Inference of selective forces on house mouse genomes during secondary contact in East Asia [RESEARCH]
The house mouse (Mus musculus), which is commensal to humans, has spread globally via human activities, leading to secondary contact between genetically divergent subspecies. This pattern of genetic admixture can provide insights into the selective forces at play in this well-studied model organism. Our analysis of 163 house mouse genomes, with a particular focus on East Asia, revealed substantial admixture between the subspecies castaneus and musculus, particularly in Japan and southern China. We revealed, despite the different level of autosomal admixture among regions, that all Y Chromosomes in the East Asian samples be...
Source: Genome Research - April 18, 2024 Category: Genetics & Stem Cells Authors: Fujiwara, K., Kubo, S., Endo, T., Takada, T., Shiroishi, T., Suzuki, H., Osada, N. Tags: RESEARCH Source Type: research
IJERPH, Vol. 21, Pages 499: Impacts of Working Hours, Wages, and Regular Employment Opportunity on Suicide Mortalities of Employed and Unemployed Individuals before and during the COVID-19 Pandemic in Japan
Okada
Standardized suicide mortality rates per 100,000 population (SMRs) in Japan consistently decreased from 2009–2019, but these decreasing trends were reversed to increase in 2020. To clarify the mechanisms of recent increasing suicide in Japan, temporal fluctuations of SMRs disaggregated by sex and employment status (employed and unemployed individuals) and labor indices such as working hours, wages, and regular employment opportunity index (REO) from January 2012 to June 2023 were analyzed using interrupted time-series analysis. Additionally, temporal causalities from labor indices to SMRs were analy...
Source: International Journal of Environmental Research and Public Health - April 18, 2024 Category: Environmental Health Authors: Ryusuke Matsumoto Eishi Motomura Motohiro Okada Tags: Article Source Type: research
Visual outcomes of intraocular inflammation after brolucizumab injection in Japanese patients with neovascular age-related macular degeneration
ConclusionsIOI occurred in 6.3% of nAMD patients after IVBr treatment. All of which showed significant improvement from logMAR of 0.43 to 0.30 with steroid treatment or without any treatment. We should consider the possibility of IOI after IVBr as a complication, however, they have a relatively good prognosis if treated at an early stage. (Source: PLoS One)
Source: PLoS One - April 18, 2024 Category: Biomedical Science Authors: Kazushi Hirono Source Type: research
Sensors, Vol. 24, Pages 2602: Hard- and Software Controlled Complex for Gas-Strain Monitoring of Transition Zones
in
Yatsuk
The article describes a hard- and software controlled complex for gas-strain monitoring, consisting of stationary laser strainmeters and a laser nanobarograph, a stationary gas analyzer, and a weather station installed at Shultz Cape in the Sea of Japan; and a mobile shipboard complex, consisting of a gas analyzer and a weather station installed in a scientific research vessel. In the course of trial methodological measurements on these systems, general patterns were identified in the dynamics of greenhouse gases and deformation of the Earth’s crust in the range of diurnal and semi-diurnal ti...
Source: Sensors - April 18, 2024 Category: Biotechnology Authors: Dolgikh Bovsun Dolgikh Stepochkin Chupin Yatsuk Tags: Article Source Type: research
Characterization of mutations in hepatitis B virus DNA isolated from Japanese HBsAg-positive blood donors in 2021 and 2022
In this study, we isolated hepatitis B virus (HBV) DNA from 58 of 169 hepatitis B surface antigen (HBsAg)-positive blood samples from Japanese blood donors and determined the nucleotide sequence encoding the small envelope protein. DNA from six (10%) of the samples had VEMs, but no missense mutations, such as G145R, were detected. Complete HBV genome sequences were obtained from 29 of the 58 samples; the viral genotype was A1 in one (3%), A2 in three (10%), B1 in nine (31%), B2 in five (17%), B4 in one (3%), and C2 in 10 (34%) samples. Tenofovir-resistance mutations were detected in two (7%) samples. In addition, several c...
Source: Archives of Virology - April 18, 2024 Category: Virology Source Type: research
Clinical outcomes of left upper segmentectomy vs. lobectomy for early non-small-cell lung cancer: a nationwide database study in Japan
ConclusionSegmentectomy may be an acceptable alternative to lobectomy with regard to the overall survival of patients with c-stage I NSCLC in the left upper lobe. (Source: Surgery Today)
Source: Surgery Today - April 18, 2024 Category: Surgery Source Type: research
Purification of central dialysis fluid delivery system for hemodialysis: practical training on the east kyushu medical valley project
ConclusionIn this study, we describe the purification of a dialysate delivery system with a focus on overseas healthcare specialists, including biomedical engineers, for simultaneous application to multiple patients receiving hemodialysis therapy. (Source: Health and Technology)
Source: Health and Technology - April 18, 2024 Category: Information Technology Source Type: research
Treatment courses and outcomes of oesophageal atresia in patients with trisomy 18: a case series of 271 patients from a nationwide database in Japan
Conclusion
This study provides information that will aid the clinical decision-making process for patients with oesophageal atresia and trisomy 18. Radical surgery may be a safe and feasible treatment option. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 18, 2024 Category: Perinatology & Neonatology Authors: Kutsukake, M., Konishi, T., Fujiogi, M., Takamoto, N., Morita, K., Yasuhisa, I., Hashimoto, Y., Matsui, H., Fushimi, K., Fujishiro, J., Yasunaga, H. Tags: Original research Source Type: research
Patient Journey of Generalized Pustular Psoriasis: A Real-world Study Using Data-mining Methods and Japanese Claims Data
Acta Derm Venereol. 2024 Apr 17;104:adv11946. doi: 10.2340/actadv.v104.11946.NO ABSTRACTPMID:38629892 | DOI:10.2340/actadv.v104.11946 (Source: Acta Derm Venereol A...)
Source: Acta Derm Venereol A... - April 17, 2024 Category: Dermatology Authors: Koremasa Hayama Yahui Tian Ryoko Iwasaki Hideki Fujita Source Type: research
A bibliometric analysis of the 100 most-cited clinical articles in the research of intracranial artery stenosis and intracranial atherosclerosis
CONCLUSION: The findings of this study provide novel insight into this field and will facilitate future research endeavors.PMID:38628533 | PMC:PMC11021113 | DOI:10.25259/SNI_1030_2023 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Yudai Hirano Satoru Miyawaki Yusuke Sakaguchi Satoshi Koizumi Hiroki Hongo Nobuhito Saito Source Type: research
Patient Journey of Generalized Pustular Psoriasis: A Real-world Study Using Data-mining Methods and Japanese Claims Data
Acta Derm Venereol. 2024 Apr 17;104:adv11946. doi: 10.2340/actadv.v104.11946.NO ABSTRACTPMID:38629892 | DOI:10.2340/actadv.v104.11946 (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - April 17, 2024 Category: Dermatology Authors: Koremasa Hayama Yahui Tian Ryoko Iwasaki Hideki Fujita Source Type: research
Genomic landscape and clinical features of advanced thyroid carcinoma: a national database study in Japan
CONCLUSION: Genetic abnormalities with treatment options were found in 62.7% of advanced thyroid carcinomas. TP53 abnormality was an independent poor prognostic factor for overall survival in differentiated thyroid carcinoma. The time to treatment failure for lenvatinib was not different based on genetic profile.PMID:38630010 | DOI:10.1210/clinem/dgae271 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Soji Toda Yukihiko Hiroshima Hiroyuki Iwasaki Katsuhiko Masudo Source Type: research
A Japanese multi-institutional phase II study of moderate hypofractionated intensity-modulated radiotherapy with image-guided technique for prostate cancer
CONCLUSION: The safety and efficacy of moderately hypofractionated IMRT with prostate-based image-guidance was confirmed among Japanese patients with prostate cancer.PMID:38630382 | DOI:10.1007/s10147-024-02517-z (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Katsumasa Nakamura Keiji Nihei Yoshihiro Saito Naoto Shikama Shin-Ei Noda Ryusuke Hara Toshiyuki Imagumbai Takashi Mizowaki Takeshi Akiba Etsuo Kunieda Masanori Someya Saiji Ohga Jiro Kawamori Takuyo Kozuka Yosuke Ota Koji Inaba Takeshi Kodaira Yoshiyuki Source Type: research
The association of long working hours and short sleep duration on mental health among Japanese physicians
Ind Health. 2024 Apr 16. doi: 10.2486/indhealth.2023-0174. Online ahead of print.ABSTRACTThis cross-sectional study investigate the association between long working hours, short sleep duration, and mental health among Japanese physicians. We enrolled 232 Japanese physicians. We used the Brief Job Stress Questionnaire to assess high-stress status, and the Japanese version of the Center for Epidemiologic Studies Depression scale to assess depressive status. Daily sleep duration (DSD) and weekly working hours (WWHs) were collected using a self-administered questionnaire. Multivariable-adjusted logistic regression analysis was...
Source: Industrial Health - April 17, 2024 Category: Occupational Health Authors: Yushi Matsuura Kiyohide Tomooka Hiroo Wada Setsuko Sato Motoki Endo Kenichiro Taneda Takeshi Tanigawa Source Type: research
Japanese Planocerid Flatworms: Difference in Composition of Tetrodotoxin and Its Analogs and the Effects of Ingestion by Toxin-Bearing Fishes in the Ryukyu Islands, Japan
Mar Biotechnol (NY). 2024 Apr 17. doi: 10.1007/s10126-024-10312-0. Online ahead of print.ABSTRACTTetrodotoxin (TTX), known as pufferfish toxin, is a potent neurotoxin blocking sodium channels in muscle and nerve tissues. TTX has been detected in various taxa other than pufferfish, including marine polyclad flatworms, suggesting that pufferfish toxin accumulates in fish bodies via food webs. The composition of TTX and its analogs in the flatworm Planocera multitentaculata was identical to those in wild grass puffer Takifugu alboplumbeus. Previously, Planocera sp. from Okinawa Island, Japan, were reported to possess high lev...
Source: Marine Biotechnology - April 17, 2024 Category: Biotechnology Authors: Hiroyuki Ueda Masaaki Ito Ryo Yonezawa Kentaro Hayashi Taiga Tomonou Maho Kashitani Hikaru Oyama Kyoko Shirai Rei Suo Kazutoshi Yoshitake Shigeharu Kinoshita Shuichi Asakawa Shiro Itoi Source Type: research
