The role of interventional radiology and molecular imaging for near infrared photoimmunotherapy
AbstractNear infrared photoimmunotherapy (NIR-PIT) is a recently approved cancer therapy for recurrent head and neck cancer. It involves the intravenous administration of an antibody-photoabsorber (IRDye700DX: IR700) conjugate (APC) to target cancer cells, followed 24 h later by exposure to near infrared light to activate cell-specific cytotoxicity. NIR-PIT selectively targets cancer cells for destruction and activates a strong anticancer host immunity. The fluorescent signal emitted by IR700 enables the visualization of the APC in vivo using fluorescence imagi ng. Similarly, the activation of IR700 during therapy can be...
Source: Japanese Journal of Radiology - April 25, 2024 Category: Radiology Source Type: research
Endometriosis, a common but enigmatic disease with many faces: current concept of pathophysiology, and diagnostic strategy
AbstractEndometriosis is a benign, common, but controversial disease due to its enigmatic etiopathogenesis and biological behavior. Recent studies suggest multiple genetic, and environmental factors may affect its onset and development. Genomic analysis revealed the presence of cancer-associated gene mutations, which may reflect the neoplastic aspect of endometriosis. The management has changed dramatically with the development of fertility-preserving, minimally invasive therapies. Diagnostic strategies based on these recent basic and clinical findings are reviewed. With a focus on the presentation of clinical cases, we di...
Source: Japanese Journal of Radiology - April 25, 2024 Category: Radiology Source Type: research
FDG uptake in the cervical muscles after neck dissection: imaging features and postoperative natural course on 18F ‑FDG‑PET/CT
ConclusionsIncreased postoperative uptakes in the cervical muscles were observed on the dissected side in approximately half of the patients after neck dissection. The SUVmax in the trapezius and sternocleidomastoid muscles decreased after surgery over time. (Source: Japanese Journal of Radiology)
Source: Japanese Journal of Radiology - April 25, 2024 Category: Radiology Source Type: research
Cancers, Vol. 16, Pages 1670: The Current Achievements of Multi-Gene Panel Tests in Clinical Settings for Patients with Non-Small-Cell Lung Cancer
sui
Taguchi
Hataji
Some multi-gene panel tests have been implemented in clinical settings to guide targeted therapy in non-small-cell lung cancer (NSCLC) in Japan. The current performance of multi-gene panel tests under the condition that the Oncomine Dx Target Test (ODxTT) and Amoy Dx® Pan Lung Cancer PCR panel (AmoyDx-multi) are available remains relatively unknown. We retrospectively reviewed consecutive patients with NSCLC, whose FFPE samples were considered for genetic testing. We assessed the submission rates, the success rates, and the driver oncogene detection rates of multi-gene panel tests. ...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Sakaguchi Iketani Esumi Esumi Suzuki Ito Fujiwara Nishii Katsuta Yasui Taguchi Hataji Tags: Article Source Type: research
Real-life experience on the effectiveness of conjunctival flap and amniotic membrane graft in the treatment of refractory fungal corneal ulcer
ConclusionsCF and AMG are both effective for the management of refractory fungal corneal ulcers. However, AMG appears to improve visual acuity better than CF. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - April 25, 2024 Category: Opthalmology Source Type: research
Contribution of systemic factors on macular vessel density: a sex-specific population-based study
ConclusionsThis large cross-sectional study shows that older age and type 2 diabetes mellitus are associated with lower superficial and deep retinal capillary vessel density in men. This may help clinicians better understand how systemic factors influence retinal vessel density in different genders and future studies can ascertain more potential sex differences. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - April 25, 2024 Category: Opthalmology Source Type: research
Inference of selective forces on house mouse genomes during secondary contact in East Asia [RESEARCH]
The house mouse (Mus musculus), which is commensal to humans, has spread globally via human activities, leading to secondary contact between genetically divergent subspecies. This pattern of genetic admixture can provide insights into the selective forces at play in this well-studied model organism. Our analysis of 163 house mouse genomes, with a particular focus on East Asia, revealed substantial admixture between the subspecies castaneus and musculus, particularly in Japan and southern China. We revealed, despite the different level of autosomal admixture among regions, that all Y Chromosomes in the East Asian samples be...
Source: Genome Research - April 25, 2024 Category: Genetics & Stem Cells Authors: Fujiwara, K., Kubo, S., Endo, T., Takada, T., Shiroishi, T., Suzuki, H., Osada, N. Tags: RESEARCH Source Type: research
Viruses, Vol. 16, Pages 674: Transcriptomic Investigation of the Virus Spectrum Carried by Midges in Border Areas of Yunnan Province
Mang Shi
Yun Feng
Yunnan province in China shares its borders with three neighboring countries: Myanmar, Vietnam, and Laos. The region is characterized by a diverse climate and is known to be a suitable habitat for various arthropods, including midges which are notorious for transmitting diseases which pose significant health burdens affecting both human and animal health. A total of 431,100 midges were collected from 15 different locations in the border region of Yunnan province from 2015 to 2020. These midges were divided into 37 groups according to the collection year and sampling site. These 37 groups of midges...
Source: Viruses - April 25, 2024 Category: Virology Authors: Lifen Yang Weichen Wu Sa Cai Jing Wang Guopeng Kuang Weihong Yang Juan Wang Xi Han Hong Pan Mang Shi Yun Feng Tags: Article Source Type: research
Burden of Antimicrobial Resistance in Japan: A Systematic Literature Review and Meta-Analysis
ConclusionOur study presents an overview of the clinical and economic burden of AMR in Japan. Patients with AMR infections experience significantly higher in-hospital mortality, LOS, and direct medical costs compared with patients without AMR infections. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - April 25, 2024 Category: Infectious Diseases Source Type: research
Diamonds grown without extreme pressures
Diamonds, the hardest material, may have gotten easier to make. Researchers today report a new way to grow synthetic diamonds without the crushing pressures normally required. Although the approach yields crystals no bigger than 100 nanometers across—about the size of a typical virus—researchers suspect it may eventually yield larger crystals and the extended diamond films that are prized for advanced electronics and optics.
“The technique is quite interesting,” says John Ciraldo, who specializes in diamond growth at WD Advanced Materials. “If they could make larger single crystals that would be fantastic,...
Source: Science of Aging Knowledge Environment - April 24, 2024 Category: Geriatrics Source Type: research
China set to fetch first rocks from mysterious far side of the Moon
There’s a giant hole on the backside of the Moon. The South Pole–Aitken (SPA) Basin, the Moon’s largest and oldest impact crater, is more than 2500 kilometers wide and 8 kilometers deep—nearly big enough to swallow two Indias and hide the Himalayas. Now, China plans to land in it.
The basin may have been blasted out during a barrage of asteroids that pummeled Earth and other inner Solar System bodies billions of years ago, and scientists have long wanted to get their hands on SPA rocks to test the idea. The China National Space Administration (CNSA) aims to provide them with the Chang’e-6 mission, which sci...
Source: Science of Aging Knowledge Environment - April 24, 2024 Category: Geriatrics Source Type: research
Incidence of Pure Orbital Fractures with Concomitant Lacrimal Drainage System Injury in the Japanese Population: A Retrospective Study
CONCLUSION: There is a 1.4% incidence rate of pure orbital fractures with concomitant lacrimal drainage system injuries among the Japanese population included in this study. Inferomedial orbital strut fractures and orbital floor fracture lateral to the infraorbital groove were found to have higher association with lacrimal drainage system injuries.PMID:38656194 | DOI:10.1080/08820538.2024.2346762 (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - April 24, 2024 Category: Opthalmology Authors: Steffani Krista Someda Jose Miguel Ambat Hidetaka Miyazaki Yasuhiro Takahashi Source Type: research
Cost-effectiveness analysis of transcatheter aortic valve implantation in aortic stenosis patients at low- and intermediate-surgical risk in Japan
CONCLUSIONS: TAVI was dominant and cost-effective compared to SAVR in intermediate- and low-risk patients, respectively. These results suggest that TAVI can provide meaningful value to Japanese patients relative to SAVR, at a reasonable incremental cost for patients at low surgical risk and potentially resulting in cost-savings in patients at intermediate surgical risk.PMID:38654415 | DOI:10.1080/13696998.2024.2346397 (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - April 24, 2024 Category: Health Management Authors: Junjiro Kobayashi Suzanne J Baron Kensuke Takagi Christin A Thompson Xiayu Jiao Kaoru Yamabe Source Type: research
Comparison of DNA Extraction Methods for Processed Foods Containing Soybean or Maize
In this study, the equivalence testing of the techniques employed for DNA extraction from processed foods containing soybean or corn was conducted. In this study, the equivalence testing of the techniques employed for DNA extraction from processed foods containing soybean or maize was conducted. The silica membrane-based DNA extraction kits, GM quicker 4 and DNeasy Plant Maxi Kit (Maxi Kit), as an existing method were compared. GM quicker 4 was considered to be equivalent to or better than Maxi Kit.PMID:38658344 | DOI:10.3358/shokueishi.65.25 (Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan)
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 24, 2024 Category: Food Science Authors: Tomohiro Egi Reona Takabatake Masahiro Kishine Keisuke Soga Satoko Yoshiba Norihito Shibata Kazunari Kondo Yasuharu Takashima Source Type: research
A Study on the Scientific Reliability of Notification Data in the Foods with Function Claims
Shokuhin Eiseigaku Zasshi. 2024;65(2):31-39. doi: 10.3358/shokueishi.65.31.ABSTRACTWe conducted a comprehensive survey of Foods with Function Claims (FFC) submitted from April to August 2022 to examine the scientific reliability of the systematic review (SR), which is the basis for functional claims. The results of the review of 611 functional claims for 398 products showed that there were 121 functionally active substances and 87 health claims (Hc) that were labeled, with some functionally active substances having multiple functions. SRs, meta-analyses, and clinical studies were submitted as the basis of functionality for...
Source: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan - April 24, 2024 Category: Food Science Authors: Ippei Suzuki Tsuyoshi Chiba Kayo Yoshimatsu Jun Takebayashi Source Type: research
