A community cluster of influenza A(H3N2) virus infection with reduced susceptibility to baloxavir due to a PA E199G substitution in Japan, February to March 2023
Euro Surveill. 2023 Sep;28(39). doi: 10.2807/1560-7917.ES.2023.28.39.2300501.ABSTRACTA community cluster of influenza A(H3N2) caused by viruses with an E199G substitution in PA was detected in Nara, Japan, between February and March 2023. The three patients with these mutant viruses had not received antiviral treatment before specimen collection but patients in the same hospital had. The sequences of the mutant viruses were closely related, suggesting clonal spread in Nara. They showed reduced susceptibility to baloxavir in vitro; however, the clinical significance of the PA E199G substitution remains unclear.PMID:37768560...
Source: Euro Surveill - September 28, 2023 Category: Infectious Diseases Authors: Emi Takashita Seiichiro Fujisaki Hiroko Morita Shiho Nagata Hideka Miura Yuki Matsuura Saya Yamamoto Shoko Chiba Yumiko Inoue Iori Minami Sayaka Yoshikawa Seiko Yamazaki Noriko Kishida Kazuya Nakamura Masayuki Shirakura Shinji Watanabe Hideki Hasegawa Source Type: research
Marked reduction in the incidence of transfusion-transmitted hepatitis B virus infection after the introduction of antibody to hepatitis B core antigen and individual donation nucleic acid amplification screening in Japan
DISCUSSION: The incidence of observed TT-HBV cases has significantly reduced to 0.19 per million in the ID-NAT screening period. OBI-related TT-HBV was eliminated by anti-HBc screening. Established TT-HBV cases were caused by blood products with large plasma volumes containing extremely low HBV concentrations derived from blood donors at a very early infection stage.PMID:37767806 | DOI:10.1111/trf.17546 (Source: Transfusion)
Source: Transfusion - September 28, 2023 Category: Hematology Authors: Ami Tanaka Naoji Yamagishi Takashi Hasegawa Keiko Miyakawa Naoko Goto Keiji Matsubayashi Masahiro Satake Source Type: research
Rapid health technology assessment of the novel endonuclease inhibitor baloxavir for the treatment of influenza
J Chemother. 2023 Sep 28:1-16. doi: 10.1080/1120009X.2023.2263270. Online ahead of print.ABSTRACTThrough a Rapid Health Technology Assessment (RHTA), we evaluated the efficacy, safety and cost-effectiveness of baloxavir in the treatment of influenza, providing the necessary scientific information and evidence-based basis for healthcare professionals and health insurance decision-makers in making rational selections. Through systematic searches of Pubmed, Embase, Web of Science, The Cochrane Register of Clinical Trials database and the official website of Health Technology Assessment (HTA) agencies, we collected systematic ...
Source: Journal of Chemotherapy - September 28, 2023 Category: Cancer & Oncology Authors: Guangliang Huang Yunfei Tian Wenyan Cui Xinhui Zhang Yonghong Zhao Xiuju Liu Source Type: research
Incidence, Predictors, and Outcome Associated With Ventricular Tachycardia or Fibrillation in Patients Undergoing Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction
CONCLUSIONS: The results clearly indicated that VT/VF is still a serious complications of AMI. We need to identify patients at high risk of developing VT/VF for careful observation and appropriate intervention.PMID:37766557 | DOI:10.1253/circj.CJ-23-0023 (Source: Circulation Journal)
Source: Circulation Journal - September 28, 2023 Category: Cardiology Authors: Kenji Hanada Takahiko Kinjo Hiroaki Yokoyama Michiko Tsushima Maiko Senoo Hiroaki Ichikawa Fumie Nishizaki Shuji Shibutani Takashi Yokota Ken Okumura Hirofumi Tomita Source Type: research
Assessment of factors associated with improved glycemic control after switching from intermittently scanned to real-time continuous glucose monitoring in Japanese patients with type 1 diabetes
Endocr J. 2023 Sep 26. doi: 10.1507/endocrj.EJ23-0125. Online ahead of print.ABSTRACTThe advantages of real-time continuous glucose monitoring (rtCGM) over intermittently scanned CGM (isCGM) reportedly include lower glycated hemoglobin (HbA1c) levels as well as reduced glycemic variability. However, there have been few studies of the effect of switching from isCGM to rtCGM on glycemic control, as well as the specific factors underlying any observed improvements. To that end, all patients with type 1 diabetes mellitus who used the DEXCOM rtCGM device (Terumo Corporation, Tokyo, Japan) at our institution were reviewed, and 1...
Source: Endocrine Journal - September 28, 2023 Category: Endocrinology Authors: Eijiro Yamada Yasuyo Nakajima Kazuhiko Horiguchi Shuichi Okada Masanobu Yamada Source Type: research
Discover inspiring stories from the 100-year history of the Japan Endocrine Society; progress toward future successes
Endocr J. 2023;70(9):847-850. doi: 10.1507/endocrj.EJ20230323.NO ABSTRACTPMID:37766578 | DOI:10.1507/endocrj.EJ20230323 (Source: Endocrine Journal)
Source: Endocrine Journal - September 28, 2023 Category: Endocrinology Authors: Masatomo Mori Source Type: research
Risk factors for mother-to-infant bonding difficulties and maternal anger/rejection towards the infant in a Japanese longitudinal study
Asian J Psychiatr. 2023 Sep 22;89:103778. doi: 10.1016/j.ajp.2023.103778. Online ahead of print.NO ABSTRACTPMID:37769544 | DOI:10.1016/j.ajp.2023.103778 (Source: Asian Journal of Psychiatry)
Source: Asian Journal of Psychiatry - September 28, 2023 Category: Psychiatry Authors: Chong Chen Sumiyo Okawa Ryo Okubo Shin Nakagawa Takahiro Tabuchi Source Type: research
Boredom and engagement at work: do they have different antecedents and consequences?
This study aimed to demonstrate the empirical distinctiveness of boredom at work and work engagement in relation to their potential antecedents (job demands and job resources) and consequences (psychological distress and turnover intention) based on the Job Demands-Resources model. A three-wave longitudinal survey was conducted among registered monitors of an Internet survey company in Japan. The questionnaire included scales for boredom at work, work engagement, psychological distress, and turnover intention as well as participants' job characteristics and demographic variables. The hypothesized model was evaluated via st...
Source: Industrial Health - September 28, 2023 Category: Occupational Health Authors: Michiko Kawada Akihito Shimazu Daisuke Miyanaka Masahito Tokita Keiko Sakakibara Naana Mori Fuad Hamsyah Lin Yuheng Kojiro Shojima Wilmar B Schaufeli Source Type: research
Impact of COVID-19 pandemic on assisted reproductive technology treatment under voluntary lockdown in Japan
Reprod Med Biol. 2023 Sep 25;22(1):e12541. doi: 10.1002/rmb2.12541. eCollection 2023 Jan-Dec.ABSTRACTTo investigate the impact of a state of emergency (i.e., voluntary lockdown) during the COVID-19 epidemic, we conducted a retrospective cohort study using the Japanese nationwide registry. In comparison with those during 2019, the number of treatment cycles decreased in April 2020 (-9.5%) to its lowest point in May (-24.1%). The magnitude of the decline was three times larger for frozen cycles (-37.0%) than for fresh cycles (-12.4%). The decrease was significantly smaller for women aged <35 years (-31.0%) than for the ol...
Source: Reproductive Biology - September 28, 2023 Category: Reproduction Medicine Authors: Seung Chik Jwa Akira Kuwahara Osamu Ishihara Hiroyuki Fujiwara Source Type: research
Removing direct oral factor Xa inhibitor interferences from routine and specialised coagulation assays using a raw activated charcoal product
CONCLUSIONS: Overall, raw AC efficiently adsorbed apixaban and rivaroxaban from human-derived plasma, without significantly affecting the majority of underlying routine and specialised coagulation parameters available on CS-series analysers.PMID:37769932 | DOI:10.1016/j.cca.2023.117565 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - September 28, 2023 Category: Chemistry Authors: Gavin T Buckley Ber Murphy Niamh Fleming Maeve P Crowley James V Harte Source Type: research
Research on Occupational Poisoning and Biological Monitoring
CONCLUSION: The health management of workers handling chemical substances at occupational sites will be shifted to autonomous management. However, it should be noted that only biological monitoring can detect and prove true exposure. Particularly, risk assessment by biological monitoring is necessary for substances that are suspected to be absorbed through the skin, and the measurement methods used should continue to be developed and refined. The significance of biological monitoring will continue to increase.PMID:37766566 | DOI:10.1539/sangyoeisei.2023-026-A (Source: Sangyo Eiseigaku Zasshi : Journal of Occupational Health)
Source: Sangyo Eiseigaku Zasshi : Journal of Occupational Health - September 28, 2023 Category: Occupational Health Authors: Yuko Yamano Source Type: research
Development and characterization of expressed sequence tag-simple sequence repeat markers for Anaphalis margaritacea var. yedoensis (Asteraceae)
Genes Genet Syst. 2023 Sep 26. doi: 10.1266/ggs.23-00037. Online ahead of print.ABSTRACTRNA-sequencing was used to develop 16 microsatellite markers for the pearly everlasting, Anaphalis margaritacea var. yedoensis (Franch. et Sav.) Ohwi (Asteraceae), which inhabits gravel bars throughout the Japanese archipelago. The mean number of alleles for these 16 markers in two populations in the Hokkaido and Shizuoka Prefectures, was 3.5 and 4.0, respectively, while the mean expected heterozygosity was 0.525 and 0.560, respectively, with a significant genetic differentiation between the two populations. All markers could also be am...
Source: Genes and Genetic Systems - September 28, 2023 Category: Genetics & Stem Cells Authors: Taishi Hoson Shoki Murakami Takuro Ito Masuyuki Maki Source Type: research
Marked reduction in the incidence of transfusion-transmitted hepatitis B virus infection after the introduction of antibody to hepatitis B core antigen and individual donation nucleic acid amplification screening in Japan
DISCUSSION: The incidence of observed TT-HBV cases has significantly reduced to 0.19 per million in the ID-NAT screening period. OBI-related TT-HBV was eliminated by anti-HBc screening. Established TT-HBV cases were caused by blood products with large plasma volumes containing extremely low HBV concentrations derived from blood donors at a very early infection stage.PMID:37767806 | DOI:10.1111/trf.17546 (Source: Transfusion)
Source: Transfusion - September 28, 2023 Category: Hematology Authors: Ami Tanaka Naoji Yamagishi Takashi Hasegawa Keiko Miyakawa Naoko Goto Keiji Matsubayashi Masahiro Satake Source Type: research
A community cluster of influenza A(H3N2) virus infection with reduced susceptibility to baloxavir due to a PA E199G substitution in Japan, February to March 2023
Euro Surveill. 2023 Sep;28(39). doi: 10.2807/1560-7917.ES.2023.28.39.2300501.ABSTRACTA community cluster of influenza A(H3N2) caused by viruses with an E199G substitution in PA was detected in Nara, Japan, between February and March 2023. The three patients with these mutant viruses had not received antiviral treatment before specimen collection but patients in the same hospital had. The sequences of the mutant viruses were closely related, suggesting clonal spread in Nara. They showed reduced susceptibility to baloxavir in vitro; however, the clinical significance of the PA E199G substitution remains unclear.PMID:37768560...
Source: Euro Surveill - September 28, 2023 Category: Infectious Diseases Authors: Emi Takashita Seiichiro Fujisaki Hiroko Morita Shiho Nagata Hideka Miura Yuki Matsuura Saya Yamamoto Shoko Chiba Yumiko Inoue Iori Minami Sayaka Yoshikawa Seiko Yamazaki Noriko Kishida Kazuya Nakamura Masayuki Shirakura Shinji Watanabe Hideki Hasegawa Source Type: research
Are Dental Procedures Associated With Pyogenic Vertebral Osteomyelitis?
CONCLUSION: Dental procedures were not associated with an increased risk of subsequent PVO in this case-crossover study. The effectiveness of antibiotic prophylaxis was not demonstrated in the additional analysis that categorized exposure according to the use of antibiotic prophylaxis. Our results suggest that the association between dental procedures and PVO may have been overestimated. Maintaining good oral hygiene may be important in preventing the development of PVO. The indications for antibiotic prophylaxis before dental procedures should be reconsidered in view of the potential risk of adverse drug reactions to anti...
Source: Clinical Orthopaedics and Related Research - September 28, 2023 Category: Orthopaedics Authors: Soichiro Masuda Toshiki Fukasawa Masato Takeuchi Korenori Arai Shunsuke Fujibayashi Bungo Otsuki Koichi Murata Takayoshi Shimizu Shuichi Matsuda Koji Kawakami Source Type: research
