Preoperative steroid for enhancing patients recovery after head and neck cancer surgery with free tissue transfer reconstruction: protocol for a phase III, placebo-controlled, randomised, double-blind study (J-SUPPORT 2022, PreSte-HN Study)
Introduction
There is no established methodology for the perioperative management of head and neck cancer surgery and free tissue transfer reconstruction (HNS-FTR). A single dose of corticosteroid administered immediately before surgery has been shown to reduce postoperative pain and nausea/vomiting after some types of surgery. However, the efficacy of this strategy has not been demonstrated in HNS-FTR, and the increased risk of infectious complications associated with its use cannot be ruled out. This phase III, placebo-controlled, randomised, double-blind, comparative, multicentre study seeks to determine if preoperative...
Source: BMJ Open - May 31, 2023 Category: General Medicine Authors: Shinozaki, T., Imai, T., Kobayashi, K., Yoshimoto, S., Zenda, S., Yamaguchi, T., Eguchi, K., Okano, T., Mashiko, T., Kurosaki, M., Miyaji, T., Matsuura, K. Tags: Open access, Surgery Source Type: research
Generic drug crisis in Japan and changes leading to the collapse of universal health insurance established in 1961: the case of Kobayashi Kako Co. Ltd.
(Source: Cost Effectiveness and Resource Allocation)
Source: Cost Effectiveness and Resource Allocation - May 31, 2023 Category: Health Management Authors: Makoto Kosaka, Akihiko Ozaki, Yudai Kaneda, Hiroaki Saito, Erika Yamashita, Anju Murayama, Hanano Mamada, Tetsuya Tanimoto and Mihajlo Jakovljevic Tags: Editorial Source Type: research
Novel HLA allele associations with susceptibility, staging, symptomatic state, autoimmune hepatitis and hepatocellular carcinoma events for primary biliary cholangitis in the Japanese population
In conclusion, we have extended the current knowledge of HLA allele associations to 3-field resolution and identified novel HLA allele associations with predisposition risk, staging, symptomatic state, and AIH and HCC events for Japanese PBC patients. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - May 31, 2023 Category: Allergy & Immunology Source Type: research
Ulcerative colitis successfully treated with vedolizumab in the presence of comorbid opportunistic infections: a case report
ConclusionsWe reported the first case of a patient with ulcerative colitis who was treated with vedolizumab and concomitant fluconazole for active cryptococcal pneumonia. Vedolizumab constitutes a high-potential treatment regimen owing to its safety in inflammatory bowel disease associated with opportunistic infections. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - May 31, 2023 Category: General Medicine Source Type: research
Denoising approach with deep learning-based reconstruction for neuromelanin-sensitive MRI: image quality and diagnostic performance
ConclusionImage quality for NEX1 + dDLR was comparable to that of NEX5. dDLR has the potential to reduce scan time of NM-MRI without degrading image quality. Both 1-NEX NM-MRI with and without dDLR showed high AUCs for diagnosing PD by CR. The results of visual assessment suggest advantages of dDLR. Further tuning of dDLR woul d be expected to provide clinical merits in diagnosing PD. (Source: Japanese Journal of Radiology)
Source: Japanese Journal of Radiology - May 31, 2023 Category: Radiology Source Type: research
IJERPH, Vol. 20, Pages 6015: The Impact of Generativity on Maintaining Higher-Level Functional Capacity of Older Adults: A Longitudinal Study in Japan
This study examined the longitudinal association between generativity and higher-level functional capacity (HLFC) decline in older Japanese adults. The two-year longitudinal data of 879 older adults aged 65–84 years were analyzed. Participants’ HLFC and generativity were assessed using the Tokyo Metropolitan Institute of Gerontology Index of Competence and the Revised Japanese version of the Generativity Scale, respectively. The binary logistic regression analysis results showed that a higher generativity score was negatively associated with HLFC decline, indicating that generativity effectively...
Source: International Journal of Environmental Research and Public Health - May 31, 2023 Category: Environmental Health Authors: Kumiko Nonaka Hiroshi Murayama Yoh Murayama Sachiko Murayama Masataka Kuraoka Yuta Nemoto Erika Kobayashi Yoshinori Fujiwara Tags: Article Source Type: research
Oncolytic herpes simplex viruses for the treatment of glioma and targeting glioblastoma stem-like cells
Glioblastoma (GBM) is one of the most lethal cancers, having a poor prognosis and a median survival of only about 15 months with standard treatment (surgery, radiation, and chemotherapy), which has not been significantly extended in decades. GBM demonstrates remarkable cellular heterogeneity, with glioblastoma stem-like cells (GSCs) at the apex. GSCs are a subpopulation of GBM cells that possess the ability to self-renew, differentiate, initiate tumor formation, and manipulate the tumor microenvironment (TME). GSCs are no longer considered a static population of cells with specific markers but are quite flexible phenotypic...
Source: Frontiers in cellular and infection microbiology - May 31, 2023 Category: Microbiology Source Type: research
1-year outcomes of patients implanted with the Perceval sutureless valve: the Japanese post-marketing surveillance study
AbstractSutureless offers an alternative to standard valves in surgical aortic valve replacement (SAVR). We sought to confirm the efficacy and safety of the Perceval sutureless valve in Japanese patients. Prospective observational study of 204 patients who underwent SAVR with Perceval at 19 sites in Japan between March and December 2019. The primary outcomes were 30-day mortality and postoperative complications; the secondary outcome was all-cause mortality at 1 year. Efficacy outcomes were changed in New York Heart Association (NYHA) class, pressure gradients, effective orifice area (EOA), EOA indexed to body surface area...
Source: Heart and Vessels - May 30, 2023 Category: Cardiology Source Type: research
Pharmacokinetics and effect of maslinic acid with physical exercise on grip strength and trunk muscle mass in healthy Japanese individuals
J Clin Biochem Nutr. 2023 May;72(3):270-277. doi: 10.3164/jcbn.23-5. Epub 2023 Mar 24.ABSTRACTAge-related changes in physical function are closely associated with daily activity impairment among the elderly. Continuous maslinic acid intake may improve skeletal muscle mass; however, the concentration-dependent benefits of maslinic acid for physical functionality remain unclear. Therefore, we evaluated the bioavailability of maslinic acid and examined the effect of maslinic acid intake on skeletal muscle and quality of life in the healthy Japanese elderly. Five healthy adult men were administered test diets containing 30, 60...
Source: Clinical Biochemistry - May 30, 2023 Category: Biochemistry Authors: Yuki Yamauchi Tetsu Kinoshita Satoshi Fukumitsu Kazuhiko Aida Koutatsu Maruyama Isao Saito Naofumi Yamamoto Source Type: research
Pharmacokinetics and effect of maslinic acid with physical exercise on grip strength and trunk muscle mass in healthy Japanese individuals
J Clin Biochem Nutr. 2023 May;72(3):270-277. doi: 10.3164/jcbn.23-5. Epub 2023 Mar 24.ABSTRACTAge-related changes in physical function are closely associated with daily activity impairment among the elderly. Continuous maslinic acid intake may improve skeletal muscle mass; however, the concentration-dependent benefits of maslinic acid for physical functionality remain unclear. Therefore, we evaluated the bioavailability of maslinic acid and examined the effect of maslinic acid intake on skeletal muscle and quality of life in the healthy Japanese elderly. Five healthy adult men were administered test diets containing 30, 60...
Source: Journal of Clinical Biochemistry and Nutrition - May 30, 2023 Category: Nutrition Authors: Yuki Yamauchi Tetsu Kinoshita Satoshi Fukumitsu Kazuhiko Aida Koutatsu Maruyama Isao Saito Naofumi Yamamoto Source Type: research
Sampling bag-based emission chamber for measuring volatile organic compounds from household materials using solid-phase extraction-type collection device
In this study, complete sampling mode was developed in addition to a conventional flow sampling mode. The extracted VOCs were then eluted with 8 mL of acetone and measured using gas chromatography-mass spectrometry. The proposed method does not require a stainless-steel chamber and a thermal desorption system; therefore, VOC emission from household materials could be easily evaluated with an affordable cost, suggesting that the method is suitable for the screening technique for evaluating VOC emission from solid materials.PMID:37254017 | DOI:10.1007/s44211-023-00375-9 (Source: Analytical Sciences : the international journa...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - May 30, 2023 Category: Chemistry Authors: Ikuo Ueta Eriko Kato Yoshihiro Saito Source Type: research
Tracking the behavior and characteristics of microplastics using a multi-analytical approach: a case study in two contrasting coastal areas of Japan
This study demonstrates a multidimensional analytical approach, including isotopic and thermogravimetric analyses to evaluate characteristics and behavior of MPs in the environment. The MP samples were collected in two contrasting coastal areas of Japan. The stable carbon isotope (δ13C) ratios of field-collected polyethylene (PE), polypropylene (PP), and polystyrene (PS) MPs ranged from -25.6‰ to -31.4‰, -23.4‰ to -30.9‰, and -27.3‰ to -28.6‰, respectively. The detected isotope signatures were similar to those of commercial products. In addition, the differences in δ13C signature were determined between MPs w...
Source: Environmental Science and Pollution Research International - May 30, 2023 Category: Environmental Health Authors: Batdulam Battulga Mariko Atarashi-Andoh Makoto Matsueda Jun Koarashi Source Type: research
Pharmacokinetics and effect of maslinic acid with physical exercise on grip strength and trunk muscle mass in healthy Japanese individuals
J Clin Biochem Nutr. 2023 May;72(3):270-277. doi: 10.3164/jcbn.23-5. Epub 2023 Mar 24.ABSTRACTAge-related changes in physical function are closely associated with daily activity impairment among the elderly. Continuous maslinic acid intake may improve skeletal muscle mass; however, the concentration-dependent benefits of maslinic acid for physical functionality remain unclear. Therefore, we evaluated the bioavailability of maslinic acid and examined the effect of maslinic acid intake on skeletal muscle and quality of life in the healthy Japanese elderly. Five healthy adult men were administered test diets containing 30, 60...
Source: Clinical Biochemistry - May 30, 2023 Category: Biochemistry Authors: Yuki Yamauchi Tetsu Kinoshita Satoshi Fukumitsu Kazuhiko Aida Koutatsu Maruyama Isao Saito Naofumi Yamamoto Source Type: research
Pediatric blood pressure category predicts longitudinal blood pressure change in adolescence and early adulthood
CONCLUSIONS: Pediatric BP category predicted BP values, but there was no factor that identified subpopulations with large BP increases in adolescence and early adulthood.IMPACT: Blood pressure category in the American Academy of Pediatrics clinical practice guideline at age 12-13 years predicted subsequent blood pressure values during adolescence and early adulthood. No baseline factor that identified a subpopulation with large increase in blood pressure during adolescence and early adulthood in clinical practice was found. Our study contributes to the existing literature by demonstrating the usefulness of the American Aca...
Source: Pediatric Research - May 30, 2023 Category: Pediatrics Authors: Tatsuhiko Azegami Keiko Uchida Yasunori Sato Ayano Murai-Takeda Mikako Inokuchi Hiroshi Itoh Masaaki Mori Source Type: research
