Progressing Basic Immunology for Development of New Therapeutic Medicines
Yakugaku Zasshi. 2024;144(5):473-474. doi: 10.1248/yakushi.23-00154-F.NO ABSTRACTPMID:38692919 | DOI:10.1248/yakushi.23-00154-F (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Jun-Ichi Kashiwakura Keigo Nishida Source Type: research
Zinc Suppresses Colorectal Cancer Development through Cell-mediated Immunity
Yakugaku Zasshi. 2024;144(5):475-481. doi: 10.1248/yakushi.23-00154-1.ABSTRACTZinc is one of the essential trace elements, and is involved in various functions in the body. Zinc deficiency is known to cause immune abnormalities, but the mechanism is not fully understood. Therefore, we focused our research on tumor immunity to elucidate the effect of zinc on colorectal cancer and its mechanisms. Mice were treated with azoxymethane (AOM) and dextran sodium sulfate (DSS) to develop colorectal cancer, then the relationship between zinc content in the diet and the number and area of tumors in the colon was observed. The number ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Keigo Nishida Naoya Nakagawa Source Type: research
Mast Cell-Neutrophil Communication Regulates Allergic Diseases
Yakugaku Zasshi. 2024;144(5):483-488. doi: 10.1248/yakushi.23-00154-2.ABSTRACTAllergic diseases (e.g., food allergies) are a growing problem, with increasing numbers of individuals experiencing them worldwide. Congruently, the adverse reactions (e.g., anaphylaxis) associated with the administration of vaccines against emerging infectious diseases such as coronavirus disease 2019 (COVID-19) have become a familiar problem. Allergic diseases, which have a wide variety of symptoms, are difficult to prevent or cure; treatment is currently limited to therapeutic drugs or allergen immunotherapy. Therefore, elucidating new allergi...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Ryo Suzuki Source Type: research
Immune Regulation by TNF Receptor-associated Factor 5
Yakugaku Zasshi. 2024;144(5):489-496. doi: 10.1248/yakushi.23-00154-3.ABSTRACTThe tumor necrosis factor receptor (TNFR)-associated factor (TRAF) family of molecules are intracellular adaptors that regulate cellular signaling through members of the TNFR and Toll-like receptor superfamily. Mammals have seven TRAF molecules numbered sequentially from TRAF1 to TRAF7. Although TRAF5 was identified as a potential regulator of TNFR superfamily members, the in vivo function of TRAF5 has not yet been fully elucidated. We identified an unconventional role of TRAF5 in interleukin-6 (IL-6) receptor signaling involving CD4+ T cells. Mo...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Takanori So Source Type: research
Understanding New Regulatory Mechanism of TCR Signal Transduction
Yakugaku Zasshi. 2024;144(5):497-501. doi: 10.1248/yakushi.23-00154-4.ABSTRACTSignal-transducing adaptor protein-2 (STAP-2) is a unique scaffold protein that regulates several immunological signaling pathways, including LIF/LIF receptor and LPS/TLR4 signals. STAP-2 is required for Fas/FasL-dependent T cell apoptosis and SDF-1α-induced T cell migration. Conversely, STAP-2 modulates integrin-mediated T cell adhesion, suggesting that STAP-2 is essential for several negative and positive T cell functions. However, whether STAP-2 is involved in T cell-antigen receptor (TCR)-mediated T cell activation is unknown. STAP-2 deficie...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Jun-Ichi Kashiwakura Tadashi Matsuda Source Type: research
Frontiers of Physical Pharmaceutical Research by Young Scientists Making Breakthroughs (Symposium of Division of Physical Sciences)
Yakugaku Zasshi. 2024;144(5):503-504. doi: 10.1248/yakushi.23-00178-F.NO ABSTRACTPMID:38692924 | DOI:10.1248/yakushi.23-00178-F (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Hiroaki Kato Mikako Ogawa Source Type: research
Development of Transdermal Formulation Based on Nanotechnology and Elucidation of Its Drug Delivery Pathways
Yakugaku Zasshi. 2024;144(5):505-510. doi: 10.1248/yakushi.23-00178-1.ABSTRACTTransdermal drug delivery is a formulation in which the drug is absorbed through the skin for systemic action. Its advantages include avoidance of first-pass effects, sustained drug supply, and ease of administration and discontinuation. Drugs administered transdermally transfer into the blood circulation through the stratum corneum, epidermis, and dermis. The stratum corneum on the skin surface plays a barrier function in skin absorption. Therefore, developing of transdermal drug delivery systems requires innovations that overcome the barrier fu...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Hiroko Otake Noriaki Nagai Source Type: research
Atomic Force Microscopy to Measure the Mechanical Property of Nanosized Lipid Vesicles and Its Applications
Yakugaku Zasshi. 2024;144(5):511-519. doi: 10.1248/yakushi.23-00178-2.ABSTRACTNanoparticles, including liposomes and lipid nanoparticles, have garnered global attention due to their potential applications in pharmaceuticals, vaccines, and gene therapies. These particles enable targeted delivery of new drug modalities such as highly active small molecules and nucleic acids. However, for widespread use of nanoparticle-based formulations, it is crucial to comprehensively analyze their characteristics to ensure both efficacy and safety, as well as enable consistent production. In this context, this review focuses on our resear...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Yuki Takechi-Haraya Source Type: research
Analysis of the Divalent Cation Blocking in Ion Channels by Crystal Structure and Molecular Dynamics Simulations
In this study, we elucidated the molecular mechanism of the divalent cation block by reproducing the divalent cation block in NavAb. The X-ray crystal structure of divalent-cation-block mutants show electron density in the ion transmission pathway of the divalent cation blocked mutants, indicating that the mutations increasing the hydrophilicity of the inner vestibule of the pore domain enable a divalent cation to stack into the ion pathway. In molecular dynamics simulations, the stacked calcium ion repels the sodium ions near the channel lumen's entrance at the selective filter's bottom. These results suggest the primary ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Katsumasa Irie Source Type: research
Challenges Facing Middle Molecule Drug Discovery and How to Overcome Them
Yakugaku Zasshi. 2024;144(5):527-528. doi: 10.1248/yakushi.23-00191-F.NO ABSTRACTPMID:38692928 | DOI:10.1248/yakushi.23-00191-F (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Hiroyuki Miyachi Katsumi Maenaka Source Type: research
Japanese Diagnostic Criteria for Pediatric Familial Hypercholesterolemia 2022
J Atheroscler Thromb. 2024 May 2. doi: 10.5551/jat.ED259. Online ahead of print.NO ABSTRACTPMID:38692904 | DOI:10.5551/jat.ED259 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - May 1, 2024 Category: Cardiology Authors: Kazushige Dobashi Source Type: research
Color Stability of Bioactive Restorative Material vs Nanohybrid Resin Composite: An < em > In Vitro < /em > Study
CONCLUSION: The color of bioactive restorative material is less stable if compared with nanohybrid resin composite.CLINICAL SIGNIFICANCE: As tea and coffee are popular beverages, particularly in Middle Eastern nations, dentists must advise patients about the color change of resin restorations. Patients are advised to brush their teeth immediately after consuming these beverages. How to cite this article: Saber EH, Abielhassan MH, Abed YA, et al. Color Stability of Bioactive Restorative Material vs Nanohybrid Resin Composite: An In Vitro Study. J Contemp Dent Pract 2024;25(3):221-225.PMID:38690693 | DOI:10.5005/jp-journals-...
Source: J Contemp Dent Pract - May 1, 2024 Category: Dentistry Authors: Esraa H Saber Mohsen H Abielhassan Yasser A Abed Shereen E Fahim Source Type: research
A study on the reliability and validity of the Japanese version of the Scenario Test for people with chronic stroke-induced aphasia: A cross-sectional study
CONCLUSIONS & IMPLICATIONS: The reliability and validity of the Scenario Test-JP align with those of the original Dutch version and the UK and Greek versions. Additionally, the assessment can now include extended alternative communication methods, such as digital devices, indicating the potential of the Scenario Test-JP for modern Japanese speech-language therapy.WHAT THIS PAPER ADDS: What is already known on the subject Interactive communication is a facet of functional communication and is crucial for evaluating engagement and participation of people with aphasia (PWA) in speech-language therapy. The Scenario Test provid...
Source: International Journal of Language and Communication Disorders - May 1, 2024 Category: Speech-Language Pathology Authors: Yuhei Kodani Kazuki Sekine Yasuhiro Tanaka Shinsuke Nagami Katsuya Nakamura Shinya Fukunaga Hikaru Nakamura Source Type: research
A preliminary survey of rheumatologists on the management of late-onset rheumatoid arthritis in Japan
Conclusion This preliminary survey highlighted various rheumatologists' perspectives regarding the management of LORA.PMID:38692915 | DOI:10.2169/internalmedicine.3288-23 (Source: Internal Medicine)
Source: Internal Medicine - May 1, 2024 Category: Internal Medicine Authors: Satoshi Takanashi Yuko Kaneko Yutaka Kawahito Takashi Kida Takahiko Sugihara Toshihisa Kojima Ryozo Harada Michinori Ishitoku Shintaro Hirata Motomu Hashimoto Toshihiko Hidaka Asami Abe Hajime Ishikawa Hiromu Ito Mitsumasa Kishimoto Kazuo Matsui Toshihiro Source Type: research
Characteristics of Human Leukocyte Antigen Class II Genes in Japanese Patients with Type 1 Diabetes and Autoimmune Thyroid Disease
Tohoku J Exp Med. 2024 May 2. doi: 10.1620/tjem.2024.J027. Online ahead of print.NO ABSTRACTPMID:38692862 | DOI:10.1620/tjem.2024.J027 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - May 1, 2024 Category: Research Authors: Risa Kajita Haruna Takahashi Satoshi Yoshino Shunichi Matsumoto Kazuhiko Horiguchi Shuichi Okada Masanobu Yamada Eijiro Yamada Source Type: research
