Value of Spinal Infection Treatment Evaluation Score, Pola Classification, and Brighton Spondylodiscitis Score from Decision to Surgery in Patients with Spondylodiscitis: A Receiver-Operating Characteristic Curve Analysis
CONCLUSIONS: The findings suggest that the SITE score is a useful measure and helps clinicians make clinically sound decisions in patients with spondylodiscitis.PMID:38650093 | DOI:10.31616/asj.2023.0317 (Source: Asian Spine Journal)
Source: Asian Spine Journal - April 23, 2024 Category: Orthopaedics Authors: Majid Rezvani Ali Ahmadvand Taravat Yazdanian Parisa Azimi Navid Askariardehjani Source Type: research
Extraction spectrophotometry using a lithium-ion selective metallacrown: temperature effect on extraction reaction and application to determination of lithium in serum and seawater
Anal Sci. 2024 Apr 23. doi: 10.1007/s44211-024-00569-9. Online ahead of print.ABSTRACTA metallacrown-type ionophore, 2,3-pyridinediolate-bridged (3,5-dimethylanisole)ruthenium trinuclear complex, has a high extraction selectivity for Li+, but the extraction reaction is very slow. To solve this problem, the effect of temperature on the rapidity and equilibrium of the extraction of Li+ and Na+ as picrates from water to toluene with the metallacrown was investigated in this study. While the extraction of Li+ requires 6 h of shaking for equilibration at 25 °C, the distribution ratio becomes nearly constant after 4 h and 2 h o...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - April 23, 2024 Category: Chemistry Authors: Shoichi Katsuta Kosuke Maeda Source Type: research
Evolution of myoglobin diffusion mechanisms: exploring pore and surface diffusion in a single silica particle
This study elucidates the mass transfer mechanism of myoglobin (Mb) within a single silica particle with a 50 nm pore size at various pH levels (6.0, 6.5, 6.8, and 7.0). Investigation of Mb distribution ratio (R) and distribution kinetics was conducted using absorption microspectroscopy. The highest R was observed at pH 6.8, near the isoelectric point of Mb, as the electrostatic repulsion between Mb molecules on the silica surface decreased. The time-course absorbance of Mb in the silica particle was rigorously analyzed based on a first-order reaction, yielding the intraparticle diffusion coefficient of Mb (Dp). Dp-(1 + R)...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - April 23, 2024 Category: Chemistry Authors: Akihisa Miyagawa Hatsuhi Kuno Shigenori Nagatomo Kiyoharu Nakatani Source Type: research
PRESERFLO MicroShunt in Severe Myopia: A Case Report and Review of the Literature
We describe here the case study of a 58-year-old woman who presented with bilateral severe myopia with bilateral advanced POAG and unreached target pressure under quadritherapy, who was successfully managed by PM surgery. A review of the literature completes our observation. At presentation, the patient had a spherical equivalent of - 7.50 RE and - 7.75 LE with an IOP of 22 mmHg right and left eye (RLE) under quadritherapy, and with severe bilateral visual field loss, including scotomas within the central 5°. The patient presented with systemic hypertension treated with an antihypertensive drug. Two selective laser trabec...
Source: Klinische Monatsblatter fur Augenheilkunde - April 23, 2024 Category: Opthalmology Authors: J érôme George Hana Abouzeid Source Type: research
Short-term trends in gastric cancer incidence after insurance coverage expansion for Helicobacter pylori eradication in Japan
Eur J Intern Med. 2024 Apr 22:S0953-6205(24)00170-5. doi: 10.1016/j.ejim.2024.04.010. Online ahead of print.NO ABSTRACTPMID:38653632 | DOI:10.1016/j.ejim.2024.04.010 (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - April 23, 2024 Category: Internal Medicine Authors: Yusaku Kajihara Source Type: research
Long-term effectiveness and safety of upadacitinib for Japanese patients with moderate-to-severe atopic dermatitis: a real-world clinical study
CONCLUSIONS: Upadacitinib was therapeutically effective and tolerable for moderate-to-severe AD through 48 weeks in real-world clinical practice.PMID:38653561 | DOI:10.1080/09546634.2024.2344591 (Source: Herpes)
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Teppei Hagino Hidehisa Saeki Eita Fujimoto Naoko Kanda Source Type: research
PD-1 inhibition with retifanlimab and/or arginase inhibition with INCB001158 in Japanese patients with solid tumors: A phase I study
CONCLUSION: Retifanlimab, INCB001158, and their combination had acceptable safety profiles. Promising retifanlimab antitumor activity warrants further investigation in Japanese patients.PMID:38651187 | DOI:10.1002/cam4.6980 (Source: Cancer Control)
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Yasutoshi Kuboki Takafumi Koyama Nobuaki Matsubara Yoichi Naito Shunsuke Kondo Kenichi Harano Kan Yonemori Kiyotaka Yoh Yuan Gu Tetsuya Mita Xuejun Chen Eiji Ueda Noboru Yamamoto Toshihiko Doi Toshio Shimizu Source Type: research
PD ‐1 inhibition with retifanlimab and/or arginase inhibition with INCB001158 in Japanese patients with solid tumors: A phase I study
ConclusionRetifanlimab, INCB001158, and their combination had acceptable safety profiles. Promising retifanlimab antitumor activity warrants further investigation in Japanese patients. (Source: Cancer Medicine)
Source: Cancer Medicine - April 23, 2024 Category: Cancer & Oncology Authors: Yasutoshi Kuboki,
Takafumi Koyama,
Nobuaki Matsubara,
Yoichi Naito,
Shunsuke Kondo,
Kenichi Harano,
Kan Yonemori,
Kiyotaka Yoh,
Yuan Gu,
Tetsuya Mita,
Xuejun Chen,
Eiji Ueda,
Noboru Yamamoto,
Toshihiko Doi,
Toshio Shimizu Tags: RESEARCH ARTICLE Source Type: research
Dissolution Profiles of Immediate Release Products of Various Drugs in Biorelevant Bicarbonate Buffer: Comparison with Compendial Phosphate Buffer
ConclusionsMany IR products showed differences in the dissolution profiles between biorelevant BCB and compendial PPB. With the floating lid method, BCB is as simple and easy to use as PPB. Biorelevant BCB is recommended for dissolution testing. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 23, 2024 Category: Drugs & Pharmacology Source Type: research
Factors associated with help-seeking regarding sexual orientation concerns among Japanese gay and bisexual men: results from a cross-sectional survey
This study investigates Japanese gay and bisexual men ’s experiences of seeking help for emotional support from others regarding their sexual orientation concerns. It examines the relationship between their hel... (Source: BMC Research Notes)
Source: BMC Research Notes - April 23, 2024 Category: Research Authors: Noriyo Kaneko, Adam Orlando Hill and Satoshi Shiono Tags: Research Note Source Type: research
Dissolution Profiles of Immediate Release Products of Various Drugs in Biorelevant Bicarbonate Buffer: Comparison with Compendial Phosphate Buffer
ConclusionsMany IR products showed differences in the dissolution profiles between biorelevant BCB and compendial PPB. With the floating lid method, BCB is as simple and easy to use as PPB. Biorelevant BCB is recommended for dissolution testing. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 23, 2024 Category: Drugs & Pharmacology Source Type: research
Optimal duration of dual antiplatelet therapy for stent-assisted coiling or flow diverter placement
Conclusions
Thromboembolic events rarely occurred beyond 30 days after SAC/FD. The duration of DAPT may be shortened if patients have a periprocedural period without events. Further prospective studies are warranted to determine the optimal duration of antiplatelet therapy.
Trial registration number
UMIN000044122 :https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000050384. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - April 23, 2024 Category: Neurosurgery Authors: Enomoto, Y., Matsubara, H., Ishihara, T., Shoda, K., Mizutani, D., Egashira, Y., Ishii, A., Sakamoto, M., Sumita, K., Nakagawa, I., Higashi, T., Yoshimura, S. Tags: Open access, Hemorrhagic stroke Source Type: research
Comparison between a single dose of PEG G-CSF and multiple doses of non-PEG G-CSF: a systematic review and meta-analysis from Clinical Practice Guidelines for the use of G-CSF 2022
ConclusionsA single dose of PEG G-CSF is strongly recommended over multiple-dose non-PEG G-CSF therapy for the primary prophylaxis of FN. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research
Identifying atopic dermatitis risk loci in 1,094,060 individuals with sub analysis of disease severity and onset
Atopic dermatitis (AD) is a common inflammatory skin disease highly attributable to genetic factors. Here, we report results from a genome-wide meta-analysis of AD in 37,541 cases and 1,056,519 controls with data from the FinnGen project, the Estonian Biobank, the UK Biobank, the EAGLE Consortium, and the BioBank Japan. We detected 77 independent AD-associated loci of which 10 were to our knowledge previously unreported. The associated loci showed enrichment in various immune regulatory processes. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 23, 2024 Category: Dermatology Authors: Anu Pasanen, Eeva Sliz, Laura Huilaja, FinnGen, Estonian Biobank Research Team, Ene Reimann, Reedik M ägi, Triin Laisk, Kaisa Tasanen, Johannes Kettunen Tags: Original Article Source Type: research
Using the geriatric nutritional risk index to predict outcomes in older patients with remnant gastric cancer after gastrectomy: a retrospective multicenter study in Japan
ConclusionsThe GNRI is a promising predictor of both short- and long-term outcomes in older patients with RGC. (Source: Surgery Today)
Source: Surgery Today - April 23, 2024 Category: Surgery Source Type: research
