicology Source Type: research

Editorial Board
Publication date: May–June 2019Source: Neurotoxicology and Teratology, Volume 73Author(s): (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - May 10, 2019 Category: Toxicology Source Type: research

Co-use of tobacco and marijuana during pregnancy: Impact on nervous system development
Publication date: Available online 3 May 2019Source: Neurotoxicology and TeratologyAuthor(s): Natacha M. De Genna, Laura R. Stroud, Rina D. Eiden (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - May 4, 2019 Category: Toxicology Source Type: research

Paternal THC exposure in rats causes long-lasting neurobehavioral effects in the offspring
This study shows that premating paternal THC exposure even at a modest dose for a brief period can cause deleterious long-term behavioral effects in the offspring, notably significant impairment in an operant attention task. Further research should be conducted to determine the degree to which this type of risk is seen in humans and to investigate the mechanisms underlying these effects and possible treatments to ameliorate these long-term adverse behavioral consequences of paternal THC exposure. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - April 25, 2019 Category: Toxicology Source Type: research

Comparative analyses of the neurobehavioral, molecular, and enzymatic effects of organophosphates on embryo-larval zebrafish (Danio rerio)
Publication date: Available online 9 April 2019Source: Neurotoxicology and TeratologyAuthor(s): Cassandra Schmitt, Michelle McManus, Naveen Kumar, Olushola Awoyemi, Jordan CragoAbstractOrganophosphates insecticides (OPs) are common surface water contaminants in both urban and agricultural landscapes. Neurobehavioral effects on larval fish are known to occur at concentrations higher than those reported in the environment. The aim of this study was to perform a comparative analysis of neurobehavioral, molecular, and biochemical responses of four OPs (diazinon, dichlorvos, malathion, methyl-parathion) via the following endpoi...
Source: Neurotoxicology and Teratology - April 10, 2019 Category: Toxicology Source Type: research

43rd Annual Meeting of the Developmental Neurotoxicology Society: Held in Conjunction with the 59th Annual Meeting of the Teratology Society and 32nd Annual Education Meeting for the Organization of Teratology Information Specialists, Sheraton San Diego Hotel and Marina, San Diego, CA, June 23–26, 2019
Publication date: Available online 5 April 2019Source: Neurotoxicology and TeratologyAuthor(s): (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - April 5, 2019 Category: Toxicology Source Type: research

Altered motor development following late gestational alcohol and cannabinoid exposure in rats
Publication date: Available online 31 March 2019Source: Neurotoxicology and TeratologyAuthor(s): Kristen R. Breit, Brandonn Zamudio, Jennifer D. ThomasAbstractCannabis is the most commonly used illicit drug among pregnant women, and rates are likely to increase given recent legalization. In addition, half of pregnant women who report consuming cannabis also report drinking alcohol. However, little is known about the consequences of prenatal cannabis alone or combination with alcohol, particularly with cannabis products that are continually increasing in potency of the primary psychoactive constituent in cannabis, Δ9-...
Source: Neurotoxicology and Teratology - April 2, 2019 Category: Toxicology Source Type: research

Analgesic and toxic effects of venenum bufonis and its constituent compound cinobufagin: A comparative study
ConclusionsBoth VB and CBG exhibited analgesic effects and low hemolytic toxicity; however, the latter showed stronger analgesic activity and less hepatotoxicity. Additionally, both VB and CBG increased the heart rate; however, CBG had stronger effects and higher acute toxicity. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - March 31, 2019 Category: Toxicology Source Type: research

Screening for neurotoxic potential of 15 flame retardants using freshwater planarians
In this study, we used our automated planarian screening platform to compare the neurotoxicity of 15 flame retardants (FRs), consisting of representative phased-out brominated (BFRs) and replacement organophosphorus FRs (OPFRs). OPFRs have emerged as a proposed safer alternative to BFRs; however, limited information is available on their health effects. We found 11 of the 15 FRs (3/6 BFRs, 7/8 OPFRs, and Firemaster 550) caused adverse effects in both adult and developing planarians with similar nominal lowest-effect-levels for BFRs and OPFRs. This suggests that replacement OPFRs are comparably neurotoxic to the phased-out ...
Source: Neurotoxicology and Teratology - March 31, 2019 Category: Toxicology Source Type: research

Associations of first trimester co-use of tobacco and Cannabis with prenatal immune response and psychosocial well-being
ConclusionPreliminary results suggest women co-using during the first trimester exhibit decreased pro-inflammatory immune responsivity on one out of eight markers. Further research is needed to determine the impact of this immune modulation on fetal health outcomes and the unique contribution of cannabis. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - March 30, 2019 Category: Toxicology Source Type: research

The citrus flavonoids hesperidin and naringin alleviate alcohol-induced behavioural alterations and developmental defects in zebrafish larvae
In conclusion, this study suggests that the citrus flavonoids hesperidin and naringin could reduce the effects of alcohol damage on embryonic development and neurobehaviour in zebrafish larvae, which would provide useful knowledge for assessing the underlying mechanism of citrus flavonoids and their protective effects.Graphical abstract (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - March 16, 2019 Category: Toxicology Source Type: research

Editorial Board
Publication date: March–April 2019Source: Neurotoxicology and Teratology, Volume 72Author(s): (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - March 6, 2019 Category: Toxicology Source Type: research

Repeated toluene exposure alters the synaptic transmission of layer 5 medial prefrontal cortex
Publication date: Available online 28 February 2019Source: Neurotoxicology and TeratologyAuthor(s): Silvia L. Cruz, Mayra Torres-Flores, Emilio J. GalvánAbstractToluene is an organic solvent commonly misused by inhalation among adolescents to experience psychoactive effects. Repeated toluene exposure produces several cognitive deficits, including working memory impairment in which the medial prefrontal cortex (mPFC) plays a central role. Among other effects, toluene antagonizes NMDA receptors, enhance GABAA receptor-mediated responses and increases dopamine release. We have recently reported that animals repeatedly ...
Source: Neurotoxicology and Teratology - March 1, 2019 Category: Toxicology Source Type: research

When fish take a bath: Psychopharmacological characterization of the effects of a synthetic cathinone bath salt ‘flakka’ on adult zebrafish
This study also suggests that aquatic models based on zebrafish can help further examine the CNS effects evoked by α-PVP and related synthetic new psychoactive drugs. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - February 21, 2019 Category: Toxicology Source Type: research

Lead exposure reduces survival, neuronal determination, and differentiation of P19 stem cells
Publication date: Available online 15 February 2019Source: Neurotoxicology and TeratologyAuthor(s): Clayton Mansel, Shaneann Fross, Jesse Rose, Emily Dema, Alexis Mann, Haley Hart, Paul Klawinski, Bhupinder P.S. VohraAbstractLead (Pb) is a teratogen that poses health risks after acute and chronic exposure. Lead is deposited in the bones of adults and is continuously leached into the blood for decades. While this chronic lead exposure can have detrimental effects on adults such as high blood pressure and kidney damage, developing fetuses and young children are particularly vulnerable. During pregnancy, bone-deposited lead i...
Source: Neurotoxicology and Teratology - February 16, 2019 Category: Toxicology Source Type: research

Developmental neurotoxicity of inorganic arsenic exposure in Sprague-Dawley rats
Publication date: Available online 6 February 2019Source: Neurotoxicology and TeratologyAuthor(s): Christopher L. Moore, Timothy J. Flanigan, Charles D. Law, Lucie Loukotková, Kellie A. Woodling, Gonçalo Gamboa da Costa, Suzanne C. Fitzpatrick, Sherry A. FergusonAbstractHigh levels of inorganic arsenic (iAs) exposure are associated with severe health effects. Less clear are effects of lower exposure levels on neurodevelopment. Relative to maternal intake, there is limited lactational transfer of arsenic in humans or rodents, yet there are few rodent studies which directly exposed preweaning animals. To more c...
Source: Neurotoxicology and Teratology - February 7, 2019 Category: Toxicology Source Type: research

Varying the exposure period and duration of neuroactive pharmaceuticals and their metabolites modulates effects on the visual motor response in zebrafish (Danio rerio) larvae
Publication date: Available online 31 January 2019Source: Neurotoxicology and TeratologyAuthor(s): Irvin J. Huang, Howard I. Sirotkin, Anne E. McElroyAbstractPharmaceuticals and personal care products are emerging contaminants that are increasingly detected in surface waters around the world. Despite the rise in environmental detections, measured concentrations are still typically low, raising the importance of environmental risk assessments that focus on ecologically relevant sublethal endpoints, such as altered behavior. Neuroactive pharmaceuticals, like mental health medications, pain killers, etc., may be particularly ...
Source: Neurotoxicology and Teratology - February 2, 2019 Category: Toxicology Source Type: research

Biocompatibility and toxicity of novel iron chelator Starch-Deferoxamine (S-DFO) compared to zinc oxide nanoparticles to zebrafish embryo: An oxidative stress based apoptosis, physicochemical and neurological study profile
ConclusionOur assays demonstrate that S-DFO does not induce cellular or biochemical stress and has no adverse effect on organ development of zebrafish embryos, suggesting its safe use as an iron chelator.Graphical abstract (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - January 31, 2019 Category: Toxicology Source Type: research

Preclinical modeling of exposure to a global marine bio-contaminant: Effects of in utero Domoic acid exposure on neonatal behavior and infant memory
Publication date: Available online 25 January 2019Source: Neurotoxicology and TeratologyAuthor(s): Kimberly S. Grant, Brenda Crouthamel, Caroline Kenney, Noelle McKain, Rebekah Petroff, Sara Shum, Jing Jing, Nina Isoherranen, Thomas M. BurbacherAbstractDomoic Acid (DA) is a naturally-occurring marine neurotoxin that is increasingly recognized as an important public health issue. Prenatal DA exposure occurs through the maternal consumption of contaminated shellfish/finfish. To better understand the fetal risks associated with DA, we initiated a longitudinal, preclinical study focused on the reproductive and developmental ef...
Source: Neurotoxicology and Teratology - January 26, 2019 Category: Toxicology Source Type: research

Protective effect of 5-HT7 receptor activation against glutamate-induced neurotoxicity in human neuroblastoma SH-SY5Y cells via antioxidative and antiapoptotic pathways
Publication date: Available online 24 January 2019Source: Neurotoxicology and TeratologyAuthor(s): Tugba NurcanYuksel, Muhammed Yayla, Zekai Halici, Elif Cadirci, Beyzagul Polat, Duygu KoseAbstractSerotonin exerts anti-inflammatory, antioxidant and antiapoptotic effects through 5-HT7 receptors. The present study determined the role of 5-HT7 receptors in glutamate-induced neurotoxicity by using human SH-SY5Y neuroblastoma cells. The cells were pretreated with different concentrations of 5-HT7 receptor agonist LP44 and antagonist SB269970 for 60 min, followed by treatment with glutamate. Cell proliferation was measured usi...
Source: Neurotoxicology and Teratology - January 25, 2019 Category: Toxicology Source Type: research

Editorial Board
Publication date: January–February 2019Source: Neurotoxicology and Teratology, Volume 71Author(s): (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - January 10, 2019 Category: Toxicology Source Type: research

Effects of oral domoic acid exposure on maternal reproduction and infant birth characteristics in a preclinical nonhuman primate model
Publication date: Available online 5 January 2019Source: Neurotoxicology and TeratologyAuthor(s): Thomas M. Burbacher, Kimberly S. Grant, Rebekah Petroff, Sara Shum, Brenda Crouthamel, Courtney Stanley, Noelle McKain, Jing Jing, Nina IsoherranenAbstractDomoic Acid (DA) is a naturally-occurring excitotoxin, produced by marine algae, which can bioaccumulate in shellfish and finfish. The consumption of seafood contaminated with DA is associated with gastrointestinal illness that, in the case of high DA exposure, can evolve into a spectrum of responses ranging from agitation to hallucinations, memory loss, seizures and coma. B...
Source: Neurotoxicology and Teratology - January 5, 2019 Category: Toxicology Source Type: research

Teratogenicity and neurotoxicity effects induced by methomyl insecticide on the developmental stages of Bufo arabicus
Publication date: Available online 2 January 2019Source: Neurotoxicology and TeratologyAuthor(s): Amin A. SeleemAbstractMethomyl (MET) is a carbamate insecticide that has been widely used to protect the crop against insects as an alternative for organophosphorus insecticide. Thus the present study aims to evaluate the potential toxic effects of MET on the developmental stages of Bufo arabicus. Tadpoles were classified into three stages (25, 37, 40). Every stage was divided into two groups, control and MET-treated group (10 ppm for two weeks) after LC50 determination in acute toxicity test for 96 h. Control and MET-trea...
Source: Neurotoxicology and Teratology - January 3, 2019 Category: Toxicology Source Type: research

Anxiolytic activity of paraoxon is associated with alterations in rat brain glutamatergic system
Publication date: Available online 19 December 2018Source: Neurotoxicology and TeratologyAuthor(s): Zohreh Zare, Mohsen Tehrani, Noorollah Rezaei, Babak Dana Ghalebarzand, Moslem MohammadiAbstractExposure to organophosphate (OP) compounds leads to behavioral alterations. To determine whether paraoxon has effects on anxiety, anxiety-like behaviors were assessed in paraoxon-exposed rats. Protein expression of glutamate transporters has also been measured in hippocampus and prefrontal cortex. Three doses of paraoxon (0.3, 0.7, or 1 mg/kg) or corn oil (vehicle) were intraperitoneally injected to adult male rats. At 14 or 28...
Source: Neurotoxicology and Teratology - December 19, 2018 Category: Toxicology Source Type: research

Neurotoxicity of anesthetics: Mechanisms and meaning from mouse intervention studies
Publication date: Available online 22 November 2018Source: Neurotoxicology and TeratologyAuthor(s): Simon C. Johnson, Amanda Pan, Li Li, Margaret Sedensky, Philip MorganAbstractVolatile anesthetics are widely used in human medicine and generally considered to be safe in healthy individuals. In recent years, the safety of volatile anesthesia in pediatric patients has been questioned following reports of anesthetic induced neurotoxicity in pre-clinical studies. These studies in mice, rats, and primates have demonstrated that exposure to anesthetic agents during early post-natal periods can cause acute neurotoxicity, as well ...
Source: Neurotoxicology and Teratology - November 23, 2018 Category: Toxicology Source Type: research

Atropine counteracts the depressive-like behaviour elicited by acute exposure to commercial chlorpyrifos in rats
Publication date: Available online 17 November 2018Source: Neurotoxicology and TeratologyAuthor(s): A.A. Siqueira, A.F. Cunha, G.M.L. Marques, I.S.A. Felippe, V.S. Minassa, T.C.S. Gramelich, M.A. Cicilini, T.A. Alarcon, R.G.W. Pires, K.N. Sampaio, V. BeijaminiAbstractAcute organophosphate (OP) poisoning induces well-known signs of toxicosis related to acetylcholinesterase (AChE) inhibition. However, the relationship between acute OP poisoning and the onset of psychiatric disorders remains unclear. Thus, we investigated behavioural and biochemical consequences of acute exposure to the OP chlorpyrifos in male rats and also t...
Source: Neurotoxicology and Teratology - November 17, 2018 Category: Toxicology Source Type: research

Intellectual functioning in clinically confirmed fetal valproate syndrome
Publication date: Available online 16 November 2018Source: Neurotoxicology and TeratologyAuthor(s): R.L. Bromley, G.A. Baker, J. Clayton-Smith, A.G. WoodAbstractBackgroundAn increased risk of impaired intelligence (IQ) has been documented in valproate-exposed children, but investigations have not previously focused on those with a clinical diagnosis of Fetal Valproate Syndrome (FVS).MethodsThis cross sectional observational study recruited individuals with a diagnosis of FVS and completed standardized assessments of intellectual abilities making comparisons to a normative comparison group. Both mean difference (MD) and pre...
Source: Neurotoxicology and Teratology - November 16, 2018 Category: Toxicology Source Type: research

Editorial Board
Publication date: November–December 2018Source: Neurotoxicology and Teratology, Volume 70Author(s): (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - November 14, 2018 Category: Toxicology Source Type: research

Prenatal alcohol exposure and offspring alcohol use and misuse at 22 years of age: A prospective longitudinal study
Publication date: Available online 3 November 2018Source: Neurotoxicology and TeratologyAuthor(s): Lidush Goldschmidt, Gale A. Richardson, Natacha M. De Genna, Marie D. Cornelius, Nancy L. DayAbstractStudies have shown that prenatal alcohol exposure (PAE) is related to drinking problems during adulthood, but the level of prenatal exposure associated with young adults' quantity and frequency of alcohol use and drinking problems has not yet been established. The relation between PAE and offspring levels of alcohol use and alcohol abuse/dependency was examined in 608 22-year-olds. Mothers were recruited in early pregnancy and...
Source: Neurotoxicology and Teratology - November 4, 2018 Category: Toxicology Source Type: research

Persistent increase in ecto‑5′‑nucleotidase activity from encephala of adult zebrafish exposed to ethanol during early development
The objective of this research was to evaluate if the ecto‑5′‑nucleotidase and adenosine deaminase activities and gene expression of adult zebrafish exposed to 1% ethanol during early development could be part of the long-lasting targets of ethanol. Zebrafish embryos were exposed to 1% ethanol in two distinct developmental phases: gastrula/segmentation (5–24 h post-fertilization) or pharyngula (24–48 h post-fertilization). At the end of three months, after checking for morphological outcomes, the evaluation of enzymatic activity and gene expression was performed. Exposure to ethanol did not promot...
Source: Neurotoxicology and Teratology - October 24, 2018 Category: Toxicology Source Type: research

Cognitive flexibility deficits in male mice exposed to neonatal hyperoxia followed by concentrated ambient ultrafine particles
Publication date: Available online 11 October 2018Source: Neurotoxicology and TeratologyAuthor(s): Keith Morris-Schaffer, Marissa Sobolewski, Kevin Welle, Katherine Conrad, Min Yee, Michael A. O'Reilly, Deborah A. Cory-SlechtaAbstractEpidemiological evidence indicates an association between early-life exposure to air pollution and preterm birth. Thus, it is essential to address the subsequent vulnerability of preterm infants, who are exposed to unique factors at birth including hyperoxia, and subsequently to air pollution. Health effects of air pollution relate to particle size and the ultrafine particulate component (
Source: Neurotoxicology and Teratology - October 12, 2018 Category: Toxicology Source Type: research

Toxicity profiling of flame retardants in zebrafish embryos using a battery of assays for developmental toxicity, neurotoxicity, cardiotoxicity and hepatotoxicity toward human relevance
Publication date: Available online 9 October 2018Source: Neurotoxicology and TeratologyAuthor(s): Ainhoa Alzualde, Mamta Behl, Nisha S. Sipes, Jui-Hua Hsieh, Aintzane Alday, Raymond R. Tice, Richard S. Paules, Arantza Muriana, Celia QuevedoAbstractFollowing the voluntary phase-out of brominated flame retardants (BFRs) due to their environmental persistence and toxicity, the organophosphorus flame retardants (OPFRs) are emerging replacements. However, there is limited information on the potential human health effects of the OPFRs. Zebrafish embryos are a viable vertebrate model organism with many advantages for high through...
Source: Neurotoxicology and Teratology - October 10, 2018 Category: Toxicology Source Type: research

Prenatal tobacco and marijuana co-use: Impact on newborn neurobehavior
Publication date: Available online 26 September 2018Source: Neurotoxicology and TeratologyAuthor(s): Laura R. Stroud, George D. Papandonatos, Meaghan McCallum, Tessa Kehoe, Amy L. Salisbury, Marilyn A. HuestisAbstractTobacco and marijuana are some of the most common prenatal substance exposures worldwide. The social acceptability and political landscape of marijuana and its potency have changed dramatically in the last two decades leading to increased use by pregnant women. Despite evidence for increasing marijuana use and high rates of co-use of tobacco (TOB) and marijuana (MJ) during pregnancy, the impact of prenatal exp...
Source: Neurotoxicology and Teratology - October 5, 2018 Category: Toxicology Source Type: research

Biological impacts of organophosphates chlorpyrifos and diazinon on development, mitochondrial bioenergetics, and locomotor activity in zebrafish (Danio rerio)
The objectives of this study were to compare the biological responses in developing zebrafish to two organophosphate insecticides, chlorpyrifos (CPF) and diazinon (DZN). Zebrafish embryos were exposed to either solvent control (0.1% DMSO, v/v), or one dose of 0.1, 1.0, 10.0 and 25.0 μM CPF, as well as one dose of 0.1, 1.0, 10.0 and 100.0 μM DZN for 96 h. CPF at 10.0 and 25.0 μM caused 70–80% and 100% mortality in embryos after 96 h exposure, whereas embryos treated with 10.0 and 100.0 μM DZN showed 30–40% and 70–80% lethality. CPF at 10.0 μM significantly decreased cumulative ...
Source: Neurotoxicology and Teratology - October 5, 2018 Category: Toxicology Source Type: research

Trajectories of pre- and postnatal co-use of cannabis and tobacco predict co-use and drug use disorders in adult offspring
We examined patterns of any maternal cigarette and cannabis use during pregnancy and the postpartum years. As young adults (M age = 22.8 years, range = 21–26), 603 offspring completed the Diagnostic Interview Schedule (DIS). Growth mixture modeling (GMM) was used to identify four maternal trajectories through 16 years postpartum: (1) no co-use (66%), (2) decreasing co-use (16%), (3) postpartum-only co-use (11%), and (4) chronic co-use (7%). Offspring whose mothers were in the decreasing co-use group (co-users primarily during prenatal and preschool periods) were more likely to be co-users than the offspri...
Source: Neurotoxicology and Teratology - September 16, 2018 Category: Toxicology Source Type: research

Moderate developmental alcohol exposure reduces repetitive alternation in a zebrafish model of fetal alcohol spectrum disorders
This study confirms that moderate levels of ethanol exposure to developing embryos have subtle effects on spatial working memory in adulthood. Our data thus suggest that zebrafish may be a promising model system for studying the effects of alcohol on learning and decision-making, but also for developing treatments and interventions to reduce the negative effects of prenatal alcohol. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - September 8, 2018 Category: Toxicology Source Type: research

Editorial Board
Publication date: September–October 2018Source: Neurotoxicology and Teratology, Volume 69Author(s): (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - September 7, 2018 Category: Toxicology Source Type: research

Obituary—Philip J. Bushnell, Ph.D. (1947–2018)
Publication date: Available online 14 August 2018Source: Neurotoxicology and TeratologyAuthor(s): (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - August 28, 2018 Category: Toxicology Source Type: research

Obituary: Philip J. Bushnell, pH.D. (1947–2018)
Publication date: Available online 14 August 2018Source: Neurotoxicology and TeratologyAuthor(s): (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - August 14, 2018 Category: Toxicology Source Type: research

Accelerated functional losses in ageing congenital Minamata disease patients
Publication date: Available online 10 August 2018Source: Neurotoxicology and TeratologyAuthor(s): Takashi Yorifuji, Shigeru Takaoka, Philippe GrandjeanAbstractSevere methylmercury poisoning occurred in Minamata and neighboring communities in Japan during the 1950s and 1960s. A considerable number of children were born with conditions resembling cerebral palsy, later known as congenital Minamata disease. Although surviving patients are now in their 50s or 60s, few assessments of functional capacities in daily living have been performed. We assessed the changes in Activities of Daily Living (ADL) status of 11 patients over a...
Source: Neurotoxicology and Teratology - August 11, 2018 Category: Toxicology Source Type: research

Co-use of tobacco and marijuana during pregnancy: Pathways to externalizing behavior problems in early childhood
Publication date: Available online 4 August 2018Source: Neurotoxicology and TeratologyAuthor(s): Stephanie A. Godleski, Shannon Shisler, Rina D. Eiden, Marilyn A. HuestisAbstractUse and co-use of tobacco and marijuana during pregnancy are associated with the development of social, cognitive, and behavioral problems for infants and children. However, less is known about the potential developmental impact of the use of tobacco and marijuana in tandem. The present study examined an etiological model for the development of externalizing behavior problems (EBP) in early childhood in a high risk sample (N = 247) of mother-in...
Source: Neurotoxicology and Teratology - August 4, 2018 Category: Toxicology Source Type: research

Metabolomics studies on corticosterone-induced PC12 cells: A strategy for evaluating an in vitro depression model and revealing the metabolic regulation mechanism
Publication date: Available online 1 August 2018Source: Neurotoxicology and TeratologyAuthor(s): Jun-sheng Tian, Shao-bo Liu, Xiao-yan He, Huan Xiang, Jian-li Chen, Yao Gao, Yu-zhi Zhou, Xue-mei QinAbstractThere are three types of differentiated (un-, poorly- and well-differentiated) PC12 cells, which have been widely used as a model system for depression studies after the administration of corticosterone (CORT). In order to investigate the underlying metabolic profiles of CORT-induced PC12 cells and evaluate the suitable differentiated types of PC12 cells for use in depressive studies, proton nuclear magnetic resonance (1...
Source: Neurotoxicology and Teratology - August 2, 2018 Category: Toxicology Source Type: research

Editorial Board
Publication date: July–August 2018Source: Neurotoxicology and Teratology, Volume 68Author(s): (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - July 18, 2018 Category: Toxicology Source Type: research

Comparison of neurotoxicity of dexmedetomidine as an adjuvant in brachial plexus block in rats of different age
Publication date: Available online 11 July 2018Source: Neurotoxicology and TeratologyAuthor(s): Zhenming Kang, Wenji Xie, Wenqin Xie, Shunyuan Li, Rushuang ChenAbstractDexmedetomidine is a local anesthetic adjuvant that exerts neuroprotective effects in addition to its sedative and analgesic properties. However, it is not clear whether dexmedetomidine causes any neurotoxicity in neonates. We injected dexmedetomidine alone or in combination with ropivacaine to induce brachial plexus block in rats of different age, corresponding to human neonate, childhood, adolescence and adulthood. We then examined pro-inflammatory cytokin...
Source: Neurotoxicology and Teratology - July 11, 2018 Category: Toxicology Source Type: research

Cluster analysis profiling of behaviors in zebrafish larvae treated with antidepressants and pesticides
Publication date: Available online 31 October 2017Source: Neurotoxicology and TeratologyAuthor(s): Holly Richendrfer, Robbert CretonAbstractAntidepressants are used by a substantial number of women in their childbearing years. Treatment may continue during pregnancy, since untreated depression poses a risk to the mother and child. However, many antidepressants readily pass through the placental barrier to reach the fetus or may be ingested by the newborn via breastmilk. Little is known about the effects of antidepressants on brain development and subsequent behavior in young children. In the current study, we used zebrafis...
Source: Neurotoxicology and Teratology - July 11, 2018 Category: Toxicology Source Type: research

Mechanistic studies on ketamine-induced mitochondrial toxicity in zebrafish embryos
This study offers evidence for a potential mechanism by which ketamine could cause ATP deficiency mediated by mitochondrial dysfunction. (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - July 11, 2018 Category: Toxicology Source Type: research

Corrigendum to “Neonatal inhibition of Na+-K+-2Cl−-cotransporter prevents ketamine induced spatial learning and memory impairments” [Neurotoxicol. Teratol. 60 (2017) 82–86]
Publication date: Available online 2 January 2018Source: Neurotoxicology and TeratologyAuthor(s): Ryan A. Stevens, Brandon D. Butler, Saurabh S. Kokane, Andrew W. Womack, Qing Lin (Source: Neurotoxicology and Teratology)
Source: Neurotoxicology and Teratology - July 11, 2018 Category: Toxicology Source Type: research