A phase 2, open-label study of ibrutinib plus rituximab in Japanese patients with Waldenstrom's macroglobulinemia
This study evaluated the efficacy and safety of ibrutinib-rituximab in Japanese patients with WM. Patients received ibrutinib 420 mg orally once daily plus weekly rituximab 375 mg/m2 IV (8 infusions total). The primary end point was major response rate (MRR; PR or better) by Independent Review Committee assessment. Secondary endpoints were progression-free survival (PFS), safety, pharmacokinetics, and biomarkers. Primary analysis was conducted in 16 patients [baseline, treatment naïve: 8 (50.0%); relapsed/refractory WM: 8 (50.0%)] who received ibrutinib-rituximab, after all patients completed Week 57 or end of treatment. ...
Source: International Journal of Hematology - April 10, 2024 Category: Hematology Authors: Koji Izutsu Hisashi Kato Naohiro Sekiguchi Tomoaki Fujisaki Toshiro Kawakita Naoshi Obara Kosei Matsue Mitsutaka Nishimoto Tomoyoshi Hatayama Mitsuo Inagaki Ei Fujikawa Source Type: research
A multidisciplinary collaborative diagnosis and rehabilitation program for dysphagia in general hospitals
This article summarizes common conditions causing dysphagia, clinical manifestations, complications, screening assessment, diagnosis, rehabilitation, and nutritional support related to dysphagia. It emphasizes the arrival at a multidisciplinary collaborative diagnosis and formulation of a rehabilitation management plan for dysphagia in general hospitals in order to provide strategic suggestions for establishing a multidisciplinary collaborative model for swallowing disorder management in general hospitals.PMID:38599879 | DOI:10.5582/bst.2024.01076 (Source: BioScience Trends)
Source: BioScience Trends - April 10, 2024 Category: Biomedical Science Authors: Dysphagia Research Team Juan Chen Lili Dai Min Guo Hui Huang Rongfen He Hui Jin Xin Jin Xiaoxiao Li Yumin Li Yonggang Liu Chao Wang Yukai Wang Li Wu Zhongcheng Xing Japan NCGM Cooperation Team Junko Fujitani Yasuo Sugiura Chihaya Hinohara Wei Tang Source Type: research
COVID-19 Vaccine Injury Compensation Program: Lessons Learned From a Review of 10 Implementing Countries
This article reviewed the Vaccine Injury Compensation Programs in 10 major countries to present implications for improving the Korean system. Expanding the scope of national accountability is essential to compensate for the consequences of adhering to national policies during public health crises. Therefore, valuable insight can be obtained from examining the systems in Germany, Japan, and Taiwan, which have implemented more relaxed criteria for determining causality in compensation cases; Thailand's system, which provides the mandatory payment of preliminary compensation for damage caused by vaccination; systems in German...
Source: Journal of Korean Medical Science - April 10, 2024 Category: Biomedical Science Authors: Cho Ryok Kang Young June Choe Seok-Jun Yoon Source Type: research
Control of pleural effusion with prednisolone in a patient with yellow nail syndrome: A case report
Exp Ther Med. 2024 Mar 22;27(5):224. doi: 10.3892/etm.2024.12512. eCollection 2024 May.ABSTRACTYellow nail syndrome (YNS) can induce bilateral exudative pleural effusion; however, to the best of our knowledge, no standard treatment for YNS has been established. The present study describes a patient with YNS for whom the pleural effusion was controlled by prednisolone. A 73-year-old man was referred to the University of Tsukuba Hospital (Ibaraki, Japan) complaining of shortness of breath, which was diagnosed as being due to bilateral pleural effusion. Based on the presence of yellowing and growth retardation of the toenails...
Source: Experimental and Therapeutic Medicine - April 10, 2024 Category: General Medicine Authors: Manato Taguchi Hironori Masuko Kai Kawashima Tetsuya Yamagishi Yuka Kitaoka Rie Shigemasa Kazufumi Yoshida Chikako Tsurushige Hiroaki Satoh Nobuyuki Hizawa Source Type: research
Efficacy of Cranial Orthosis for Plagiocephaly Based on 2D and 3D Evaluation
Conclusion Cranial orthosis treatment was effective in correcting deformational plagiocephaly in infants, as demonstrated by improvements in both 2D and 3D metrics. Patients with more severe initial deformities and those who underwent treatment at a younger age showed greater improvement.PMID:38596144 | PMC:PMC11001441 | DOI:10.1055/a-2222-1494 (Source: Archives of Plastic Surgery)
Source: Archives of Plastic Surgery - April 10, 2024 Category: Cosmetic Surgery Authors: Hiroki Kajita Ichiro Tanaka Hiroaki Komuro Shigeru Nishimaki Isao Kusakawa Koichiro Sakamoto Source Type: research
International Microsurgery Club and World Society for Reconstructive Microsurgery Webinar: Career Building in Microsurgery
Arch Plast Surg. 2024 Apr 8;51(2):258-261. doi: 10.1055/a-2229-3420. eCollection 2024 Mar.ABSTRACTCareer building can be challenging for young surgeons, especially when topics such as lifestyle, work-life balance and subspecialization arise. Suggestions and advice from senior colleagues is very valuable but many young surgeons do not have such opportunities or are limited to a few senior surgeons. The International Microsurgery Club (IMC), in collaboration with the World Society of Reconstructive Microsurgery, organized a combined webinar for this topic and invited world renowned microsurgery masters polled by the IMC memb...
Source: Archives of Plastic Surgery - April 10, 2024 Category: Cosmetic Surgery Authors: Joachim N Meuli Jung-Ju Huang Susana Heredero Wei F Chen Tommy Nj Chang Source Type: research
A Case of 17 α-hydroxylase/17,20-lyase Deficiency Diagnosed at 45 Years of Age with Hyperaldosteronism
Intern Med. 2024 Apr 9. doi: 10.2169/internalmedicine.3084-23. Online ahead of print.ABSTRACT17α-hydroxylase deficiency is a type of congenital adrenocortical hyperplasia that is typically diagnosed in childhood or adolescence. It manifests as hypertension with gonadal dysfunction as the primary symptom. We herein report 17α-hydroxylase/17,20-lyase deficiency (17OHD) diagnosed at the age of 45 years. The patient presented with hypertension, irregular menstruation, and hyperaldosteronism. The clinical manifestations of 17OHD vary based on the specific variant pattern of CYP17A1. In this case, the variant was c.157_159 TCC...
Source: Internal Medicine - April 10, 2024 Category: Internal Medicine Authors: Akira Ikeya Miho Yamashita Keisuke Kakizawa Yuto Kawauchi Akio Matsushita Yasuko Fujisawa Tsutomu Ogata Shigekazu Sasaki Source Type: research
Successful Gastrografin Vermifugation for Taenia saginata-associated Appendicitis
We report the case a Japanese man who had previously resided in Vietnam, who experienced appendicitis and the presence of segments in his stool. Gastrografin led to the expulsion of Taenia saginata, as confirmed by scolex identification. Remarkably, the appendicitis symptoms subsided after deworming. This case underscores the importance of considering cestode infections in the differential diagnosis of appendicitis, particularly for patients with relevant travel histories, and highlights the evolving challenges in global health and the significance of acquiring detailed patient histories.PMID:38599859 | DOI:10.2169/interna...
Source: Internal Medicine - April 10, 2024 Category: Internal Medicine Authors: Keigo Kobayashi Yasuhiro Umekawa Source Type: research
A phase 2, open-label study of ibrutinib plus rituximab in Japanese patients with Waldenstrom's macroglobulinemia
This study evaluated the efficacy and safety of ibrutinib-rituximab in Japanese patients with WM. Patients received ibrutinib 420 mg orally once daily plus weekly rituximab 375 mg/m2 IV (8 infusions total). The primary end point was major response rate (MRR; PR or better) by Independent Review Committee assessment. Secondary endpoints were progression-free survival (PFS), safety, pharmacokinetics, and biomarkers. Primary analysis was conducted in 16 patients [baseline, treatment naïve: 8 (50.0%); relapsed/refractory WM: 8 (50.0%)] who received ibrutinib-rituximab, after all patients completed Week 57 or end of treatment. ...
Source: International Journal of Hematology - April 10, 2024 Category: Hematology Authors: Koji Izutsu Hisashi Kato Naohiro Sekiguchi Tomoaki Fujisaki Toshiro Kawakita Naoshi Obara Kosei Matsue Mitsutaka Nishimoto Tomoyoshi Hatayama Mitsuo Inagaki Ei Fujikawa Source Type: research
Impact of Polypharmacy and Risk Factors for Exacerbation of Lower Urinary Tract Symptoms in Patients with Urological Conditions: A Retrospective Study in a Japanese Municipal Hospital
In conclusion, this study revealed that "polypharmacy" and "taking multiple anticholinergic medications" were risk factors for LUTS. Particularly, "polypharmacy" is associated with storage symptom exacerbation. Therefore, eliminating "polypharmacy" and "taking multiple anticholinergic medications" is expected to improve LUTS.PMID:38599882 | DOI:10.1248/bpb.b23-00762 (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - April 10, 2024 Category: Drugs & Pharmacology Authors: Shunsuke Yoshizawa Tomoya Tachi Yuta Takahashi Satoshi Aoyama Yoshihiro Noguchi Kazuhide Tanaka Masahiro Yasuda Takashi Mizui Hisao Komeda Tomoaki Yoshimura Hitomi Teramachi Source Type: research
Stage at diagnosis of colorectal cancer through diagnostic route: Who should be screened?
CONCLUSION: CRCs detected during hospital visits for comorbidities were diagnosed earlier, similar to cancer screening. CRC screening should be recommended, particularly for patients without periodical hospital visits for comorbidities.PMID:38596494 | PMC:PMC11000077 | DOI:10.3748/wjg.v30.i10.1368 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 10, 2024 Category: Gastroenterology Authors: Nobukazu Agatsuma Takahiro Utsumi Yoshitaka Nishikawa Takahiro Horimatsu Takeshi Seta Yukitaka Yamashita Yukari Tanaka Takahiro Inoue Yuki Nakanishi Takahiro Shimizu Mikako Ohno Akane Fukushima Takeo Nakayama Hiroshi Seno Source Type: research
Stage at diagnosis of colorectal cancer through diagnostic route: Who should be screened?
CONCLUSION: CRCs detected during hospital visits for comorbidities were diagnosed earlier, similar to cancer screening. CRC screening should be recommended, particularly for patients without periodical hospital visits for comorbidities.PMID:38596494 | PMC:PMC11000077 | DOI:10.3748/wjg.v30.i10.1368 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 10, 2024 Category: Gastroenterology Authors: Nobukazu Agatsuma Takahiro Utsumi Yoshitaka Nishikawa Takahiro Horimatsu Takeshi Seta Yukitaka Yamashita Yukari Tanaka Takahiro Inoue Yuki Nakanishi Takahiro Shimizu Mikako Ohno Akane Fukushima Takeo Nakayama Hiroshi Seno Source Type: research
COVID-19 Vaccine Injury Compensation Program: Lessons Learned From a Review of 10 Implementing Countries
This article reviewed the Vaccine Injury Compensation Programs in 10 major countries to present implications for improving the Korean system. Expanding the scope of national accountability is essential to compensate for the consequences of adhering to national policies during public health crises. Therefore, valuable insight can be obtained from examining the systems in Germany, Japan, and Taiwan, which have implemented more relaxed criteria for determining causality in compensation cases; Thailand's system, which provides the mandatory payment of preliminary compensation for damage caused by vaccination; systems in German...
Source: J Korean Med Sci - April 10, 2024 Category: General Medicine Authors: Cho Ryok Kang Young June Choe Seok-Jun Yoon Source Type: research
A single arm Phase I/II trial on the combination of carboplatin, nab-paclitaxel and avastin as first-line treatment for advanced non-squamous non-small cell lung cancer (TORG1424/OLCSG1402: CARNAVAL)
CONCLUSIONS: All adverse effects were manageable and none resulted in patient death. In conclusion, the nanoparticle albumin-bound paclitaxel + carboplatin + bevacizumab combination is favorable and well tolerated in Japanese patients as first-line treatment for advanced non-squamous non-small cell lung cancer.PMID:38594880 | DOI:10.1093/jjco/hyae044 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Naoyuki Nogami Toshio Kubo Akihiro Bessho Makoto Sakugawa Satoshi Ikeo Toshihide Yokoyama Nobuhiko Seki Ryosuke Ochiai Nobukazu Fujimoto Shuji Murakami Kyoichi Kaira Toshiyuki Harada Daizo Kishino Yuichi Takiguchi Tsuneo Shimokawa Katsuyuki Kiura Natsumi Source Type: research
Risk factors for recurrence in patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative early breast cancer in Japan: a systematic literature review and meta-analysis
CONCLUSIONS: Identified risk factors were consistent with the previous reports, and this study provides quantitative summary of risk factors for HR+/HER2- early breast cancer recurrence in Japan. (PROSPERO Registration ID, CRD42022338391.).PMID:38597173 | DOI:10.1080/03007995.2024.2332436 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 10, 2024 Category: Research Authors: Naoki Miyazaki Toshiki Iwasaki Hitomi Sakai Rurina Watanuki Yoshinori Tanizawa Zhihong Cai Tsutomu Kawaguchi Junji Tsurutani Kengo Nagashima Source Type: research
